IMP

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Homo sapiens

4 genes annotated in human

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negative regulation of rho gtpase activity

GO:0034259

Any process that stops or reduces the rate of activity of a GTPase of the Rho family.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of rho gtpase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of rho gtpase activity" (in gray)

Name	Description	Probability	Func Analog Organism
CALM1	calmodulin 1 (phosphorylase kinase, delta)	1.000
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.999
ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	0.998	Human
ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.997
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.976
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.965	Human
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.927
RALBP1	ralA binding protein 1	0.900
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.840
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.840	Human
GMFB	glia maturation factor, beta	0.700
BBS10	Bardet-Biedl syndrome 10	0.651
RIN1	Ras and Rab interactor 1	0.575
MAP2K1	mitogen-activated protein kinase kinase 1	0.545
RALGDS	ral guanine nucleotide dissociation stimulator	0.541
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.393
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.300
WNT5A	wingless-type MMTV integration site family, member 5A	0.268
PAWR	PRKC, apoptosis, WT1, regulator	0.213
SCYL2	SCY1-like 2 (S. cerevisiae)	0.199
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.188
PEBP4	phosphatidylethanolamine-binding protein 4	0.188
BAG1	BCL2-associated athanogene	0.181
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.175
RHEB	Ras homolog enriched in brain	0.153
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.153
STK4	serine/threonine kinase 4	0.133
RAP1A	RAP1A, member of RAS oncogene family	0.128
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.126
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.114
PEBP1	phosphatidylethanolamine binding protein 1	0.106
CLTB	clathrin, light chain B	0.102
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.101
WNT3A	wingless-type MMTV integration site family, member 3A	0.100
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.100
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.098
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.096
SOS1	son of sevenless homolog 1 (Drosophila)	0.094
ATP6V1C1	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1	0.089
ELF5	E74-like factor 5 (ets domain transcription factor)	0.084
NBN	nibrin	0.077
NDP	Norrie disease (pseudoglioma)	0.075
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.074
MYO10	myosin X	0.074
EXOC2	exocyst complex component 2	0.071
EHF	ets homologous factor	0.068
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.064
HIPK1	homeodomain interacting protein kinase 1	0.063
KIF5B	kinesin family member 5B	0.062
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.059	Human
GFPT1	glutamine--fructose-6-phosphate transaminase 1	0.059
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.058
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.057
SS18	synovial sarcoma translocation, chromosome 18	0.054
KCNE3	potassium voltage-gated channel, Isk-related family, member 3	0.054
CP110	CP110 protein	0.053
FKBP8	FK506 binding protein 8, 38kDa	0.053
IGSF21	immunoglobin superfamily, member 21	0.052
TMOD3	tropomodulin 3 (ubiquitous)	0.052
TSSC4	tumor suppressing subtransferable candidate 4	0.052
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.052
EXOC5	exocyst complex component 5	0.041
UBQLN1	ubiquilin 1	0.039
RALGAPB	Ral GTPase activating protein, beta subunit (non-catalytic)	0.039
TSPAN4	tetraspanin 4	0.038
CLIC4	chloride intracellular channel 4	0.038
CDV3	CDV3 homolog (mouse)	0.038
EMP3	epithelial membrane protein 3	0.037
AZIN1	antizyme inhibitor 1	0.037
DGKZ	diacylglycerol kinase, zeta	0.036
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.035
GOLT1B	golgi transport 1B	0.035
CD151	CD151 molecule (Raph blood group)	0.034
BZW1	basic leucine zipper and W2 domains 1	0.034
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.032
ATP13A3	ATPase type 13A3	0.030
S100A11	S100 calcium binding protein A11	0.030
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.030
CORO1C	coronin, actin binding protein, 1C	0.029
GCLM	glutamate-cysteine ligase, modifier subunit	0.029
ARF6	ADP-ribosylation factor 6	0.029
AP1G1	adaptor-related protein complex 1, gamma 1 subunit	0.029
SMAD1	SMAD family member 1	0.028
CDK17	cyclin-dependent kinase 17	0.028
ABI1	abl-interactor 1	0.027
FMNL1	formin-like 1	0.027
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.027
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.027
STK3	serine/threonine kinase 3	0.026
PSEN2	presenilin 2 (Alzheimer disease 4)	0.026
SMAD4	SMAD family member 4	0.025
MAPK1	mitogen-activated protein kinase 1	0.025
GABPB1	GA binding protein transcription factor, beta subunit 1	0.025
KIF21A	kinesin family member 21A	0.025
MFN1	mitofusin 1	0.024
PTK2	PTK2 protein tyrosine kinase 2	0.023
PDCD7	programmed cell death 7	0.023
SFRP1	secreted frizzled-related protein 1	0.023
PKN2	protein kinase N2	0.023
HOXB7	homeobox B7	0.022
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.022
NUS1	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	0.022
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.022
TMC6	transmembrane channel-like 6	0.022
PICALM	phosphatidylinositol binding clathrin assembly protein	0.022
PYCARD	PYD and CARD domain containing	0.021
MXRA5	matrix-remodelling associated 5	0.021
CCDC6	coiled-coil domain containing 6	0.021
LGALS1	lectin, galactoside-binding, soluble, 1	0.021
SRI	sorcin	0.020
PLCE1	phospholipase C, epsilon 1	0.020
EGLN1	egl nine homolog 1 (C. elegans)	0.020
DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)	0.019
GNA13	guanine nucleotide binding protein (G protein), alpha 13	0.019
RAB2A	RAB2A, member RAS oncogene family	0.019
UBA6	ubiquitin-like modifier activating enzyme 6	0.019
IQGAP1	IQ motif containing GTPase activating protein 1	0.019
PRKCI	protein kinase C, iota	0.019
AGFG1	ArfGAP with FG repeats 1	0.018
SMAD7	SMAD family member 7	0.018
RGS2	regulator of G-protein signaling 2, 24kDa	0.017
SLC38A2	solute carrier family 38, member 2	0.017
SIPA1	signal-induced proliferation-associated 1	0.016
FOXF2	forkhead box F2	0.016
PLOD1	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	0.016
RAB10	RAB10, member RAS oncogene family	0.016
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.016
TAX1BP3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.016
ZNF217	zinc finger protein 217	0.016
GPBP1L1	GC-rich promoter binding protein 1-like 1	0.015
MFAP5	microfibrillar associated protein 5	0.015
IGFBP6	insulin-like growth factor binding protein 6	0.015
ARPP19	cAMP-regulated phosphoprotein, 19kDa	0.015
STIM2	stromal interaction molecule 2	0.015
FAM3C	family with sequence similarity 3, member C	0.015
LMAN1	lectin, mannose-binding, 1	0.014
APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.014
FZD6	frizzled homolog 6 (Drosophila)	0.014	Human
PKM2	pyruvate kinase, muscle	0.014
LRP6	low density lipoprotein receptor-related protein 6	0.014
DEF6	differentially expressed in FDCP 6 homolog (mouse)	0.014
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.014
SELM	selenoprotein M	0.014
KIAA0494	KIAA0494	0.014
OGN	osteoglycin	0.014
TCIRG1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	0.014
PVRL3	poliovirus receptor-related 3	0.014
MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1	0.014
ACY3	aspartoacylase (aminocyclase) 3	0.014
PLXDC1	plexin domain containing 1	0.014
TPD52	tumor protein D52	0.014
KCTD12	potassium channel tetramerisation domain containing 12	0.014
CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta	0.014
PDE4DIP	phosphodiesterase 4D interacting protein	0.014
OMD	osteomodulin	0.013
AGPS	alkylglycerone phosphate synthase	0.013
GLT8D2	glycosyltransferase 8 domain containing 2	0.013
PHF20L1	PHD finger protein 20-like 1	0.013
KCNE4	potassium voltage-gated channel, Isk-related family, member 4	0.013
TWF1	twinfilin, actin-binding protein, homolog 1 (Drosophila)	0.013
GPC4	glypican 4	0.013
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.013
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.013
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.013
B3GNT2	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	0.013
LMO2	LIM domain only 2 (rhombotin-like 1)	0.013
DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	0.013
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.012
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.012
PEA15	phosphoprotein enriched in astrocytes 15	0.012
MTMR2	myotubularin related protein 2	0.012
SGPP1	sphingosine-1-phosphate phosphatase 1	0.012
CAPG	capping protein (actin filament), gelsolin-like	0.012
NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	0.012	Human
PERP	PERP, TP53 apoptosis effector	0.012
GPR124	G protein-coupled receptor 124	0.012
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.012
RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	0.012
KRT18	keratin 18	0.012
GP6	glycoprotein VI (platelet)	0.012
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.012
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.012
FZD7	frizzled homolog 7 (Drosophila)	0.012	Human
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.012
VKORC1	vitamin K epoxide reductase complex, subunit 1	0.011
DNAJC13	DnaJ (Hsp40) homolog, subfamily C, member 13	0.011
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.011
RAP2C	RAP2C, member of RAS oncogene family	0.011
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.011
LRRC17	leucine rich repeat containing 17	0.011
EPHB3	EPH receptor B3	0.011
XIAP	X-linked inhibitor of apoptosis	0.011
ITIH5	inter-alpha (globulin) inhibitor H5	0.011
BMP4	bone morphogenetic protein 4	0.011
PRPF40A	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	0.011
NAPG	N-ethylmaleimide-sensitive factor attachment protein, gamma	0.011
CD2AP	CD2-associated protein	0.011
CD99	CD99 molecule	0.011
CHMP1A	chromatin modifying protein 1A	0.011
ASPN	asporin	0.011
FZD1	frizzled homolog 1 (Drosophila)	0.011	Human
DSG2	desmoglein 2	0.011
CAV2	caveolin 2	0.011
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.011
CAV1	caveolin 1, caveolae protein, 22kDa	0.011
JOSD1	Josephin domain containing 1	0.011
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.010
SNAPC1	small nuclear RNA activating complex, polypeptide 1, 43kDa	0.010
PARVA	parvin, alpha	0.010
ARL5B	ADP-ribosylation factor-like 5B	0.010
OSBP	oxysterol binding protein	0.010
GAS2L1	growth arrest-specific 2 like 1	0.010
ARHGAP4	Rho GTPase activating protein 4	0.010
PENK	proenkephalin	0.010
PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	0.010
SOX9	SRY (sex determining region Y)-box 9	0.010
RAP1B	RAP1B, member of RAS oncogene family	0.010
CCNYL1	cyclin Y-like 1	0.010
FHL1	four and a half LIM domains 1	0.010
RB1CC1	RB1-inducible coiled-coil 1	0.010
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.010
PRKCDBP	protein kinase C, delta binding protein	0.010
C17orf62	chromosome 17 open reading frame 62	0.010
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.010
MAST3	microtubule associated serine/threonine kinase 3	0.010
HUS1	HUS1 checkpoint homolog (S. pombe)	0.010
FZD8	frizzled homolog 8 (Drosophila)	0.010	Human