IMP

Process View

Homo sapiens

4 genes annotated in human

dendritic spine organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dendritic spine organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dendritic spine organization" (in gray)

Name	Description	Probability	Func Analog Organism
ACTG1	actin, gamma 1	0.375
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.234
ACTB	actin, beta	0.211
FHL2	four and a half LIM domains 2	0.183
USPL1	ubiquitin specific peptidase like 1	0.139
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.137
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.116
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.089
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.067
HP	haptoglobin	0.063
WBP11	WW domain binding protein 11	0.056
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.052
PELP1	proline, glutamate and leucine rich protein 1	0.047
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.043
WASL	Wiskott-Aldrich syndrome-like	0.037
APOC1	apolipoprotein C-I	0.036
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.036
CFL2	cofilin 2 (muscle)	0.036	Human
SNX9	sorting nexin 9	0.035
BCAR1	breast cancer anti-estrogen resistance 1	0.035
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.034
RIN1	Ras and Rab interactor 1	0.031
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.028
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.028
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.026
GRB7	growth factor receptor-bound protein 7	0.026
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.026
ITGB4	integrin, beta 4	0.025
PRKCG	protein kinase C, gamma	0.024
UBA2	ubiquitin-like modifier activating enzyme 2	0.024
APOC3	apolipoprotein C-III	0.024
ANAPC7	anaphase promoting complex subunit 7	0.024
CYTH2	cytohesin 2	0.024
SPRR2A	small proline-rich protein 2A	0.023
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.023
SENP1	SUMO1/sentrin specific peptidase 1	0.023	Fly
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.023
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.023
IQGAP1	IQ motif containing GTPase activating protein 1	0.022
TEX10	testis expressed 10	0.022
CABLES1	Cdk5 and Abl enzyme substrate 1	0.022
LCAT	lecithin-cholesterol acyltransferase	0.020
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.020
TMSB4X	thymosin beta 4, X-linked	0.019
PRLHR	prolactin releasing hormone receptor	0.019
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.019
RANGAP1	Ran GTPase activating protein 1	0.019
APOA2	apolipoprotein A-II	0.019
ANAPC4	anaphase promoting complex subunit 4	0.018
LRP6	low density lipoprotein receptor-related protein 6	0.018
BAI2	brain-specific angiogenesis inhibitor 2	0.018
ACCN2	amiloride-sensitive cation channel 2, neuronal	0.018
ITSN1	intersectin 1 (SH3 domain protein)	0.018
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.018
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.017
ALAS1	aminolevulinate, delta-, synthase 1	0.017
PIAS4	protein inhibitor of activated STAT, 4	0.017
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.017
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.016
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.016
LRP5	low density lipoprotein receptor-related protein 5	0.016
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.016
TNK2	tyrosine kinase, non-receptor, 2	0.016
C4orf14	chromosome 4 open reading frame 14	0.016
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.016
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.016
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.015
PFDN1	prefoldin subunit 1	0.015
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.015
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.014
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.014
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.014
APOE	apolipoprotein E	0.014
WIPF1	WAS/WASL interacting protein family, member 1	0.014
ADRB2	adrenergic, beta-2-, receptor, surface	0.014
DLG2	discs, large homolog 2 (Drosophila)	0.014
ALB	albumin	0.014
CAV2	caveolin 2	0.013
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.013
MAP2K6	mitogen-activated protein kinase kinase 6	0.013
PALLD	palladin, cytoskeletal associated protein	0.013
PCBP1	poly(rC) binding protein 1	0.013
BAIAP2	BAI1-associated protein 2	0.013
FIBP	fibroblast growth factor (acidic) intracellular binding protein	0.013
CAV1	caveolin 1, caveolae protein, 22kDa	0.013
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.012
SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)	0.012	Fly
ANAPC5	anaphase promoting complex subunit 5	0.012
HSF2	heat shock transcription factor 2	0.012
FHL3	four and a half LIM domains 3	0.012
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.012
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.012
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.012
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.012
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.012
NLGN1	neuroligin 1	0.012
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.012
MAP1B	microtubule-associated protein 1B	0.012
RAB5B	RAB5B, member RAS oncogene family	0.012
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	0.012
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.012
BAI1	brain-specific angiogenesis inhibitor 1	0.012
AAMP	angio-associated, migratory cell protein	0.012
C7orf25	chromosome 7 open reading frame 25	0.012
LAS1L	LAS1-like (S. cerevisiae)	0.011
HIPK2	homeodomain interacting protein kinase 2	0.011
CPSF6	cleavage and polyadenylation specific factor 6, 68kDa	0.011
TTR	transthyretin	0.011
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.011
ANAPC1	anaphase promoting complex subunit 1	0.011
AP1B1	adaptor-related protein complex 1, beta 1 subunit	0.011
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.011
TRIP10	thyroid hormone receptor interactor 10	0.011
C7orf64	chromosome 7 open reading frame 64	0.011
ARFGAP1	ADP-ribosylation factor GTPase activating protein 1	0.011
USP11	ubiquitin specific peptidase 11	0.011
BMI1	BMI1 polycomb ring finger oncogene	0.011
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	0.011
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.011
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.011
MDN1	MDN1, midasin homolog (yeast)	0.011
AATK	apoptosis-associated tyrosine kinase	0.011
C8orf33	chromosome 8 open reading frame 33	0.010
TJP1	tight junction protein 1 (zona occludens 1)	0.010
TBC1D10A	TBC1 domain family, member 10A	0.010
NRXN1	neurexin 1	0.010
USP10	ubiquitin specific peptidase 10	0.010
PRDX2	peroxiredoxin 2	0.010
CHGB	chromogranin B (secretogranin 1)	0.010
ZNF235	zinc finger protein 235	0.010
MTSS1	metastasis suppressor 1	0.010