IMP

Process View

Homo sapiens

16 genes annotated in human

positive regulation of tyrosine phosphorylation of stat3 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of tyrosine phosphorylation of stat3 protein"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of tyrosine phosphorylation of stat3 protein" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	1.000
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.999
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.999
FGF1	fibroblast growth factor 1 (acidic)	0.998
SOCS3	suppressor of cytokine signaling 3	0.998
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.994	Human
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.979
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.966
CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	0.961	Human
VEGFA	vascular endothelial growth factor A	0.947
LAT	linker for activation of T cells	0.943
FGFR1	fibroblast growth factor receptor 1	0.924	Human
IL6R	interleukin 6 receptor	0.899
GAB1	GRB2-associated binding protein 1	0.898
JAK1	Janus kinase 1	0.872
GH1	growth hormone 1	0.870
IL6	interleukin 6 (interferon, beta 2)	0.841
HDAC2	histone deacetylase 2	0.839
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.831
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.830
IL23A	interleukin 23, alpha subunit p19	0.800
JAK2	Janus kinase 2	0.733	Mouse
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.718
PLCG1	phospholipase C, gamma 1	0.696
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.610
CSH2	chorionic somatomammotropin hormone 2	0.595	Human
NRP1	neuropilin 1	0.593
SOS1	son of sevenless homolog 1 (Drosophila)	0.545
BCAR1	breast cancer anti-estrogen resistance 1	0.465
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.422	Human
FRS2	fibroblast growth factor receptor substrate 2	0.406
IGF1R	insulin-like growth factor 1 receptor	0.402
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.397	Human
FGFR2	fibroblast growth factor receptor 2	0.382	Human
SOCS1	suppressor of cytokine signaling 1	0.382
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.358
CAV1	caveolin 1, caveolae protein, 22kDa	0.348
STAT1	signal transducer and activator of transcription 1, 91kDa	0.326
INSR	insulin receptor	0.326
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.311
CSHL1	chorionic somatomammotropin hormone-like 1	0.305	Human
GHR	growth hormone receptor	0.272
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.233
GH2	growth hormone 2	0.227	Human
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.208
PDGFA	platelet-derived growth factor alpha polypeptide	0.202
PTPRB	protein tyrosine phosphatase, receptor type, B	0.162
IRS1	insulin receptor substrate 1	0.159
GAB2	GRB2-associated binding protein 2	0.137
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.131
STAT4	signal transducer and activator of transcription 4	0.125
FGF2	fibroblast growth factor 2 (basic)	0.124
PGF	placental growth factor	0.124
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.119
FGF10	fibroblast growth factor 10	0.113
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.102	Human
FGF7	fibroblast growth factor 7	0.095
CDH5	cadherin 5, type 2 (vascular endothelium)	0.094
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.094
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.087
GRB2	growth factor receptor-bound protein 2	0.079
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.076
CD33	CD33 molecule	0.068
CXCL2	chemokine (C-X-C motif) ligand 2	0.068
CNTF	ciliary neurotrophic factor	0.063
LIFR	leukemia inhibitory factor receptor alpha	0.062	Human
PDGFC	platelet derived growth factor C	0.060
BBS10	Bardet-Biedl syndrome 10	0.056
SYK	spleen tyrosine kinase	0.052
JAK3	Janus kinase 3	0.051
KITLG	KIT ligand	0.050
IFNGR1	interferon gamma receptor 1	0.049
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.047
SLA	Src-like-adaptor	0.045
KRT8	keratin 8	0.043
CMIP	c-Maf-inducing protein	0.039
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.038
CD28	CD28 molecule	0.037
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.036
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.035
EPOR	erythropoietin receptor	0.031
OSMR	oncostatin M receptor	0.031	Human
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.030
EXT1	exostosin 1	0.030
LDLR	low density lipoprotein receptor	0.030
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.030
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.028
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.028
CDK9	cyclin-dependent kinase 9	0.027
IL8	interleukin 8	0.027
ICAM1	intercellular adhesion molecule 1	0.027
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.027
STC1	stanniocalcin 1	0.026
OSM	oncostatin M	0.026
AXL	AXL receptor tyrosine kinase	0.025
CSNK1E	casein kinase 1, epsilon	0.024
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.024
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.024
IL10	interleukin 10	0.024
GFPT2	glutamine-fructose-6-phosphate transaminase 2	0.023
STAT2	signal transducer and activator of transcription 2, 113kDa	0.023
ICA1	islet cell autoantigen 1, 69kDa	0.023
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.023
FGFR3	fibroblast growth factor receptor 3	0.020
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.020
CXCL3	chemokine (C-X-C motif) ligand 3	0.020
PIK3CD	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.019
SNAI1	snail homolog 1 (Drosophila)	0.018
GRB7	growth factor receptor-bound protein 7	0.018
IL12RB2	interleukin 12 receptor, beta 2	0.017	Human
HDAC3	histone deacetylase 3	0.017
MAP1S	microtubule-associated protein 1S	0.017
SH2B1	SH2B adaptor protein 1	0.017
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.017
VHL	von Hippel-Lindau tumor suppressor	0.016
CSF1	colony stimulating factor 1 (macrophage)	0.016
IFNA16	interferon, alpha 16	0.016	Human
CCL20	chemokine (C-C motif) ligand 20	0.016
IL1B	interleukin 1, beta	0.015
VEGFC	vascular endothelial growth factor C	0.014
MPZL1	myelin protein zero-like 1	0.014
IL1R1	interleukin 1 receptor, type I	0.013
FOSL1	FOS-like antigen 1	0.013
GYPB	glycophorin B (MNS blood group)	0.013
CCL2	chemokine (C-C motif) ligand 2	0.013
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.012
KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	0.012
CCL7	chemokine (C-C motif) ligand 7	0.012
TLR3	toll-like receptor 3	0.012
RBBP7	retinoblastoma binding protein 7	0.012
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.011
IFNA10	interferon, alpha 10	0.011	Human
IFNA4	interferon, alpha 4	0.011
KAT2B	K(lysine) acetyltransferase 2B	0.011
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.011
AKAP2	A kinase (PRKA) anchor protein 2	0.011
HRH1	histamine receptor H1	0.010