IMP

Process View

Homo sapiens

9 genes annotated in human

embryonic appendage morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "embryonic appendage morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "embryonic appendage morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC1	histone deacetylase 1	0.947	Mouse
PSEN1	presenilin 1	0.667	Mouse
HDAC2	histone deacetylase 2	0.648	Mouse
JAG1	jagged 1	0.563
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.449	Mouse
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.438
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.409
MEIS1	Meis homeobox 1	0.278
BMP2	bone morphogenetic protein 2	0.270
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.231
SMAD3	SMAD family member 3	0.195
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.172
SETD8	SET domain containing (lysine methyltransferase) 8	0.172
SOX2	SRY (sex determining region Y)-box 2	0.140
ARRB1	arrestin, beta 1	0.120
MSX2	msh homeobox 2	0.119	Human Mouse
TJP1	tight junction protein 1 (zona occludens 1)	0.112
HOXD9	homeobox D9	0.105	Mouse
PML	promyelocytic leukemia	0.101
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.099
HOXA11	homeobox A11	0.089	Mouse
MSX1	msh homeobox 1	0.088
BMP7	bone morphogenetic protein 7	0.085	Mouse
GATA4	GATA binding protein 4	0.080
HOXD13	homeobox D13	0.077	Mouse
SMAD4	SMAD family member 4	0.069
CHD8	chromodomain helicase DNA binding protein 8	0.069
HOXA10	homeobox A10	0.060
COL2A1	collagen, type II, alpha 1	0.060
BAX	BCL2-associated X protein	0.057	Mouse
YY1	YY1 transcription factor	0.056
MEIS2	Meis homeobox 2	0.054
BAK1	BCL2-antagonist/killer 1	0.046
BCL2L1	BCL2-like 1	0.045
FOXF2	forkhead box F2	0.045
PRRX2	paired related homeobox 2	0.043	Mouse
AR	androgen receptor	0.043
NCOR1	nuclear receptor corepressor 1	0.040
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.039
TRIP6	thyroid hormone receptor interactor 6	0.039
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.039
DLX5	distal-less homeobox 5	0.039	Mouse
HOXD10	homeobox D10	0.039	Mouse
GSK3B	glycogen synthase kinase 3 beta	0.038
BCL2	B-cell CLL/lymphoma 2	0.038
HOXC8	homeobox C8	0.037	Zebrafish
HOXD11	homeobox D11	0.037	Mouse
BMPR1B	bone morphogenetic protein receptor, type IB	0.037
ELL2	elongation factor, RNA polymerase II, 2	0.036
RUNX1	runt-related transcription factor 1	0.036
BAD	BCL2-associated agonist of cell death	0.036
FGF18	fibroblast growth factor 18	0.035
BARX1	BARX homeobox 1	0.035
HOXC11	homeobox C11	0.034	Mouse
TERF2	telomeric repeat binding factor 2	0.034
HUWE1	HECT, UBA and WWE domain containing 1	0.034
LRP6	low density lipoprotein receptor-related protein 6	0.034	Mouse
PSEN2	presenilin 2 (Alzheimer disease 4)	0.034	Mouse
CDX2	caudal type homeobox 2	0.032
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.032
ACAN	aggrecan	0.032
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.031
NGFR	nerve growth factor receptor	0.030
SKIL	SKI-like oncogene	0.030
DAXX	death-domain associated protein	0.030
DLX4	distal-less homeobox 4	0.028
FOXC1	forkhead box C1	0.028
FGF3	fibroblast growth factor 3	0.028
AFF1	AF4/FMR2 family, member 1	0.028
HIPK2	homeodomain interacting protein kinase 2	0.027
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.027	Mouse
HOXC6	homeobox C6	0.027
RBBP4	retinoblastoma binding protein 4	0.026
HOXC13	homeobox C13	0.025
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.025
WNT1	wingless-type MMTV integration site family, member 1	0.025	Human
NOG	noggin	0.025
MED13	mediator complex subunit 13	0.024
PAX3	paired box 3	0.024
ERBB2IP	erbb2 interacting protein	0.024
TBX1	T-box 1	0.024	Human
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.024
SMAD6	SMAD family member 6	0.024
CREBBP	CREB binding protein	0.024
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.023
HES2	hairy and enhancer of split 2 (Drosophila)	0.023
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.022
NOTCH3	notch 3	0.022
FLNB	filamin B, beta	0.021
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.021
WNT11	wingless-type MMTV integration site family, member 11	0.021	Human
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.020
PDX1	pancreatic and duodenal homeobox 1	0.020
SIX2	SIX homeobox 2	0.020
SMAD1	SMAD family member 1	0.019
NKX3-2	NK3 homeobox 2	0.019
ZFYVE9	zinc finger, FYVE domain containing 9	0.019
NCSTN	nicastrin	0.019
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.019
TP53	tumor protein p53	0.019
BTRC	beta-transducin repeat containing	0.018
PKP4	plakophilin 4	0.018
OTP	orthopedia homeobox	0.017
FOXD3	forkhead box D3	0.017
MED13L	mediator complex subunit 13-like	0.017
RARG	retinoic acid receptor, gamma	0.017	Mouse
HOXC10	homeobox C10	0.017	Mouse
FGF2	fibroblast growth factor 2 (basic)	0.017
HOXB13	homeobox B13	0.017
TBX2	T-box 2	0.017
SP1	Sp1 transcription factor	0.017
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.016
SATB2	SATB homeobox 2	0.016
HMGA2	high mobility group AT-hook 2	0.016
LBX1	ladybird homeobox 1	0.016
PAX7	paired box 7	0.016
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.016
APC	adenomatous polyposis coli	0.016
SIM2	single-minded homolog 2 (Drosophila)	0.015
TNRC6C	trinucleotide repeat containing 6C	0.015
GAS1	growth arrest-specific 1	0.015	Mouse
WNT3A	wingless-type MMTV integration site family, member 3A	0.015
RYBP	RING1 and YY1 binding protein	0.015
PAX2	paired box 2	0.015
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.015
EN1	engrailed homeobox 1	0.015	Mouse
NOV	nephroblastoma overexpressed gene	0.015
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.015
CCNT1	cyclin T1	0.014
CDK8	cyclin-dependent kinase 8	0.014
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.014
HNF1B	HNF1 homeobox B	0.014
HOXD12	homeobox D12	0.014	Mouse
HOXC5	homeobox C5	0.014
HIC1	hypermethylated in cancer 1	0.013
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.013
MAML1	mastermind-like 1 (Drosophila)	0.013
SORBS3	sorbin and SH3 domain containing 3	0.013
CABLES1	Cdk5 and Abl enzyme substrate 1	0.013
SHOX2	short stature homeobox 2	0.013	Mouse
NPAS1	neuronal PAS domain protein 1	0.013
TBX5	T-box 5	0.013
PKNOX1	PBX/knotted 1 homeobox 1	0.013
GATA5	GATA binding protein 5	0.013
MED10	mediator complex subunit 10	0.013
TLX1	T-cell leukemia homeobox 1	0.013
FZD1	frizzled homolog 1 (Drosophila)	0.013
HOXD3	homeobox D3	0.012
FGF8	fibroblast growth factor 8 (androgen-induced)	0.012
PBRM1	polybromo 1	0.012
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.012
JAG2	jagged 2	0.012
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.012
PIAS1	protein inhibitor of activated STAT, 1	0.012
GLIS2	GLIS family zinc finger 2	0.012
TCF4	transcription factor 4	0.012
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.012
SFRP4	secreted frizzled-related protein 4	0.012
SIX6	SIX homeobox 6	0.012
FOXF1	forkhead box F1	0.011
CRLF1	cytokine receptor-like factor 1	0.011
HOXA6	homeobox A6	0.011
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.011
FOXL1	forkhead box L1	0.011
TWIST2	twist homolog 2 (Drosophila)	0.011
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.011
NKX6-1	NK6 homeobox 1	0.011
DLX2	distal-less homeobox 2	0.011
HOXB8	homeobox B8	0.011
RUNX2	runt-related transcription factor 2	0.011	Mouse
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.011
TERT	telomerase reverse transcriptase	0.011
COL6A1	collagen, type VI, alpha 1	0.011
HOXA3	homeobox A3	0.011
SFRP5	secreted frizzled-related protein 5	0.010
SFRP1	secreted frizzled-related protein 1	0.010
WNT3	wingless-type MMTV integration site family, member 3	0.010	Human
ENTPD2	ectonucleoside triphosphate diphosphohydrolase 2	0.010
FZD10	frizzled homolog 10 (Drosophila)	0.010
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.010
DIO3	deiodinase, iodothyronine, type III	0.010
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.010	Mouse
ARID1A	AT rich interactive domain 1A (SWI-like)	0.010
MYOD1	myogenic differentiation 1	0.010
BMP4	bone morphogenetic protein 4	0.010	Zebrafish Mouse