IMP

Process View

Homo sapiens

3 genes annotated in human

positive regulation of fibroblast migration

Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of fibroblast migration"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of fibroblast migration" (in gray)

Name	Description	Probability	Func Analog Organism
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.991
ENG	endoglin	0.988
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.985
TGFB1	transforming growth factor, beta 1	0.982
TGFB3	transforming growth factor, beta 3	0.968
THBS1	thrombospondin 1	0.928
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.895
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.875
S100B	S100 calcium binding protein B	0.847
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.793
COL1A1	collagen, type I, alpha 1	0.769
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.703
APP	amyloid beta (A4) precursor protein	0.626
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.541
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.444
TGFBR1	transforming growth factor, beta receptor 1	0.434
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.415
COL4A1	collagen, type IV, alpha 1	0.412
BGN	biglycan	0.397
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.393
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.381
COL11A2	collagen, type XI, alpha 2	0.351
FAP	fibroblast activation protein, alpha	0.275
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.269
INHBA	inhibin, beta A	0.253
ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	0.250	Human
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.229
COL1A2	collagen, type I, alpha 2	0.193
FSTL1	follistatin-like 1	0.183
FN1	fibronectin 1	0.172
COL8A1	collagen, type VIII, alpha 1	0.164
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.159
SH2D1A	SH2 domain containing 1A	0.158
COL5A1	collagen, type V, alpha 1	0.135
PCOLCE	procollagen C-endopeptidase enhancer	0.133
GPRASP2	G protein-coupled receptor associated sorting protein 2	0.130
TMEM108	transmembrane protein 108	0.128
TTR	transthyretin	0.123
COL6A1	collagen, type VI, alpha 1	0.122
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.119
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.113
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.108
RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	0.105
CALD1	caldesmon 1	0.104
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.100
COL6A2	collagen, type VI, alpha 2	0.097
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.077
SH3KBP1	SH3-domain kinase binding protein 1	0.076
IQGAP1	IQ motif containing GTPase activating protein 1	0.075
LOX	lysyl oxidase	0.075
COL3A1	collagen, type III, alpha 1	0.071
THY1	Thy-1 cell surface antigen	0.071
COL4A2	collagen, type IV, alpha 2	0.066
TIMP3	TIMP metallopeptidase inhibitor 3	0.065
CTGF	connective tissue growth factor	0.062
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.060
FGF2	fibroblast growth factor 2 (basic)	0.059
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.055
TGFB2	transforming growth factor, beta 2	0.054	Human
OSMR	oncostatin M receptor	0.053
LAMB1	laminin, beta 1	0.053
FILIP1L	filamin A interacting protein 1-like	0.052
AEBP1	AE binding protein 1	0.051
VEGFC	vascular endothelial growth factor C	0.051
TNC	tenascin C	0.050
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.048
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.047
COL16A1	collagen, type XVI, alpha 1	0.046
PLAU	plasminogen activator, urokinase	0.044
GREM1	gremlin 1	0.044
CRIPAK	cysteine-rich PAK1 inhibitor	0.041
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.041
COL5A2	collagen, type V, alpha 2	0.040
GRB2	growth factor receptor-bound protein 2	0.040
EDNRA	endothelin receptor type A	0.039
COL6A3	collagen, type VI, alpha 3	0.038
FBN1	fibrillin 1	0.037
S100A1	S100 calcium binding protein A1	0.036
COL11A1	collagen, type XI, alpha 1	0.036
LRP1	low density lipoprotein receptor-related protein 1	0.036
RHOU	ras homolog gene family, member U	0.035
COL18A1	collagen, type XVIII, alpha 1	0.034
CD84	CD84 molecule	0.033
FBLN2	fibulin 2	0.033
SULF1	sulfatase 1	0.031
TIMP2	TIMP metallopeptidase inhibitor 2	0.031
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.031
FLNA	filamin A, alpha	0.030
LRRK2	leucine-rich repeat kinase 2	0.030
PARVA	parvin, alpha	0.030
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.030
PRKCA	protein kinase C, alpha	0.029
CYR61	cysteine-rich, angiogenic inducer, 61	0.028
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.028
ACVR2B	activin A receptor, type IIB	0.026
TLN1	talin 1	0.026
HSPG2	heparan sulfate proteoglycan 2	0.025
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.025
IGFBP5	insulin-like growth factor binding protein 5	0.025
MXRA5	matrix-remodelling associated 5	0.024
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.024
PRRX1	paired related homeobox 1	0.023
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.022
NRP1	neuropilin 1	0.022
FKBP10	FK506 binding protein 10, 65 kDa	0.021
NRP2	neuropilin 2	0.021
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.021
ANGPTL2	angiopoietin-like 2	0.021
NNMT	nicotinamide N-methyltransferase	0.021
SORBS2	sorbin and SH3 domain containing 2	0.021
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.020
CD244	CD244 molecule, natural killer cell receptor 2B4	0.020
WWTR1	WW domain containing transcription regulator 1	0.020
SLAMF1	signaling lymphocytic activation molecule family member 1	0.020
MYH9	myosin, heavy chain 9, non-muscle	0.020
LTBP1	latent transforming growth factor beta binding protein 1	0.020
LOXL2	lysyl oxidase-like 2	0.020
SPHK1	sphingosine kinase 1	0.020
LIMK1	LIM domain kinase 1	0.019
DCN	decorin	0.019
SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	0.019
SH3RF3	SH3 domain containing ring finger 3	0.019
THBS2	thrombospondin 2	0.019	Human
LTBP2	latent transforming growth factor beta binding protein 2	0.019
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.019
PDPN	podoplanin	0.018
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.018
NID2	nidogen 2 (osteonidogen)	0.018
MRC2	mannose receptor, C type 2	0.017
PXDN	peroxidasin homolog (Drosophila)	0.016
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.016
GAB2	GRB2-associated binding protein 2	0.016
DUSP23	dual specificity phosphatase 23	0.016
ADAM12	ADAM metallopeptidase domain 12	0.015
TWIST1	twist homolog 1 (Drosophila)	0.015
COL7A1	collagen, type VII, alpha 1	0.015
OLFML2B	olfactomedin-like 2B	0.015
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.015
NTM	neurotrimin	0.015
FYN	FYN oncogene related to SRC, FGR, YES	0.015
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.014
ILK	integrin-linked kinase	0.014
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.014
WISP1	WNT1 inducible signaling pathway protein 1	0.014
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.014
POSTN	periostin, osteoblast specific factor	0.014
TIMP1	TIMP metallopeptidase inhibitor 1	0.014
EDIL3	EGF-like repeats and discoidin I-like domains 3	0.014
NID1	nidogen 1	0.014
CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	0.014
FNDC1	fibronectin type III domain containing 1	0.014
PMEPA1	prostate transmembrane protein, androgen induced 1	0.014
TFPI2	tissue factor pathway inhibitor 2	0.014
FMOD	fibromodulin	0.014
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.013
EMILIN1	elastin microfibril interfacer 1	0.013
TAGLN	transgelin	0.013
RAI14	retinoic acid induced 14	0.013
KRT18	keratin 18	0.013
TGFBR3	transforming growth factor, beta receptor III	0.013
TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	0.013
BMP1	bone morphogenetic protein 1	0.012
MAP1B	microtubule-associated protein 1B	0.012
S100P	S100 calcium binding protein P	0.012
COL8A2	collagen, type VIII, alpha 2	0.012
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.012
PBXIP1	pre-B-cell leukemia homeobox interacting protein 1	0.012
LAMB2	laminin, beta 2 (laminin S)	0.012
A2M	alpha-2-macroglobulin	0.012
SDC2	syndecan 2	0.012
ASPN	asporin	0.011
THBS4	thrombospondin 4	0.011	Human
SLIT2	slit homolog 2 (Drosophila)	0.011
ANGPT1	angiopoietin 1	0.011
SEC16A	SEC16 homolog A (S. cerevisiae)	0.011
FKBP1A	FK506 binding protein 1A, 12kDa	0.011
VCAN	versican	0.011
PLXDC1	plexin domain containing 1	0.011
TEK	TEK tyrosine kinase, endothelial	0.011
STC1	stanniocalcin 1	0.011
CDK11B	cyclin-dependent kinase 11B	0.011
COL12A1	collagen, type XII, alpha 1	0.011
LOXL1	lysyl oxidase-like 1	0.011
F3	coagulation factor III (thromboplastin, tissue factor)	0.011
COMP	cartilage oligomeric matrix protein	0.011	Human
PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	0.010
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.010
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.010
CTSK	cathepsin K	0.010
TPST1	tyrosylprotein sulfotransferase 1	0.010
SNAI2	snail homolog 2 (Drosophila)	0.010
SFRP4	secreted frizzled-related protein 4	0.010
SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.010
HTRA1	HtrA serine peptidase 1	0.010
TPM2	tropomyosin 2 (beta)	0.010