IMP

Process View

Homo sapiens

7 genes annotated in human

phagocytosis engulfment

The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "phagocytosis engulfment"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "phagocytosis engulfment" (in gray)

Name	Description	Probability	Func Analog Organism
FN1	fibronectin 1	0.650
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.593
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.560
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.528	Worm Fly
DNM1	dynamin 1	0.509
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.410
MAPK8	mitogen-activated protein kinase 8	0.369	Fly
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.366
EGFR	epidermal growth factor receptor	0.328
GRB2	growth factor receptor-bound protein 2	0.287
MAP2K4	mitogen-activated protein kinase kinase 4	0.275
RIN3	Ras and Rab interactor 3	0.227
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.223
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.200	Worm
ITSN1	intersectin 1 (SH3 domain protein)	0.182
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.172	Fly
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.170
PXN	paxillin	0.132
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.125	Worm
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.125
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.120
ATF2	activating transcription factor 2	0.104
DNM2	dynamin 2	0.097	Worm
SYK	spleen tyrosine kinase	0.092
ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	0.089
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.085
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.083	Worm
JUN	jun proto-oncogene	0.081
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.079
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.078
CTGF	connective tissue growth factor	0.076
TFF1	trefoil factor 1	0.076
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.075
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.069
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.068
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.066	Worm
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.063
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.058
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.057
DYNLT3	dynein, light chain, Tctex-type 3	0.052
PRKCZ	protein kinase C, zeta	0.050
ADAM19	ADAM metallopeptidase domain 19	0.049
SNX9	sorting nexin 9	0.048
DYNC1I2	dynein, cytoplasmic 1, intermediate chain 2	0.048	Worm
CAV1	caveolin 1, caveolae protein, 22kDa	0.047
ANKRD27	ankyrin repeat domain 27 (VPS9 domain)	0.045
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.045	Worm
S100B	S100 calcium binding protein B	0.045
HCK	hemopoietic cell kinase	0.044
SH3KBP1	SH3-domain kinase binding protein 1	0.041
SPRR2A	small proline-rich protein 2A	0.040
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.039
EPS8	epidermal growth factor receptor pathway substrate 8	0.039
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.037	Worm
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.036
PDCD6IP	programmed cell death 6 interacting protein	0.035
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.035
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.031
SH3GL2	SH3-domain GRB2-like 2	0.031
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.031
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.028
GOLGA2	golgin A2	0.028
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.028
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	0.027
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.025
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.025
ABI1	abl-interactor 1	0.025	Worm
TLN1	talin 1	0.023
NCF2	neutrophil cytosolic factor 2	0.023
S100A10	S100 calcium binding protein A10	0.023
ANXA1	annexin A1	0.022	Worm
SOS1	son of sevenless homolog 1 (Drosophila)	0.022
ARRB1	arrestin, beta 1	0.022
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.022
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.020
RHOA	ras homolog gene family, member A	0.020
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.019
PLCG1	phospholipase C, gamma 1	0.019
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.019
VCL	vinculin	0.019
TCF4	transcription factor 4	0.019
BCOR	BCL6 corepressor	0.018
SYNJ1	synaptojanin 1	0.018
MYL12B	myosin, light chain 12B, regulatory	0.018
ENG	endoglin	0.017
CBFB	core-binding factor, beta subunit	0.015
PTAFR	platelet-activating factor receptor	0.015
SNAP23	synaptosomal-associated protein, 23kDa	0.015
NAV1	neuron navigator 1	0.015
SMAD2	SMAD family member 2	0.015
ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.015	Worm
KIF5B	kinesin family member 5B	0.015
FLNA	filamin A, alpha	0.014
FGF1	fibroblast growth factor 1 (acidic)	0.014
ANXA2	annexin A2	0.013	Worm
RAB11A	RAB11A, member RAS oncogene family	0.013
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.013
ADAM9	ADAM metallopeptidase domain 9	0.013
RIN1	Ras and Rab interactor 1	0.013
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.013
XPO7	exportin 7	0.013
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.012
CD33	CD33 molecule	0.012
NCKAP1	NCK-associated protein 1	0.012
PICALM	phosphatidylinositol binding clathrin assembly protein	0.012
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.012
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.012
FYN	FYN oncogene related to SRC, FGR, YES	0.012
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.012
STX12	syntaxin 12	0.012
AGFG1	ArfGAP with FG repeats 1	0.012
ANXA5	annexin A5	0.011	Worm
WASL	Wiskott-Aldrich syndrome-like	0.011
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.011
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.011
HK3	hexokinase 3 (white cell)	0.011
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.011
VAV1	vav 1 guanine nucleotide exchange factor	0.011
PILRA	paired immunoglobin-like type 2 receptor alpha	0.011
CCR1	chemokine (C-C motif) receptor 1	0.011
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.011
SS18	synovial sarcoma translocation, chromosome 18	0.010
MSH5	mutS homolog 5 (E. coli)	0.010
CD53	CD53 molecule	0.010
MAPK14	mitogen-activated protein kinase 14	0.010
RAB14	RAB14, member RAS oncogene family	0.010
WASF1	WAS protein family, member 1	0.010