IMP

Process View

Homo sapiens

29 genes annotated in human

negative regulation of nucleotide metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of nucleotide metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of nucleotide metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.739
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.690
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.598	Human
GUCY2C	guanylate cyclase 2C (heat stable enterotoxin receptor)	0.416
TNNC1	troponin C type 1 (slow)	0.260
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.244
MPDZ	multiple PDZ domain protein	0.222
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.216
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.203	Fly
ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	0.186	Human
GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	0.165	Rat
ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.121
ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	0.100
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.100
TBC1D10A	TBC1 domain family, member 10A	0.097
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.086
RND1	Rho family GTPase 1	0.065
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.063
SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	0.061
GOPC	golgi-associated PDZ and coiled-coil motif containing	0.058
TNNI1	troponin I type 1 (skeletal, slow)	0.053	Human
LMAN1	lectin, mannose-binding, 1	0.050
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.048
PTEN	phosphatase and tensin homolog	0.047
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.046
TRIM63	tripartite motif containing 63	0.046
ADORA2A	adenosine A2a receptor	0.046
EPAS1	endothelial PAS domain protein 1	0.046
CANX	calnexin	0.045
RALGDS	ral guanine nucleotide dissociation stimulator	0.044
TBCD	tubulin folding cofactor D	0.044
UNC119	unc-119 homolog (C. elegans)	0.043
ARRB1	arrestin, beta 1	0.042
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.041
HAP1	huntingtin-associated protein 1	0.041
ADRB2	adrenergic, beta-2-, receptor, surface	0.038	Human
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.037
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.036
BBS10	Bardet-Biedl syndrome 10	0.034
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.032
RALBP1	ralA binding protein 1	0.029
TRAM1	translocation associated membrane protein 1	0.028
BCR	breakpoint cluster region	0.027
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.025	Human
PCDHA4	protocadherin alpha 4	0.025
DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0.025
DES	desmin	0.025
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.025
TMED9	transmembrane emp24 protein transport domain containing 9	0.024
TFRC	transferrin receptor (p90, CD71)	0.023
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.023
SH3GL3	SH3-domain GRB2-like 3	0.023
NSF	N-ethylmaleimide-sensitive factor	0.023
DNM2	dynamin 2	0.023
FKBP8	FK506 binding protein 8, 38kDa	0.023
LRP6	low density lipoprotein receptor-related protein 6	0.022
WNT3A	wingless-type MMTV integration site family, member 3A	0.022
PRMT6	protein arginine methyltransferase 6	0.022
YAP1	Yes-associated protein 1	0.021
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.021
NDP	Norrie disease (pseudoglioma)	0.020
PEBP4	phosphatidylethanolamine-binding protein 4	0.020
EZR	ezrin	0.020
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.020
MCFD2	multiple coagulation factor deficiency 2	0.020
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.020
QARS	glutaminyl-tRNA synthetase	0.019
AMOTL1	angiomotin like 1	0.019
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.019
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.019
STK4	serine/threonine kinase 4	0.018
TMED2	transmembrane emp24 domain trafficking protein 2	0.018
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.018
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.018	Human
SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	0.017
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.017
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.017
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.017
CDV3	CDV3 homolog (mouse)	0.017
HDGF	hepatoma-derived growth factor	0.017
GFPT1	glutamine--fructose-6-phosphate transaminase 1	0.017
SSR1	signal sequence receptor, alpha	0.017
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.017
MST1R	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	0.017
TOMM22	translocase of outer mitochondrial membrane 22 homolog (yeast)	0.016
GPR6	G protein-coupled receptor 6	0.016
NUS1	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	0.016
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.016
COX6A2	cytochrome c oxidase subunit VIa polypeptide 2	0.016
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.016
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.016
ACTA1	actin, alpha 1, skeletal muscle	0.015
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.015
SERP1	stress-associated endoplasmic reticulum protein 1	0.015
ARRDC3	arrestin domain containing 3	0.015
TTN	titin	0.015
ITSN1	intersectin 1 (SH3 domain protein)	0.015
WNT5A	wingless-type MMTV integration site family, member 5A	0.015
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.015
FAM18B1	family with sequence similarity 18, member B1	0.015
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.015
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.015
GOLT1B	golgi transport 1B	0.015
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.015
ELF5	E74-like factor 5 (ets domain transcription factor)	0.014
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.014
SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	0.014	Mouse
PDZK1	PDZ domain containing 1	0.014	Human
EHF	ets homologous factor	0.014
RGS2	regulator of G-protein signaling 2, 24kDa	0.014
PLXNB1	plexin B1	0.014	Human
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.014
C9orf25	chromosome 9 open reading frame 25	0.014
GORASP2	golgi reassembly stacking protein 2, 55kDa	0.014
SH3KBP1	SH3-domain kinase binding protein 1	0.014
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.014
EGLN3	egl nine homolog 3 (C. elegans)	0.014
NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.014
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.013
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.013
TMC6	transmembrane channel-like 6	0.013
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	0.013
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.013	Human
SPRY2	sprouty homolog 2 (Drosophila)	0.013	Mouse
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.013
RIN1	Ras and Rab interactor 1	0.013
NF2	neurofibromin 2 (merlin)	0.013
LDB3	LIM domain binding 3	0.013
BAG1	BCL2-associated athanogene	0.012
GRPEL1	GrpE-like 1, mitochondrial (E. coli)	0.012
PDE4DIP	phosphodiesterase 4D interacting protein	0.012
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.012
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.012
SSTR3	somatostatin receptor 3	0.012
ARFGAP1	ADP-ribosylation factor GTPase activating protein 1	0.012
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.012	Human
CLCN3	chloride channel 3	0.012
CSNK1E	casein kinase 1, epsilon	0.012
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.012
CCKBR	cholecystokinin B receptor	0.012
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.012
SEC23A	Sec23 homolog A (S. cerevisiae)	0.012
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.012	Human
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.012
SLC26A3	solute carrier family 26, member 3	0.011
SURF4	surfeit 4	0.011
TNNI3K	TNNI3 interacting kinase	0.011
ARL3	ADP-ribosylation factor-like 3	0.011
HMOX2	heme oxygenase (decycling) 2	0.011
ADORA1	adenosine A1 receptor	0.011
GMPR2	guanosine monophosphate reductase 2	0.011
CD151	CD151 molecule (Raph blood group)	0.011
GDF10	growth differentiation factor 10	0.011
CKM	creatine kinase, muscle	0.011
MAPK10	mitogen-activated protein kinase 10	0.011
LMNB2	lamin B2	0.011
NONO	non-POU domain containing, octamer-binding	0.011
MCM3	minichromosome maintenance complex component 3	0.011
CYR61	cysteine-rich, angiogenic inducer, 61	0.011
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.011
MAP1B	microtubule-associated protein 1B	0.011
MAP2K6	mitogen-activated protein kinase kinase 6	0.011
RHEB	Ras homolog enriched in brain	0.011
RAB5B	RAB5B, member RAS oncogene family	0.011
KIAA1199	KIAA1199	0.011
PKD2L1	polycystic kidney disease 2-like 1	0.011
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.011
AMOTL2	angiomotin like 2	0.011
MAPT	microtubule-associated protein tau	0.011
ORC6	origin recognition complex, subunit 6	0.010
SGPP1	sphingosine-1-phosphate phosphatase 1	0.010
CD34	CD34 molecule	0.010
TWF1	twinfilin, actin-binding protein, homolog 1 (Drosophila)	0.010
TNNI2	troponin I type 2 (skeletal, fast)	0.010	Human
ELL	elongation factor RNA polymerase II	0.010