IMP

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Homo sapiens

2 genes annotated in human

regulation of circadian sleep wake cycle sleep

Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of circadian sleep wake cycle sleep"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of circadian sleep wake cycle sleep" (in gray)

Name	Description	Probability	Func Analog Organism
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.998	Fly
DLG4	discs, large homolog 4 (Drosophila)	0.997
ACTN2	actinin, alpha 2	0.964
GRB10	growth factor receptor-bound protein 10	0.947
ADORA2A	adenosine A2a receptor	0.938	Rat
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.914	Fly
NLRC4	NLR family, CARD domain containing 4	0.884
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.801	Fly
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.751
DRD2	dopamine receptor D2	0.738	Rat
HSPH1	heat shock 105kDa/110kDa protein 1	0.369
IRS1	insulin receptor substrate 1	0.247
AKAP11	A kinase (PRKA) anchor protein 11	0.200
ADORA1	adenosine A1 receptor	0.189	Rat
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.155
IRS2	insulin receptor substrate 2	0.148
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.144
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.144
MYOZ1	myozenin 1	0.142
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.127
AKIP1	A kinase (PRKA) interacting protein 1	0.123
RYR2	ryanodine receptor 2 (cardiac)	0.122
NECAB2	N-terminal EF-hand calcium binding protein 2	0.105
NAMPT	nicotinamide phosphoribosyltransferase	0.101
PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	0.098
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.096
IGF1R	insulin-like growth factor 1 receptor	0.095	Fly
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.093
EGFR	epidermal growth factor receptor	0.089
INSR	insulin receptor	0.084	Fly
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.079	Fly
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.078
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.069
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.060
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.055	Fly
TTN	titin	0.053
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.051
CARD16	caspase recruitment domain family, member 16	0.051
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.045
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.043	Fly
MCC	mutated in colorectal cancers	0.040
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.040
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.039
NLGN1	neuroligin 1	0.038
JAK2	Janus kinase 2	0.035
GHR	growth hormone receptor	0.035
AKAP1	A kinase (PRKA) anchor protein 1	0.034
PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	0.030
MTNR1A	melatonin receptor 1A	0.030
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.029	Fly
TBXA2R	thromboxane A2 receptor	0.028
NPAS2	neuronal PAS domain protein 2	0.028	Fly
AHR	aryl hydrocarbon receptor	0.028
CNR1	cannabinoid receptor 1 (brain)	0.028
CSNK1E	casein kinase 1, epsilon	0.027
VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	0.026
LIMK1	LIM domain kinase 1	0.024
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.024
PRDM8	PR domain containing 8	0.024
MADD	MAP-kinase activating death domain	0.024
TAOK1	TAO kinase 1	0.023
KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.023	Fly
EPAS1	endothelial PAS domain protein 1	0.023
KCNA2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.022	Fly
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.022
GSK3B	glycogen synthase kinase 3 beta	0.022
SPRR2A	small proline-rich protein 2A	0.022
CLOCK	clock homolog (mouse)	0.020	Fly
RIPK2	receptor-interacting serine-threonine kinase 2	0.020
NOD1	nucleotide-binding oligomerization domain containing 1	0.020
CRY2	cryptochrome 2 (photolyase-like)	0.020
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.019	Fly
IL18	interleukin 18 (interferon-gamma-inducing factor)	0.019
BBS10	Bardet-Biedl syndrome 10	0.019
AKAP5	A kinase (PRKA) anchor protein 5	0.019
PTPRN	protein tyrosine phosphatase, receptor type, N	0.018
CARD6	caspase recruitment domain family, member 6	0.018
USP25	ubiquitin specific peptidase 25	0.018
TNP2	transition protein 2 (during histone to protamine replacement)	0.018
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.018
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.017
PDX1	pancreatic and duodenal homeobox 1	0.017
F10	coagulation factor X	0.017
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.017
TRPV6	transient receptor potential cation channel, subfamily V, member 6	0.017
AKAP7	A kinase (PRKA) anchor protein 7	0.017
PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta	0.017
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.017
PIAS3	protein inhibitor of activated STAT, 3	0.017
DISC1	disrupted in schizophrenia 1	0.017
EIF4H	eukaryotic translation initiation factor 4H	0.017
EGLN1	egl nine homolog 1 (C. elegans)	0.017
HSPA1A	heat shock 70kDa protein 1A	0.017
PTGDR	prostaglandin D2 receptor (DP)	0.017
BTN3A2	butyrophilin, subfamily 3, member A2	0.016
EGLN3	egl nine homolog 3 (C. elegans)	0.016
FKBP5	FK506 binding protein 5	0.016
C2orf88	chromosome 2 open reading frame 88	0.016
GAB1	GRB2-associated binding protein 1	0.016
SQRDL	sulfide quinone reductase-like (yeast)	0.016
CYTH2	cytohesin 2	0.016
EPOR	erythropoietin receptor	0.016
ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2	0.016	Fly
EPB41L1	erythrocyte membrane protein band 4.1-like 1	0.016
LDB3	LIM domain binding 3	0.015
TEF	thyrotrophic embryonic factor	0.015
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.015
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.015
IP6K1	inositol hexakisphosphate kinase 1	0.015
TRAF3	TNF receptor-associated factor 3	0.015
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.015
BCAR1	breast cancer anti-estrogen resistance 1	0.015
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.015
TMSB4Y	thymosin beta 4, Y-linked	0.015
AQP7	aquaporin 7	0.015
FGFR1	fibroblast growth factor receptor 1	0.015
GRB14	growth factor receptor-bound protein 14	0.015
GAB2	GRB2-associated binding protein 2	0.015
KCNE1	potassium voltage-gated channel, Isk-related family, member 1	0.015
FRS2	fibroblast growth factor receptor substrate 2	0.015
MFAP4	microfibrillar-associated protein 4	0.014
IL1A	interleukin 1, alpha	0.014
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.014
ROM1	retinal outer segment membrane protein 1	0.014
CCDC117	coiled-coil domain containing 117	0.014
LAT	linker for activation of T cells	0.014
SIRT6	sirtuin 6	0.014
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.014
NELL2	NEL-like 2 (chicken)	0.014
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.014
TBX5	T-box 5	0.014
TMEM59L	transmembrane protein 59-like	0.014
TREH	trehalase (brush-border membrane glycoprotein)	0.014
CACNA1I	calcium channel, voltage-dependent, T type, alpha 1I subunit	0.014
PYGM	phosphorylase, glycogen, muscle	0.013
RGS6	regulator of G-protein signaling 6	0.013
HSPA8	heat shock 70kDa protein 8	0.013
EVX1	even-skipped homeobox 1	0.013
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.013
NDUFA4L2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2	0.013
S100A2	S100 calcium binding protein A2	0.013
RASL12	RAS-like, family 12	0.013
CADM4	cell adhesion molecule 4	0.013
KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.013
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.013
POU6F1	POU class 6 homeobox 1	0.013
VHL	von Hippel-Lindau tumor suppressor	0.013
CPLX2	complexin 2	0.013
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.013
BAI1	brain-specific angiogenesis inhibitor 1	0.013
APP	amyloid beta (A4) precursor protein	0.013
HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	0.013
KCNIP2	Kv channel interacting protein 2	0.013
KIF5C	kinesin family member 5C	0.013
FUT5	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	0.013
RAB35	RAB35, member RAS oncogene family	0.012
PER2	period homolog 2 (Drosophila)	0.012	Human
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.012
LRP6	low density lipoprotein receptor-related protein 6	0.012
GRIA4	glutamate receptor, ionotrophic, AMPA 4	0.012
FKBP4	FK506 binding protein 4, 59kDa	0.012
FAM110C	family with sequence similarity 110, member C	0.012
BTN3A3	butyrophilin, subfamily 3, member A3	0.012
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.012
SSTR5	somatostatin receptor 5	0.012
AKAP10	A kinase (PRKA) anchor protein 10	0.012
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.012
TRPV4	transient receptor potential cation channel, subfamily V, member 4	0.012
KCNJ4	potassium inwardly-rectifying channel, subfamily J, member 4	0.012
LTK	leukocyte receptor tyrosine kinase	0.012
PTGIR	prostaglandin I2 (prostacyclin) receptor (IP)	0.012
OPCML	opioid binding protein/cell adhesion molecule-like	0.012
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	0.012
LY75	lymphocyte antigen 75	0.012
LHB	luteinizing hormone beta polypeptide	0.012
SOD2	superoxide dismutase 2, mitochondrial	0.012
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.012
MAGEB3	melanoma antigen family B, 3	0.012
TLX1	T-cell leukemia homeobox 1	0.012
CREBL2	cAMP responsive element binding protein-like 2	0.012
P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	0.012
GRIK1	glutamate receptor, ionotropic, kainate 1	0.012
ESRRB	estrogen-related receptor beta	0.012
MYOM2	myomesin (M-protein) 2, 165kDa	0.012
CYP46A1	cytochrome P450, family 46, subfamily A, polypeptide 1	0.012
MYBPC2	myosin binding protein C, fast type	0.012
AVPI1	arginine vasopressin-induced 1	0.012
IL15	interleukin 15	0.012
KLKB1	kallikrein B, plasma (Fletcher factor) 1	0.012
SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.012
CETP	cholesteryl ester transfer protein, plasma	0.012
NIN	ninein (GSK3B interacting protein)	0.012
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.012
TUBA8	tubulin, alpha 8	0.012
MAP1A	microtubule-associated protein 1A	0.012
OBFC2A	oligonucleotide/oligosaccharide-binding fold containing 2A	0.012
SNED1	sushi, nidogen and EGF-like domains 1	0.011
KCND3	potassium voltage-gated channel, Shal-related subfamily, member 3	0.011
KCNAB1	potassium voltage-gated channel, shaker-related subfamily, beta member 1	0.011
SORBS3	sorbin and SH3 domain containing 3	0.011
NR1D1	nuclear receptor subfamily 1, group D, member 1	0.011
SLC9A6	solute carrier family 9 (sodium/hydrogen exchanger), member 6	0.011
NCS1	neuronal calcium sensor 1	0.011
C2orf55	chromosome 2 open reading frame 55	0.011
GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	0.011
PTPRU	protein tyrosine phosphatase, receptor type, U	0.011
FGF8	fibroblast growth factor 8 (androgen-induced)	0.011
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.011
ZNF331	zinc finger protein 331	0.011
ACTN3	actinin, alpha 3	0.011
NFASC	neurofascin	0.011
CTSS	cathepsin S	0.011
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.011
CA4	carbonic anhydrase IV	0.011
NDRG1	N-myc downstream regulated 1	0.011
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.011
AKAP6	A kinase (PRKA) anchor protein 6	0.011
PRLH	prolactin releasing hormone	0.011
FTO	fat mass and obesity associated	0.011
GPR22	G protein-coupled receptor 22	0.011
TNP1	transition protein 1 (during histone to protamine replacement)	0.011
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.011
LARGE	like-glycosyltransferase	0.011
RGS20	regulator of G-protein signaling 20	0.011
KCNC2	potassium voltage-gated channel, Shaw-related subfamily, member 2	0.011
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.011
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.011
CDK11A	cyclin-dependent kinase 11A	0.011
PSAT1	phosphoserine aminotransferase 1	0.011
DSPP	dentin sialophosphoprotein	0.011
NPPA	natriuretic peptide A	0.011
KCNC4	potassium voltage-gated channel, Shaw-related subfamily, member 4	0.011
MT3	metallothionein 3	0.011
SOX10	SRY (sex determining region Y)-box 10	0.011
COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.011
BTRC	beta-transducin repeat containing	0.011
OSBP	oxysterol binding protein	0.011
PER1	period homolog 1 (Drosophila)	0.011	Human
DPYD	dihydropyrimidine dehydrogenase	0.011
FAM110A	family with sequence similarity 110, member A	0.011
LPAR4	lysophosphatidic acid receptor 4	0.011
MTMR7	myotubularin related protein 7	0.011
OLAH	oleoyl-ACP hydrolase	0.011
CDH20	cadherin 20, type 2	0.011
ERAP2	endoplasmic reticulum aminopeptidase 2	0.011
FLT3	fms-related tyrosine kinase 3	0.011
HLF	hepatic leukemia factor	0.011
COX7A1	cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)	0.011
PDE2A	phosphodiesterase 2A, cGMP-stimulated	0.011
LILRA4	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	0.011
ARL6IP5	ADP-ribosylation-like factor 6 interacting protein 5	0.011
PLAC8	placenta-specific 8	0.011
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.011
ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	0.011
TRAK2	trafficking protein, kinesin binding 2	0.011
FBXL22	F-box and leucine-rich repeat protein 22	0.011
GOLGA2	golgin A2	0.011
DOCK3	dedicator of cytokinesis 3	0.011
DRD1	dopamine receptor D1	0.011
FAM65B	family with sequence similarity 65, member B	0.011
ACVRL1	activin A receptor type II-like 1	0.011
AARS	alanyl-tRNA synthetase	0.010
OPRD1	opioid receptor, delta 1	0.010
SPTB	spectrin, beta, erythrocytic	0.010
GATA4	GATA binding protein 4	0.010
GIPR	gastric inhibitory polypeptide receptor	0.010
TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	0.010
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.010
DAPK2	death-associated protein kinase 2	0.010
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.010
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.010
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.010
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.010
MLXIPL	MLX interacting protein-like	0.010
PSD	pleckstrin and Sec7 domain containing	0.010
SIK3	SIK family kinase 3	0.010
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.010
S100A1	S100 calcium binding protein A1	0.010
PGM5	phosphoglucomutase 5	0.010
PRKACG	protein kinase, cAMP-dependent, catalytic, gamma	0.010	Fly
MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	0.010
PLXNC1	plexin C1	0.010
PCYT1A	phosphate cytidylyltransferase 1, choline, alpha	0.010
CTSF	cathepsin F	0.010
ATP1B2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.010
TLR1	toll-like receptor 1	0.010
TCAP	titin-cap (telethonin)	0.010
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.010
PTPRH	protein tyrosine phosphatase, receptor type, H	0.010
SEMA3D	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	0.010
KCNN3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	0.010
NBL1	neuroblastoma, suppression of tumorigenicity 1	0.010
WNT10B	wingless-type MMTV integration site family, member 10B	0.010
KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	0.010
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.010
TSPYL2	TSPY-like 2	0.010
ALKBH5	alkB, alkylation repair homolog 5 (E. coli)	0.010
PDE4A	phosphodiesterase 4A, cAMP-specific	0.010
FAM83B	family with sequence similarity 83, member B	0.010
RORB	RAR-related orphan receptor B	0.010
VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)	0.010
WDR7	WD repeat domain 7	0.010
FXYD1	FXYD domain containing ion transport regulator 1	0.010
GIP	gastric inhibitory polypeptide	0.010
NEUROG3	neurogenin 3	0.010
GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	0.010
ZNF169	zinc finger protein 169	0.010
GRIK4	glutamate receptor, ionotropic, kainate 4	0.010
CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	0.010