IMP

Process View

Mus musculus

3 genes annotated in mouse

dct cell differentiation

GO:0072069

The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the kidney as it progresses from its formation to the mature state.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dct cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dct cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Pax2	paired box gene 2	0.997
Pax3	paired box gene 3	0.960
Otx2	orthodenticle homolog 2 (Drosophila)	0.956
Sox2	SRY-box containing gene 2	0.948
Lhx1	LIM homeobox protein 1	0.917
Vangl2	vang-like 2 (van gogh, Drosophila)	0.896
Emx2	empty spiracles homolog 2 (Drosophila)	0.857
Shh	sonic hedgehog	0.736
Eya1	eyes absent 1 homolog (Drosophila)	0.693
Lmx1a	LIM homeobox transcription factor 1 alpha	0.618
Gbx2	gastrulation brain homeobox 2	0.607
Fgfr2	fibroblast growth factor receptor 2	0.593
Hmx3	H6 homeobox 3	0.591
Rarg	retinoic acid receptor, gamma	0.540
Pax8	paired box gene 8	0.499
Otx1	orthodenticle homolog 1 (Drosophila)	0.482
Pax6	paired box gene 6	0.439
Nanog	Nanog homeobox	0.419
Chd7	chromodomain helicase DNA binding protein 7	0.417
Wnt9b	wingless-type MMTV integration site 9B	0.412
Sall3	sal-like 3 (Drosophila)	0.373
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.372
Hmx1	H6 homeobox 1	0.315
Foxg1	forkhead box G1	0.312
Tbx10	T-box 10	0.307
Gli3	GLI-Kruppel family member GLI3	0.289
Gdf11	growth differentiation factor 11	0.276
Sall4	sal-like 4 (Drosophila)	0.256
Dlx5	distal-less homeobox 5	0.248
Lef1	lymphoid enhancer binding factor 1	0.245
Emx1	empty spiracles homolog 1 (Drosophila)	0.232
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.228
Atoh7	atonal homolog 7 (Drosophila)	0.210
Fgf3	fibroblast growth factor 3	0.206
Hoxd11	homeobox D11	0.179
Hoxa11	homeobox A11	0.175
Foxi1	forkhead box I1	0.171
Fgf10	fibroblast growth factor 10	0.170
Zic2	zinc finger protein of the cerebellum 2	0.154
Lhx3	LIM homeobox protein 3	0.146
Pou4f3	POU domain, class 4, transcription factor 3	0.121	Mouse
Dlx1	distal-less homeobox 1	0.121
Vax1	ventral anterior homeobox containing gene 1	0.118
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.117
Sall1	sal-like 1 (Drosophila)	0.112
Fgf8	fibroblast growth factor 8	0.111
Pou3f2	POU domain, class 3, transcription factor 2	0.110	Mouse
Uncx	UNC homeobox	0.107
Hes5	hairy and enhancer of split 5 (Drosophila)	0.101
Msx1	homeobox, msh-like 1	0.094
Atoh1	atonal homolog 1 (Drosophila)	0.094
Hoxd13	homeobox D13	0.090
Bcl2	B-cell leukemia/lymphoma 2	0.086
Tbx1	T-box 1	0.083
Pou4f2	POU domain, class 4, transcription factor 2	0.083	Mouse
Cdx1	caudal type homeobox 1	0.083
Tcfcp2l1	transcription factor CP2-like 1	0.083
Cga	glycoprotein hormones, alpha subunit	0.082
Hoxd3	homeobox D3	0.081
Bdnf	brain derived neurotrophic factor	0.076
Rara	retinoic acid receptor, alpha	0.075
Hand1	heart and neural crest derivatives expressed transcript 1	0.075
Foxd2	forkhead box D2	0.073
Wnt1	wingless-related MMTV integration site 1	0.073
Thrb	thyroid hormone receptor beta	0.072
Alx4	aristaless-like homeobox 4	0.070
Tlx3	T-cell leukemia, homeobox 3	0.069
Pou3f3	POU domain, class 3, transcription factor 3	0.066
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.065
Foxh1	forkhead box H1	0.065
Sim1	single-minded homolog 1 (Drosophila)	0.063
Lhx5	LIM homeobox protein 5	0.062
Neurod1	neurogenic differentiation 1	0.060
Sox3	SRY-box containing gene 3	0.060
Fgf15	fibroblast growth factor 15	0.058
Hoxa1	homeobox A1	0.058
Lmx1b	LIM homeobox transcription factor 1 beta	0.057
T	brachyury	0.056
Tcfap2c	transcription factor AP-2, gamma	0.056
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.055
Fgf4	fibroblast growth factor 4	0.055
Gata3	GATA binding protein 3	0.054
Drd2	dopamine receptor D2	0.054
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.052
Dmgdh	dimethylglycine dehydrogenase precursor	0.051
Hoxb1	homeobox B1	0.050
Pitx3	paired-like homeodomain transcription factor 3	0.049
Foxb1	forkhead box B1	0.049
Srrm4	serine/arginine repetitive matrix 4	0.047
Msi1	Musashi homolog 1(Drosophila)	0.047
Msx2	homeobox, msh-like 2	0.047
Ar	androgen receptor	0.046
Bmp7	bone morphogenetic protein 7	0.046
Wnt6	wingless-related MMTV integration site 6	0.046
Isl1	ISL1 transcription factor, LIM/homeodomain	0.045
Rhcg	Rhesus blood group-associated C glycoprotein	0.045
Sox1	SRY-box containing gene 1	0.045
Wnt3a	wingless-related MMTV integration site 3A	0.044
Lhx9	LIM homeobox protein 9	0.044
Wnt7a	wingless-related MMTV integration site 7A	0.042
Insm1	insulinoma-associated 1	0.042
Ret	ret proto-oncogene	0.042
Nog	noggin	0.040
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.040
Ptprt	protein tyrosine phosphatase, receptor type, T	0.039
Foxc1	forkhead box C1	0.039
Mmp24	matrix metallopeptidase 24	0.038
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.038
Col2a1	collagen, type II, alpha 1	0.038
Zeb1	zinc finger E-box binding homeobox 1	0.037
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.037
Gsc	goosecoid homeobox	0.036
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.036
Dlx2	distal-less homeobox 2	0.035
Tlx2	T-cell leukemia, homeobox 2	0.035
Rarb	retinoic acid receptor, beta	0.035
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.035
Sox10	SRY-box containing gene 10	0.034
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.034
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.032
Dll3	delta-like 3 (Drosophila)	0.032
Alx3	aristaless-like homeobox 3	0.032
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.031
Neurog1	neurogenin 1	0.031
Pou3f1	POU domain, class 3, transcription factor 1	0.031	Mouse
Sox11	SRY-box containing gene 11	0.031
Nkx2-1	NK2 homeobox 1	0.030
Dlx6	distal-less homeobox 6	0.030
Arid3b	AT rich interactive domain 3B (BRIGHT-like)	0.030
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.030
Phox2a	paired-like homeobox 2a	0.030
Prop1	paired like homeodomain factor 1	0.030
Foxe1	forkhead box E1	0.030
BC024139	cDNA sequence BC024139	0.029
Onecut1	one cut domain, family member 1	0.028
Utf1	undifferentiated embryonic cell transcription factor 1	0.028
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.028
Wnt7b	wingless-related MMTV integration site 7B	0.028
Cacng4	calcium channel, voltage-dependent, gamma subunit 4	0.027
Mnx1	motor neuron and pancreas homeobox 1	0.027
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.027
Neurog3	neurogenin 3	0.027
Gli2	GLI-Kruppel family member GLI2	0.027
Esrrb	estrogen related receptor, beta	0.026
Gpr3	G-protein coupled receptor 3	0.026
Tacr1	tachykinin receptor 1	0.025
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.025
Wt1	Wilms tumor 1 homolog	0.025
Pax1	paired box gene 1	0.025	Mouse
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.025
Nup62-il4i1	Nup62-Il4i1 protein	0.024
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.024
Pten	phosphatase and tensin homolog	0.023
Rag2	recombination activating gene 2	0.023
Theg	testicular haploid expressed gene	0.023
Nos1	nitric oxide synthase 1, neuronal	0.023
En1	engrailed 1	0.023
Fam59b	family with sequence similarity 59, member B	0.023
Hes3	hairy and enhancer of split 3 (Drosophila)	0.023
C1ql1	complement component 1, q subcomponent-like 1	0.022
Gsx2	GS homeobox 2	0.022
Rnf2	ring finger protein 2	0.022
Dmrt1	doublesex and mab-3 related transcription factor 1	0.022
En2	engrailed 2	0.022
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.022
Dlx4	distal-less homeobox 4	0.022
Msx3	homeobox, msh-like 3	0.022
Dcc	deleted in colorectal carcinoma	0.021
Neurog2	neurogenin 2	0.021
Zfp42	zinc finger protein 42	0.021
Gsx1	GS homeobox 1	0.020
Fgf21	fibroblast growth factor 21	0.020
Hoxb7	homeobox B7	0.020
Gdnf	glial cell line derived neurotrophic factor	0.020
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.020
AI118078	expressed sequence AI118078	0.020
Fgfr3	fibroblast growth factor receptor 3	0.020
Robo3	roundabout homolog 3 (Drosophila)	0.019
Scrt1	scratch homolog 1, zinc finger protein (Drosophila)	0.019
Khdrbs2	KH domain containing, RNA binding, signal transduction associated 2	0.019
Gjb4	gap junction protein, beta 4	0.019
Nkx6-1	NK6 homeobox 1	0.019
Mbtd1	mbt domain containing 1	0.019
Plcg1	phospholipase C, gamma 1	0.019
Fgf5	fibroblast growth factor 5	0.019
Sspo	SCO-spondin	0.019
Cux2	cut-like homeobox 2	0.019
Hoxa3	homeobox A3	0.019
Neurod2	neurogenic differentiation 2	0.019
Chrna4	cholinergic receptor, nicotinic, alpha polypeptide 4	0.019
Hoxa13	homeobox A13	0.019
Gpr27	G protein-coupled receptor 27	0.019
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.018
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.018
Rpl24	ribosomal protein L24	0.018
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.018
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.018
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.018
Arid1a	AT rich interactive domain 1A (SWI-like)	0.018
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.018
Sox8	SRY-box containing gene 8	0.018
Pitx2	paired-like homeodomain transcription factor 2	0.018
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.017
Hoxa4	homeobox A4	0.017
Wnt4	wingless-related MMTV integration site 4	0.017
Il11	interleukin 11	0.017
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.017
Tcfap2a	transcription factor AP-2, alpha	0.017
Foxl2	forkhead box L2	0.017
Foxa2	forkhead box A2	0.017
Elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.017
Gpr50	G-protein-coupled receptor 50	0.017
Hoxb3	homeobox B3	0.017
Wnt8a	wingless-related MMTV integration site 8A	0.017
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.017
Cyp2w1	cytochrome P450, family 2, subfamily w, polypeptide 1	0.017
Kcne1l	potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene	0.017
Adra2b	adrenergic receptor, alpha 2b	0.017
Pvrl1	poliovirus receptor-related 1	0.016
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.016
Nrtn	neurturin	0.016
Grid1	glutamate receptor, ionotropic, delta 1	0.016
Chrd	chordin	0.016
Thsd7b	thrombospondin, type I, domain containing 7B	0.016
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.016
Hoxb13	homeobox B13	0.016
Zic3	zinc finger protein of the cerebellum 3	0.016
Zbtb12	zinc finger and BTB domain containing 12	0.016
Slc26a4	solute carrier family 26, member 4	0.016
Cbln1	cerebellin 1 precursor protein	0.016
Odz2	odd Oz/ten-m homolog 2 (Drosophila)	0.016
Hoxc13	homeobox C13	0.016
Rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.015
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.015
Rbm39	RNA binding motif protein 39	0.015
Grm2	glutamate receptor, metabotropic 2	0.015
Amh	anti-Mullerian hormone	0.015
Efna4	ephrin A4	0.015
Efna2	ephrin A2	0.015
Tssk2	testis-specific serine kinase 2	0.015
Rxra	retinoid X receptor alpha	0.015
Prm1	protamine 1	0.015
Socs1	suppressor of cytokine signaling 1	0.015
Plxna3	plexin A3	0.015
Apoa1	apolipoprotein A-I	0.015
Wnt2b	wingless related MMTV integration site 2b	0.015
Etv2	ets variant gene 2	0.015
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.015
Zic4	zinc finger protein of the cerebellum 4	0.015
Trp63	transformation related protein 63	0.015
Hoxd1	homeobox D1	0.015
Vsx2	visual system homeobox 2	0.014
Polr1a	polymerase (RNA) I polypeptide A	0.014
Pou3f4	POU domain, class 3, transcription factor 4	0.014	Mouse
Dab1	disabled homolog 1 (Drosophila)	0.014
Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	0.014
Iglon5	IgLON family member 5	0.014
Fgf17	fibroblast growth factor 17	0.014
Paxip1	PAX interacting (with transcription-activation domain) protein 1	0.014
Htr5b	5-hydroxytryptamine (serotonin) receptor 5B	0.014
Kcnh3	potassium voltage-gated channel, subfamily H (eag-related), member 3	0.014
Tshr	thyroid stimulating hormone receptor	0.014
Igk	immunoglobulin kappa chain complex	0.014
Rax	retina and anterior neural fold homeobox	0.014
Jag1	jagged 1	0.014
Tnp2	transition protein 2	0.014
Cd4	CD4 antigen	0.014
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.014
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.013
Sept1	septin 1	0.013
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.013
Brd8	bromodomain containing 8	0.013
Syt6	synaptotagmin VI	0.013
Nodal	nodal	0.013
Bptf	bromodomain PHD finger transcription factor	0.013
Bcl7a	B-cell CLL/lymphoma 7A	0.013
Ceacam9	carcinoembryonic antigen-related cell adhesion molecule 9	0.013
Oprd1	opioid receptor, delta 1	0.013
Hist1h1t	histone cluster 1, H1t	0.013
Aym1	activator of yeast meiotic promoters 1	0.013
Cel	carboxyl ester lipase	0.013
Slc10a1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.013
Sox9	SRY-box containing gene 9	0.013
Cabp7	calcium binding protein 7	0.013
Nhlh1	nescient helix loop helix 1	0.013
Ebf2	early B-cell factor 2	0.013
Efna3	ephrin A3	0.013
Epha8	Eph receptor A8	0.013
Hoxc5	homeobox C5	0.013
Lhx4	LIM homeobox protein 4	0.013
Oxt	oxytocin	0.013
2610109H07Rik	RIKEN cDNA 2610109H07 gene	0.013
Hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	0.012
Foxd4	forkhead box D4	0.012
Hpd	4-hydroxyphenylpyruvic acid dioxygenase	0.012
Hmx2	H6 homeobox 2	0.012
4930549C01Rik	RIKEN cDNA 4930549C01 gene	0.012
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.012
Cnpy1	canopy 1 homolog (zebrafish)	0.012
Nccrp1	non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)	0.012
Mdfi	MyoD family inhibitor	0.012
Hoxa7	homeobox A7	0.012
Dmc1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.012
Igfbpl1	insulin-like growth factor binding protein-like 1	0.012
Olig3	oligodendrocyte transcription factor 3	0.012
Sox21	SRY-box containing gene 21	0.012
Trpc4	transient receptor potential cation channel, subfamily C, member 4	0.012
Ybx2	Y box protein 2	0.012
Trim62	tripartite motif-containing 62	0.012
Magel2	melanoma antigen, family L, 2	0.012
Rybp	RING1 and YY1 binding protein	0.012
Cyp2c38	cytochrome P450, family 2, subfamily c, polypeptide 38	0.012
Wnt8b	wingless related MMTV integration site 8b	0.012
Igh	immunoglobulin heavy chain complex	0.012
Mlph	melanophilin	0.012
Foxn4	forkhead box N4	0.011
Npas1	neuronal PAS domain protein 1	0.011
Olfr71	olfactory receptor 71	0.011
Foxn1	forkhead box N1	0.011
Rasgrp1	RAS guanyl releasing protein 1	0.011
Nppc	natriuretic peptide type C	0.011
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.011
Kirrel2	kin of IRRE like 2 (Drosophila)	0.011
Lamc1	laminin, gamma 1	0.011
Vgf	VGF nerve growth factor inducible	0.011
Celf3	VCUGBP, Elav-like family member 3	0.011
Btbd17	BTB (POZ) domain containing 17	0.011
Chrm4	cholinergic receptor, muscarinic 4	0.011
Insr	insulin receptor	0.011
Neurod4	neurogenic differentiation 4	0.011
Ftmt	ferritin mitochondrial	0.011
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.011
Duox2	dual oxidase 2	0.011
Gatad2b	GATA zinc finger domain containing 2B	0.011
Mc1r	melanocortin 1 receptor	0.011
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.011
Tacr2	tachykinin receptor 2	0.011
Foxd3	forkhead box D3	0.011
Grem1	gremlin 1	0.011
Foxo4	forkhead box O4	0.011
Myo6	myosin VI	0.011
Psca	prostate stem cell antigen	0.011
Slc2a5	solute carrier family 2 (facilitated glucose transporter), member 5	0.011
Runx2	runt related transcription factor 2	0.011
Tbx15	T-box 15	0.011
Sema6c	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	0.010
Adcyap1	adenylate cyclase activating polypeptide 1	0.010
Lcn3	lipocalin 3	0.010
Nrg3	neuregulin 3	0.010
Kirrel3	kin of IRRE like 3 (Drosophila)	0.010
Nat3	N-acetyltransferase 3	0.010
Syt2	synaptotagmin II	0.010
Onecut2	one cut domain, family member 2	0.010
Krt27	keratin 27	0.010
Nkx3-2	NK3 homeobox 2	0.010
Pnoc	prepronociceptin	0.010
Zfp92	zinc finger protein 92	0.010
Esr1	estrogen receptor 1 (alpha)	0.010
Slc18a3	solute carrier family 18 (vesicular monoamine), member 3	0.010
Phox2b	paired-like homeobox 2b	0.010
Igl	immunoglobulin lambda chain complex	0.010
Mta3	metastasis associated 3	0.010