IMP

Process View

Mus musculus

4 genes annotated in mouse

Multi-species View

negative regulation of heart rate

GO:0010459

Any process that stops, prevents or reduces the frequency or rate of heart contraction.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of heart rate"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of heart rate" (in gray)

Name	Description	Probability	Func Analog Organism
Ren1	renin 1 structural	0.997
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.875
Agtr1a	angiotensin II receptor, type 1a	0.867	Mouse
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.728
Nos3	nitric oxide synthase 3, endothelial cell	0.674
Ank1	ankyrin 1, erythroid	0.500
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.437
Lepr	leptin receptor	0.428
Spna1	spectrin alpha 1	0.363
Add2	adducin 2 (beta)	0.297
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.246
Wt1	Wilms tumor 1 homolog	0.236
Agtrap	angiotensin II, type I receptor-associated protein	0.235
Bdkrb2	bradykinin receptor, beta 2	0.184	Mouse
Slc12a1	solute carrier family 12, member 1	0.181
Fbn1	fibrillin 1	0.170
Nr3c2	nuclear receptor subfamily 3, group C, member 2	0.125
Tgfbr2	transforming growth factor, beta receptor II	0.112
Aqp2	aquaporin 2	0.091
Lox	lysyl oxidase	0.091
Gab1	growth factor receptor bound protein 2-associated protein 1	0.084
Fyn	Fyn proto-oncogene	0.079
Ldlr	low density lipoprotein receptor	0.078
Umod	uromodulin	0.075
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.070
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.068
Agtr2	angiotensin II receptor, type 2	0.065
Adra1b	adrenergic receptor, alpha 1b	0.063	Mouse
Irs1	insulin receptor substrate 1	0.062
Eln	elastin	0.062
Pklr	pyruvate kinase liver and red blood cell	0.060
Prkag1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	0.053
Vdr	vitamin D receptor	0.051
Mas1	MAS1 oncogene	0.048
Epb4.1	erythrocyte protein band 4.1	0.046
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.045
Hbb-b1	hemoglobin, beta adult major chain	0.045
Slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.043
Exoc6	exocyst complex component 6	0.039
Pcdh12	protocadherin 12	0.037
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.037
Tek	endothelial-specific receptor tyrosine kinase	0.034
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.034
Fech	ferrochelatase	0.033
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.029
Robo2	roundabout homolog 2 (Drosophila)	0.029
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.026
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.026
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.025
Adra1a	adrenergic receptor, alpha 1a	0.025
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.025
Glis2	GLIS family zinc finger 2	0.024
Nos1	nitric oxide synthase 1, neuronal	0.024
Ret	ret proto-oncogene	0.024
Spna2	spectrin alpha 2	0.024
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.023
9430031J16Rik	RIKEN cDNA 9430031J16 gene	0.023
Col4a3	collagen, type IV, alpha 3	0.022
Nos2	nitric oxide synthase 2, inducible	0.021
Kitl	kit ligand	0.021
Cyp4a14	cytochrome P450, family 4, subfamily a, polypeptide 14	0.021
Kif1b	kinesin family member 1B	0.020
Vegfa	vascular endothelial growth factor A	0.020
Aprt	adenine phosphoribosyl transferase	0.020
Hk1	hexokinase 1	0.019
Tgfbr3	transforming growth factor, beta receptor III	0.019
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.019
Agtr1b	angiotensin II receptor, type 1b	0.019	Mouse
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.019
Fgfr4	fibroblast growth factor receptor 4	0.019
Tgfbr1	transforming growth factor, beta receptor I	0.018
Ryk	receptor-like tyrosine kinase	0.018
Epor	erythropoietin receptor	0.018
Ttc7	tetratricopeptide repeat domain 7	0.017
Bcan	brevican	0.017
Ptgs2	prostaglandin-endoperoxide synthase 2	0.017
Tm4sf1	transmembrane 4 superfamily member 1	0.017
Crhr1	corticotropin releasing hormone receptor 1	0.016
Wdr1	WD repeat domain 1	0.016
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.016
Klf1	Kruppel-like factor 1 (erythroid)	0.016
Met	met proto-oncogene	0.015
Adcy6	adenylate cyclase 6	0.015
Prkacb	protein kinase, cAMP dependent, catalytic, beta	0.015
Snta1	syntrophin, acidic 1	0.015
Olfr90	olfactory receptor 90	0.015
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.015
Bcl6b	B-cell CLL/lymphoma 6, member B	0.014
Klk1b11	kallikrein 1-related peptidase b11	0.014
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.014
Fgf2	fibroblast growth factor 2	0.014
Fgf17	fibroblast growth factor 17	0.014
Syt6	synaptotagmin VI	0.014
Tmprss6	transmembrane serine protease 6	0.014
Tcf15	transcription factor 15	0.014
Gsk3b	glycogen synthase kinase 3 beta	0.014
Slc29a4	solute carrier family 29 (nucleoside transporters), member 4	0.014
Ryr2	ryanodine receptor 2, cardiac	0.014
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.014
Steap3	STEAP family member 3	0.014
Tcf4	transcription factor 4	0.014
Cyp11b2	cytochrome P450, family 11, subfamily b, polypeptide 2	0.014
Zbtb20	zinc finger and BTB domain containing 20	0.014
Irg1	immunoresponsive gene 1	0.014
Macf1	microtubule-actin crosslinking factor 1	0.014
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.014
Mef2a	myocyte enhancer factor 2A	0.014
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.013
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.013
Mrap	melanocortin 2 receptor accessory protein	0.013
Pcmtd1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	0.013
Tuba1a	tubulin, alpha 1A	0.013
Pax2	paired box gene 2	0.013
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.013
Camk2d	calcium/calmodulin-dependent protein kinase II, delta	0.013
Krt25	keratin 25	0.013
She	src homology 2 domain-containing transforming protein E	0.013
Rem1	rad and gem related GTP binding protein 1	0.013
Apln	apelin	0.012
Dlk1	delta-like 1 homolog (Drosophila)	0.012
Kcns1	K+ voltage-gated channel, subfamily S, 1	0.012
Rac1	RAS-related C3 botulinum substrate 1	0.012
Kcnk4	potassium channel, subfamily K, member 4	0.012
Pcsk1n	proprotein convertase subtilisin/kexin type 1 inhibitor	0.012
H1foo	H1 histone family, member O, oocyte-specific	0.012
Icam5	intercellular adhesion molecule 5, telencephalin	0.012
Notch4	Notch gene homolog 4 (Drosophila)	0.012
Rab12	RAB12, member RAS oncogene family	0.012
Klf7	Kruppel-like factor 7 (ubiquitous)	0.012
Tnfaip1	tumor necrosis factor, alpha-induced protein 1 (endothelial)	0.012
Shroom1	shroom family member 1	0.011
Atoh7	atonal homolog 7 (Drosophila)	0.011
Pcnxl2	pecanex-like 2 (Drosophila)	0.011
Gab2	growth factor receptor bound protein 2-associated protein 2	0.011
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.011
Krt36	keratin 36	0.011
Gng4	guanine nucleotide binding protein (G protein), gamma 4	0.011
Clip2	CAP-GLY domain containing linker protein 2	0.011
Srcin1	SRC kinase signaling inhibitor 1	0.011
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.011
Scn5a	sodium channel, voltage-gated, type V, alpha	0.011
Slc1a6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.011
Mog	myelin oligodendrocyte glycoprotein	0.011
Foxf1a	forkhead box F1a	0.011
Calm1	calmodulin 1	0.011
Mdfi	MyoD family inhibitor	0.011
Jak1	Janus kinase 1	0.010
Cntn4	contactin 4	0.010
Pax4	paired box gene 4	0.010
Nckap1	NCK-associated protein 1	0.010
Snn	stannin	0.010
Klhl24	kelch-like 24 (Drosophila)	0.010
Cdh5	cadherin 5	0.010
Nrip2	nuclear receptor interacting protein 2	0.010
Nfib	nuclear factor I/B	0.010
Gja10	gap junction protein, alpha 10	0.010
Ccl22	chemokine (C-C motif) ligand 22	0.010
Kdr	kinase insert domain protein receptor	0.010
Nrip1	nuclear receptor interacting protein 1	0.010
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.010
Ghr	growth hormone receptor	0.010
Zeb2	zinc finger E-box binding homeobox 2	0.010
Cyp11b1	cytochrome P450, family 11, subfamily b, polypeptide 1	0.010