IMP

Process View

Mus musculus

11 genes annotated in mouse

regulation of interleukin 6 biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of interleukin 6 biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of interleukin 6 biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
Tnf	tumor necrosis factor	0.895
Tlr4	toll-like receptor 4	0.871	Mouse
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.815
Il10	interleukin 10	0.813
Cd40	CD40 antigen	0.581
Cd19	CD19 antigen	0.576
Igh	immunoglobulin heavy chain complex	0.542
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.514
Fas	Fas (TNF receptor superfamily member 6)	0.490
Ccl2	chemokine (C-C motif) ligand 2	0.348
Ccr2	chemokine (C-C motif) receptor 2	0.341
Il6	interleukin 6	0.325
Myd88	myeloid differentiation primary response gene 88	0.317
Il1r1	interleukin 1 receptor, type I	0.310
Lepr	leptin receptor	0.289
Mmp9	matrix metallopeptidase 9	0.259
Lyz2	lysozyme 2	0.232
Foxp3	forkhead box P3	0.183
Btk	Bruton agammaglobulinemia tyrosine kinase	0.169
Lta	lymphotoxin A	0.163
Irak4	interleukin-1 receptor-associated kinase 4	0.137
Nos2	nitric oxide synthase 2, inducible	0.123
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.112
Spp1	secreted phosphoprotein 1	0.092
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.086
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.073
Tlr2	toll-like receptor 2	0.069	Mouse
Ncoa3	nuclear receptor coactivator 3	0.065
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.064
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.062
Csf1	colony stimulating factor 1 (macrophage)	0.060
Mavs	mitochondrial antiviral signaling protein	0.058
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.054
Siglec5	sialic acid binding Ig-like lectin 5	0.052
Apoe	apolipoprotein E	0.050
Birc3	baculoviral IAP repeat-containing 3	0.050
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.049
Traf3ip2	TRAF3 interacting protein 2	0.048
Pparg	peroxisome proliferator activated receptor gamma	0.048
Mmp8	matrix metallopeptidase 8	0.046
Stat3	signal transducer and activator of transcription 3	0.045
Il1b	interleukin 1 beta	0.045
Il4	interleukin 4	0.045
Lif	leukemia inhibitory factor	0.040
Ldlr	low density lipoprotein receptor	0.040
Rag1	recombination activating gene 1	0.039
Ikbkg	inhibitor of kappaB kinase gamma	0.036
Cxcl1	chemokine (C-X-C motif) ligand 1	0.034
Tgfb1	transforming growth factor, beta 1	0.034
Ccr5	chemokine (C-C motif) receptor 5	0.032
Ifng	interferon gamma	0.032
Ptgs2	prostaglandin-endoperoxide synthase 2	0.030
Lrp1	low density lipoprotein receptor-related protein 1	0.029
Noto	notochord homolog (Xenopus laevis)	0.029
Trp53	transformation related protein 53	0.029
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.028	Mouse
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.028
Shc1	src homology 2 domain-containing transforming protein C1	0.027
Il1a	interleukin 1 alpha	0.027	Mouse
Rag2	recombination activating gene 2	0.026
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.024
Kif19a	kinesin family member 19A	0.024
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.024
Ikzf1	IKAROS family zinc finger 1	0.023
Col1a1	collagen, type I, alpha 1	0.022
Foxo1	forkhead box O1	0.021
Hif1a	hypoxia inducible factor 1, alpha subunit	0.020
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.019
Icos	inducible T-cell co-stimulator	0.019
Irak3	interleukin-1 receptor-associated kinase 3	0.019
Nlrp3	NLR family, pyrin domain containing 3	0.019
Cd14	CD14 antigen	0.019
Tcra	T-cell receptor alpha chain	0.018
Ccr7	chemokine (C-C motif) receptor 7	0.018
Irg1	immunoresponsive gene 1	0.018
Marco	macrophage receptor with collagenous structure	0.018
Cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.017
Dok2	docking protein 2	0.017
Fpr1	formyl peptide receptor 1	0.016
Cxcl2	chemokine (C-X-C motif) ligand 2	0.016
Dnahc11	dynein, axonemal, heavy chain 11	0.015
Sykb	spleen tyrosine kinase	0.015
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.015
Clec4d	C-type lectin domain family 4, member d	0.015
Cbl	Casitas B-lineage lymphoma	0.014
Selp	selectin, platelet	0.014
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.014
Cd44	CD44 antigen	0.014
Msr1	macrophage scavenger receptor 1	0.014
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.013
Il21r	interleukin 21 receptor	0.013
Pou2af1	POU domain, class 2, associating factor 1	0.013
Il1f9	interleukin 1 family, member 9	0.013
Pyhin1	pyrin and HIN domain family, member 1	0.013
Cd300ld	CD300 molecule-like family member d	0.012
Foxa2	forkhead box A2	0.012
Clec4e	C-type lectin domain family 4, member e	0.012
Ticam1	toll-like receptor adaptor molecule 1	0.012
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.012
Tlr6	toll-like receptor 6	0.012	Mouse
Vdr	vitamin D receptor	0.012
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.011
Sharpin	SHANK-associated RH domain interacting protein	0.011
Cd22	CD22 antigen	0.011
Cd33	CD33 antigen	0.011
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.011
Ltbr	lymphotoxin B receptor	0.010
Il18rap	interleukin 18 receptor accessory protein	0.010
Il1rn	interleukin 1 receptor antagonist	0.010	Mouse