IMP
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regulation of ligase activity
Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
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Click on a gene's description to view its network relationships with genes known to be involved in "regulation of ligase activity"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Trp53 | transformation related protein 53 | 0.916 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.626 | ||
| Atf4 | activating transcription factor 4 | 0.602 | ||
| Lrrk2 | leucine-rich repeat kinase 2 | 0.602 | ||
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.540 | ||
| Psen1 | presenilin 1 | 0.536 | ||
| Axin1 | axin 1 | 0.427 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.338 | ||
| Gclc | glutamate-cysteine ligase, catalytic subunit | 0.208 | ||
| Cdca8 | cell division cycle associated 8 | 0.174 | ||
| Gsk3b | glycogen synthase kinase 3 beta | 0.159 | ||
| Apc | adenomatosis polyposis coli | 0.159 | ||
| Smad7 | MAD homolog 7 (Drosophila) | 0.144 | Human | |
| Cdk2 | cyclin-dependent kinase 2 | 0.135 | ||
| Ppp2r1a | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform | 0.115 | ||
| Rnf111 | ring finger 111 | 0.107 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.094 | ||
| Ccnb1 | cyclin B1 | 0.083 | ||
| Traf6 | TNF receptor-associated factor 6 | 0.080 | ||
| Rpgrip1l | Rpgrip1-like | 0.074 | ||
| Ywhab | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.074 | Yeast | |
| Ncstn | nicastrin | 0.069 | ||
| Dohh | deoxyhypusine hydroxylase/monooxygenase | 0.067 | ||
| Abl2 | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | 0.066 | ||
| Cdk1 | cyclin-dependent kinase 1 | 0.051 | ||
| Cdc20 | cell division cycle 20 homolog (S. cerevisiae) | 0.050 | Human Yeast | |
| Mybl2 | myeloblastosis oncogene-like 2 | 0.047 | ||
| Dok1 | docking protein 1 | 0.046 | ||
| Crk | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.044 | ||
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.043 | ||
| Irf6 | interferon regulatory factor 6 | 0.035 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.034 | ||
| Kif22 | kinesin family member 22 | 0.034 | ||
| Smad4 | MAD homolog 4 (Drosophila) | 0.032 | ||
| Skp1a | S-phase kinase-associated protein 1A | 0.032 | ||
| Ccne1 | cyclin E1 | 0.031 | Fly | |
| Ccnb2 | cyclin B2 | 0.029 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.028 | ||
| Casp8 | caspase 8 | 0.027 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.027 | ||
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.026 | ||
| Sfn | stratifin | 0.025 | Yeast | |
| Tbcb | tubulin folding cofactor B | 0.025 | ||
| Cops6 | COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) | 0.024 | ||
| Ptch1 | patched homolog 1 | 0.023 | ||
| Ube2c | ubiquitin-conjugating enzyme E2C | 0.023 | ||
| Smurf1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.023 | ||
| Ccna2 | cyclin A2 | 0.022 | ||
| Skil | SKI-like | 0.021 | ||
| Traf2 | TNF receptor-associated factor 2 | 0.020 | ||
| Bub1b | budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) | 0.020 | ||
| Sgol2 | shugoshin-like 2 (S. pombe) | 0.020 | ||
| Ywhah | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 0.020 | ||
| Aph1a | anterior pharynx defective 1a homolog (C. elegans) | 0.019 | ||
| Ywhag | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 0.019 | Yeast | |
| Mbd3 | methyl-CpG binding domain protein 3 | 0.019 | ||
| Nedd4l | neural precursor cell expressed, developmentally down-regulated gene 4-like | 0.018 | ||
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.018 | ||
| Hsp90ab1 | heat shock protein 90 alpha (cytosolic), class B member 1 | 0.018 | ||
| Zbtb7a | zinc finger and BTB domain containing 7a | 0.017 | ||
| Aurka | aurora kinase A | 0.017 | ||
| Birc5 | baculoviral IAP repeat-containing 5 | 0.016 | ||
| Rnf2 | ring finger protein 2 | 0.015 | ||
| Map2k3 | mitogen-activated protein kinase kinase 3 | 0.015 | ||
| Akt1 | thymoma viral proto-oncogene 1 | 0.014 | ||
| Dok2 | docking protein 2 | 0.014 | ||
| Lef1 | lymphoid enhancer binding factor 1 | 0.014 | ||
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | 0.014 | ||
| Gtse1 | G two S phase expressed protein 1 | 0.013 | ||
| Rfwd2 | ring finger and WD repeat domain 2 | 0.013 | ||
| Ube2v2 | ubiquitin-conjugating enzyme E2 variant 2 | 0.013 | ||
| Runx1 | runt related transcription factor 1 | 0.013 | ||
| Kif20a | kinesin family member 20A | 0.013 | ||
| Ripk4 | receptor-interacting serine-threonine kinase 4 | 0.013 | Mouse | |
| Smad6 | MAD homolog 6 (Drosophila) | 0.013 | ||
| Psen2 | presenilin 2 | 0.012 | ||
| Efnb2 | ephrin B2 | 0.012 | ||
| Drap1 | Dr1 associated protein 1 (negative cofactor 2 alpha) | 0.012 | ||
| Prkce | protein kinase C, epsilon | 0.011 | ||
| Acot7 | acyl-CoA thioesterase 7 | 0.011 | ||
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.011 | ||
| Ric8 | resistance to inhibitors of cholinesterase 8 homolog (C. elegans) | 0.011 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.010 | ||
| Trp73 | transformation related protein 73 | 0.010 | ||
| Dll1 | delta-like 1 (Drosophila) | 0.010 |