IMP

Process View

Mus musculus

19 genes annotated in mouse

protein activation cascade

A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
C1qc	complement component 1, q subcomponent, C chain	0.998	Zebrafish Mouse
Klk1b5	kallikrein 1-related peptidase b5	0.996	Mouse
C1ra	complement component 1, r subcomponent A	0.991	Mouse
Klk1b26	kallikrein 1-related petidase b26	0.981	Mouse
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.979
Klk1b8	kallikrein 1-related peptidase b8	0.977	Mouse
Klk1b1	kallikrein 1-related peptidase b1	0.973
Klk1	kallikrein 1	0.964	Mouse
Folr2	folate receptor 2 (fetal)	0.930
Klk1b11	kallikrein 1-related peptidase b11	0.923	Mouse
Fga	fibrinogen alpha chain	0.907	Human Zebrafish
Itih4	inter alpha-trypsin inhibitor, heavy chain 4	0.895
Klk1b21	kallikrein 1-related peptidase b21	0.890	Mouse
Klk1b4	kallikrein 1-related pepidase b4	0.871	Mouse
C3	complement component 3	0.860
C4b	complement component 4B (Childo blood group)	0.828
Cd59a	CD59a antigen	0.817
C1qb	complement component 1, q subcomponent, beta polypeptide	0.810	Zebrafish Mouse
Cfh	complement component factor h	0.803
Kng1	kininogen 1	0.793
Aif1	allograft inflammatory factor 1	0.786
Klk1b27	kallikrein 1-related peptidase b27	0.762	Mouse
Klk1b3	kallikrein 1-related peptidase b3	0.754	Mouse
Klk1b9	kallikrein 1-related peptidase b9	0.736	Mouse
Apoe	apolipoprotein E	0.727
C2	complement component 2 (within H-2S)	0.717
Fgg	fibrinogen gamma chain	0.713	Mouse
Cd59b	CD59b antigen	0.676
C1rb	complement component 1, r subcomponent B	0.673
C1s	complement component 1, s subcomponent	0.608	Mouse
Klk1b16	kallikrein 1-related peptidase b16	0.607	Mouse
Klk1b24	kallikrein 1-related peptidase b24	0.585	Mouse
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.545
Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	0.479	Human
F9	coagulation factor IX	0.477
Hrg	histidine-rich glycoprotein	0.431
Tmem176a	transmembrane protein 176A	0.402
Rarres2	retinoic acid receptor responder (tazarotene induced) 2	0.397
Cp	ceruloplasmin	0.377
Mrc1	mannose receptor, C type 1	0.371
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.361
Egfbp2	epidermal growth factor binding protein type B	0.341
Saa4	serum amyloid A 4	0.327
Cd19	CD19 antigen	0.325
Ifitm3	interferon induced transmembrane protein 3	0.311
Tyrobp	TYRO protein tyrosine kinase binding protein	0.301
1300017J02Rik	RIKEN cDNA 1300017J02 gene	0.286
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.281
Mug1	murinoglobulin 1	0.279	Mouse
Tmem176b	transmembrane protein 176B	0.276
Mup3	major urinary protein 3	0.275
Igh	immunoglobulin heavy chain complex	0.254
Cd5l	CD5 antigen-like	0.253
Pzp	pregnancy zone protein	0.244	Mouse
Hgd	homogentisate 1, 2-dioxygenase	0.243
Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	0.238
Cyp2d10	cytochrome P450, family 2, subfamily d, polypeptide 10	0.216
Agxt	alanine-glyoxylate aminotransferase	0.212
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.210
Apcs	serum amyloid P-component	0.204
Serpina12	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	0.195
Otc	ornithine transcarbamylase	0.195
Hc	hemolytic complement	0.174	Mouse
Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.165
Nnmt	nicotinamide N-methyltransferase	0.148
F13b	coagulation factor XIII, beta subunit	0.132	Mouse
Ahsg	alpha-2-HS-glycoprotein	0.129
Col14a1	collagen, type XIV, alpha 1	0.126
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.126
Akr1c6	aldo-keto reductase family 1, member C6	0.121
Adh4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.121
Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	0.120
Ces1c	carboxylesterase 1C	0.119
Smr3a	submaxillary gland androgen regulated protein 3A	0.112
Timd2	T-cell immunoglobulin and mucin domain containing 2	0.112
Apoc4	apolipoprotein C-IV	0.108
Orm2	orosomucoid 2	0.106
Eln	elastin	0.102
Ccl6	chemokine (C-C motif) ligand 6	0.099
Ambp	alpha 1 microglobulin/bikunin	0.099
C9	complement component 9	0.092	Mouse
Grn	granulin	0.090
Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	0.090
Dpt	dermatopontin	0.090
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.089
Ctsq	cathepsin Q	0.089
Ctsh	cathepsin H	0.088
Proc	protein C	0.083
Hal	histidine ammonia lyase	0.083
F7	coagulation factor VII	0.079
Mug2	murinoglobulin 2	0.078
Ivl	involucrin	0.076
F12	coagulation factor XII (Hageman factor)	0.076	Human
Cpn1	carboxypeptidase N, polypeptide 1	0.075
Fcna	ficolin A	0.074
Ly86	lymphocyte antigen 86	0.071
Mbl2	mannose-binding lectin (protein C) 2	0.071
Cfb	complement factor B	0.069
Lipc	lipase, hepatic	0.068
H2-Eb1	histocompatibility 2, class II antigen E beta	0.067
Cfi	complement component factor i	0.066
Cela2a	chymotrypsin-like elastase family, member 2A	0.065
Apoa1	apolipoprotein A-I	0.064
Gm4788	predicted gene 4788	0.064	Rat
Serpina3c	serine (or cysteine) peptidase inhibitor, clade A, member 3C	0.064
Egfr	epidermal growth factor receptor	0.062
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.061
Plg	plasminogen	0.060
Csf1r	colony stimulating factor 1 receptor	0.059
Gc	group specific component	0.058
Lyz1	lysozyme 1	0.057
Rdh7	retinol dehydrogenase 7	0.056
Aadac	arylacetamide deacetylase (esterase)	0.056
Tdo2	tryptophan 2,3-dioxygenase	0.056
Mrpl3	mitochondrial ribosomal protein L3	0.055
Cfhr1	complement factor H-related 1	0.055
Serpina1c	serine (or cysteine) peptidase inhibitor, clade A, member 1C	0.054
Atad3a	ATPase family, AAA domain containing 3A	0.054
Hpx	hemopexin	0.052
Foxn1	forkhead box N1	0.052
Cfhr2	complement factor H-related 2	0.051	Rat
Mbl1	mannose-binding lectin (protein A) 1	0.051
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.051
Cyp2j5	cytochrome P450, family 2, subfamily j, polypeptide 5	0.050
Klk1b22	kallikrein 1-related peptidase b22	0.049	Mouse
Hsd3b2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.049
Pcdh12	protocadherin 12	0.048
Sftpb	surfactant associated protein B	0.048
F10	coagulation factor X	0.047
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.046
Cd302	CD302 antigen	0.045
Slc26a1	solute carrier family 26 (sulfate transporter), member 1	0.044
Aadat	aminoadipate aminotransferase	0.044
Fbp1	fructose bisphosphatase 1	0.044
Hp	haptoglobin	0.044
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.044
Rdh16	retinol dehydrogenase 16	0.042
Rpe65	retinal pigment epithelium 65	0.041
Dmgdh	dimethylglycine dehydrogenase precursor	0.041
Ctss	cathepsin S	0.039
LOC100048884	novel member of the major urinary protein (Mup) gene family	0.039
Timm10	translocase of inner mitochondrial membrane 10 homolog (yeast)	0.039
Serpina1a	serine (or cysteine) peptidase inhibitor, clade A, member 1A	0.039
Expi	extracellular proteinase inhibitor	0.038
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.038
Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase	0.038
Igf1	insulin-like growth factor 1	0.038
Mup5	major urinary protein 5	0.038
Apof	apolipoprotein F	0.037
1100001G20Rik	RIKEN cDNA 1100001G20 gene	0.037
Mucl1	mucin-like 1	0.037
Ces3a	carboxylesterase 3A	0.037
Prr15	proline rich 15	0.037
Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2	0.037
Psp	parotid secretory protein	0.037
Asgr2	asialoglycoprotein receptor 2	0.036
C4bp	complement component 4 binding protein	0.036	Human Mouse
Uox	urate oxidase	0.036
Masp2	mannan-binding lectin serine peptidase 2	0.035
Msln	mesothelin	0.035
F8	coagulation factor VIII	0.035
Vsig4	V-set and immunoglobulin domain containing 4	0.035
Cfd	complement factor D (adipsin)	0.035
Dmbt1	deleted in malignant brain tumors 1	0.035
Hpd	4-hydroxyphenylpyruvic acid dioxygenase	0.034
F2	coagulation factor II	0.033
Aicda	activation-induced cytidine deaminase	0.032
Cfp	complement factor properdin	0.032
Itih1	inter-alpha trypsin inhibitor, heavy chain 1	0.032
Fgb	fibrinogen beta chain	0.031
Htra3	HtrA serine peptidase 3	0.030
Slc6a12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.030
Hamp	hepcidin antimicrobial peptide	0.030
Cd163	CD163 antigen	0.030
Serpinf1	serine (or cysteine) peptidase inhibitor, clade F, member 1	0.030
Pou1f1	POU domain, class 1, transcription factor 1	0.030
Afm	afamin	0.029
C8a	complement component 8, alpha polypeptide	0.029	Human Mouse
Cd55	CD55 antigen	0.029
Amdhd1	amidohydrolase domain containing 1	0.029
Lgals3bp	lectin, galactoside-binding, soluble, 3 binding protein	0.029
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.028
Pros1	protein S (alpha)	0.028
Cuzd1	CUB and zona pellucida-like domains 1	0.028
Rag2	recombination activating gene 2	0.027
Pah	phenylalanine hydroxylase	0.027
Tnxb	tenascin XB	0.027
Klkb1	kallikrein B, plasma 1	0.027
Alb	albumin	0.027
Lrg1	leucine-rich alpha-2-glycoprotein 1	0.026
ND6	NADH dehydrogenase subunit 6	0.026
Ugt3a2	UDP glycosyltransferases 3 family, polypeptide A2	0.026
F11	coagulation factor XI	0.026
Lum	lumican	0.026
Cxcl13	chemokine (C-X-C motif) ligand 13	0.026
Apoa5	apolipoprotein A-V	0.026
Cnn1	calponin 1	0.025
Clps	colipase, pancreatic	0.025
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.025
Cd68	CD68 antigen	0.025
Ceacam2	carcinoembryonic antigen-related cell adhesion molecule 2	0.025
Rab27a	RAB27A, member RAS oncogene family	0.024
Orm1	orosomucoid 1	0.023
Cyp2c29	cytochrome P450, family 2, subfamily c, polypeptide 29	0.023
Pla2g2c	phospholipase A2, group IIC	0.023
Slc3a1	solute carrier family 3, member 1	0.023
Avpr1a	arginine vasopressin receptor 1A	0.022
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.022
Hsd3b3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3	0.022
Cela1	chymotrypsin-like elastase family, member 1	0.022
Igl	immunoglobulin lambda chain complex	0.021
Steap4	STEAP family member 4	0.021
Zg16	zymogen granule protein 16	0.021
Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	0.021
Ctsg	cathepsin G	0.021
G6pc	glucose-6-phosphatase, catalytic	0.021
Saa2	serum amyloid A 2	0.021
Car3	carbonic anhydrase 3	0.020
Glyat	glycine-N-acyltransferase	0.020
Mfap5	microfibrillar associated protein 5	0.020
Gucy2e	guanylate cyclase 2e	0.020
Serpina3m	serine (or cysteine) peptidase inhibitor, clade A, member 3M	0.020
Azgp1	alpha-2-glycoprotein 1, zinc	0.020
Clec4g	C-type lectin domain family 4, member g	0.019
Dpys	dihydropyrimidinase	0.019
Dio1	deiodinase, iodothyronine, type I	0.019
Pigr	polymeric immunoglobulin receptor	0.019
Fabp1	fatty acid binding protein 1, liver	0.019
Mosc1	MOCO sulphurase C-terminal domain containing 1	0.019
Pld4	phospholipase D family, member 4	0.019
Ang	angiogenin, ribonuclease, RNase A family, 5	0.019
Stab1	stabilin 1	0.019
Lyz2	lysozyme 2	0.018
Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	0.018
Lbp	lipopolysaccharide binding protein	0.018
Lrrc23	leucine rich repeat containing 23	0.018
Nr1i3	nuclear receptor subfamily 1, group I, member 3	0.018
Sycn	syncollin	0.018
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.018
Masp1	mannan-binding lectin serine peptidase 1	0.018
Serpind1	serine (or cysteine) peptidase inhibitor, clade D, member 1	0.018
Cps1	carbamoyl-phosphate synthetase 1	0.018
Rgn	regucalcin	0.017
Ces4a	carboxylesterase 4A	0.017
Mup4	major urinary protein 4	0.017
F5	coagulation factor V	0.017
Lect2	leukocyte cell-derived chemotaxin 2	0.017
Nags	N-acetylglutamate synthase	0.017
Cyp2f2	cytochrome P450, family 2, subfamily f, polypeptide 2	0.017
Prl7a1	prolactin family 7, subfamily a, member 1	0.017
Mat1a	methionine adenosyltransferase I, alpha	0.017
Csn1s1	casein alpha s1	0.017
Adrb3	adrenergic receptor, beta 3	0.017
Nr1h4	nuclear receptor subfamily 1, group H, member 4	0.017
Itih3	inter-alpha trypsin inhibitor, heavy chain 3	0.017
Cyp2a12	cytochrome P450, family 2, subfamily a, polypeptide 12	0.016
Gkn2	gastrokine 2	0.016
Ager	advanced glycosylation end product-specific receptor	0.016
Cyp2c44	cytochrome P450, family 2, subfamily c, polypeptide 44	0.016
Cd209f	CD209f antigen	0.016
Saa3	serum amyloid A 3	0.016
Cyp2c54	cytochrome P450, family 2, subfamily c, polypeptide 54	0.016
Try5	trypsin 5	0.016
Cpxm2	carboxypeptidase X 2 (M14 family)	0.016
Prodh2	proline dehydrogenase (oxidase) 2	0.016
Cyp2c37	cytochrome P450, family 2. subfamily c, polypeptide 37	0.016
Serpina1e	serine (or cysteine) peptidase inhibitor, clade A, member 1E	0.016
Tnp2	transition protein 2	0.016
Papolb	poly (A) polymerase beta (testis specific)	0.016
Sfrp4	secreted frizzled-related protein 4	0.016
Gm6484	predicted gene 6484	0.015
Cpn2	carboxypeptidase N, polypeptide 2	0.015
Fcgrt	Fc receptor, IgG, alpha chain transporter	0.015
Sult1b1	sulfotransferase family 1B, member 1	0.015
H2-Q10	histocompatibility 2, Q region locus 10	0.015
Ms4a4d	membrane-spanning 4-domains, subfamily A, member 4D	0.015
Prtn3	proteinase 3	0.015
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.015
Cd209g	CD209g antigen	0.015
Apoa4	apolipoprotein A-IV	0.015
Pla1a	phospholipase A1 member A	0.015
Crp	C-reactive protein, pentraxin-related	0.015
Cyp7b1	cytochrome P450, family 7, subfamily b, polypeptide 1	0.014
Hsd3b6	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6	0.014
Mpeg1	macrophage expressed gene 1	0.014
Slco1b2	solute carrier organic anion transporter family, member 1b2	0.014
Ccl9	chemokine (C-C motif) ligand 9	0.014
A2m	alpha-2-macroglobulin	0.014	Human
Prg4	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)	0.014
Fgfr4	fibroblast growth factor receptor 4	0.014
Bhmt2	betaine-homocysteine methyltransferase 2	0.014
Retn	resistin	0.014
Clec10a	C-type lectin domain family 10, member A	0.014
Reg2	regenerating islet-derived 2	0.014
Il1r1	interleukin 1 receptor, type I	0.014
Gnmt	glycine N-methyltransferase	0.014
Itih2	inter-alpha trypsin inhibitor, heavy chain 2	0.014
Oxsm	3-oxoacyl-ACP synthase, mitochondrial	0.014
Pgk2	phosphoglycerate kinase 2	0.014
Inhbe	inhibin beta E	0.013
Ifitm2	interferon induced transmembrane protein 2	0.013
Cyp2c68	cytochrome P450, family 2, subfamily c, polypeptide 68	0.013
Sva	seminal vesicle antigen	0.013
Clic3	chloride intracellular channel 3	0.013
Cyp4a12a	cytochrome P450, family 4, subfamily a, polypeptide 12a	0.013
Lce1d	late cornified envelope 1D	0.013
Trfr2	transferrin receptor 2	0.013
Tcl1b3	T-cell leukemia/lymphoma 1B, 3	0.013
Creb3l3	cAMP responsive element binding protein 3-like 3	0.013
Sync	syncoilin	0.013
Ces1e	carboxylesterase 1E	0.013
Tfpi2	tissue factor pathway inhibitor 2	0.013
H2-K1	histocompatibility 2, K1, K region	0.012
Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	0.012
Cyp4v3	cytochrome P450, family 4, subfamily v, polypeptide 3	0.012
Il9	interleukin 9	0.012
Fetub	fetuin beta	0.012
Itgbl1	integrin, beta-like 1	0.012
Lgals7	lectin, galactose binding, soluble 7	0.012
Ugt2b5	UDP glucuronosyltransferase 2 family, polypeptide B5	0.012
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.012
Chad	chondroadherin	0.012
Lcn13	lipocalin 13	0.012
Khdc1b	KH domain containing 1B	0.012
Slc10a1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.012
Trf	transferrin	0.012
Ropn1l	ropporin 1-like	0.012
Fmo3	flavin containing monooxygenase 3	0.012
Inca1	inhibitor of CDK, cyclin A1 interacting protein 1	0.012
Lcat	lecithin cholesterol acyltransferase	0.012
Rgs10	regulator of G-protein signalling 10	0.012
Ifi27l2a	interferon, alpha-inducible protein 27 like 2A	0.011
Wfdc12	WAP four-disulfide core domain 12	0.011
Ugt2b37	UDP glucuronosyltransferase 2 family, polypeptide B37	0.011
Lcn4	lipocalin 4	0.011
Kcnj15	potassium inwardly-rectifying channel, subfamily J, member 15	0.011
Acsm1	acyl-CoA synthetase medium-chain family member 1	0.011
Apon	apolipoprotein N	0.011
Rnase4	ribonuclease, RNase A family 4	0.011
Cpa3	carboxypeptidase A3, mast cell	0.011
Orm3	orosomucoid 3	0.011
Pip	prolactin induced protein	0.011
Fcamr	Fc receptor, IgA, IgM, high affinity	0.011
Colec12	collectin sub-family member 12	0.011
Sardh	sarcosine dehydrogenase	0.011
Cyp3a16	cytochrome P450, family 3, subfamily a, polypeptide 16	0.011
Slc17a2	solute carrier family 17 (sodium phosphate), member 2	0.011
5430421N21Rik	RIKEN cDNA 5430421N21 gene	0.011
Gm11428	predicted gene 11428	0.011
Fcrls	Fc receptor-like S, scavenger receptor	0.011
Ces1g	carboxylesterase 1G	0.010
Tekt2	tektin 2	0.010
Art3	ADP-ribosyltransferase 3	0.010
Serpina6	serine (or cysteine) peptidase inhibitor, clade A, member 6	0.010
4933436I01Rik	RIKEN cDNA 4933436I01 gene	0.010
Ninj1	ninjurin 1	0.010
Pdcd1	programmed cell death 1	0.010
Ces1f	carboxylesterase 1F	0.010
Upk1a	uroplakin 1A	0.010
Haao	3-hydroxyanthranilate 3,4-dioxygenase	0.010
Pon1	paraoxonase 1	0.010
Cdrt4	CMT1A duplicated region transcript 4	0.010
Igfbp6	insulin-like growth factor binding protein 6	0.010
Apobec2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2	0.010