IMP

Process View

Mus musculus

2 genes annotated in mouse

extraocular skeletal muscle development

GO:0002074

The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "extraocular skeletal muscle development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "extraocular skeletal muscle development" (in gray)

Name	Description	Probability	Func Analog Organism
Pax3	paired box gene 3	0.947
Eya1	eyes absent 1 homolog (Drosophila)	0.732
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.687	Zebrafish
Pax7	paired box gene 7	0.686
Lhx3	LIM homeobox protein 3	0.634
Myf6	myogenic factor 6	0.578
Tbx1	T-box 1	0.573
Fgfr2	fibroblast growth factor receptor 2	0.541
Shh	sonic hedgehog	0.499
En1	engrailed 1	0.497
Tbx4	T-box 4	0.468
Sox9	SRY-box containing gene 9	0.463
Tbx15	T-box 15	0.457
Gli3	GLI-Kruppel family member GLI3	0.439
Foxc1	forkhead box C1	0.430
Prrx1	paired related homeobox 1	0.409
Isl1	ISL1 transcription factor, LIM/homeodomain	0.368
Bmp4	bone morphogenetic protein 4	0.342
Ednra	endothelin receptor type A	0.331
Thrb	thyroid hormone receptor beta	0.328
Pax6	paired box gene 6	0.321
Tcfap2a	transcription factor AP-2, alpha	0.305
Myog	myogenin	0.299
Fgf10	fibroblast growth factor 10	0.279
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.269
Vangl2	vang-like 2 (van gogh, Drosophila)	0.263
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.259
Mybph	myosin binding protein H	0.237
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.236
Pax8	paired box gene 8	0.201
Lmx1b	LIM homeobox transcription factor 1 beta	0.189
Gsc	goosecoid homeobox	0.181
Hoxa2	homeobox A2	0.174
Drd2	dopamine receptor D2	0.172
Ryr1	ryanodine receptor 1, skeletal muscle	0.165
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.163
Gata4	GATA binding protein 4	0.140
Runx2	runt related transcription factor 2	0.137
Msx1	homeobox, msh-like 1	0.136
Fgf8	fibroblast growth factor 8	0.135
Tbx3	T-box 3	0.125
Zfpm2	zinc finger protein, multitype 2	0.117
Foxc2	forkhead box C2	0.116
Tgfb2	transforming growth factor, beta 2	0.109
Rarg	retinoic acid receptor, gamma	0.098
Foxe3	forkhead box E3	0.098
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.096
Btbd17	BTB (POZ) domain containing 17	0.093
Meox2	mesenchyme homeobox 2	0.090
Cdh23	cadherin 23 (otocadherin)	0.089
Pitx2	paired-like homeodomain transcription factor 2	0.089
Sox2	SRY-box containing gene 2	0.087
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.086
Otx2	orthodenticle homolog 2 (Drosophila)	0.082
Tnnt3	troponin T3, skeletal, fast	0.081
Insm1	insulinoma-associated 1	0.074
Rarb	retinoic acid receptor, beta	0.073
Hrc	histidine rich calcium binding protein	0.070
Alx4	aristaless-like homeobox 4	0.064
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.063
Rapsn	receptor-associated protein of the synapse	0.062
Sim2	single-minded homolog 2 (Drosophila)	0.058
Tnnc2	troponin C2, fast	0.057
Hand2	heart and neural crest derivatives expressed transcript 2	0.054
Cacnb2	calcium channel, voltage-dependent, beta 2 subunit	0.054
Myod1	myogenic differentiation 1	0.053	Zebrafish
Cav3	caveolin 3	0.053
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.052
Gli2	GLI-Kruppel family member GLI2	0.051
Rhbdl3	rhomboid, veinlet-like 3 (Drosophila)	0.049
Hand1	heart and neural crest derivatives expressed transcript 1	0.049
Ebf3	early B-cell factor 3	0.046
Nos1	nitric oxide synthase 1, neuronal	0.043
Tcf15	transcription factor 15	0.043
Nog	noggin	0.040
Rxra	retinoid X receptor alpha	0.039
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.037
Twist2	twist homolog 2 (Drosophila)	0.037
Lmx1a	LIM homeobox transcription factor 1 alpha	0.037
Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	0.036
Prop1	paired like homeodomain factor 1	0.035
Msx2	homeobox, msh-like 2	0.034
Prrx2	paired related homeobox 2	0.033
Dnahc11	dynein, axonemal, heavy chain 11	0.033
Chd7	chromodomain helicase DNA binding protein 7	0.033
Cga	glycoprotein hormones, alpha subunit	0.033
Foxd3	forkhead box D3	0.033
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.032
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.032
Lhx4	LIM homeobox protein 4	0.032
Zic3	zinc finger protein of the cerebellum 3	0.031
Wnt1	wingless-related MMTV integration site 1	0.030
Cdh15	cadherin 15	0.030
Eef1a2	eukaryotic translation elongation factor 1 alpha 2	0.030
Shox2	short stature homeobox 2	0.030
Foxd2	forkhead box D2	0.030
Cfc1	cripto, FRL-1, cryptic family 1	0.030
Tnni2	troponin I, skeletal, fast 2	0.030
Foxh1	forkhead box H1	0.029
Dlx5	distal-less homeobox 5	0.029
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.028
Tac4	tachykinin 4	0.028
Myf5	myogenic factor 5	0.028	Zebrafish
Hoxa13	homeobox A13	0.027
Amh	anti-Mullerian hormone	0.027
Ldb3	LIM domain binding 3	0.027
BC057022	cDNA sequence BC057022	0.027
Lefty1	left right determination factor 1	0.026
Alx3	aristaless-like homeobox 3	0.026
Myoz1	myozenin 1	0.026
Nodal	nodal	0.026
Alx1	ALX homeobox 1	0.025
Tg	thyroglobulin	0.025
Myo15	myosin XV	0.025
Vsx2	visual system homeobox 2	0.024
Isl2	insulin related protein 2 (islet 2)	0.024
Smad3	MAD homolog 3 (Drosophila)	0.023
Srpk3	serine/arginine-rich protein specific kinase 3	0.023
Slc17a8	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	0.023
Evx2	even skipped homeotic gene 2 homolog	0.023
Art5	ADP-ribosyltransferase 5	0.023
Olig3	oligodendrocyte transcription factor 3	0.023
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.023
Mesp1	mesoderm posterior 1	0.022
Fuz	fuzzy homolog (Drosophila)	0.022
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.021
Dmpk	dystrophia myotonica-protein kinase	0.021
Tcap	titin-cap	0.021
Gzmm	granzyme M (lymphocyte met-ase 1)	0.021
Pou3f1	POU domain, class 3, transcription factor 1	0.021
Pkd1	polycystic kidney disease 1 homolog	0.021
Fgfr3	fibroblast growth factor receptor 3	0.021
Smo	smoothened homolog (Drosophila)	0.021
Cacng6	calcium channel, voltage-dependent, gamma subunit 6	0.020
Neurod1	neurogenic differentiation 1	0.020
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.020
Jag1	jagged 1	0.020
Plin4	perilipin 4	0.020
Slc26a5	solute carrier family 26, member 5	0.020
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.020
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.020
Pitx3	paired-like homeodomain transcription factor 3	0.019	Mouse
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	0.019
Hoxd1	homeobox D1	0.019
Bmp7	bone morphogenetic protein 7	0.019
Adra2b	adrenergic receptor, alpha 2b	0.019
Mll2	myeloid/lymphoid or mixed-lineage leukemia 2	0.018
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.018
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.018
Rax	retina and anterior neural fold homeobox	0.018
Hoxa4	homeobox A4	0.018
Xirp1	xin actin-binding repeat containing 1	0.017
Myoz3	myozenin 3	0.017
Neurog2	neurogenin 2	0.017
Hoxa11	homeobox A11	0.017
Eya4	eyes absent 4 homolog (Drosophila)	0.017
Rho	rhodopsin	0.017
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.016
Dlk1	delta-like 1 homolog (Drosophila)	0.016
Gfi1b	growth factor independent 1B	0.016
Zfhx4	zinc finger homeodomain 4	0.016
2310010M20Rik	RIKEN cDNA 2310010M20 gene	0.016
Hr	hairless	0.016
Vgll2	vestigial like 2 homolog (Drosophila)	0.016
Myh8	myosin, heavy polypeptide 8, skeletal muscle, perinatal	0.016
Dnajb5	DnaJ (Hsp40) homolog, subfamily B, member 5	0.015
Tnni1	troponin I, skeletal, slow 1	0.015
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.015
Sct	secretin	0.015
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.015
Foxl2	forkhead box L2	0.015	Human
Mpz	myelin protein zero	0.015
Wnt10a	wingless related MMTV integration site 10a	0.015
Chrne	cholinergic receptor, nicotinic, epsilon polypeptide	0.015
Myot	myotilin	0.015
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.015
Popdc2	popeye domain containing 2	0.015
Actn3	actinin alpha 3	0.015
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.014
Emx2	empty spiracles homolog 2 (Drosophila)	0.014
Fitm1	fat storage-inducing transmembrane protein 1	0.014
Pax2	paired box gene 2	0.014
Asb10	ankyrin repeat and SOCS box-containing 10	0.014
Shbg	sex hormone binding globulin	0.014
Chrna9	cholinergic receptor, nicotinic, alpha polypeptide 9	0.014
Mmp24	matrix metallopeptidase 24	0.014
Irx6	Iroquois related homeobox 6 (Drosophila)	0.014
Tulp1	tubby like protein 1	0.013
Alox12e	arachidonate lipoxygenase, epidermal	0.013
Hoxa10	homeobox A10	0.013
Psen1	presenilin 1	0.013
Casq2	calsequestrin 2	0.013
Hes5	hairy and enhancer of split 5 (Drosophila)	0.013
Esr1	estrogen receptor 1 (alpha)	0.013
Dhh	desert hedgehog	0.013
Jag2	jagged 2	0.013
Foxf2	forkhead box F2	0.013
Col17a1	collagen, type XVII, alpha 1	0.013
Tecta	tectorin alpha	0.013
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.013
Actc1	actin, alpha, cardiac muscle 1	0.013
Sox3	SRY-box containing gene 3	0.013
Tlx3	T-cell leukemia, homeobox 3	0.013
Robo3	roundabout homolog 3 (Drosophila)	0.013
Fgf13	fibroblast growth factor 13	0.012
Pvalb	parvalbumin	0.012
Vegfa	vascular endothelial growth factor A	0.012
Il12a	interleukin 12a	0.012
Pyy	peptide YY	0.012
Ebf2	early B-cell factor 2	0.012
Ciita	class II transactivator	0.012
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.012
Bnc1	basonuclin 1	0.012
Zfr2	zinc finger RNA binding protein 2	0.012
Chrd	chordin	0.012
Hcrt	hypocretin	0.012
Hmx1	H6 homeobox 1	0.012
Gbx2	gastrulation brain homeobox 2	0.012
Fut7	fucosyltransferase 7	0.012
Pomc	pro-opiomelanocortin-alpha	0.012
Hoxd8	homeobox D8	0.012
Otp	orthopedia homolog (Drosophila)	0.011
Hif3a	hypoxia inducible factor 3, alpha subunit	0.011
Plxna1	plexin A1	0.011
Lmod2	leiomodin 2 (cardiac)	0.011
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.011
Ank1	ankyrin 1, erythroid	0.011
Efna2	ephrin A2	0.011
Clcn1	chloride channel 1	0.011
Kcnk4	potassium channel, subfamily K, member 4	0.011
Gpha2	glycoprotein hormone alpha 2	0.011
Gja3	gap junction protein, alpha 3	0.011
Lhb	luteinizing hormone beta	0.011
Sox11	SRY-box containing gene 11	0.011
Smyd1	SET and MYND domain containing 1	0.011
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.011
Barx1	BarH-like homeobox 1	0.011
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.011
Wnt10b	wingless related MMTV integration site 10b	0.011
Uts2r	urotensin 2 receptor	0.011
Trex2	three prime repair exonuclease 2	0.011
Nptx1	neuronal pentraxin 1	0.011
Etv2	ets variant gene 2	0.011
Thra	thyroid hormone receptor alpha	0.011
Tll1	tolloid-like	0.011
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.011
Kcna7	potassium voltage-gated channel, shaker-related subfamily, member 7	0.011
Sgcg	sarcoglycan, gamma (dystrophin-associated glycoprotein)	0.011
Ihh	Indian hedgehog	0.011
Nhlh1	nescient helix loop helix 1	0.011
Actn2	actinin alpha 2	0.011
Hmga2	high mobility group AT-hook 2	0.010
Grem1	gremlin 1	0.010
Amhr2	anti-Mullerian hormone type 2 receptor	0.010
Dusp13	dual specificity phosphatase 13	0.010
Pdgfb	platelet derived growth factor, B polypeptide	0.010
Prph2	peripherin 2	0.010
Nkx6-1	NK6 homeobox 1	0.010
Chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	0.010
Pax9	paired box gene 9	0.010
Dnahc5	dynein, axonemal, heavy chain 5	0.010
Nrtn	neurturin	0.010
Fgf6	fibroblast growth factor 6	0.010
Tas1r1	taste receptor, type 1, member 1	0.010
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.010
Kprp	keratinocyte expressed, proline-rich	0.010