IMP

Process View

Mus musculus

13 genes annotated in mouse

Multi-species View

heat generation

GO:0031649

Any homeostatic process in which an organism produces heat, thereby raising its internal temperature.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "heat generation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "heat generation" (in gray)

Name	Description	Probability	Func Analog Organism
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.991
Tnf	tumor necrosis factor	0.990
Lta	lymphotoxin A	0.927	Mouse
Ptgs2	prostaglandin-endoperoxide synthase 2	0.755
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.703
Pnpla2	patatin-like phospholipase domain containing 2	0.688
ND6	NADH dehydrogenase subunit 6	0.626
Nos2	nitric oxide synthase 2, inducible	0.620
Cd40	CD40 antigen	0.611	Mouse
Adrb3	adrenergic receptor, beta 3	0.602
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.566	Mouse
LOC100048884	novel member of the major urinary protein (Mup) gene family	0.407	Mouse
Il10	interleukin 10	0.362
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.312
Mup10	major urinary protein 10	0.292	Mouse
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.267
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.258
Il6	interleukin 6	0.255
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.238
Mup19	major urinary protein 19	0.218	Mouse
Mup9	major urinary protein 9	0.208	Mouse
Mup1	major urinary protein 1	0.199
Kl	klotho	0.193
Mup12	major urinary protein 12	0.192	Mouse
Pparg	peroxisome proliferator activated receptor gamma	0.191
Adrb1	adrenergic receptor, beta 1	0.182
Ltb	lymphotoxin B	0.167
Cxcl13	chemokine (C-X-C motif) ligand 13	0.167
Il1r1	interleukin 1 receptor, type I	0.153
Mup15	major urinary protein 15	0.147	Mouse
Il1b	interleukin 1 beta	0.146
Mup13	major urinary protein 13	0.145
Mup8	major urinary protein 8	0.137	Mouse
Mup17	major urinary protein 17	0.133
Npy1r	neuropeptide Y receptor Y1	0.132
Mup14	major urinary protein 14	0.132	Mouse
Ren1	renin 1 structural	0.128
Mup7	major urinary protein 7	0.124	Mouse
S1pr2	sphingosine-1-phosphate receptor 2	0.116
Cd40lg	CD40 ligand	0.103	Mouse
Mup2	major urinary protein 2	0.102	Mouse
Mup11	major urinary protein 11	0.096	Mouse
Tlr4	toll-like receptor 4	0.092
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.092
LOC100048885	major urinary protein LOC100048885	0.085	Mouse
Plat	plasminogen activator, tissue	0.085
Il12b	interleukin 12b	0.083
Il4	interleukin 4	0.082
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.072
Esr2	estrogen receptor 2 (beta)	0.072
Il1a	interleukin 1 alpha	0.070	Mouse
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.069	Mouse
Mup5	major urinary protein 5	0.060	Mouse
Ifng	interferon gamma	0.059
Oprm1	opioid receptor, mu 1	0.054
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.054
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.051
Mup4	major urinary protein 4	0.050	Mouse
Acvrl1	activin A receptor, type II-like 1	0.045
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.045
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.044
Kcnk3	potassium channel, subfamily K, member 3	0.044
Sstr3	somatostatin receptor 3	0.040
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.040
Nhedc2	Na+/H+ exchanger domain containing 2	0.039
Grm2	glutamate receptor, metabotropic 2	0.039
Cldn16	claudin 16	0.036
Il22	interleukin 22	0.036
Clec4d	C-type lectin domain family 4, member d	0.035
Adora2a	adenosine A2a receptor	0.035
Cd160	CD160 antigen	0.034
Lepr	leptin receptor	0.034
Hrk	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.033
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.033
Apoe	apolipoprotein E	0.032
Sstr1	somatostatin receptor 1	0.031
Glycam1	glycosylation dependent cell adhesion molecule 1	0.031
Bcl6	B-cell leukemia/lymphoma 6	0.029
Nos3	nitric oxide synthase 3, endothelial cell	0.027
Spp1	secreted phosphoprotein 1	0.027
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.027
Ccl2	chemokine (C-C motif) ligand 2	0.026
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.026
Tlr6	toll-like receptor 6	0.026
Pdcd1	programmed cell death 1	0.026
Gpr132	G protein-coupled receptor 132	0.026
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.026
Col4a3	collagen, type IV, alpha 3	0.025
Edn1	endothelin 1	0.025
Htra3	HtrA serine peptidase 3	0.024
Itga2	integrin alpha 2	0.024
Hamp	hepcidin antimicrobial peptide	0.024
Npy5r	neuropeptide Y receptor Y5	0.024
Clcnka	chloride channel Ka	0.024
Fpr2	formyl peptide receptor 2	0.023
Cd70	CD70 antigen	0.023
Dmbx1	diencephalon/mesencephalon homeobox 1	0.022
Traf2	TNF receptor-associated factor 2	0.022
Adrb2	adrenergic receptor, beta 2	0.022
Fndc7	fibronectin type III domain containing 7	0.022
Oprd1	opioid receptor, delta 1	0.021
Cxcr5	chemokine (C-X-C motif) receptor 5	0.021
Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	0.021
Pdgfb	platelet derived growth factor, B polypeptide	0.021
Lep	leptin	0.021
Cd86	CD86 antigen	0.020
Igh	immunoglobulin heavy chain complex	0.020
Fzd1	frizzled homolog 1 (Drosophila)	0.020
Pspn	persephin	0.020
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.020
Mup3	major urinary protein 3	0.020	Mouse
Adipoq	adiponectin, C1Q and collagen domain containing	0.020
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.020
Irg1	immunoresponsive gene 1	0.019
Mitf	microphthalmia-associated transcription factor	0.019
Shc3	src homology 2 domain-containing transforming protein C3	0.019
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.019
Epha6	Eph receptor A6	0.019
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.019
Pou3f4	POU domain, class 3, transcription factor 4	0.018
Cfh	complement component factor h	0.017
Krt36	keratin 36	0.017
Il3	interleukin 3	0.017
Sstr4	somatostatin receptor 4	0.017
Ikbkg	inhibitor of kappaB kinase gamma	0.017
Il9r	interleukin 9 receptor	0.017
Cd19	CD19 antigen	0.016
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.016
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.016
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.016
Gpr83	G protein-coupled receptor 83	0.015
Casp1	caspase 1	0.015
Ccr1l1	chemokine (C-C motif) receptor 1-like 1	0.014
Icos	inducible T-cell co-stimulator	0.014
Dlx6	distal-less homeobox 6	0.014
Cxcl2	chemokine (C-X-C motif) ligand 2	0.014
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.014
Galr2	galanin receptor 2	0.013
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.013
Gm14743	predicted gene 14743	0.013	Mouse
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3	0.013
Tbxa2r	thromboxane A2 receptor	0.013	Mouse
Drd2	dopamine receptor D2	0.012
Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2	0.012
Btn1a1	butyrophilin, subfamily 1, member A1	0.012
Prkcd	protein kinase C, delta	0.012
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.012
Wnt7a	wingless-related MMTV integration site 7A	0.012
Slpi	secretory leukocyte peptidase inhibitor	0.012
H1foo	H1 histone family, member O, oocyte-specific	0.012
F13b	coagulation factor XIII, beta subunit	0.012
Lag3	lymphocyte-activation gene 3	0.012
Il1r2	interleukin 1 receptor, type II	0.012
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.011
Cps1	carbamoyl-phosphate synthetase 1	0.011
Pou2af1	POU domain, class 2, associating factor 1	0.011
Icam5	intercellular adhesion molecule 5, telencephalin	0.011
Gif	gastric intrinsic factor	0.011
Lcn4	lipocalin 4	0.011	Mouse
Expi	extracellular proteinase inhibitor	0.011
H2-M9	histocompatibility 2, M region locus 9	0.011
Irs3	insulin receptor substrate 3	0.011
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.011
Kifc2	kinesin family member C2	0.011
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.011
Slc6a12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.011
Mug2	murinoglobulin 2	0.011
Sardh	sarcosine dehydrogenase	0.010
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.010
Slc22a12	solute carrier family 22 (organic anion/cation transporter), member 12	0.010
Dlx4	distal-less homeobox 4	0.010