IMP

Process View

Mus musculus

7 genes annotated in mouse

Multi-species View

inner cell mass cell differentiation

GO:0001826

The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "inner cell mass cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "inner cell mass cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Otx2	orthodenticle homolog 2 (Drosophila)	0.999
Shh	sonic hedgehog	0.999
Gli3	GLI-Kruppel family member GLI3	0.997
Pax6	paired box gene 6	0.996
Pax3	paired box gene 3	0.994
Fgfr2	fibroblast growth factor receptor 2	0.985
Isl1	ISL1 transcription factor, LIM/homeodomain	0.982
Sox2	SRY-box containing gene 2	0.978	Mouse
Fgf8	fibroblast growth factor 8	0.973
Chd7	chromodomain helicase DNA binding protein 7	0.967
Emx1	empty spiracles homolog 1 (Drosophila)	0.961
Pax2	paired box gene 2	0.958
Nanog	Nanog homeobox	0.957
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.932
Eya1	eyes absent 1 homolog (Drosophila)	0.893
Tcfap2a	transcription factor AP-2, alpha	0.828
Sall4	sal-like 4 (Drosophila)	0.818
Foxg1	forkhead box G1	0.817
Hes1	hairy and enhancer of split 1 (Drosophila)	0.805
Sox11	SRY-box containing gene 11	0.788	Mouse
Sall3	sal-like 3 (Drosophila)	0.769
Hes5	hairy and enhancer of split 5 (Drosophila)	0.718
Bmp4	bone morphogenetic protein 4	0.704
Alx4	aristaless-like homeobox 4	0.688
Atoh7	atonal homolog 7 (Drosophila)	0.628
Gbx2	gastrulation brain homeobox 2	0.602
Hmx3	H6 homeobox 3	0.596
Pitx2	paired-like homeodomain transcription factor 2	0.590
Emx2	empty spiracles homolog 2 (Drosophila)	0.565
Vangl2	vang-like 2 (van gogh, Drosophila)	0.556
Hand1	heart and neural crest derivatives expressed transcript 1	0.501
Otx1	orthodenticle homolog 1 (Drosophila)	0.424
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.422
Lhx3	LIM homeobox protein 3	0.345
Meox2	mesenchyme homeobox 2	0.328
Nog	noggin	0.313
Zeb1	zinc finger E-box binding homeobox 1	0.312
Fgfr3	fibroblast growth factor receptor 3	0.305
Foxc1	forkhead box C1	0.298
Insm1	insulinoma-associated 1	0.284
Fgf3	fibroblast growth factor 3	0.283
Fgf10	fibroblast growth factor 10	0.240
Pou5f1	POU domain, class 5, transcription factor 1	0.234
Bdnf	brain derived neurotrophic factor	0.232
Msx1	homeobox, msh-like 1	0.228
Jag1	jagged 1	0.224
Sox3	SRY-box containing gene 3	0.217	Mouse
Sall1	sal-like 1 (Drosophila)	0.211
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.206
Lmx1b	LIM homeobox transcription factor 1 beta	0.204
Dlx5	distal-less homeobox 5	0.196
Neurod1	neurogenic differentiation 1	0.191
Hand2	heart and neural crest derivatives expressed transcript 2	0.189
Pou3f3	POU domain, class 3, transcription factor 3	0.187	Mouse
Fgfr1	fibroblast growth factor receptor 1	0.180
Lef1	lymphoid enhancer binding factor 1	0.174
Tcfap2c	transcription factor AP-2, gamma	0.169
Hoxd13	homeobox D13	0.168
Tbx10	T-box 10	0.163
Gli2	GLI-Kruppel family member GLI2	0.159
Fgf4	fibroblast growth factor 4	0.157
Ntf3	neurotrophin 3	0.147
Tcfcp2l1	transcription factor CP2-like 1	0.146
Zic3	zinc finger protein of the cerebellum 3	0.142
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.142
Hesx1	homeobox gene expressed in ES cells	0.139
Sin3a	transcriptional regulator, SIN3A (yeast)	0.136
Dlx1	distal-less homeobox 1	0.136
Ctnnb1	catenin (cadherin associated protein), beta 1	0.135
Alx3	aristaless-like homeobox 3	0.132
En2	engrailed 2	0.131
Msx2	homeobox, msh-like 2	0.129
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.128
Foxc2	forkhead box C2	0.128
Lhx5	LIM homeobox protein 5	0.127
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.124
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.108
Efnb2	ephrin B2	0.101
She	src homology 2 domain-containing transforming protein E	0.098
Nodal	nodal	0.093
Zic2	zinc finger protein of the cerebellum 2	0.093
Rb1	retinoblastoma 1	0.088
Sox17	SRY-box containing gene 17	0.082
Rarb	retinoic acid receptor, beta	0.078
Cldn5	claudin 5	0.077
Gata3	GATA binding protein 3	0.076
Atoh1	atonal homolog 1 (Drosophila)	0.073
Lhx1	LIM homeobox protein 1	0.072
Ptprb	protein tyrosine phosphatase, receptor type, B	0.070
Nf1	neurofibromatosis 1	0.069
Tcf15	transcription factor 15	0.067
Hoxa1	homeobox A1	0.067
Tlx3	T-cell leukemia, homeobox 3	0.066
Sox4	SRY-box containing gene 4	0.065	Mouse
Fgf17	fibroblast growth factor 17	0.064
Arid1a	AT rich interactive domain 1A (SWI-like)	0.064
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.062
Foxd2	forkhead box D2	0.061
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.058
Neurog2	neurogenin 2	0.055
Gata4	GATA binding protein 4	0.053
Sox1	SRY-box containing gene 1	0.053
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.053
Bmp7	bone morphogenetic protein 7	0.049
Cdx1	caudal type homeobox 1	0.049
Lmx1a	LIM homeobox transcription factor 1 alpha	0.048
Trp53	transformation related protein 53	0.047
Wnt3a	wingless-related MMTV integration site 3A	0.045
Nacc1	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	0.044
Kdr	kinase insert domain protein receptor	0.044
Efna2	ephrin A2	0.043
Ptch1	patched homolog 1	0.042
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.041
Rarg	retinoic acid receptor, gamma	0.040
Npas1	neuronal PAS domain protein 1	0.040
Hoxb13	homeobox B13	0.040
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.040
Robo3	roundabout homolog 3 (Drosophila)	0.037
Foxa2	forkhead box A2	0.037
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.037
Tbx2	T-box 2	0.036
Smo	smoothened homolog (Drosophila)	0.034
Dll1	delta-like 1 (Drosophila)	0.034
Pou3f1	POU domain, class 3, transcription factor 1	0.034	Mouse
Ret	ret proto-oncogene	0.034
BC024139	cDNA sequence BC024139	0.034
Esrrb	estrogen related receptor, beta	0.033
Cdh5	cadherin 5	0.033
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.033
Uncx	UNC homeobox	0.032
Btbd17	BTB (POZ) domain containing 17	0.032
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.032
Pou4f2	POU domain, class 4, transcription factor 2	0.032	Mouse
Phox2a	paired-like homeobox 2a	0.032
Aplnr	apelin receptor	0.032
En1	engrailed 1	0.032
Wnt7b	wingless-related MMTV integration site 7B	0.031
Edar	ectodysplasin-A receptor	0.031
Wnt1	wingless-related MMTV integration site 1	0.031
Col2a1	collagen, type II, alpha 1	0.030
Hhex	hematopoietically expressed homeobox	0.030
Msx3	homeobox, msh-like 3	0.029
Hes3	hairy and enhancer of split 3 (Drosophila)	0.029
Phox2b	paired-like homeobox 2b	0.029
Xpo4	exportin 4	0.029
Chrd	chordin	0.028
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.028
Tbx3	T-box 3	0.027
Igfbpl1	insulin-like growth factor binding protein-like 1	0.026
Wnt7a	wingless-related MMTV integration site 7A	0.026
Gpr3	G-protein coupled receptor 3	0.025
Gata6	GATA binding protein 6	0.025
Prop1	paired like homeodomain factor 1	0.025
Wnt6	wingless-related MMTV integration site 6	0.025
H1foo	H1 histone family, member O, oocyte-specific	0.025
Espn	espin	0.024
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.024
Pnoc	prepronociceptin	0.024
T	brachyury	0.024
Foxf1a	forkhead box F1a	0.024
Sox9	SRY-box containing gene 9	0.024	Mouse
Fgf15	fibroblast growth factor 15	0.024
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.024
Rasip1	Ras interacting protein 1	0.024
Onecut1	one cut domain, family member 1	0.023
Notch1	Notch gene homolog 1 (Drosophila)	0.023
Mitf	microphthalmia-associated transcription factor	0.022
Esam	endothelial cell-specific adhesion molecule	0.022
Ihh	Indian hedgehog	0.022
Foxh1	forkhead box H1	0.022
Nkx6-1	NK6 homeobox 1	0.022
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.022
Alx1	ALX homeobox 1	0.022
Pbx1	pre B-cell leukemia transcription factor 1	0.022
Emcn	endomucin	0.021
Nrg1	neuregulin 1	0.021
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.021
Tlx2	T-cell leukemia, homeobox 2	0.021
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.021
Pax1	paired box gene 1	0.020
Gdnf	glial cell line derived neurotrophic factor	0.020
Hmx1	H6 homeobox 1	0.020
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.020
Tgfb2	transforming growth factor, beta 2	0.020
Arx	aristaless related homeobox	0.019
Lrp6	low density lipoprotein receptor-related protein 6	0.018
Vax1	ventral anterior homeobox containing gene 1	0.018
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.018
Hrh2	histamine receptor H2	0.018
Amh	anti-Mullerian hormone	0.018
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.018
Tbx1	T-box 1	0.018
Lrp2	low density lipoprotein receptor-related protein 2	0.018
Hoxa13	homeobox A13	0.017
Neurog3	neurogenin 3	0.017
Prrx1	paired related homeobox 1	0.017
BC020535	cDNA sequence BC020535	0.017
Nrtn	neurturin	0.017
Smad6	MAD homolog 6 (Drosophila)	0.017
Olig2	oligodendrocyte transcription factor 2	0.017
S1pr2	sphingosine-1-phosphate receptor 2	0.017
Hoxa5	homeobox A5	0.017
Gja4	gap junction protein, alpha 4	0.017
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.016
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.016
Pcdh12	protocadherin 12	0.016
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.016
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.016
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.016
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.015
Cldn6	claudin 6	0.015
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.015
Rax	retina and anterior neural fold homeobox	0.015
Kitl	kit ligand	0.015
2810046L04Rik	RIKEN cDNA 2810046L04 gene	0.015
Cux2	cut-like homeobox 2	0.015
Ptch2	patched homolog 2	0.015
Gsc	goosecoid homeobox	0.015
Hoxa4	homeobox A4	0.014
Pax8	paired box gene 8	0.014
Pitx1	paired-like homeodomain transcription factor 1	0.014
Hoxd11	homeobox D11	0.014
Tek	endothelial-specific receptor tyrosine kinase	0.014
Cdx2	caudal type homeobox 2	0.014
Fgf18	fibroblast growth factor 18	0.014
Rhox6	reproductive homeobox 6	0.014
Cdsn	corneodesmosin	0.013
Flt1	FMS-like tyrosine kinase 1	0.013
Srrm4	serine/arginine repetitive matrix 4	0.013
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.013
Gh	growth hormone	0.013
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.013
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.013
Gdf11	growth differentiation factor 11	0.013
Elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.013
Sox7	SRY-box containing gene 7	0.013	Mouse
Rcor2	REST corepressor 2	0.013
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.012
Dmrtb1	DMRT-like family B with proline-rich C-terminal, 1	0.012
Hoxd4	homeobox D4	0.012
Adcy4	adenylate cyclase 4	0.012
Arid3b	AT rich interactive domain 3B (BRIGHT-like)	0.012
Eng	endoglin	0.012
Rara	retinoic acid receptor, alpha	0.012
Cacng4	calcium channel, voltage-dependent, gamma subunit 4	0.012
Dll4	delta-like 4 (Drosophila)	0.012
Notch3	Notch gene homolog 3 (Drosophila)	0.012
Dlx2	distal-less homeobox 2	0.012
Hr	hairless	0.012
Foxi3	forkhead box I3	0.012
Pou3f2	POU domain, class 3, transcription factor 2	0.012	Mouse
Tcfap2b	transcription factor AP-2 beta	0.012
Chrm4	cholinergic receptor, muscarinic 4	0.012
Krt17	keratin 17	0.011
Efna4	ephrin A4	0.011
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.011
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.011
Hoxb4	homeobox B4	0.011
Emid1	EMI domain containing 1	0.011
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.011
Hnf1a	HNF1 homeobox A	0.011	Mouse
Hoxd12	homeobox D12	0.011
Foxj1	forkhead box J1	0.011
Hoxb1	homeobox B1	0.011
Hcfc1	host cell factor C1	0.011
Utf1	undifferentiated embryonic cell transcription factor 1	0.011
Pkd1	polycystic kidney disease 1 homolog	0.011
Foxb1	forkhead box B1	0.011
Hira	histone cell cycle regulation defective homolog A (S. cerevisiae)	0.011
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.011
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.011
Fgf5	fibroblast growth factor 5	0.011
Hnf4a	hepatic nuclear factor 4, alpha	0.011
Ushbp1	Usher syndrome 1C binding protein 1	0.011
Cbln1	cerebellin 1 precursor protein	0.010
Aym1	activator of yeast meiotic promoters 1	0.010
Hoxa3	homeobox A3	0.010
Adra2b	adrenergic receptor, alpha 2b	0.010
Zfp42	zinc finger protein 42	0.010
Hoxa2	homeobox A2	0.010
Icam2	intercellular adhesion molecule 2	0.010
Epha4	Eph receptor A4	0.010
Ednrb	endothelin receptor type B	0.010
Zbtb12	zinc finger and BTB domain containing 12	0.010
Clec14a	C-type lectin domain family 14, member a	0.010
Kit	kit oncogene	0.010