IMP

Process View

Mus musculus

9 genes annotated in mouse

mesenchymal to epithelial transition involved in metanephros morphogenesis

A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mesenchymal to epithelial transition involved in metanephros morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mesenchymal to epithelial transition involved in metanephros morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Fgf8	fibroblast growth factor 8	0.999
Fgfr2	fibroblast growth factor receptor 2	0.999
Gli3	GLI-Kruppel family member GLI3	0.999
Rarg	retinoic acid receptor, gamma	0.998
Pax2	paired box gene 2	0.996
Foxc1	forkhead box C1	0.994
Fgfr1	fibroblast growth factor receptor 1	0.993
Msx1	homeobox, msh-like 1	0.991
Pax3	paired box gene 3	0.977
Eya1	eyes absent 1 homolog (Drosophila)	0.974
Otx2	orthodenticle homolog 2 (Drosophila)	0.972
Lhx1	LIM homeobox protein 1	0.970
Bmp7	bone morphogenetic protein 7	0.966
Tbx1	T-box 1	0.960
Gli2	GLI-Kruppel family member GLI2	0.959
Sall4	sal-like 4 (Drosophila)	0.950	Mouse
Pax8	paired box gene 8	0.947
Sox9	SRY-box containing gene 9	0.927
Hand1	heart and neural crest derivatives expressed transcript 1	0.908
Foxc2	forkhead box C2	0.903
Wnt3a	wingless-related MMTV integration site 3A	0.901	Mouse
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.899	Mouse
Nog	noggin	0.886
Pitx2	paired-like homeodomain transcription factor 2	0.870
Chrd	chordin	0.856
Rarb	retinoic acid receptor, beta	0.835
Smo	smoothened homolog (Drosophila)	0.825
Gdnf	glial cell line derived neurotrophic factor	0.821
Bmp4	bone morphogenetic protein 4	0.820	Human
Prrx1	paired related homeobox 1	0.818
Wnt4	wingless-related MMTV integration site 4	0.805	Mouse
Prrx2	paired related homeobox 2	0.779
Dlx5	distal-less homeobox 5	0.775
Msx2	homeobox, msh-like 2	0.773
Hoxd11	homeobox D11	0.754
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.726
Emx2	empty spiracles homolog 2 (Drosophila)	0.705
Tcfap2a	transcription factor AP-2, alpha	0.704
Fgf10	fibroblast growth factor 10	0.678
Sox2	SRY-box containing gene 2	0.667
Hoxa2	homeobox A2	0.615
Alx4	aristaless-like homeobox 4	0.610
Fgf3	fibroblast growth factor 3	0.562
Rara	retinoic acid receptor, alpha	0.557
Hoxa1	homeobox A1	0.528
Pou5f1	POU domain, class 5, transcription factor 1	0.514
Ret	ret proto-oncogene	0.496
Ctnnb1	catenin (cadherin associated protein), beta 1	0.496
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.483
Hoxa3	homeobox A3	0.474
T	brachyury	0.467
Otx1	orthodenticle homolog 1 (Drosophila)	0.449
Nodal	nodal	0.412
Hand2	heart and neural crest derivatives expressed transcript 2	0.373
Pax9	paired box gene 9	0.363	Mouse
Nanog	Nanog homeobox	0.359
Gsc	goosecoid homeobox	0.355
Isl1	ISL1 transcription factor, LIM/homeodomain	0.349
Twist2	twist homolog 2 (Drosophila)	0.335
Hoxa11	homeobox A11	0.331
Tgfb2	transforming growth factor, beta 2	0.320
Gbx2	gastrulation brain homeobox 2	0.266
Hoxd3	homeobox D3	0.249
Ptk7	PTK7 protein tyrosine kinase 7	0.230
Col2a1	collagen, type II, alpha 1	0.213
Pbx1	pre B-cell leukemia transcription factor 1	0.207
Wnt10b	wingless related MMTV integration site 10b	0.197	Mouse
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.196
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.189
Lef1	lymphoid enhancer binding factor 1	0.181
Hmx3	H6 homeobox 3	0.174
Sall3	sal-like 3 (Drosophila)	0.173	Mouse
Lmx1b	LIM homeobox transcription factor 1 beta	0.168
Ednra	endothelin receptor type A	0.166
En1	engrailed 1	0.162
Hmx1	H6 homeobox 1	0.148
Hoxd13	homeobox D13	0.146
Fgfr3	fibroblast growth factor receptor 3	0.143
Hoxa13	homeobox A13	0.142
Hoxb3	homeobox B3	0.142
Tbx15	T-box 15	0.141
Wnt1	wingless-related MMTV integration site 1	0.133	Mouse
Sall1	sal-like 1 (Drosophila)	0.127
Ntf3	neurotrophin 3	0.122
Pou3f3	POU domain, class 3, transcription factor 3	0.122
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.121
Tcfap2c	transcription factor AP-2, gamma	0.119
Bnc1	basonuclin 1	0.118
Tbx2	T-box 2	0.118
Hoxd9	homeobox D9	0.113
Foxg1	forkhead box G1	0.110
Alx3	aristaless-like homeobox 3	0.109
Lama5	laminin, alpha 5	0.108
Vax1	ventral anterior homeobox containing gene 1	0.101
Lmx1a	LIM homeobox transcription factor 1 alpha	0.098
Efna4	ephrin A4	0.097
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.092	Mouse
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.092
Neurog1	neurogenin 1	0.089
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.088
Emx1	empty spiracles homolog 1 (Drosophila)	0.088
Acan	aggrecan	0.088
Tbx3	T-box 3	0.087
Esrrb	estrogen related receptor, beta	0.082
Runx2	runt related transcription factor 2	0.082
Crlf1	cytokine receptor-like factor 1	0.081
Tcfcp2l1	transcription factor CP2-like 1	0.076
Dlx6	distal-less homeobox 6	0.073
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.070
Adra2b	adrenergic receptor, alpha 2b	0.069
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.068
Foxf2	forkhead box F2	0.067
Fzd8	frizzled homolog 8 (Drosophila)	0.067
Wnt2b	wingless related MMTV integration site 2b	0.066	Mouse
Kl	klotho	0.066
Vangl2	vang-like 2 (van gogh, Drosophila)	0.065
Pax1	paired box gene 1	0.065	Mouse
Pitx1	paired-like homeodomain transcription factor 1	0.064
Foxd2	forkhead box D2	0.063
Foxn1	forkhead box N1	0.063
Gli1	GLI-Kruppel family member GLI1	0.063
Pax6	paired box gene 6	0.062
Hoxb6	homeobox B6	0.061
Socs1	suppressor of cytokine signaling 1	0.059
Smad6	MAD homolog 6 (Drosophila)	0.057
Wt1	Wilms tumor 1 homolog	0.056
Lhx3	LIM homeobox protein 3	0.056
Hoxa10	homeobox A10	0.054
Fgf18	fibroblast growth factor 18	0.053
Hoxc5	homeobox C5	0.052
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.051
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.051
Col22a1	collagen, type XXII, alpha 1	0.051
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.050	Mouse
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.050
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.049
Dlx1	distal-less homeobox 1	0.048
Trp63	transformation related protein 63	0.048
Gja5	gap junction protein, alpha 5	0.048
Hoxd4	homeobox D4	0.047
Hoxa4	homeobox A4	0.047
Foxa2	forkhead box A2	0.044
Foxf1a	forkhead box F1a	0.044
Sim2	single-minded homolog 2 (Drosophila)	0.044
Gpr50	G-protein-coupled receptor 50	0.043
Efnb2	ephrin B2	0.043
Hes1	hairy and enhancer of split 1 (Drosophila)	0.042
Gas1	growth arrest specific 1	0.042
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.040
Fgf17	fibroblast growth factor 17	0.039
Wnt9b	wingless-type MMTV integration site 9B	0.039
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.039
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.039
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.039
Cdx1	caudal type homeobox 1	0.039
Hoxb13	homeobox B13	0.038
Wnt11	wingless-related MMTV integration site 11	0.038	Mouse
Barx1	BarH-like homeobox 1	0.037
Barx2	BarH-like homeobox 2	0.037
Zeb1	zinc finger E-box binding homeobox 1	0.037
Emid2	EMI domain containing 2	0.037
Fzd2	frizzled homolog 2 (Drosophila)	0.037
Fgf15	fibroblast growth factor 15	0.036
Nkx3-2	NK3 homeobox 2	0.035
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.035
Foxb1	forkhead box B1	0.034
Rxra	retinoid X receptor alpha	0.034
Uncx	UNC homeobox	0.034
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.034
Acvr1	activin A receptor, type 1	0.033
Pthlh	parathyroid hormone-like peptide	0.033
Sorbs3	sorbin and SH3 domain containing 3	0.033
Phox2a	paired-like homeobox 2a	0.033
Pou3f1	POU domain, class 3, transcription factor 1	0.032
Nrtn	neurturin	0.032	Mouse
Wnt3	wingless-related MMTV integration site 3	0.032	Mouse
Twist1	twist homolog 1 (Drosophila)	0.032
Zfp651	zinc finger protein 651	0.032
H1fx	H1 histone family, member X	0.031
Hoxb1	homeobox B1	0.031
Tead3	TEA domain family member 3	0.031
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.031
Nkx6-1	NK6 homeobox 1	0.030
Pitx3	paired-like homeodomain transcription factor 3	0.030
Gata3	GATA binding protein 3	0.030
Omp	olfactory marker protein	0.029
Krt15	keratin 15	0.029
Bmper	BMP-binding endothelial regulator	0.029
Fgf5	fibroblast growth factor 5	0.029
Snai1	snail homolog 1 (Drosophila)	0.029
Wnt6	wingless-related MMTV integration site 6	0.028	Mouse
Lrp6	low density lipoprotein receptor-related protein 6	0.028
Foxh1	forkhead box H1	0.028
Rem1	rad and gem related GTP binding protein 1	0.028
Hes5	hairy and enhancer of split 5 (Drosophila)	0.027
Nkx2-1	NK2 homeobox 1	0.026
Sox11	SRY-box containing gene 11	0.026
Npas1	neuronal PAS domain protein 1	0.026
Col13a1	collagen, type XIII, alpha 1	0.026
Fzd10	frizzled homolog 10 (Drosophila)	0.026
Artn	artemin	0.025	Mouse
Hoxa5	homeobox A5	0.025
Mesp1	mesoderm posterior 1	0.025
Ephb3	Eph receptor B3	0.025
Il11	interleukin 11	0.024
Zic2	zinc finger protein of the cerebellum 2	0.024
Foxe3	forkhead box E3	0.023
Grem1	gremlin 1	0.023
Nos3	nitric oxide synthase 3, endothelial cell	0.023
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.023
Eya4	eyes absent 4 homolog (Drosophila)	0.022
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.022
Wnt5a	wingless-related MMTV integration site 5A	0.022	Mouse
Gjb4	gap junction protein, beta 4	0.022
Muc5ac	mucin 5, subtypes A and C, tracheobronchial/gastric	0.022
Gata6	GATA binding protein 6	0.022
Btbd17	BTB (POZ) domain containing 17	0.022
Itga3	integrin alpha 3	0.022
Fgf4	fibroblast growth factor 4	0.021
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.021
Tcf15	transcription factor 15	0.021
Phox2b	paired-like homeobox 2b	0.021
Alx1	ALX homeobox 1	0.021
Ephb2	Eph receptor B2	0.021
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.020
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.020	Mouse
Tnni2	troponin I, skeletal, fast 2	0.020
Wnt5b	wingless-related MMTV integration site 5B	0.019	Mouse
Dlx2	distal-less homeobox 2	0.019
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.019
Chd7	chromodomain helicase DNA binding protein 7	0.019
Ptch1	patched homolog 1	0.019
Tcf21	transcription factor 21	0.019
Bmp2	bone morphogenetic protein 2	0.019
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.019
Neurog3	neurogenin 3	0.019
Sox1	SRY-box containing gene 1	0.019
Zfp503	zinc finger protein 503	0.019
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.018	Mouse
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.018
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.018
BC024139	cDNA sequence BC024139	0.018
Lhx9	LIM homeobox protein 9	0.018
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.017
Hoxb9	homeobox B9	0.017
Tead2	TEA domain family member 2	0.017
Lrp5	low density lipoprotein receptor-related protein 5	0.017
Clcnka	chloride channel Ka	0.017
Tacr1	tachykinin receptor 1	0.017
Des	desmin	0.017
Hoxb4	homeobox B4	0.017
Sox3	SRY-box containing gene 3	0.017
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.016
Prop1	paired like homeodomain factor 1	0.016
Sox4	SRY-box containing gene 4	0.016
Mybph	myosin binding protein H	0.016
Lhb	luteinizing hormone beta	0.016
Grhl2	grainyhead-like 2 (Drosophila)	0.016
Hoxb5	homeobox B5	0.016
Hoxc4	homeobox C4	0.016
Ihh	Indian hedgehog	0.016
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.016
Efna2	ephrin A2	0.016
Hrc	histidine rich calcium binding protein	0.016
Efs	embryonal Fyn-associated substrate	0.016
Nynrin	NYN domain and retroviral integrase containing	0.015
Sox7	SRY-box containing gene 7	0.015
Krt14	keratin 14	0.015
Wnt9a	wingless-type MMTV integration site 9A	0.015	Mouse
Jag2	jagged 2	0.015
Foxd1	forkhead box D1	0.015
Meox2	mesenchyme homeobox 2	0.015
Fgfr4	fibroblast growth factor receptor 4	0.015
Matn3	matrilin 3	0.015
Gpr3	G-protein coupled receptor 3	0.014
Cyp24a1	cytochrome P450, family 24, subfamily a, polypeptide 1	0.014
Osr1	odd-skipped related 1 (Drosophila)	0.014
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.014
Efnb1	ephrin B1	0.014
Bdnf	brain derived neurotrophic factor	0.014
Hoxd12	homeobox D12	0.014
Lhx5	LIM homeobox protein 5	0.014
Lrp2	low density lipoprotein receptor-related protein 2	0.014
Angpt4	angiopoietin 4	0.014
Hoxc8	homeobox C8	0.014
Adra2a	adrenergic receptor, alpha 2a	0.014
Wnt8a	wingless-related MMTV integration site 8A	0.014	Mouse
Bik	BCL2-interacting killer	0.014
Rtkn	rhotekin	0.014
Sftpc	surfactant associated protein C	0.013
Gpc3	glypican 3	0.013
Cldn3	claudin 3	0.013
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.013
Gata4	GATA binding protein 4	0.013
Onecut1	one cut domain, family member 1	0.013
Pou3f4	POU domain, class 3, transcription factor 4	0.013
Bdkrb2	bradykinin receptor, beta 2	0.013
Hoxd10	homeobox D10	0.013
En2	engrailed 2	0.013
Adamts7	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7	0.013
Col4a3	collagen, type IV, alpha 3	0.013
Foxi1	forkhead box I1	0.013
Btn1a1	butyrophilin, subfamily 1, member A1	0.013
Zic3	zinc finger protein of the cerebellum 3	0.013
Hoxc6	homeobox C6	0.012
Esr1	estrogen receptor 1 (alpha)	0.012
Amh	anti-Mullerian hormone	0.012
Krt17	keratin 17	0.012
Krtdap	keratinocyte differentiation associated protein	0.012
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.012
Aldh1a3	aldehyde dehydrogenase family 1, subfamily A3	0.012
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.012
Rax	retina and anterior neural fold homeobox	0.012
Zbtb7c	zinc finger and BTB domain containing 7C	0.012
Zfp771	zinc finger protein 771	0.011
Rhbdl3	rhomboid, veinlet-like 3 (Drosophila)	0.011
Jag1	jagged 1	0.011
Cldn6	claudin 6	0.011
Zfp703	zinc finger protein 703	0.011
Gjb5	gap junction protein, beta 5	0.011
Sult5a1	sulfotransferase family 5A, member 1	0.011
Mrc2	mannose receptor, C type 2	0.011
Tlx3	T-cell leukemia, homeobox 3	0.011
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.011
Pcdh12	protocadherin 12	0.011
Rspo1	R-spondin homolog (Xenopus laevis)	0.011
Ngf	nerve growth factor	0.011
Nobox	NOBOX oogenesis homeobox	0.011
Ager	advanced glycosylation end product-specific receptor	0.010
Emp2	epithelial membrane protein 2	0.010
Dmgdh	dimethylglycine dehydrogenase precursor	0.010
Epx	eosinophil peroxidase	0.010
Ece1	endothelin converting enzyme 1	0.010
Gdf11	growth differentiation factor 11	0.010
Csf3	colony stimulating factor 3 (granulocyte)	0.010
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.010
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.010
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.010
Pgr	progesterone receptor	0.010