IMP

Process View

Mus musculus

10 genes annotated in mouse

isotype switching to igg isotypes

The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "isotype switching to igg isotypes"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "isotype switching to igg isotypes" (in gray)

Name	Description	Probability	Func Analog Organism
Ifng	interferon gamma	0.999
Tnf	tumor necrosis factor	0.955
Foxp3	forkhead box P3	0.901
Il2rg	interleukin 2 receptor, gamma chain	0.875
Fyn	Fyn proto-oncogene	0.828
Il10	interleukin 10	0.694
Tcra	T-cell receptor alpha chain	0.688
Fas	Fas (TNF receptor superfamily member 6)	0.672
Rag1	recombination activating gene 1	0.649
Cd19	CD19 antigen	0.623
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.591
Cd28	CD28 antigen	0.573
Il4	interleukin 4	0.561
Prf1	perforin 1 (pore forming protein)	0.489
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.465
Ikzf1	IKAROS family zinc finger 1	0.373
Rag2	recombination activating gene 2	0.300
Il6	interleukin 6	0.274
Socs1	suppressor of cytokine signaling 1	0.251
Lta	lymphotoxin A	0.240
Card11	caspase recruitment domain family, member 11	0.202
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.201
Lat	linker for activation of T cells	0.189
Ccl2	chemokine (C-C motif) ligand 2	0.178
Zap70	zeta-chain (TCR) associated protein kinase	0.171
Pdcd1	programmed cell death 1	0.136
Inpp5d	inositol polyphosphate-5-phosphatase D	0.130
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.108
Fasl	Fas ligand (TNF superfamily, member 6)	0.094
Itk	IL2-inducible T-cell kinase	0.087
Pou5f1	POU domain, class 5, transcription factor 1	0.084
Ptgs2	prostaglandin-endoperoxide synthase 2	0.079
Il27ra	interleukin 27 receptor, alpha	0.078
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.077
Ccr7	chemokine (C-C motif) receptor 7	0.067
Cd4	CD4 antigen	0.067
Cd247	CD247 antigen	0.064
Mmp9	matrix metallopeptidase 9	0.060
Il2	interleukin 2	0.058
Pitx2	paired-like homeodomain transcription factor 2	0.058
Foxn1	forkhead box N1	0.055
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.054
Hoxa1	homeobox A1	0.053
Sh2d1a	SH2 domain protein 1A	0.050
Tbx3	T-box 3	0.043	Mouse
Igh	immunoglobulin heavy chain complex	0.041
Gja5	gap junction protein, alpha 5	0.040
Pitx1	paired-like homeodomain transcription factor 1	0.036
Chd7	chromodomain helicase DNA binding protein 7	0.034
Ccr6	chemokine (C-C motif) receptor 6	0.033
Cd5	CD5 antigen	0.032
Nos2	nitric oxide synthase 2, inducible	0.032
Cd40lg	CD40 ligand	0.030
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.030
Il4ra	interleukin 4 receptor, alpha	0.027
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.027	Mouse
S1pr2	sphingosine-1-phosphate receptor 2	0.025
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.025
Il17a	interleukin 17A	0.024
Apoe	apolipoprotein E	0.024
Scn5a	sodium channel, voltage-gated, type V, alpha	0.022
Tbx4	T-box 4	0.022	Mouse
Stat3	signal transducer and activator of transcription 3	0.021
Icos	inducible T-cell co-stimulator	0.021	Mouse
Lck	lymphocyte protein tyrosine kinase	0.021
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.019
Sall1	sal-like 1 (Drosophila)	0.019
Il21r	interleukin 21 receptor	0.019
Alx1	ALX homeobox 1	0.018
Slamf1	signaling lymphocytic activation molecule family member 1	0.018
Tlr4	toll-like receptor 4	0.017
Lyz2	lysozyme 2	0.017
Cd40	CD40 antigen	0.016
Gpr132	G protein-coupled receptor 132	0.016
Tbx5	T-box 5	0.015	Mouse
Cd160	CD160 antigen	0.015
Btk	Bruton agammaglobulinemia tyrosine kinase	0.015
Mefv	Mediterranean fever	0.014
Dll4	delta-like 4 (Drosophila)	0.014
Il1r1	interleukin 1 receptor, type I	0.014
Cd6	CD6 antigen	0.014
Foxp2	forkhead box P2	0.014	Mouse
Il6st	interleukin 6 signal transducer	0.013	Mouse
Il12rb1	interleukin 12 receptor, beta 1	0.013
Lag3	lymphocyte-activation gene 3	0.013
Ltb	lymphotoxin B	0.013
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.013
Sox2	SRY-box containing gene 2	0.012
Gata4	GATA binding protein 4	0.012
Foxp1	forkhead box P1	0.012	Mouse
Bdnf	brain derived neurotrophic factor	0.012
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.011
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.011
Batf	basic leucine zipper transcription factor, ATF-like	0.011
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.011
Lcp2	lymphocyte cytosolic protein 2	0.011
Ccr1	chemokine (C-C motif) receptor 1	0.011
Lif	leukemia inhibitory factor	0.011
Ciita	class II transactivator	0.010
Ighmbp2	immunoglobulin mu binding protein 2	0.010
Nanog	Nanog homeobox	0.010
Gdf3	growth differentiation factor 3	0.010
Spp1	secreted phosphoprotein 1	0.010
Traf6	TNF receptor-associated factor 6	0.010