IMP

Process View

Mus musculus

17 genes annotated in mouse

cardiac conduction

Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cardiac conduction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cardiac conduction" (in gray)

Name	Description	Probability	Func Analog Organism
Scn5a	sodium channel, voltage-gated, type V, alpha	0.997
Ryr2	ryanodine receptor 2, cardiac	0.997
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.994
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.929
Tbx5	T-box 5	0.915
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.706
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.634
Tbx3	T-box 3	0.601
Gja1	gap junction protein, alpha 1	0.349
Tjp1	tight junction protein 1	0.296
Hdac4	histone deacetylase 4	0.255
Dsg2	desmoglein 2	0.185	Human
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.173	Mouse
Cxadr	coxsackie virus and adenovirus receptor	0.162
Spna1	spectrin alpha 1	0.140
Hrc	histidine rich calcium binding protein	0.135
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.113
Mybpc3	myosin binding protein C, cardiac	0.110
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.104
Slc26a4	solute carrier family 26, member 4	0.096
Hdac5	histone deacetylase 5	0.090
Add2	adducin 2 (beta)	0.088
Scn1a	sodium channel, voltage-gated, type I, alpha	0.088	Mouse
Casq2	calsequestrin 2	0.082
Rnf112	ring finger protein 112	0.075
Srpk3	serine/arginine-rich protein specific kinase 3	0.074
Xirp1	xin actin-binding repeat containing 1	0.072
Gata4	GATA binding protein 4	0.069
Hbb-b1	hemoglobin, beta adult major chain	0.068
Hr	hairless	0.061
Mpz	myelin protein zero	0.061
Kcnk3	potassium channel, subfamily K, member 3	0.057
Bsn	bassoon	0.056
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.056
Cacnb2	calcium channel, voltage-dependent, beta 2 subunit	0.054
Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	0.051
Mef2c	myocyte enhancer factor 2C	0.051	Mouse
Gata6	GATA binding protein 6	0.048
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.047
Hand2	heart and neural crest derivatives expressed transcript 2	0.047
Tnni2	troponin I, skeletal, fast 2	0.046
Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.046
Macf1	microtubule-actin crosslinking factor 1	0.046
Srrm4	serine/arginine repetitive matrix 4	0.045
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.042
Il16	interleukin 16	0.040
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.039
Zfpm2	zinc finger protein, multitype 2	0.038
Aplnr	apelin receptor	0.037
Gjd3	gap junction protein, delta 3	0.036	Mouse
Hdac7	histone deacetylase 7	0.035
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.035
Kel	Kell blood group	0.034
Kcna6	potassium voltage-gated channel, shaker-related, subfamily, member 6	0.034
Speg	SPEG complex locus	0.034
She	src homology 2 domain-containing transforming protein E	0.034
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.033
Jup	junction plakoglobin	0.033	Human
Des	desmin	0.033
Rgs5	regulator of G-protein signaling 5	0.033
Dsp	desmoplakin	0.032	Human
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.032
Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	0.032
Spna2	spectrin alpha 2	0.032
Gja5	gap junction protein, alpha 5	0.031
Fjx1	four jointed box 1 (Drosophila)	0.031
Tcf15	transcription factor 15	0.031
Nos3	nitric oxide synthase 3, endothelial cell	0.030
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.030
Sstr3	somatostatin receptor 3	0.030
Gad2	glutamic acid decarboxylase 2	0.029
Gjb2	gap junction protein, beta 2	0.029	Mouse
Epor	erythropoietin receptor	0.028
Slc17a8	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	0.028
Klf7	Kruppel-like factor 7 (ubiquitous)	0.028
Lnx1	ligand of numb-protein X 1	0.027
Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	0.026
Astn1	astrotactin 1	0.026
Zmynd11	zinc finger, MYND domain containing 11	0.026
Myl3	myosin, light polypeptide 3	0.025
Abcc9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.025
Tbx20	T-box 20	0.025
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.024
Dsc2	desmocollin 2	0.024	Human
Klk6	kallikrein related-peptidase 6	0.024
Ncor2	nuclear receptor co-repressor 2	0.024
Kitl	kit ligand	0.024
Ppl	periplakin	0.024
Hdac9	histone deacetylase 9	0.023
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.023
Cdh23	cadherin 23 (otocadherin)	0.023
Cntn4	contactin 4	0.023
Gjb6	gap junction protein, beta 6	0.023	Mouse
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.023
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.023
Nefm	neurofilament, medium polypeptide	0.023
Frmd5	FERM domain containing 5	0.022
Myom2	myomesin 2	0.022
Pcdh12	protocadherin 12	0.022
Gjb4	gap junction protein, beta 4	0.022	Mouse
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.021
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.021
Mef2d	myocyte enhancer factor 2D	0.021	Mouse
Gja3	gap junction protein, alpha 3	0.020	Mouse
Irx4	Iroquois related homeobox 4 (Drosophila)	0.020
Dsc1	desmocollin 1	0.020
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.020
Cdh15	cadherin 15	0.020
Rgs6	regulator of G-protein signaling 6	0.020
Ldb3	LIM domain binding 3	0.019
Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.019
Podxl	podocalyxin-like	0.019
Tcfap2c	transcription factor AP-2, gamma	0.019
Sema4f	sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain	0.019
Kcna7	potassium voltage-gated channel, shaker-related subfamily, member 7	0.019
Shank3	SH3/ankyrin domain gene 3	0.019
Cdh4	cadherin 4	0.019
Dag1	dystroglycan 1	0.019
Adam22	a disintegrin and metallopeptidase domain 22	0.019
Myl7	myosin, light polypeptide 7, regulatory	0.019
Crybb1	crystallin, beta B1	0.018
Adam23	a disintegrin and metallopeptidase domain 23	0.018
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.018
Sox7	SRY-box containing gene 7	0.018
Mmp15	matrix metallopeptidase 15	0.018
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.018
Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	0.018
Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	0.018
Pclo	piccolo (presynaptic cytomatrix protein)	0.018
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.018
Prss22	protease, serine, 22	0.018
Emp2	epithelial membrane protein 2	0.018
Ckmt2	creatine kinase, mitochondrial 2	0.018
Gucy1a3	guanylate cyclase 1, soluble, alpha 3	0.017
Smyd1	SET and MYND domain containing 1	0.017
Jag1	jagged 1	0.017
Nodal	nodal	0.017
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.017
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.017
Ttn	titin	0.016
Exoc6	exocyst complex component 6	0.016
Capn12	calpain 12	0.016
Perp	PERP, TP53 apoptosis effector	0.016
Crhr2	corticotropin releasing hormone receptor 2	0.016
Lin7b	lin-7 homolog B (C. elegans)	0.016
Tnnt2	troponin T2, cardiac	0.016
Usp13	ubiquitin specific peptidase 13 (isopeptidase T-3)	0.016
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.016
Grm8	glutamate receptor, metabotropic 8	0.016
AI118078	expressed sequence AI118078	0.015
Crxos1	Crx opposite strand transcript 1	0.015
Popdc2	popeye domain containing 2	0.015
Mpp3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.015
Fut2	fucosyltransferase 2	0.015
Prkacb	protein kinase, cAMP dependent, catalytic, beta	0.015
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.015
Slco5a1	solute carrier organic anion transporter family, member 5A1	0.015
Mtap1b	microtubule-associated protein 1B	0.015
Col17a1	collagen, type XVII, alpha 1	0.015
Mfsd4	major facilitator superfamily domain containing 4	0.014
Cldn5	claudin 5	0.014
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.014
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.014
Dtna	dystrobrevin alpha	0.014
Prox1	prospero-related homeobox 1	0.014
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.014
Kif5a	kinesin family member 5A	0.014
Il5ra	interleukin 5 receptor, alpha	0.014
Bmp8b	bone morphogenetic protein 8b	0.014
Krt8	keratin 8	0.014
Ocln	occludin	0.014
Cdh5	cadherin 5	0.014
Stac2	SH3 and cysteine rich domain 2	0.014
Gtf2ird1	general transcription factor II I repeat domain-containing 1	0.014
Dmpk	dystrophia myotonica-protein kinase	0.014
Utf1	undifferentiated embryonic cell transcription factor 1	0.014
Scn10a	sodium channel, voltage-gated, type X, alpha	0.013
Wnk2	WNK lysine deficient protein kinase 2	0.013
Upk3b	uroplakin 3B	0.013
Slurp1	secreted Ly6/Plaur domain containing 1	0.013
Scarb2	scavenger receptor class B, member 2	0.013
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.013
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.013	Mouse
Ptprb	protein tyrosine phosphatase, receptor type, B	0.013
Ctnnd1	catenin (cadherin associated protein), delta 1	0.013
Kifc2	kinesin family member C2	0.013
Myh10	myosin, heavy polypeptide 10, non-muscle	0.013
Rnf207	ring finger protein 207	0.013
Scn8a	sodium channel, voltage-gated, type VIII, alpha	0.013	Mouse
Wnt8a	wingless-related MMTV integration site 8A	0.013
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.013
Dlk2	delta-like 2 homolog (Drosophila)	0.013
Trpc4	transient receptor potential cation channel, subfamily C, member 4	0.013
Tcap	titin-cap	0.013
Dmd	dystrophin, muscular dystrophy	0.013
Fgf12	fibroblast growth factor 12	0.013
Dnajb5	DnaJ (Hsp40) homolog, subfamily B, member 5	0.013
Gzmm	granzyme M (lymphocyte met-ase 1)	0.013
Hsf4	heat shock transcription factor 4	0.013
Flt1	FMS-like tyrosine kinase 1	0.012
Thrb	thyroid hormone receptor beta	0.012
Add1	adducin 1 (alpha)	0.012
Pla2g10	phospholipase A2, group X	0.012
Tgfb2	transforming growth factor, beta 2	0.012
Col8a1	collagen, type VIII, alpha 1	0.012
Park2	Parkinson disease (autosomal recessive, juvenile) 2, parkin	0.012
Pygm	muscle glycogen phosphorylase	0.012
Csrp3	cysteine and glycine-rich protein 3	0.012
Adra2c	adrenergic receptor, alpha 2c	0.012
Hrh1	histamine receptor H1	0.012
Syt7	synaptotagmin VII	0.012
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.012
Srcin1	SRC kinase signaling inhibitor 1	0.012
Krt31	keratin 31	0.012
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.012
Myct1	myc target 1	0.012
Ighmbp2	immunoglobulin mu binding protein 2	0.011
Rasip1	Ras interacting protein 1	0.011
Hopx	HOP homeobox	0.011
Cldn4	claudin 4	0.011
Sebox	SEBOX homeobox	0.011
Epb4.1l1	erythrocyte protein band 4.1-like 1	0.011
Pklr	pyruvate kinase liver and red blood cell	0.011
Nox3	NADPH oxidase 3	0.011
Icam2	intercellular adhesion molecule 2	0.011
Apobec2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2	0.011
Tead1	TEA domain family member 1	0.011
E230006M18Rik	RIKEN cDNA E230006M18 gene	0.011
Lphn1	latrophilin 1	0.011
Tek	endothelial-specific receptor tyrosine kinase	0.011
Syt3	synaptotagmin III	0.011
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.011
C78859	expressed sequence C78859	0.011
Slc4a3	solute carrier family 4 (anion exchanger), member 3	0.011
Cadm3	cell adhesion molecule 3	0.011
Lmo7	LIM domain only 7	0.011
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.011
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.011
Epn3	epsin 3	0.011
Txlnb	taxilin beta	0.011
Anxa7	annexin A7	0.011
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.010
Gpr37	G protein-coupled receptor 37	0.010
Krt13	keratin 13	0.010
Msln	mesothelin	0.010
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.010
Rasgrf2	RAS protein-specific guanine nucleotide-releasing factor 2	0.010
Pde1c	phosphodiesterase 1C	0.010
Qk	quaking	0.010
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.010
Frk	fyn-related kinase	0.010
Sorcs2	sortilin-related VPS10 domain containing receptor 2	0.010
P2ry1	purinergic receptor P2Y, G-protein coupled 1	0.010
Kif1b	kinesin family member 1B	0.010
Fgf22	fibroblast growth factor 22	0.010
Esrp1	epithelial splicing regulatory protein 1	0.010