IMP

Process View

Mus musculus

2 genes annotated in mouse

membrane depolarization during sa node cell action potential

The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "membrane depolarization during sa node cell action potential"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "membrane depolarization during sa node cell action potential" (in gray)

Name	Description	Probability	Func Analog Organism
Ryr2	ryanodine receptor 2, cardiac	0.997
Bsn	bassoon	0.837
Tbx5	T-box 5	0.751
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.707
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.685
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.529
Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	0.466
Cdh23	cadherin 23 (otocadherin)	0.457
Gja5	gap junction protein, alpha 5	0.422
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.374
Ryr1	ryanodine receptor 1, skeletal muscle	0.354
Cacnb2	calcium channel, voltage-dependent, beta 2 subunit	0.292
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.265
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.253
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.243
Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	0.241
Slc17a8	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	0.225
Tbx3	T-box 3	0.225
Grid2	glutamate receptor, ionotropic, delta 2	0.200
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.200
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.172
Rho	rhodopsin	0.167
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.167
Hrc	histidine rich calcium binding protein	0.140
Gja1	gap junction protein, alpha 1	0.135
Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.129
Tnni2	troponin I, skeletal, fast 2	0.108
Casq2	calsequestrin 2	0.107
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	0.106
Cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.104
Rnf112	ring finger protein 112	0.094
Kif5a	kinesin family member 5A	0.093
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.083
Cdh4	cadherin 4	0.082
Xirp1	xin actin-binding repeat containing 1	0.082
Ebf2	early B-cell factor 2	0.081
Drd2	dopamine receptor D2	0.078
Stx1a	syntaxin 1A (brain)	0.074
Kcna6	potassium voltage-gated channel, shaker-related, subfamily, member 6	0.074
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.074
Astn1	astrotactin 1	0.072
Nap1l2	nucleosome assembly protein 1-like 2	0.066
Scn1a	sodium channel, voltage-gated, type I, alpha	0.065	Mouse
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.063
Dtna	dystrobrevin alpha	0.062
Aff2	AF4/FMR2 family, member 2	0.061
Gjd3	gap junction protein, delta 3	0.060
Grm1	glutamate receptor, metabotropic 1	0.059
Gad2	glutamic acid decarboxylase 2	0.057
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.056
Crhr2	corticotropin releasing hormone receptor 2	0.054
Tmprss5	transmembrane protease, serine 5 (spinesin)	0.054
Srrm3	serine/arginine repetitive matrix 3	0.054
Col19a1	collagen, type XIX, alpha 1	0.050
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.049	Mouse
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.049
Mtap1b	microtubule-associated protein 1B	0.049
Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.048
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.047
Fgf13	fibroblast growth factor 13	0.047
Art5	ADP-ribosyltransferase 5	0.047
Mas1	MAS1 oncogene	0.047
C78859	expressed sequence C78859	0.046
Smyd1	SET and MYND domain containing 1	0.044
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.044
Srpk3	serine/arginine-rich protein specific kinase 3	0.044
Sstr3	somatostatin receptor 3	0.042
Snap25	synaptosomal-associated protein 25	0.042
Pgr	progesterone receptor	0.042
Stx1b	syntaxin 1B	0.042
Usp13	ubiquitin specific peptidase 13 (isopeptidase T-3)	0.041
Cntn3	contactin 3	0.040
Kifc2	kinesin family member C2	0.040
Scn8a	sodium channel, voltage-gated, type VIII, alpha	0.039	Mouse
Rasgrf2	RAS protein-specific guanine nucleotide-releasing factor 2	0.039
Kcnk3	potassium channel, subfamily K, member 3	0.038
Hrk	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.037
Cntn4	contactin 4	0.036
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.036
Prox1	prospero-related homeobox 1	0.036
Crxos1	Crx opposite strand transcript 1	0.035
Phkg1	phosphorylase kinase gamma 1	0.034
Grm8	glutamate receptor, metabotropic 8	0.034
Thrb	thyroid hormone receptor beta	0.034
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.034
Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	0.033
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.033
Hcn1	hyperpolarization-activated, cyclic nucleotide-gated K+ 1	0.033
Scn9a	sodium channel, voltage-gated, type IX, alpha	0.033	Mouse
Adam22	a disintegrin and metallopeptidase domain 22	0.032
Ldb3	LIM domain binding 3	0.032
Bmp8b	bone morphogenetic protein 8b	0.031
Scrt1	scratch homolog 1, zinc finger protein (Drosophila)	0.031
Kif5c	kinesin family member 5C	0.031
Dynlt1b	dynein light chain Tctex-type 1D	0.031
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.031
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.030
Crybb1	crystallin, beta B1	0.030
Syt2	synaptotagmin II	0.030
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.030
Rit2	Ras-like without CAAX 2	0.029
Ina	internexin neuronal intermediate filament protein, alpha	0.029
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.028
Ky	kyphoscoliosis peptidase	0.028
Syn3	synapsin III	0.028
Sgip1	SH3-domain GRB2-like (endophilin) interacting protein 1	0.028
Il12b	interleukin 12b	0.027
Szt2	seizure threshold 2	0.027
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.027
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.027
Ckmt2	creatine kinase, mitochondrial 2	0.027
Mpz	myelin protein zero	0.026
Slco5a1	solute carrier organic anion transporter family, member 5A1	0.026
Epha5	Eph receptor A5	0.026
Gdap1	ganglioside-induced differentiation-associated-protein 1	0.026
Pax7	paired box gene 7	0.026
BC024139	cDNA sequence BC024139	0.025
Nefm	neurofilament, medium polypeptide	0.025
Nxph1	neurexophilin 1	0.024
Syt7	synaptotagmin VII	0.024
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.024
Prop1	paired like homeodomain factor 1	0.024
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.024
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.023
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.023
Neto1	neuropilin (NRP) and tolloid (TLL)-like 1	0.023
Tnnc2	troponin C2, fast	0.023
Gabrb1	gamma-aminobutyric acid (GABA) A receptor, subunit beta 1	0.022
Myt1	myelin transcription factor 1	0.022
Slc4a3	solute carrier family 4 (anion exchanger), member 3	0.022
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.022
Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	0.022
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.022
Kcna7	potassium voltage-gated channel, shaker-related subfamily, member 7	0.022
Epha7	Eph receptor A7	0.022
Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	0.022
Syt1	synaptotagmin I	0.022
D530037H12Rik	RIKEN cDNA D530037H12 gene	0.021
Chrna9	cholinergic receptor, nicotinic, alpha polypeptide 9	0.021
Il16	interleukin 16	0.021
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, subunit beta 2	0.021
Syt3	synaptotagmin III	0.020
Tjp1	tight junction protein 1	0.020
Cadps	Ca2+-dependent secretion activator	0.020
Clvs1	clavesin 1	0.020
Scn2a1	sodium channel, voltage-gated, type II, alpha 1	0.019	Mouse
BC053393	cDNA sequence BC053393	0.019
Ebf3	early B-cell factor 3	0.019
Fam184b	family with sequence similarity 184, member B	0.019
Mmp16	matrix metallopeptidase 16	0.019
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.019
Nrg3	neuregulin 3	0.019
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.019
AI118078	expressed sequence AI118078	0.019
Il12a	interleukin 12a	0.019
Cdh15	cadherin 15	0.018
Hoxd1	homeobox D1	0.018
Vsx1	visual system homeobox 1 homolog (zebrafish)	0.018
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.018
Grik1	glutamate receptor, ionotropic, kainate 1	0.018
Apobec2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2	0.017
Rgs20	regulator of G-protein signaling 20	0.017
Adra1a	adrenergic receptor, alpha 1a	0.017
Tectb	tectorin beta	0.017
6430704M03Rik	RIKEN cDNA 6430704M03 gene	0.017
Cdh8	cadherin 8	0.017
Hivep3	human immunodeficiency virus type I enhancer binding protein 3	0.017
Mef2c	myocyte enhancer factor 2C	0.017
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.017
Slc26a5	solute carrier family 26, member 5	0.017
Cav3	caveolin 3	0.016
Pcdhb15	protocadherin beta 15	0.016
Mucl1	mucin-like 1	0.016
Unc13a	unc-13 homolog A (C. elegans)	0.016
Zfpm2	zinc finger protein, multitype 2	0.016
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.016
Nefl	neurofilament, light polypeptide	0.016
Alox8	arachidonate 8-lipoxygenase	0.016
Fbn1	fibrillin 1	0.016
St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.016
Tnnt3	troponin T3, skeletal, fast	0.016
Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	0.016
Gabrg2	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	0.016
Napb	N-ethylmaleimide sensitive fusion protein attachment protein beta	0.016
Pcdh10	protocadherin 10	0.016
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.015
Gsbs	G substrate	0.015
Cadm3	cell adhesion molecule 3	0.015
Myt1l	myelin transcription factor 1-like	0.015
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.015
Sema4f	sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain	0.015
Myl3	myosin, light polypeptide 3	0.015
Bcl2l10	Bcl2-like 10	0.015
Rai2	retinoic acid induced 2	0.015
Syt4	synaptotagmin IV	0.015
Sugp2	SURP and G patch domain containing 2	0.015
Cdh9	cadherin 9	0.015
Kcns1	K+ voltage-gated channel, subfamily S, 1	0.015
Csmd1	CUB and Sushi multiple domains 1	0.015
Gzmm	granzyme M (lymphocyte met-ase 1)	0.015
Myh10	myosin, heavy polypeptide 10, non-muscle	0.015
Ighmbp2	immunoglobulin mu binding protein 2	0.015
Defa4	defensin, alpha, 4	0.015
Snhg11	small nucleolar RNA host gene 11	0.015
Npas2	neuronal PAS domain protein 2	0.015
C79122	expressed sequence C79122	0.015
Lcn4	lipocalin 4	0.014
Lin7b	lin-7 homolog B (C. elegans)	0.014
Tcap	titin-cap	0.014
Kcna5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.014
Ptprz1	protein tyrosine phosphatase, receptor type Z, polypeptide 1	0.014
Slc8a2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.014
Epha3	Eph receptor A3	0.014
Lep	leptin	0.014
Coro6	coronin 6	0.014
Tbx20	T-box 20	0.014
Ryr3	ryanodine receptor 3	0.014
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.014
Maneal	mannosidase, endo-alpha-like	0.014
Actl6b	actin-like 6B	0.014
Ttn	titin	0.014
Cntnap4	contactin associated protein-like 4	0.014
Rph3a	rabphilin 3A	0.014
Mapk10	mitogen-activated protein kinase 10	0.014
H2-T18	histocompatibility 2, T region locus 18	0.013
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.013
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.013
Dscam	Down syndrome cell adhesion molecule	0.013
Cntn1	contactin 1	0.013
Celf4	CUGBP, Elav-like family member 4	0.013
Foxf2	forkhead box F2	0.013
Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.013
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.013
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.013
Fgf14	fibroblast growth factor 14	0.013
Mast1	microtubule associated serine/threonine kinase 1	0.013
Lrrtm2	leucine rich repeat transmembrane neuronal 2	0.013
Lrp1b	low density lipoprotein-related protein 1B (deleted in tumors)	0.013
Pnpla3	patatin-like phospholipase domain containing 3	0.013
Tacr1	tachykinin receptor 1	0.013
Srcin1	SRC kinase signaling inhibitor 1	0.013
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.013
Park2	Parkinson disease (autosomal recessive, juvenile) 2, parkin	0.013
Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2	0.012
Hr	hairless	0.012
Prph2	peripherin 2	0.012
Ar	androgen receptor	0.012
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.012
Pcdh15	protocadherin 15	0.012
Myh1	myosin, heavy polypeptide 1, skeletal muscle, adult	0.012
Pdx1	pancreatic and duodenal homeobox 1	0.012
Gjd2	gap junction protein, delta 2	0.012
Wnk2	WNK lysine deficient protein kinase 2	0.012
Mpp3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.012
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.012
Neurod2	neurogenic differentiation 2	0.012
Zfp28	zinc finger protein 28	0.012
Calcoco2	calcium binding and coiled-coil domain 2	0.012
Pcdhb20	protocadherin beta 20	0.012
Elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.012
Tnnt2	troponin T2, cardiac	0.012
Npas1	neuronal PAS domain protein 1	0.012
Sntg1	syntrophin, gamma 1	0.012
Frmd5	FERM domain containing 5	0.012
Adam23	a disintegrin and metallopeptidase domain 23	0.012
Sgcg	sarcoglycan, gamma (dystrophin-associated glycoprotein)	0.012
Tac4	tachykinin 4	0.012
Tmprss3	transmembrane protease, serine 3	0.012
Klf12	Kruppel-like factor 12	0.012
Cga	glycoprotein hormones, alpha subunit	0.012
Galr1	galanin receptor 1	0.012
Klhl1	kelch-like 1 (Drosophila)	0.012
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.012
C78893	expressed sequence C78893	0.012
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.012
Zfp352	zinc finger protein 352	0.012
Mpdz	multiple PDZ domain protein	0.011
Prkce	protein kinase C, epsilon	0.011
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.011
Trpc3	transient receptor potential cation channel, subfamily C, member 3	0.011
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.011
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.011
Tlx1	T-cell leukemia, homeobox 1	0.011
Neurog2	neurogenin 2	0.011
AA407107	expressed sequence AA407107	0.011
Cox8b	cytochrome c oxidase, subunit VIIIb	0.011
Grk1	G protein-coupled receptor kinase 1	0.011
Hrh3	histamine receptor H3	0.011
Aicda	activation-induced cytidine deaminase	0.011
Actn2	actinin alpha 2	0.011
Abcc9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.011
Cnr1	cannabinoid receptor 1 (brain)	0.011
Cdh10	cadherin 10	0.011
Slc4a10	solute carrier family 4, sodium bicarbonate cotransporter-like, member 10	0.011
Vipr1	vasoactive intestinal peptide receptor 1	0.011
Asb10	ankyrin repeat and SOCS box-containing 10	0.011
Mybpc3	myosin binding protein C, cardiac	0.011
Per3	period homolog 3 (Drosophila)	0.011
Plin4	perilipin 4	0.011
Ncan	neurocan	0.011
Srrm4	serine/arginine repetitive matrix 4	0.011
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.011
Krt84	keratin 84	0.011
Cacnb3	calcium channel, voltage-dependent, beta 3 subunit	0.011
Bai1	brain-specific angiogenesis inhibitor 1	0.011
Rpl3l	ribosomal protein L3-like	0.011
Cryba2	crystallin, beta A2	0.011
Ebf1	early B-cell factor 1	0.011
Hsf4	heat shock transcription factor 4	0.011
Olig3	oligodendrocyte transcription factor 3	0.011
Speg	SPEG complex locus	0.011
Rgs7bp	regulator of G-protein signalling 7 binding protein	0.010
Cacna2d3	calcium channel, voltage-dependent, alpha2/delta subunit 3	0.010
Mapt	microtubule-associated protein tau	0.010
Magix	MAGI family member, X-linked	0.010
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.010
Cabp2	calcium binding protein 2	0.010
Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.010
Tubb4	tubulin, beta 4	0.010
Rgs7	regulator of G protein signaling 7	0.010
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.010
Dnd1	dead end homolog 1 (zebrafish)	0.010
Obp1a	odorant binding protein Ia	0.010
Cd160	CD160 antigen	0.010
Cacng1	calcium channel, voltage-dependent, gamma subunit 1	0.010
Myoz1	myozenin 1	0.010
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.010
Gabrr2	gamma-aminobutyric acid (GABA) C receptor, subunit rho 2	0.010
Fgf7	fibroblast growth factor 7	0.010
Myh2	myosin, heavy polypeptide 2, skeletal muscle, adult	0.010
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.010
Snai2	snail homolog 2 (Drosophila)	0.010