The network for 'negative regulation of angiogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of angiogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.

Homo sapiens
Name Description Probability Func Analog Organism
TEK TEK tyrosine kinase, endothelial 0.982
JAG1 jagged 1 0.952
NOTCH1 notch 1 0.879
CCR5 chemokine (C-C motif) receptor 5 0.829
NOTCH3 notch 3 0.811
COL4A1 collagen, type IV, alpha 1 0.732
COL4A2 collagen, type IV, alpha 2 0.661
IL2RB interleukin 2 receptor, beta 0.634
HOXB5 homeobox B5 0.597
FGA fibrinogen alpha chain 0.597
YAP1 Yes-associated protein 1 0.556
ANGPT2 angiopoietin 2 0.488
CXCL2 chemokine (C-X-C motif) ligand 2 0.486
NCOR2 nuclear receptor corepressor 2 0.458
COL5A1 collagen, type V, alpha 1 0.413
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.353
IFNG interferon, gamma 0.342
IL8 interleukin 8 0.314
COL3A1 collagen, type III, alpha 1 0.313
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.309
CCL5 chemokine (C-C motif) ligand 5 0.306
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.278
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.264
JUN jun proto-oncogene 0.257
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.254
CXCL3 chemokine (C-X-C motif) ligand 3 0.250
MEF2C myocyte enhancer factor 2C 0.244
HOXA5 homeobox A5 0.240
AMOT angiomotin 0.214
NCOR1 nuclear receptor corepressor 1 0.214
KAT2B K(lysine) acetyltransferase 2B 0.208
DPP4 dipeptidyl-peptidase 4 0.184
PLAT plasminogen activator, tissue 0.180
HOXA7 homeobox A7 0.167
COL1A1 collagen, type I, alpha 1 0.167
CCL8 chemokine (C-C motif) ligand 8 0.161
TJP1 tight junction protein 1 (zona occludens 1) 0.156
HIPK2 homeodomain interacting protein kinase 2 0.154
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.153
IRF9 interferon regulatory factor 9 0.147
HOXA10 homeobox A10 0.147
CYR61 cysteine-rich, angiogenic inducer, 61 0.146
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.143
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.143
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.140
JAK1 Janus kinase 1 0.139
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.138
MAPK7 mitogen-activated protein kinase 7 0.134
CAV1 caveolin 1, caveolae protein, 22kDa 0.131
COL4A4 collagen, type IV, alpha 4 0.129
COL4A5 collagen, type IV, alpha 5 0.127
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.126
CXCR3 chemokine (C-X-C motif) receptor 3 0.124
TIMP3 TIMP metallopeptidase inhibitor 3 0.123
COL1A2 collagen, type I, alpha 2 0.123
CD34 CD34 molecule 0.122
CCR7 chemokine (C-C motif) receptor 7 0.121
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.121
SKIL SKI-like oncogene 0.115
HOXB6 homeobox B6 0.113
FHL2 four and a half LIM domains 2 0.113
BCL6 B-cell CLL/lymphoma 6 0.110
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.109
HOXA4 homeobox A4 0.101
IRS2 insulin receptor substrate 2 0.099
F13A1 coagulation factor XIII, A1 polypeptide 0.099
HTT huntingtin 0.098
CCR2 chemokine (C-C motif) receptor 2 0.098
PXDN peroxidasin homolog (Drosophila) 0.093
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.092
RHOA ras homolog gene family, member A 0.091
DUSP1 dual specificity phosphatase 1 0.089
HOXB3 homeobox B3 0.089
NOTCH2 notch 2 0.088
HOXC6 homeobox C6 0.086
ENG endoglin 0.086
MEF2A myocyte enhancer factor 2A 0.085
CREBBP CREB binding protein 0.084
ATF3 activating transcription factor 3 0.083
DLL1 delta-like 1 (Drosophila) 0.081
PLAUR plasminogen activator, urokinase receptor 0.081
CCL20 chemokine (C-C motif) ligand 20 0.080
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.079
CCL4 chemokine (C-C motif) ligand 4 0.077
CDH5 cadherin 5, type 2 (vascular endothelium) 0.077
NCOA6 nuclear receptor coactivator 6 0.076
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.074
PLAU plasminogen activator, urokinase 0.073
CXCR6 chemokine (C-X-C motif) receptor 6 0.072
ANGPT1 angiopoietin 1 0.071
TMSB4X thymosin beta 4, X-linked 0.069
AMOTL1 angiomotin like 1 0.069
CXCL9 chemokine (C-X-C motif) ligand 9 0.069
CD163 CD163 molecule 0.066
CREB1 cAMP responsive element binding protein 1 0.066
CCL2 chemokine (C-C motif) ligand 2 0.066
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.064
IL6 interleukin 6 (interferon, beta 2) 0.064
HOXB7 homeobox B7 0.064
EP300 E1A binding protein p300 0.063
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 0.756
notch3 notch homolog 3 0.305
tie1 endothelium-specific receptor tyrosine kinase 1 0.287
col12a1 collagen, type XII, alpha 1 0.242
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.220
ccm2 cerebral cavernous malformation 2 0.208
etv2 ets variant gene 2 0.179
nrp1a neuropilin 1a 0.172
pitx3 paired-like homeodomain transcription factor 3 0.148
vegfc vascular endothelial growth factor c 0.144
tbx1 T-box 1 0.144
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.141
plcg1 phospholipase C, gamma 1 0.127
efnb2a ephrin B2a 0.104
dll4 delta-like 4 (Drosophila) 0.101
plxnd1 plexin D1 0.090
flt4 fms-related tyrosine kinase 4 0.085
col2a1a collagen type II, alpha-1a 0.076
hoxb4a homeo box B4a 0.069
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.065
arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.063
nf1a neurofibromin 1a 0.061
cdh5 cadherin 5 0.058
tie2 endothelium-specific receptor tyrosine kinase 2 0.057
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.045
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.042
fbn2b fibrillin 2b 0.038
col11a1a collagen, type XI, alpha 1a 0.034
foxn4 forkhead box N4 0.034
bmp4 bone morphogenetic protein 4 0.033
flot2a flotillin 2a 0.033
hapln3 hyaluronan and proteoglycan link protein 3 0.032
bmp2b bone morphogenetic protein 2b 0.032
vegfaa vascular endothelial growth factor Aa 0.032
hoxb6b homeo box B6b 0.028
nf1b neurofibromin 1b 0.028
she Src homology 2 domain containing E 0.028
cnn2 calponin 2 0.027
hoxd3a homeo box D3a 0.024
gja3 gap junction protein, alpha 3 0.024
acvrl1 activin A receptor type II-like 1 0.024
si:ch73-60e21.1 si:ch73-60e21.1 0.023
agtr2 angiotensin II receptor, type 2 0.022
mrc1a mannose receptor, C type 1a 0.021
mcamb melanoma cell adhesion molecule b 0.021
tbx20 T-box 20 0.020
sox7 SRY-box containing gene 7 0.020
sulf1 sulfatase 1 0.020
selp selectin P 0.020
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.020
ephb4a eph receptor B4a 0.020
tcf12 transcription factor 12 0.019
foxa1 forkhead box A1 0.019
lama5 laminin, alpha 5 0.018
LOC100332039 ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like 0.017
si:ch211-212m21.5 si:ch211-212m21.5 0.017
timp2b tissue inhibitor of metalloproteinase 2b 0.016
birc2 baculoviral IAP repeat-containing 2 0.016
vhl von Hippel-Lindau tumor suppressor 0.016
hoxa3a homeo box A3a 0.016
per2 period homolog 2 (Drosophila) 0.016
matn4 matrilin 4 0.016
cx43 connexin 43 0.016
pdgfrb2 platelet derived growth factor receptor beta 2 0.016
hspa12b heat shock protein 12B 0.015
si:ch211-235f6.2 si:ch211-235f6.2 0.014
epas1b endothelial PAS domain protein 1b 0.014
dlc deltaC 0.014
akap2 A kinase (PRKA) anchor protein 2 0.014
fli1a friend leukemia integration 1a 0.014
slit3 slit (Drosophila) homolog 3 0.014
si:dkeyp-50f5.1 si:dkeyp-50f5.1 0.013
twist1a twist1a 0.013
prkci protein kinase C, iota 0.013
eng2a engrailed 2a 0.013
dusp5 dual specificity phosphatase 5 0.013
aldh1l1 aldehyde dehydrogenase 1 family, member L1 0.013
ntn4 netrin 4 0.013
prdm5 PR domain containing 5 0.012
zfp36l1b zinc finger protein 36, C3H type-like 1b 0.012
dab2 disabled homolog 2 (Drosophila) 0.012
hnf1ba HNF1 homeobox Ba 0.012
calua calumenin a 0.012
hoxb3a homeo box B3a 0.012
lrrc6 leucine rich repeat containing 6 0.012
egr1 early growth response 1 0.012
notch2 notch homolog 2 0.011
efemp2 EGF-containing fibulin-like extracellular matrix protein 2 0.011
zbtb4 zinc finger and BTB domain containing 4 0.011
hoxa4a homeo box A4a 0.011
wu:fj39b01 wu:fj39b01 0.011
klf2a Kruppel-like factor 2a 0.010
col5a2l collagen, type V, alpha 2-like 0.010
nrarpa notch-regulated ankyrin repeat protein a 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Smad3 MAD homolog 3 (Drosophila) 0.845
Ccl2 chemokine (C-C motif) ligand 2 0.823
Clock circadian locomotor output cycles kaput 0.817
Lepr leptin receptor 0.756
Ccr2 chemokine (C-C motif) receptor 2 0.660
Lyz2 lysozyme 2 0.557
Col1a1 collagen, type I, alpha 1 0.511
Cd44 CD44 antigen 0.507
Col4a1 collagen, type IV, alpha 1 0.502
Apoe apolipoprotein E 0.478
Pgr progesterone receptor 0.462
Col4a5 collagen, type IV, alpha 5 0.370
Tlr4 toll-like receptor 4 0.366
Pcdh12 protocadherin 12 0.361
Col5a2 collagen, type V, alpha 2 0.338
Nos2 nitric oxide synthase 2, inducible 0.324
Bmp5 bone morphogenetic protein 5 0.305
Eln elastin 0.278
Prl8a2 prolactin family 8, subfamily a, member 2 0.270
Il1r1 interleukin 1 receptor, type I 0.268
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.256
Col4a2 collagen, type IV, alpha 2 0.247
Col3a1 collagen, type III, alpha 1 0.219
Emcn endomucin 0.208
Cdh5 cadherin 5 0.202
Pparg peroxisome proliferator activated receptor gamma 0.200
Prl7d1 prolactin family 7, subfamily d, member 1 0.195
Skil SKI-like 0.193
Ifng interferon gamma 0.192
Psg19 pregnancy specific glycoprotein 19 0.192
Fzd1 frizzled homolog 1 (Drosophila) 0.185
Lum lumican 0.185
Ptgs2 prostaglandin-endoperoxide synthase 2 0.166
Kdr kinase insert domain protein receptor 0.162
Fbln2 fibulin 2 0.161
Mfap2 microfibrillar-associated protein 2 0.156
Dll4 delta-like 4 (Drosophila) 0.153
Ctsr cathepsin R 0.143
Cfh complement component factor h 0.136
Twist2 twist homolog 2 (Drosophila) 0.135
Mdm2 transformed mouse 3T3 cell double minute 2 0.132
Selp selectin, platelet 0.129
Thbs2 thrombospondin 2 0.128
Fgf7 fibroblast growth factor 7 0.126
Cd59a CD59a antigen 0.119
Fstl1 follistatin-like 1 0.118
Tpbpa trophoblast specific protein alpha 0.118
Lox lysyl oxidase 0.118
Wisp2 WNT1 inducible signaling pathway protein 2 0.116
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.114
Efnb2 ephrin B2 0.114
Cxcl12 chemokine (C-X-C motif) ligand 12 0.112
Ccl3 chemokine (C-C motif) ligand 3 0.112
Notch2 Notch gene homolog 2 (Drosophila) 0.112
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.111
Rhbdf1 rhomboid family 1 (Drosophila) 0.110
Inpp5d inositol polyphosphate-5-phosphatase D 0.104
Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.103
Cav1 caveolin 1, caveolae protein 0.102
Snai1 snail homolog 1 (Drosophila) 0.101
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.098
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.095
Sox17 SRY-box containing gene 17 0.093
Ccr5 chemokine (C-C motif) receptor 5 0.092
Skor1 SKI family transcriptional corepressor 1 0.092
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.092
Ptgfr prostaglandin F receptor 0.091
Grb10 growth factor receptor bound protein 10 0.091
Col6a1 collagen, type VI, alpha 1 0.090
Nos3 nitric oxide synthase 3, endothelial cell 0.088
Efna1 ephrin A1 0.087
Fzd2 frizzled homolog 2 (Drosophila) 0.086
Ceacam9 carcinoembryonic antigen-related cell adhesion molecule 9 0.083
Gzmc granzyme C 0.082
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.081
Angpt1 angiopoietin 1 0.081
Prl3b1 prolactin family 3, subfamily b, member 1 0.081
Ptprb protein tyrosine phosphatase, receptor type, B 0.080
Prdm1 PR domain containing 1, with ZNF domain 0.080
Ang2 angiogenin, ribonuclease A family, member 2 0.076
Col12a1 collagen, type XII, alpha 1 0.075
Egfr epidermal growth factor receptor 0.074
Vegfa vascular endothelial growth factor A 0.073
Eng endoglin 0.072
Nid1 nidogen 1 0.071
Prl5a1 prolactin family 5, subfamily a, member 1 0.071
Tlr2 toll-like receptor 2 0.070
Tgfbr3 transforming growth factor, beta receptor III 0.068
Vav2 vav 2 oncogene 0.068
Gprc6a G protein-coupled receptor, family C, group 6, member A 0.066
Postn periostin, osteoblast specific factor 0.066
Runx1 runt related transcription factor 1 0.064
Ciita class II transactivator 0.064
Mmp1a matrix metallopeptidase 1a (interstitial collagenase) 0.064
C1qtnf3 C1q and tumor necrosis factor related protein 3 0.064
Meox2 mesenchyme homeobox 2 0.064
Adrb3 adrenergic receptor, beta 3 0.063
1600015I10Rik RIKEN cDNA 1600015I10 gene 0.063
Cyr61 cysteine rich protein 61 0.063
Prl7c1 prolactin family 7, subfamily c, member 1 0.062
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Rattus norvegicus
Name Description Probability Func Analog Organism
Junb jun B proto-oncogene 0.205
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.082
Ccl4 chemokine (C-C motif) ligand 4 0.074
Ccl2 chemokine (C-C motif) ligand 2 0.072
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.072
Alb albumin 0.062
Il6 interleukin 6 0.060
Ahsg alpha-2-HS-glycoprotein 0.059
Gc group specific component 0.050
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.048
Oprd1 opioid receptor, delta 1 0.042
Fosl1 fos-like antigen 1 0.040
Cxcl2 chemokine (C-X-C motif) ligand 2 0.039
Col10a1 collagen, type X, alpha 1 0.035
Serpina11 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 0.031
Rup2 urinary protein 2 0.031
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.030
LOC299282 Serine protease inhibitor 0.028
Chrna6 cholinergic receptor, nicotinic, alpha 6 0.027
Spp2 secreted phosphoprotein 2 0.024
Fos FBJ osteosarcoma oncogene 0.024
Apoa5 apolipoprotein A-V 0.022
Egr2 early growth response 2 0.022
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.021
Fgf2 fibroblast growth factor 2 0.021
Asgr2 asialoglycoprotein receptor 2 0.021
Ctrc chymotrypsin C (caldecrin) 0.020
Aqp8 aquaporin 8 0.019
Tacr1 tachykinin receptor 1 0.018
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.017
Atf3 activating transcription factor 3 0.017
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.017
Lpl lipoprotein lipase 0.017
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.016
Csf1 colony stimulating factor 1 (macrophage) 0.015
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.014
Ccr2 chemokine (C-C motif) receptor 2 0.014
Prrx1 paired related homeobox 1 0.014
Prdm2 PR domain containing 2, with ZNF domain 0.014
Pemt phosphatidylethanolamine N-methyltransferase 0.013
Pzp pregnancy-zone protein 0.013
Cxcr5 chemokine (C-X-C motif) receptor 5 0.013
Gfap glial fibrillary acidic protein 0.013
Ins1 insulin 1 0.013
Apcs amyloid P component, serum 0.013
Csrp3 cysteine and glycine-rich protein 3 0.012
Mbl1 mannose-binding lectin (protein A) 1 0.012
Arl11 ADP-ribosylation factor-like 11 0.012
Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 0.011
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.011
Cga glycoprotein hormones, alpha polypeptide 0.011
Cd4 Cd4 molecule 0.011
Trpc5 transient receptor potential cation channel, subfamily C, member 5 0.011
Rhob ras homolog gene family, member B 0.011
Dusp1 dual specificity phosphatase 1 0.011
Il1rn interleukin 1 receptor antagonist 0.010
Myt1l myelin transcription factor 1-like 0.010
Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism