The network for 'detection of external biotic stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

detection of external biotic stimulus

The series of events in which an external biotic stimulus is detected and converted into a molecular signal. An external biotic stimulus is defined as one caused or produced by a living organism other than the one being stimulated.

Homo sapiens
Name Description Probability Func Analog Organism
HLA-C major histocompatibility complex, class I, C 1.000
B2M beta-2-microglobulin 1.000
HLA-A major histocompatibility complex, class I, A 1.000
HLA-B major histocompatibility complex, class I, B 1.000
HLA-E major histocompatibility complex, class I, E 1.000
HLA-F major histocompatibility complex, class I, F 1.000
HLA-G major histocompatibility complex, class I, G 1.000
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.948
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.937
MYD88 myeloid differentiation primary response gene (88) 0.849
RIPK2 receptor-interacting serine-threonine kinase 2 0.823
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.640
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.605
HLA-DRA major histocompatibility complex, class II, DR alpha 0.587
CTSS cathepsin S 0.480
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.368
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.359
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.336
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.314
TLR2 toll-like receptor 2 0.310
HLA-DMB major histocompatibility complex, class II, DM beta 0.276
PYCARD PYD and CARD domain containing 0.220
HLA-DMA major histocompatibility complex, class II, DM alpha 0.219
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.141
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.105
TLR1 toll-like receptor 1 0.099
PGCP plasma glutamate carboxypeptidase 0.099
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.086
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.067
PYDC2 pyrin domain containing 2 0.059
TPP1 tripeptidyl peptidase I 0.056
CD14 CD14 molecule 0.050
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.044
NLRC4 NLR family, CARD domain containing 4 0.041
TLR4 toll-like receptor 4 0.039
PILRA paired immunoglobin-like type 2 receptor alpha 0.038
PTAFR platelet-activating factor receptor 0.038
HCP5 HLA complex P5 0.038
CLEC7A C-type lectin domain family 7, member A 0.037
FTH1 ferritin, heavy polypeptide 1 0.035
TAPBP TAP binding protein (tapasin) 0.035
VNN2 vanin 2 0.033
HFE hemochromatosis 0.033
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.029
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.029
NOD2 nucleotide-binding oligomerization domain containing 2 0.028
IRAK3 interleukin-1 receptor-associated kinase 3 0.027
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.027
CCR1 chemokine (C-C motif) receptor 1 0.024
NPC2 Niemann-Pick disease, type C2 0.024
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.023
BATF2 basic leucine zipper transcription factor, ATF-like 2 0.023
ANG angiogenin, ribonuclease, RNase A family, 5 0.022
CARD16 caspase recruitment domain family, member 16 0.019
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.019
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.018
GBP5 guanylate binding protein 5 0.018
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.017
SLA Src-like-adaptor 0.016
TLR6 toll-like receptor 6 0.016
IL1B interleukin 1, beta 0.015
MARCH1 membrane-associated ring finger (C3HC4) 1 0.015
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.015
TICAM2 toll-like receptor adaptor molecule 2 0.014
TLR5 toll-like receptor 5 0.014
IRAK2 interleukin-1 receptor-associated kinase 2 0.014
C4BPA complement component 4 binding protein, alpha 0.014
IGSF6 immunoglobulin superfamily, member 6 0.013
IFI30 interferon, gamma-inducible protein 30 0.013
LAPTM5 lysosomal protein transmembrane 5 0.012
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.011
P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4 0.011
CARD6 caspase recruitment domain family, member 6 0.011
C1orf38 chromosome 1 open reading frame 38 0.011
BTN3A1 butyrophilin, subfamily 3, member A1 0.010
MEFV Mediterranean fever 0.010
LTF lactotransferrin 0.010
CAMP cathelicidin antimicrobial peptide 0.010
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.010
TF transferrin 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
modSP modular serine protease 0.072
CG9990 CG9990 gene product from transcript CG9990-RA 0.054
CG31743 CG31743 gene product from transcript CG31743-RA 0.036
CG11147 CG11147 gene product from transcript CG11147-RA 0.036
CG5390 CG5390 gene product from transcript CG5390-RA 0.034
Glt Glutactin 0.023
CG9184 CG9184 gene product from transcript CG9184-RB 0.023
bbg big bang 0.021
upd3 unpaired 3 0.021
CG14526 CG14526 gene product from transcript CG14526-RB 0.020
CG32666 CG32666 gene product from transcript CG32666-RC 0.020
CG7997 CG7997 gene product from transcript CG7997-RB 0.020
CG13795 CG13795 gene product from transcript CG13795-RB 0.018
futsch CG34387 gene product from transcript CG34387-RC 0.017
AttA Attacin-A 0.017
Acer Angiotensin-converting enzyme-related 0.017
l(3)mbn lethal (3) malignant blood neoplasm 0.016
Msr-110 CG10596 gene product from transcript CG10596-RB 0.015
GNBP3 Gram-negative bacteria binding protein 3 0.015
CG9628 CG9628 gene product from transcript CG9628-RA 0.015
Pvf2 PDGF- and VEGF-related factor 2 0.014
Irc Immune-regulated catalase 0.014
upd2 unpaired 2 0.013
CG32185 CG32185 gene product from transcript CG32185-RA 0.013
CG7675 CG7675 gene product from transcript CG7675-RC 0.013
Gel Gelsolin 0.013
CG10026 CG10026 gene product from transcript CG10026-RA 0.013
Parp Poly-(ADP-ribose) polymerase 0.013
CG14527 CG14527 gene product from transcript CG14527-RA 0.013
IM10 Immune induced molecule 10 0.012
CG13526 CG13526 gene product from transcript CG13526-RA 0.012
CG31778 CG31778 gene product from transcript CG31778-RA 0.012
bond james bond 0.012
CG8654 CG8654 gene product from transcript CG8654-RA 0.012
TepII Thiolester containing protein II 0.012
Jon66Ci Jonah 66Ci 0.012
Mtp Microsomal triacylglycerol transfer protein 0.012
Tig Tiggrin 0.011
CG5853 CG5853 gene product from transcript CG5853-RA 0.011
CG1516 CG1516 gene product from transcript CG1516-RP 0.011
CG14933 CG14933 gene product from transcript CG14933-RA 0.011
pain painless 0.011
CG4335 CG4335 gene product from transcript CG4335-RA 0.011
Gbeta76C G protein beta-subunit 76C 0.011
amos absent MD neurons and olfactory sensilla 0.011
CG3984 CG3984 gene product from transcript CG3984-RA 0.011
alpha-Est2 alpha-Esterase-2 0.011
Gadd45 CG11086 gene product from transcript CG11086-RA 0.011
CG15247 CG15247 gene product from transcript CG15247-RA 0.011
IM23 Immune induced molecule 23 0.011
CG1678 CG1678 gene product from transcript CG1678-RA 0.011
comm commissureless 0.011
CG14567 CG14567 gene product from transcript CG14567-RA 0.010
CG10916 CG10916 gene product from transcript CG10916-RA 0.010
fusl fuseless 0.010
CG31689 CG31689 gene product from transcript CG31689-RC 0.010
CG8449 CG8449 gene product from transcript CG8449-RA 0.010
l(2)efl lethal (2) essential for life 0.010
CG18594 CG18594 gene product from transcript CG18594-RA 0.010
Ctr1B Copper transporter 1B 0.010
CREG Cellular Repressor of E1A-stimulated Genes 0.010
Obp19a Odorant-binding protein 19a 0.010
CG5326 CG5326 gene product from transcript CG5326-RA 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Clec4d C-type lectin domain family 4, member d 0.938
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.901
Tlr4 toll-like receptor 4 0.785
Lair1 leukocyte-associated Ig-like receptor 1 0.505
Clec4e C-type lectin domain family 4, member e 0.497
Ncr1 natural cytotoxicity triggering receptor 1 0.496
Itgax integrin alpha X 0.485
Pilrb1 paired immunoglobin-like type 2 receptor beta 1 0.369
Mefv Mediterranean fever 0.357
Naip6 NLR family, apoptosis inhibitory protein 6 0.341
Tlr8 toll-like receptor 8 0.300
Msr1 macrophage scavenger receptor 1 0.291
Clec4a2 C-type lectin domain family 4, member a2 0.256
Cd14 CD14 antigen 0.237
Cd209b CD209b antigen 0.236
Cd300ld CD300 molecule-like family member d 0.223
Igsf6 immunoglobulin superfamily, member 6 0.215
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.195
Blk B lymphoid kinase 0.162
Emr4 EGF-like module containing, mucin-like, hormone receptor-like sequence 4 0.162
Pilra paired immunoglobin-like type 2 receptor alpha 0.160
Cd209d CD209d antigen 0.156
AF251705 cDNA sequence AF251705 0.149
Cd209a CD209a antigen 0.138
Naip2 NLR family, apoptosis inhibitory protein 2 0.127
Trpv1 transient receptor potential cation channel, subfamily V, member 1 0.125
Naip5 NLR family, apoptosis inhibitory protein 5 0.124
Cd33 CD33 antigen 0.121
Fpr2 formyl peptide receptor 2 0.119
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.113
Ear2 eosinophil-associated, ribonuclease A family, member 2 0.105
Rgs18 regulator of G-protein signaling 18 0.104
Trem3 triggering receptor expressed on myeloid cells 3 0.103
Fcgr4 Fc receptor, IgG, low affinity IV 0.091
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.090
Klra7 killer cell lectin-like receptor, subfamily A, member 7 0.088
Cd180 CD180 antigen 0.086
Ccr6 chemokine (C-C motif) receptor 6 0.085
Pira2 paired-Ig-like receptor A2 0.081
Ccl6 chemokine (C-C motif) ligand 6 0.080
Myd88 myeloid differentiation primary response gene 88 0.080
Adamdec1 ADAM-like, decysin 1 0.071
Il18rap interleukin 18 receptor accessory protein 0.068
Pyhin1 pyrin and HIN domain family, member 1 0.067
Klra17 killer cell lectin-like receptor, subfamily A, member 17 0.063
Slamf7 SLAM family member 7 0.062
Hcst hematopoietic cell signal transducer 0.059
Cd84 CD84 antigen 0.058
Gzma granzyme A 0.058
Ly96 lymphocyte antigen 96 0.058
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.057
Tlr2 toll-like receptor 2 0.054
Fcrla Fc receptor-like A 0.053
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.053
Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 0.053
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.044
Ms4a8a membrane-spanning 4-domains, subfamily A, member 8A 0.042
Sirpb1a signal-regulatory protein beta 1A 0.042
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.042
Tcfec transcription factor EC 0.041
Igk immunoglobulin kappa chain complex 0.041
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.041
Clec7a C-type lectin domain family 7, member a 0.041
Klra3 killer cell lectin-like receptor, subfamily A, member 3 0.039
Clec5a C-type lectin domain family 5, member a 0.038
Fpr1 formyl peptide receptor 1 0.037
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.037
Cd7 CD7 antigen 0.035
Slamf8 SLAM family member 8 0.034
Ms4a6d membrane-spanning 4-domains, subfamily A, member 6D 0.033
Il1b interleukin 1 beta 0.033
1810033B17Rik RIKEN cDNA 1810033B17 gene 0.032
Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 0.032
Ccr5 chemokine (C-C motif) receptor 5 0.032
Il1f9 interleukin 1 family, member 9 0.032
Siglece sialic acid binding Ig-like lectin E 0.031
Cd200r1 CD200 receptor 1 0.030
Gda guanine deaminase 0.029
Havcr2 hepatitis A virus cellular receptor 2 0.028
Traf2 TNF receptor-associated factor 2 0.028
Klra6 killer cell lectin-like receptor, subfamily A, member 6 0.027
Mgl2 macrophage galactose N-acetyl-galactosamine specific lectin 2 0.025
Hccs holocytochrome c synthetase 0.025
Cysltr1 cysteinyl leukotriene receptor 1 0.025
Fcgr3 Fc receptor, IgG, low affinity III 0.024
Ccl9 chemokine (C-C motif) ligand 9 0.024
Ccl24 chemokine (C-C motif) ligand 24 0.024
Lpxn leupaxin 0.023
Bex6 brain expressed gene 6 0.023
Klrb1f killer cell lectin-like receptor subfamily B member 1F 0.022
Ptf1a pancreas specific transcription factor, 1a 0.022
Cd300a CD300A antigen 0.021
Stap1 signal transducing adaptor family member 1 0.021
Il18r1 interleukin 18 receptor 1 0.020
Cd209e CD209e antigen 0.020
Evi2b ecotropic viral integration site 2b 0.019
Rgs1 regulator of G-protein signaling 1 0.019
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.019
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.019
Trem1 triggering receptor expressed on myeloid cells 1 0.019
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism