IMP
Process View
The network for 'negative regulation of tumor necrosis factor production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of tumor necrosis factor production
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.999 | |
| MYD88 | myeloid differentiation primary response gene (88) | 0.998 | |
| TIRAP | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 0.933 | |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.923 | |
| TRAF6 | TNF receptor-associated factor 6 | 0.816 | |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.813 | |
| LILRB1 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | 0.639 | |
| LILRA6 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 | 0.634 | |
| C1QA | complement component 1, q subcomponent, A chain | 0.500 | |
| PILRA | paired immunoglobin-like type 2 receptor alpha | 0.487 | |
| GAS6 | growth arrest-specific 6 | 0.428 | |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.427 | |
| MED15 | mediator complex subunit 15 | 0.359 | |
| LILRB3 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | 0.349 | |
| C1QB | complement component 1, q subcomponent, B chain | 0.346 | |
| PELI3 | pellino homolog 3 (Drosophila) | 0.261 | |
| RNF126 | ring finger protein 126 | 0.260 | |
| UBE2D4 | ubiquitin-conjugating enzyme E2D 4 (putative) | 0.223 | |
| AXL | AXL receptor tyrosine kinase | 0.215 | |
| CD14 | CD14 molecule | 0.195 | |
| LILRB2 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 | 0.191 | |
| ZC3H12A | zinc finger CCCH-type containing 12A | 0.169 | |
| SETD8 | SET domain containing (lysine methyltransferase) 8 | 0.168 | |
| ZNF263 | zinc finger protein 263 | 0.099 | |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.084 | |
| LILRA1 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 | 0.078 | |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.076 | |
| SPOP | speckle-type POZ protein | 0.074 | |
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 0.066 | |
| APOE | apolipoprotein E | 0.056 | |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.055 | |
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.048 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.048 | |
| RARA | retinoic acid receptor, alpha | 0.046 | |
| SIGLEC1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.043 | |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.041 | |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.040 | |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.039 | |
| TRIM5 | tripartite motif containing 5 | 0.037 | |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.037 | |
| TRIM39 | tripartite motif containing 39 | 0.036 | |
| PTAFR | platelet-activating factor receptor | 0.036 | |
| CD163 | CD163 molecule | 0.035 | |
| IRAK4 | interleukin-1 receptor-associated kinase 4 | 0.034 | |
| TRIM26 | tripartite motif containing 26 | 0.032 | |
| TICAM2 | toll-like receptor adaptor molecule 2 | 0.032 | |
| IL10RA | interleukin 10 receptor, alpha | 0.032 | |
| TOLLIP | toll interacting protein | 0.030 | |
| SIGLEC7 | sialic acid binding Ig-like lectin 7 | 0.029 | |
| IRF7 | interferon regulatory factor 7 | 0.029 | |
| TRIM21 | tripartite motif containing 21 | 0.029 | |
| HK3 | hexokinase 3 (white cell) | 0.026 | |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.026 | |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.026 | |
| MARCO | macrophage receptor with collagenous structure | 0.025 | |
| SP110 | SP110 nuclear body protein | 0.024 | |
| CSK | c-src tyrosine kinase | 0.024 | |
| BAG3 | BCL2-associated athanogene 3 | 0.023 | |
| RXRA | retinoid X receptor, alpha | 0.022 | |
| RNF5 | ring finger protein 5 | 0.022 | |
| IKZF3 | IKAROS family zinc finger 3 (Aiolos) | 0.021 | |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.021 | |
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | 0.021 | |
| MSR1 | macrophage scavenger receptor 1 | 0.021 | |
| TLR2 | toll-like receptor 2 | 0.020 | |
| ZNF473 | zinc finger protein 473 | 0.020 | |
| RNF11 | ring finger protein 11 | 0.020 | |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.019 | |
| APOA1 | apolipoprotein A-I | 0.019 | |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4 | 0.019 | |
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | 0.018 | |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.018 | |
| TLR7 | toll-like receptor 7 | 0.018 | |
| TRIM17 | tripartite motif containing 17 | 0.018 | |
| SLAMF8 | SLAM family member 8 | 0.017 | |
| TRIM34 | tripartite motif containing 34 | 0.017 | |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | 0.017 | |
| RELB | v-rel reticuloendotheliosis viral oncogene homolog B | 0.017 | |
| AIF1 | allograft inflammatory factor 1 | 0.017 | |
| TICAM1 | toll-like receptor adaptor molecule 1 | 0.017 | |
| C1QC | complement component 1, q subcomponent, C chain | 0.017 | |
| PML | promyelocytic leukemia | 0.016 | |
| C1S | complement component 1, s subcomponent | 0.016 | |
| ITGB1BP2 | integrin beta 1 binding protein (melusin) 2 | 0.016 | |
| PPARA | peroxisome proliferator-activated receptor alpha | 0.016 | |
| AOAH | acyloxyacyl hydrolase (neutrophil) | 0.016 | |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.015 | |
| CCR1 | chemokine (C-C motif) receptor 1 | 0.015 | |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.014 | |
| TYMP | thymidine phosphorylase | 0.014 | |
| XIAP | X-linked inhibitor of apoptosis | 0.014 | |
| BCL10 | B-cell CLL/lymphoma 10 | 0.014 | |
| SP100 | SP100 nuclear antigen | 0.014 | |
| NCOA1 | nuclear receptor coactivator 1 | 0.014 | |
| CMKLR1 | chemokine-like receptor 1 | 0.014 | |
| STAB1 | stabilin 1 | 0.014 | |
| MED25 | mediator complex subunit 25 | 0.014 | |
| CHRNA1 | cholinergic receptor, nicotinic, alpha 1 (muscle) | 0.013 | |
| HP | haptoglobin | 0.013 | |
| SLC15A3 | solute carrier family 15, member 3 | 0.013 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Tlr4 | toll-like receptor 4 | 0.799 | |
| Myd88 | myeloid differentiation primary response gene 88 | 0.693 | |
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.562 | |
| Tnf | tumor necrosis factor | 0.497 | |
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.481 | |
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.475 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.426 | |
| Chrna3 | cholinergic receptor, nicotinic, alpha polypeptide 3 | 0.422 | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.290 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.276 | |
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.272 | |
| Chrnb4 | cholinergic receptor, nicotinic, beta polypeptide 4 | 0.208 | |
| Gnrh1 | gonadotropin releasing hormone 1 | 0.201 | |
| Cd44 | CD44 antigen | 0.192 | |
| Ptf1a | pancreas specific transcription factor, 1a | 0.172 | |
| Lyz2 | lysozyme 2 | 0.159 | |
| Traf6 | TNF receptor-associated factor 6 | 0.157 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.140 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.134 | |
| Neurod1 | neurogenic differentiation 1 | 0.127 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.108 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.108 | |
| Pax6 | paired box gene 6 | 0.102 | |
| Pax9 | paired box gene 9 | 0.102 | |
| Chrnb2 | cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) | 0.101 | |
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.095 | |
| Irak4 | interleukin-1 receptor-associated kinase 4 | 0.094 | |
| Trim30d | tripartite motif-containing 30D | 0.086 | |
| Il1r1 | interleukin 1 receptor, type I | 0.069 | |
| Neurog2 | neurogenin 2 | 0.066 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.062 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.058 | |
| Socs1 | suppressor of cytokine signaling 1 | 0.058 | |
| Prph2 | peripherin 2 | 0.054 | |
| Mmp9 | matrix metallopeptidase 9 | 0.049 | |
| Pou4f2 | POU domain, class 4, transcription factor 2 | 0.049 | |
| En1 | engrailed 1 | 0.048 | |
| Stat6 | signal transducer and activator of transcription 6 | 0.045 | |
| Trim30a | tripartite motif-containing 30A | 0.043 | |
| Card11 | caspase recruitment domain family, member 11 | 0.043 | |
| Ripk1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.041 | |
| Slc6a5 | solute carrier family 6 (neurotransmitter transporter, glycine), member 5 | 0.039 | |
| Shh | sonic hedgehog | 0.038 | |
| Mecom | MDS1 and EVI1 complex locus | 0.036 | |
| Myog | myogenin | 0.036 | |
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.035 | |
| Irak3 | interleukin-1 receptor-associated kinase 3 | 0.033 | |
| Il10 | interleukin 10 | 0.033 | |
| Timp1 | tissue inhibitor of metalloproteinase 1 | 0.032 | |
| Pax3 | paired box gene 3 | 0.031 | |
| Gab1 | growth factor receptor bound protein 2-associated protein 1 | 0.030 | |
| Gata4 | GATA binding protein 4 | 0.030 | |
| Slc6a3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.029 | |
| Allc | allantoicase | 0.029 | |
| Pycard | PYD and CARD domain containing | 0.029 | |
| Cacna1f | calcium channel, voltage-dependent, alpha 1F subunit | 0.028 | |
| Tal1 | T-cell acute lymphocytic leukemia 1 | 0.027 | |
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.027 | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.026 | |
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.024 | |
| Il6 | interleukin 6 | 0.023 | |
| Isl2 | insulin related protein 2 (islet 2) | 0.022 | |
| Trim12a | tripartite motif-containing 12A | 0.022 | |
| Unc93b1 | unc-93 homolog B1 (C. elegans) | 0.021 | |
| Sox11 | SRY-box containing gene 11 | 0.021 | |
| Ikbkb | inhibitor of kappaB kinase beta | 0.021 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.021 | |
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.021 | |
| Birc3 | baculoviral IAP repeat-containing 3 | 0.020 | |
| Pde6b | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | 0.020 | |
| Myf5 | myogenic factor 5 | 0.020 | |
| Hoxa11 | homeobox A11 | 0.019 | |
| Cyld | cylindromatosis (turban tumor syndrome) | 0.019 | |
| Gsc | goosecoid homeobox | 0.019 | |
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.019 | |
| Lin28a | lin-28 homolog A (C. elegans) | 0.018 | |
| Sykb | spleen tyrosine kinase | 0.018 | |
| Pik3ap1 | phosphoinositide-3-kinase adaptor protein 1 | 0.018 | |
| Gsx2 | GS homeobox 2 | 0.018 | |
| Il4ra | interleukin 4 receptor, alpha | 0.018 | |
| Rim4 | recombination induced mutation 4 | 0.017 | |
| Gbp5 | guanylate binding protein 5 | 0.017 | |
| Msx1 | homeobox, msh-like 1 | 0.017 | |
| Ddx60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.017 | |
| Hba-x | hemoglobin X, alpha-like embryonic chain in Hba complex | 0.016 | |
| Foxd2 | forkhead box D2 | 0.016 | |
| Casp1 | caspase 1 | 0.016 | |
| Socs3 | suppressor of cytokine signaling 3 | 0.016 | |
| BC013712 | cDNA sequence BC013712 | 0.015 | |
| Irf1 | interferon regulatory factor 1 | 0.015 | |
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | 0.015 | |
| Parp14 | poly (ADP-ribose) polymerase family, member 14 | 0.015 | |
| Onecut1 | one cut domain, family member 1 | 0.015 | |
| Tgfbr2 | transforming growth factor, beta receptor II | 0.015 | |
| Dcx | doublecortin | 0.014 | |
| Six6 | sine oculis-related homeobox 6 homolog (Drosophila) | 0.014 | |
| Prrx1 | paired related homeobox 1 | 0.014 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.014 | |
| Cdh23 | cadherin 23 (otocadherin) | 0.014 | |
| Runx1 | runt related transcription factor 1 | 0.014 |