The network for 'regulation of cytokine secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cytokine secretion

Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell.

Homo sapiens
Name Description Probability Func Analog Organism
TAL1 T-cell acute lymphocytic leukemia 1 0.920
BTN3A3 butyrophilin, subfamily 3, member A3 0.787
TRAF1 TNF receptor-associated factor 1 0.784
NLRC4 NLR family, CARD domain containing 4 0.781
APOE apolipoprotein E 0.741
BTN3A1 butyrophilin, subfamily 3, member A1 0.717
CD80 CD80 molecule 0.710
BTN3A2 butyrophilin, subfamily 3, member A2 0.708
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.643
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.642
PILRA paired immunoglobin-like type 2 receptor alpha 0.538
IL10RA interleukin 10 receptor, alpha 0.487
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.462
HLA-DRA major histocompatibility complex, class II, DR alpha 0.447
FGA fibrinogen alpha chain 0.424
CRP C-reactive protein, pentraxin-related 0.419
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.409
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.393
CCR1 chemokine (C-C motif) receptor 1 0.391
HLA-G major histocompatibility complex, class I, G 0.383
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.360
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.349
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.348
HP haptoglobin 0.321
AXL AXL receptor tyrosine kinase 0.318
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.271
IL1B interleukin 1, beta 0.270
CCL4 chemokine (C-C motif) ligand 4 0.264
LAT linker for activation of T cells 0.258
HCK hemopoietic cell kinase 0.255
S100A10 S100 calcium binding protein A10 0.247
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.239
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.232
CDH5 cadherin 5, type 2 (vascular endothelium) 0.232
IL1R1 interleukin 1 receptor, type I 0.230
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.218
CAV1 caveolin 1, caveolae protein, 22kDa 0.218
CD86 CD86 molecule 0.208
ANXA1 annexin A1 0.202
NLRP3 NLR family, pyrin domain containing 3 0.192
TRIM39 tripartite motif containing 39 0.186
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.182
SIGLEC7 sialic acid binding Ig-like lectin 7 0.179
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.178
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.173
SP100 SP100 nuclear antigen 0.173
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.172
PTPRB protein tyrosine phosphatase, receptor type, B 0.169
ITGB5 integrin, beta 5 0.166
RUNX1 runt-related transcription factor 1 0.155
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.155
LCAT lecithin-cholesterol acyltransferase 0.152
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.152
ANXA4 annexin A4 0.151
IRF8 interferon regulatory factor 8 0.149
IL10 interleukin 10 0.148
PECAM1 platelet/endothelial cell adhesion molecule 0.145
SETD8 SET domain containing (lysine methyltransferase) 8 0.143
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.142
TLR2 toll-like receptor 2 0.140
ALB albumin 0.138
ZNF263 zinc finger protein 263 0.134
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.133
FCAR Fc fragment of IgA, receptor for 0.129
TREM1 triggering receptor expressed on myeloid cells 1 0.128
SMN1 survival of motor neuron 1, telomeric 0.127
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.126
IL1R2 interleukin 1 receptor, type II 0.126
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.125
BTN2A2 butyrophilin, subfamily 2, member A2 0.125
S100A12 S100 calcium binding protein A12 0.125
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.123
CD48 CD48 molecule 0.122
A2M alpha-2-macroglobulin 0.121
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.121
ANGPT2 angiopoietin 2 0.120
CYBB cytochrome b-245, beta polypeptide 0.119
MEFV Mediterranean fever 0.118
TRIM22 tripartite motif containing 22 0.115
S100A9 S100 calcium binding protein A9 0.114
S100A8 S100 calcium binding protein A8 0.112
CD163 CD163 molecule 0.112
CCR2 chemokine (C-C motif) receptor 2 0.111
IL22RA1 interleukin 22 receptor, alpha 1 0.109
FZD1 frizzled homolog 1 (Drosophila) 0.108
COTL1 coactosin-like 1 (Dictyostelium) 0.105
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.103
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.103
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.103
CUL2 cullin 2 0.101
IL18RAP interleukin 18 receptor accessory protein 0.099
FPR1 formyl peptide receptor 1 0.099
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.097
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.096
C19orf50 chromosome 19 open reading frame 50 0.096
CFI complement factor I 0.095
IFNG interferon, gamma 0.091
PYDC2 pyrin domain containing 2 0.091
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.090
TRAF5 TNF receptor-associated factor 5 0.088
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Pax8 paired box gene 8 0.989
Tnf tumor necrosis factor 0.939
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.896
Gpr33 G protein-coupled receptor 33 0.895
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.892
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.813
Lepr leptin receptor 0.778
Il1b interleukin 1 beta 0.776
Lta lymphotoxin A 0.748
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.701
Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) 0.691
Cd40 CD40 antigen 0.688
Tlr4 toll-like receptor 4 0.688
Il10ra interleukin 10 receptor, alpha 0.672
Agtr1a angiotensin II receptor, type 1a 0.669
Ccr6 chemokine (C-C motif) receptor 6 0.663
Ccl2 chemokine (C-C motif) ligand 2 0.641
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.641
Pdcd1 programmed cell death 1 0.633
Ren1 renin 1 structural 0.627
Cd160 CD160 antigen 0.607
Pax2 paired box gene 2 0.581
Il1rn interleukin 1 receptor antagonist 0.580
Clec4d C-type lectin domain family 4, member d 0.568
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.552
Cd44 CD44 antigen 0.540
Cd80 CD80 antigen 0.534
Icos inducible T-cell co-stimulator 0.526
Ncr1 natural cytotoxicity triggering receptor 1 0.511
Il2rb interleukin 2 receptor, beta chain 0.492
Nos2 nitric oxide synthase 2, inducible 0.491
Ccl8 chemokine (C-C motif) ligand 8 0.489
Sh2d2a SH2 domain protein 2A 0.478
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.455
Blk B lymphoid kinase 0.442
Grap2 GRB2-related adaptor protein 2 0.440
Ctsw cathepsin W 0.435
Csf1 colony stimulating factor 1 (macrophage) 0.416
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.408
Sfrp4 secreted frizzled-related protein 4 0.407
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.407
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.392
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.391
Selp selectin, platelet 0.387
Itgax integrin alpha X 0.387
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.377
Irf1 interferon regulatory factor 1 0.376
Clec4e C-type lectin domain family 4, member e 0.375
Cd209b CD209b antigen 0.374
Fasl Fas ligand (TNF superfamily, member 6) 0.373
Il18rap interleukin 18 receptor accessory protein 0.372
Socs1 suppressor of cytokine signaling 1 0.362
Il1r1 interleukin 1 receptor, type I 0.361
Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.357
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.351
Adrb1 adrenergic receptor, beta 1 0.350
Cxcr5 chemokine (C-X-C motif) receptor 5 0.343
Tgfbr2 transforming growth factor, beta receptor II 0.336
Cxcl2 chemokine (C-X-C motif) ligand 2 0.334
Mefv Mediterranean fever 0.331
Pdcd1lg2 programmed cell death 1 ligand 2 0.314
Xcl1 chemokine (C motif) ligand 1 0.304
Cd8a CD8 antigen, alpha chain 0.299
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.298
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.298
Cd86 CD86 antigen 0.297
Gpr132 G protein-coupled receptor 132 0.296
Ggt5 gamma-glutamyltransferase 5 0.292
Ghrhr growth hormone releasing hormone receptor 0.287
Ccl22 chemokine (C-C motif) ligand 22 0.272
Cd4 CD4 antigen 0.271
Cybb cytochrome b-245, beta polypeptide 0.269
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.267
Ccl6 chemokine (C-C motif) ligand 6 0.267
Casp1 caspase 1 0.265
Ptgir prostaglandin I receptor (IP) 0.264
Itk IL2-inducible T-cell kinase 0.259
Gzmb granzyme B 0.256
Tbx21 T-box 21 0.254
Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 0.253
Eln elastin 0.253
ND6 NADH dehydrogenase subunit 6 0.250
Drd2 dopamine receptor D2 0.248
Clec7a C-type lectin domain family 7, member a 0.245
Dok1 docking protein 1 0.241
Apoe apolipoprotein E 0.239
Batf basic leucine zipper transcription factor, ATF-like 0.233
Ccl3 chemokine (C-C motif) ligand 3 0.233
Mmp12 matrix metallopeptidase 12 0.231
Il27ra interleukin 27 receptor, alpha 0.223
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.222
Pcdh12 protocadherin 12 0.221
Gab2 growth factor receptor bound protein 2-associated protein 2 0.217
Slpi secretory leukocyte peptidase inhibitor 0.205
Ubd ubiquitin D 0.204
Ltb lymphotoxin B 0.203
Birc3 baculoviral IAP repeat-containing 3 0.202
Cd28 CD28 antigen 0.201
Atp4b ATPase, H+/K+ exchanging, beta polypeptide 0.201
Il1rl1 interleukin 1 receptor-like 1 0.198
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Il1b interleukin 1 beta 0.135
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.110
Tlr4 toll-like receptor 4 0.093
Cybb cytochrome b-245, beta polypeptide 0.083
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.073
Sirpa signal-regulatory protein alpha 0.065
Cd80 Cd80 molecule 0.063
Arl11 ADP-ribosylation factor-like 11 0.061
Mca32 mast cell antigen 32 0.060
Il6 interleukin 6 0.057
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.054
Il1a interleukin 1 alpha 0.046
Ctsc cathepsin C 0.046
Bdkrb2 bradykinin receptor B2 0.044
Il2rb interleukin 2 receptor, beta 0.039
Mmp12 matrix metallopeptidase 12 0.036
Plau plasminogen activator, urokinase 0.035
Ptprc protein tyrosine phosphatase, receptor type, C 0.034
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.032
Jak2 Janus kinase 2 0.029
LOC24906 RoBo-1 0.029
Nat1 N-acetyltransferase 1 0.027
Pdcl phosducin-like 0.026
Casp1 caspase 1 0.025
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.025
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.024
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.024
Ltbp2 latent transforming growth factor beta binding protein 2 0.022
Cd44 Cd44 molecule 0.022
Ccl3 chemokine (C-C motif) ligand 3 0.020
Ednra endothelin receptor type A 0.019
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.019
Lilrb3l leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like 0.019
Cxcr3 chemokine (C-X-C motif) receptor 3 0.019
Gja4 gap junction protein, alpha 4 0.018
Fosl1 fos-like antigen 1 0.018
Prl8a9 prolactin family 8, subfamily a, member 9 0.018
Selp selectin P 0.018
Cpa3 carboxypeptidase A3, mast cell 0.017
Vcan versican 0.017
Tchh trichohyalin 0.016
Csk c-src tyrosine kinase 0.016
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.016
Ccl22 chemokine (C-C motif) ligand 22 0.016
S1pr2 sphingosine-1-phosphate receptor 2 0.016
Mcpt1 mast cell protease 1 0.016
Ccr2 chemokine (C-C motif) receptor 2 0.016
Fcnb ficolin B 0.015
Pax8 paired box 8 0.015
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.015
Lst1 leukocyte specific transcript 1 0.015
Akr1c14 aldo-keto reductase family 1, member C14 0.015
Nradd neurotrophin receptor associated death domain 0.015
Mov10 Moloney leukemia virus 10 0.014
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.014
Hcls1 hematopoietic cell specific Lyn substrate 1 0.014
Crot carnitine O-octanoyltransferase 0.014
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.014
Cd14 CD14 molecule 0.014
Klrc2 killer cell lectin-like receptor subfamily C, member 2 0.014
Socs3 suppressor of cytokine signaling 3 0.014
Mmp8 matrix metallopeptidase 8 0.013
Cd8a CD8a molecule 0.013
Serpini2 serine (or cysteine) peptidase inhibitor, clade I, member 2 0.013
Inpp5d inositol polyphosphate-5-phosphatase D 0.013
Oprk1 opioid receptor, kappa 1 0.013
Ctsq cathepsin Q 0.013
Il8rb interleukin 8 receptor, beta 0.013
Ifng interferon gamma 0.013
Cp ceruloplasmin 0.013
Il2rg interleukin 2 receptor, gamma 0.012
Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 0.012
Cxcl2 chemokine (C-X-C motif) ligand 2 0.012
C1qtnf6 C1q and tumor necrosis factor related protein 6 0.012
Cd86 CD86 molecule 0.012
C5ar1 complement component 5a receptor 1 0.012
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.012
Lpl lipoprotein lipase 0.012
Anpep alanyl (membrane) aminopeptidase 0.012
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.012
Havcr1 hepatitis A virus cellular receptor 1 0.012
Tbxas1 thromboxane A synthase 1, platelet 0.011
Cd79b Cd79b molecule, immunoglobulin-associated beta 0.011
Cd38 CD38 molecule 0.011
Ccl5 chemokine (C-C motif) ligand 5 0.011
Accn5 amiloride-sensitive cation channel 5, intestinal 0.011
Rag1 recombination activating gene 1 0.011
Adam17 ADAM metallopeptidase domain 17 0.011
Col15a1 collagen, type XV, alpha 1 0.011
Olfml2b olfactomedin-like 2B 0.011
Cma1 chymase 1, mast cell 0.011
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.011
Olr1500 olfactory receptor 1500 0.011
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.010
Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.010
Dspp dentin sialophosphoprotein 0.010
Ocln occludin 0.010
Psgb1 pregnancy-specific beta 1-glycoprotein 0.010
Gja5 gap junction protein, alpha 5 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism