The network for 'cellular response to glucocorticoid stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to glucocorticoid stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

Homo sapiens
Name Description Probability Func Analog Organism
SMN1 survival of motor neuron 1, telomeric 1.000
ANXA1 annexin A1 0.884
NRP1 neuropilin 1 0.843
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.789
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.725
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.700
S100A10 S100 calcium binding protein A10 0.695
RNF144B ring finger protein 144B 0.672
ENG endoglin 0.664
APAF1 apoptotic peptidase activating factor 1 0.624
TK1 thymidine kinase 1, soluble 0.601
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.561
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.448
PLAU plasminogen activator, urokinase 0.438
NRIP1 nuclear receptor interacting protein 1 0.409
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.362
XIAP X-linked inhibitor of apoptosis 0.360
ANXA5 annexin A5 0.346
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.309
HBP1 HMG-box transcription factor 1 0.299
EMP1 epithelial membrane protein 1 0.298
IFNGR1 interferon gamma receptor 1 0.294
LGALS1 lectin, galactoside-binding, soluble, 1 0.292
PLAT plasminogen activator, tissue 0.292
CRHR1 corticotropin releasing hormone receptor 1 0.254
FSTL1 follistatin-like 1 0.207
S100A11 S100 calcium binding protein A11 0.199
NCOA1 nuclear receptor coactivator 1 0.193
TGFB3 transforming growth factor, beta 3 0.168
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.166
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.160
ANXA4 annexin A4 0.158
EIF3F eukaryotic translation initiation factor 3, subunit F 0.158
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.155
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.146
MBNL1 muscleblind-like (Drosophila) 0.139
RICTOR RPTOR independent companion of MTOR, complex 2 0.138
ANXA2 annexin A2 0.135
ADAMTSL4 ADAMTS-like 4 0.128
TMF1 TATA element modulatory factor 1 0.127
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.116
SOCS1 suppressor of cytokine signaling 1 0.113
THBS1 thrombospondin 1 0.112
PLAUR plasminogen activator, urokinase receptor 0.107
MPDZ multiple PDZ domain protein 0.106
ARNT aryl hydrocarbon receptor nuclear translocator 0.097
DUSP6 dual specificity phosphatase 6 0.093
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.093
JAG1 jagged 1 0.093
KLHL24 kelch-like 24 (Drosophila) 0.089
ARRDC3 arrestin domain containing 3 0.089
C16orf53 chromosome 16 open reading frame 53 0.087
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.086
ARIH2 ariadne homolog 2 (Drosophila) 0.085
ZFYVE9 zinc finger, FYVE domain containing 9 0.084
ITGB5 integrin, beta 5 0.084
NMT2 N-myristoyltransferase 2 0.083
GRIP1 glutamate receptor interacting protein 1 0.079
RNF31 ring finger protein 31 0.078
DES desmin 0.077
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.073
TM4SF1 transmembrane 4 L six family member 1 0.073
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.073
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.072
ADAM9 ADAM metallopeptidase domain 9 0.071
CAST calpastatin 0.070
MEF2A myocyte enhancer factor 2A 0.070
NEB nebulin 0.069
FNDC3B fibronectin type III domain containing 3B 0.068
IQGAP1 IQ motif containing GTPase activating protein 1 0.067
MRPL41 mitochondrial ribosomal protein L41 0.066
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.066
KLF4 Kruppel-like factor 4 (gut) 0.065
NCOA7 nuclear receptor coactivator 7 0.064
TSC22D1 TSC22 domain family, member 1 0.063
TTN titin 0.063
H3F3C H3 histone, family 3C 0.062
TGFBR1 transforming growth factor, beta receptor 1 0.061
STAT1 signal transducer and activator of transcription 1, 91kDa 0.059
ESR2 estrogen receptor 2 (ER beta) 0.059
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.059
BAX BCL2-associated X protein 0.059
ORM1 orosomucoid 1 0.057
NOMO1 NODAL modulator 1 0.057
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.056
MYOF myoferlin 0.055
S100A6 S100 calcium binding protein A6 0.054
ACTA1 actin, alpha 1, skeletal muscle 0.054
KCTD17 potassium channel tetramerisation domain containing 17 0.054
IL8 interleukin 8 0.053
MSN moesin 0.053
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.053
AHR aryl hydrocarbon receptor 0.052
ALG2 asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) 0.052
PDCD6 programmed cell death 6 0.051
NMI N-myc (and STAT) interactor 0.050
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.048
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.048
ACTN2 actinin, alpha 2 0.048
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.047
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.962
Lyz2 lysozyme 2 0.922
Vegfa vascular endothelial growth factor A 0.893
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.877
Pitx2 paired-like homeodomain transcription factor 2 0.821
Ptgs2 prostaglandin-endoperoxide synthase 2 0.812
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.689
Trim55 tripartite motif-containing 55 0.674
Tgfb1 transforming growth factor, beta 1 0.600
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.592
Ren1 renin 1 structural 0.564
Pax3 paired box gene 3 0.509
Hif1a hypoxia inducible factor 1, alpha subunit 0.486
Gata4 GATA binding protein 4 0.484
Dmd dystrophin, muscular dystrophy 0.456
Tgfbr2 transforming growth factor, beta receptor II 0.395
Agtr1a angiotensin II receptor, type 1a 0.393
Fgfr2 fibroblast growth factor receptor 2 0.392
Bmpr1a bone morphogenetic protein receptor, type 1A 0.375
Foxc1 forkhead box C1 0.353
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.349
Adam17 a disintegrin and metallopeptidase domain 17 0.335
Gbp5 guanylate binding protein 5 0.321
Mstn myostatin 0.311
Nos1 nitric oxide synthase 1, neuronal 0.285
Osmr oncostatin M receptor 0.273
Csf1 colony stimulating factor 1 (macrophage) 0.267
H2-Eb1 histocompatibility 2, class II antigen E beta 0.262
Tgfb2 transforming growth factor, beta 2 0.223
Stat3 signal transducer and activator of transcription 3 0.213
Rb1 retinoblastoma 1 0.206
H2-Aa histocompatibility 2, class II antigen A, alpha 0.187
Trim63 tripartite motif-containing 63 0.187
Fst follistatin 0.167
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.147
Lepr leptin receptor 0.134
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.134
Casp1 caspase 1 0.132
Pycard PYD and CARD domain containing 0.118
Pax6 paired box gene 6 0.110
Fbn1 fibrillin 1 0.105
Wwox WW domain-containing oxidoreductase 0.101
Pomc pro-opiomelanocortin-alpha 0.097
Rxra retinoid X receptor alpha 0.096
Ctnnb1 catenin (cadherin associated protein), beta 1 0.095
Meox2 mesenchyme homeobox 2 0.090
Shh sonic hedgehog 0.088
Myf6 myogenic factor 6 0.084
Htt huntingtin 0.084
Klf3 Kruppel-like factor 3 (basic) 0.083
Il18 interleukin 18 0.079
Il6st interleukin 6 signal transducer 0.079
Smad3 MAD homolog 3 (Drosophila) 0.078
Hbegf heparin-binding EGF-like growth factor 0.077
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.077
Tgfbr1 transforming growth factor, beta receptor I 0.074
Plau plasminogen activator, urokinase 0.070
Thbs1 thrombospondin 1 0.070
Prlr prolactin receptor 0.069
Myf5 myogenic factor 5 0.068
Ptprc protein tyrosine phosphatase, receptor type, C 0.067
Vhl von Hippel-Lindau tumor suppressor 0.067
Egfr epidermal growth factor receptor 0.067
Il1r1 interleukin 1 receptor, type I 0.064
Hand2 heart and neural crest derivatives expressed transcript 2 0.063
Jag1 jagged 1 0.063
Slc12a1 solute carrier family 12, member 1 0.062
Errfi1 ERBB receptor feedback inhibitor 1 0.061
Esr1 estrogen receptor 1 (alpha) 0.061
Nos3 nitric oxide synthase 3, endothelial cell 0.061
Lep leptin 0.059
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.057
Gja1 gap junction protein, alpha 1 0.054
Il1b interleukin 1 beta 0.054
Aim2 absent in melanoma 2 0.050
Apc adenomatosis polyposis coli 0.050
Lhx3 LIM homeobox protein 3 0.049
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.048
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.047
Vdr vitamin D receptor 0.046
H2-DMa histocompatibility 2, class II, locus DMa 0.046
Hr hairless 0.044
Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 0.043
Socs5 suppressor of cytokine signaling 5 0.042
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.042
Rbl2 retinoblastoma-like 2 0.039
Rora RAR-related orphan receptor alpha 0.038
Sox4 SRY-box containing gene 4 0.037
Lox lysyl oxidase 0.036
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.035
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.035
Pax7 paired box gene 7 0.035
Nf1 neurofibromatosis 1 0.035
Mybph myosin binding protein H 0.034
Klhl24 kelch-like 24 (Drosophila) 0.034
Tnni2 troponin I, skeletal, fast 2 0.033
Cd14 CD14 antigen 0.033
Foxp3 forkhead box P3 0.033
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.032
Esr2 estrogen receptor 2 (beta) 0.031
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Rattus norvegicus
Name Description Probability Func Analog Organism
Agtr1a angiotensin II receptor, type 1a 0.511
Ephx1 epoxide hydrolase 1, microsomal 0.490
COX2 COXII 0.477
Ahsg alpha-2-HS-glycoprotein 0.382
Serpina4 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.356
Itgb1 integrin, beta 1 0.339
Idi1 isopentenyl-diphosphate delta isomerase 1 0.334
Tgfbr2 transforming growth factor, beta receptor II 0.318
Bcl2 B-cell CLL/lymphoma 2 0.305
Agxt2 alanine-glyoxylate aminotransferase 2 0.295
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.290
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.283
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.278
Acsm2 acyl-CoA synthetase medium-chain family member 2 0.275
RT1-Bb RT1 class II, locus Bb 0.267
Apoa4 apolipoprotein A-IV 0.260
Col12a1 collagen, type XII, alpha 1 0.251
Gstm1 glutathione S-transferase mu 1 0.250
Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.246
Tgfbr3 transforming growth factor, beta receptor III 0.245
Pla1a phospholipase A1 member A 0.239
Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 0.236
Lgals3 lectin, galactoside-binding, soluble, 3 0.234
Fgb fibrinogen beta chain 0.227
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.227
Gsta3 glutathione S-transferase A3 0.223
Prlr prolactin receptor 0.218
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.217
Fxyd4 FXYD domain-containing ion transport regulator 4 0.216
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.207
Pcdhb12 protocadherin beta 12 0.207
Testin testin gene 0.205
Mmp2 matrix metallopeptidase 2 0.202
Mgst1 microsomal glutathione S-transferase 1 0.200
Dnase1l3 deoxyribonuclease 1-like 3 0.197
Met met proto-oncogene 0.193
G6pc glucose-6-phosphatase, catalytic subunit 0.193
COX1 cytochrome c oxidase subunit 1 0.185
Fgf21 fibroblast growth factor 21 0.185
Aqp8 aquaporin 8 0.184
Slco1a1 solute carrier organic anion transporter family, member 1a1 0.183
Flt1 FMS-related tyrosine kinase 1 0.180
Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.178
LOC494499 LOC494499 protein 0.176
Plau plasminogen activator, urokinase 0.175
Serpind1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.175
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.172
Mrgprf MAS-related GPR, member F 0.171
Glra1 glycine receptor, alpha 1 0.170
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.168
Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 0.164
Cyb5a cytochrome b5 type A (microsomal) 0.164
Abcc2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 0.153
RT1-Ba RT1 class II, locus Ba 0.151
Proc protein C 0.149
Fn1 fibronectin 1 0.147
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.147
Cd4 Cd4 molecule 0.146
Ctsj cathepsin J 0.146
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.145
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.141
Mgst2 microsomal glutathione S-transferase 2 0.140
Klkb1 kallikrein B, plasma 1 0.139
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.138
Serpinb3a serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A 0.136
Gja6 gap junction protein, alpha 6 0.134
Cd14 CD14 molecule 0.130
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.130
Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 0.129
C8b complement component 8, beta polypeptide 0.129
P22k15 cystatin related protein 2 0.128
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.125
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.124
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.124
Gck glucokinase 0.124
Anxa1 annexin A1 0.122
S100a10 S100 calcium binding protein A10 0.121
Hfe hemochromatosis 0.119
Ggt5 gamma-glutamyltransferase 5 0.118
Mcpt3 mast cell peptidase 3 0.118
Jak2 Janus kinase 2 0.115
Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 0.114
Asgr2 asialoglycoprotein receptor 2 0.113
Csf1 colony stimulating factor 1 (macrophage) 0.113
Gsta5 glutathione S-transferase Yc2 subunit 0.111
Il1rl1 interleukin 1 receptor-like 1 0.108
Insrr insulin receptor-related receptor 0.106
Hes3 hairy and enhancer of split 3 (Drosophila) 0.105
Atp2a3 ATPase, Ca++ transporting, ubiquitous 0.105
Shank2 SH3 and multiple ankyrin repeat domains 2 0.105
Sult1c3 sulfotransferase family, cytosolic, 1C, member 3 0.105
Onecut1 one cut homeobox 1 0.104
Sult1c2 sulfotransferase family, cytosolic, 1C, member 2 0.103
Gja1 gap junction protein, alpha 1 0.103
Lmna lamin A 0.100
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.099
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.098
Crygf crystallin, gamma F 0.097
Smad7 SMAD family member 7 0.097
Ugt2b37 UDP-glucuronosyltransferase 2 family, member 37 0.094
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism