The network for 'skeletal system morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

skeletal system morphogenesis

The process in which the anatomical structures of the skeleton are generated and organized.

Homo sapiens
Name Description Probability Func Analog Organism
COL1A1 collagen, type I, alpha 1 0.961
HOXB5 homeobox B5 0.951
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.934
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.911
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.882
PAX3 paired box 3 0.797
TGFB1 transforming growth factor, beta 1 0.787
NCOR1 nuclear receptor corepressor 1 0.592
EP300 E1A binding protein p300 0.568
HOXA5 homeobox A5 0.511
COL2A1 collagen, type II, alpha 1 0.511
CREBBP CREB binding protein 0.465
DDR2 discoidin domain receptor tyrosine kinase 2 0.463
MMS22L MMS22-like, DNA repair protein 0.461
HOXA10 homeobox A10 0.457
FGF1 fibroblast growth factor 1 (acidic) 0.451
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.438
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.407
SMAD4 SMAD family member 4 0.381
POU3F2 POU class 3 homeobox 2 0.356
FGFR2 fibroblast growth factor receptor 2 0.335
HOXB6 homeobox B6 0.316
PBX1 pre-B-cell leukemia homeobox 1 0.250
USP11 ubiquitin specific peptidase 11 0.248
NOTCH3 notch 3 0.243
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.232
FOXF2 forkhead box F2 0.231
MSX1 msh homeobox 1 0.218
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.216
LOX lysyl oxidase 0.215
RUNX1 runt-related transcription factor 1 0.213
NOTCH1 notch 1 0.213
COL6A1 collagen, type VI, alpha 1 0.203
HOXA4 homeobox A4 0.193
ENG endoglin 0.193
HOXD9 homeobox D9 0.189
COL1A2 collagen, type I, alpha 2 0.186
BMP7 bone morphogenetic protein 7 0.185
HOXC8 homeobox C8 0.178
MEF2A myocyte enhancer factor 2A 0.175
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.166
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.165
SMAD3 SMAD family member 3 0.158
TBX2 T-box 2 0.154
SH3BP4 SH3-domain binding protein 4 0.153
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.151
POU5F1 POU class 5 homeobox 1 0.150
HOXB3 homeobox B3 0.150
HOXB13 homeobox B13 0.149
HOXB9 homeobox B9 0.148
MDFI MyoD family inhibitor 0.141
IGFBP5 insulin-like growth factor binding protein 5 0.140
SMAD7 SMAD family member 7 0.133
TP53 tumor protein p53 0.133
FBLN2 fibulin 2 0.126
COL3A1 collagen, type III, alpha 1 0.126
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.125
COL5A1 collagen, type V, alpha 1 0.119
SOX2 SRY (sex determining region Y)-box 2 0.119
RARA retinoic acid receptor, alpha 0.117
PRRX2 paired related homeobox 2 0.117
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.116
FOXC1 forkhead box C1 0.115
TWIST1 twist homolog 1 (Drosophila) 0.112
PTHLH parathyroid hormone-like hormone 0.112
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.111
FGF3 fibroblast growth factor 3 0.111
LBX1 ladybird homeobox 1 0.110
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.110
GATA4 GATA binding protein 4 0.109
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.109
HOXA3 homeobox A3 0.109
ELN elastin 0.107
BMP4 bone morphogenetic protein 4 0.106
HOXC11 homeobox C11 0.104
WISP1 WNT1 inducible signaling pathway protein 1 0.103
HMGA2 high mobility group AT-hook 2 0.103
ADAM12 ADAM metallopeptidase domain 12 0.102
EGR2 early growth response 2 0.100
TAL1 T-cell acute lymphocytic leukemia 1 0.099
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.097
JAG1 jagged 1 0.095
ANGPT1 angiopoietin 1 0.092
COL11A1 collagen, type XI, alpha 1 0.091
MEOX2 mesenchyme homeobox 2 0.091
FGF7 fibroblast growth factor 7 0.090
FOXF1 forkhead box F1 0.089
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.088
FSTL1 follistatin-like 1 0.087
RNF31 ring finger protein 31 0.086
FBLN1 fibulin 1 0.086
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.083
GATA2 GATA binding protein 2 0.083
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.081
HOXD11 homeobox D11 0.081
WNT2 wingless-type MMTV integration site family member 2 0.080
FGF18 fibroblast growth factor 18 0.079
PTEN phosphatase and tensin homolog 0.078
SOX11 SRY (sex determining region Y)-box 11 0.078
OTP orthopedia homeobox 0.078
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
sox9a SRY-box containing gene 9a 0.997
barx1 BarH-like homeobox 1 0.986
wu:fv91b12 wu:fv91b12 0.977
myod1 myogenic differentiation 1 0.968
hoxb3a homeo box B3a 0.951
foxd3 forkhead box D3 0.946
foxi1 forkhead box I1 0.936
jag1b jagged 1b 0.932
twist1a twist1a 0.907
bmp2b bone morphogenetic protein 2b 0.898
gata3 GATA-binding protein 3 0.883
bmp2a bone morphogenetic protein 2a 0.853
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.853
raraa retinoic acid receptor, alpha a 0.837
pax8 paired box gene 8 0.832
brpf1 bromodomain and PHD finger containing, 1 0.828
tp63 tumor protein p63 0.807
prdm1a PR domain containing 1a, with ZNF domain 0.801
wnt5b wingless-type MMTV integration site family, member 5b 0.790
bmp4 bone morphogenetic protein 4 0.781
dlx3b distal-less homeobox gene 3b 0.773
ptch2 patched 2 0.760
fras1 Fraser syndrome 1 0.747
pitx3 paired-like homeodomain transcription factor 3 0.743
foxa2 forkhead box A2 0.724
boc brother of CDO 0.723
col2a1a collagen type II, alpha-1a 0.706
col5a1 procollagen, type V, alpha 1 0.700
ptch1 patched 1 0.700
hoxd4a homeo box D4a 0.660
LOC100000500 sclerostin-like 0.659
shha sonic hedgehog a 0.653
pax2a paired box gene 2a 0.631
hoxb5b homeo box B5b 0.618
hoxa2b homeo box A2b 0.615
mab21l2 mab-21-like 2 0.613
dlx5a distal-less homeobox gene 5a 0.607
twist1b twist1b 0.590
pax6a paired box gene 6a 0.582
egr2b early growth response 2b 0.581
hoxa4a homeo box A4a 0.580
twist3 twist3 0.579
myf5 myogenic factor 5 0.564
pthlh parathyroid hormone-like hormone 0.552
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.550
wnt11r wingless-type MMTV integration site family, member 11, related 0.536
dlx2a distal-less homeobox gene 2a 0.531
cmyb transcription factor cmyb 0.529
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.517
hapln1a hyaluronan and proteoglycan link protein 1a 0.511
sulf1 sulfatase 1 0.511
dlb deltaB 0.506
gria3b glutamate receptor, ionotrophic, AMPA 3b 0.499
snai1a snail homolog 1a (Drosophila) 0.499
hoxd10a homeo box D10a 0.499
gli2a GLI-Kruppel family member GLI2a 0.495
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.493
dlx4a distal-less homeobox gene 4a 0.491
brd4 bromodomain containing 4 0.491
sox32 SRY-box containing gene 32 0.482
tbx1 T-box 1 0.479
rarab retinoic acid receptor, alpha b 0.476
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.468
frem2a Fras1 related extracellular matrix protein 2a 0.464
grem2 gremlin 2, cysteine knot superfamily 0.464
runx3 runt-related transcription factor 3 0.463
disp1 dispatched homolog 1 (Drosophila) 0.456
msxc muscle segment homeobox C 0.454
hoxb4a homeo box B4a 0.447
dag1 dystroglycan 1 0.440
acvr1l activin A receptor, type I like 0.429
efnb2a ephrin B2a 0.413
wnt11 wingless-type MMTV integration site family, member 11 0.409
gpr126 G protein-coupled receptor 126 0.405
lhx5 LIM homeobox 5 0.389
prrx1a paired related homeobox 1a 0.383
rargb retinoic acid receptor, gamma b 0.382
gata4 GATA-binding protein 4 0.375
fbn2b fibrillin 2b 0.373
foxn4 forkhead box N4 0.373
kdrl kinase insert domain receptor like 0.371
six4b sine oculis homeobox homolog 4b 0.371
hoxa9b homeo box A9b 0.368
smad1 MAD homolog 1 (Drosophila) 0.367
hoxa3a homeo box A3a 0.365
gsc goosecoid 0.365
fgfr2 fibroblast growth factor receptor 2 0.364
plod2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.357
eya1 eyes absent homolog 1 0.356
prdm5 PR domain containing 5 0.355
gata2a GATA-binding protein 2a 0.352
msxd muscle segment homeobox D 0.350
fgf20b fibroblast growth factor 20b 0.348
lect1 leukocyte cell derived chemotaxin 1 0.336
tbx5a T-box 5a 0.334
pax9 paired box gene 9 0.334
crabp2a cellular retinoic acid binding protein 2, a 0.333
runx2b runt-related transcription factor 2b 0.333
gria4a glutamate receptor, ionotropic, AMPA 4a 0.332
edn1 endothelin 1 0.330
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 1.000
Foxc1 forkhead box C1 1.000
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Fgfr3 fibroblast growth factor receptor 3 1.000
Runx2 runt related transcription factor 2 1.000
Pax3 paired box gene 3 1.000
Fgf8 fibroblast growth factor 8 1.000
Rarg retinoic acid receptor, gamma 1.000
Hoxa1 homeobox A1 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Msx2 homeobox, msh-like 2 1.000
Fgfr1 fibroblast growth factor receptor 1 0.999
Tcfap2a transcription factor AP-2, alpha 0.999
Hand1 heart and neural crest derivatives expressed transcript 1 0.999
Tbx1 T-box 1 0.999
Pax2 paired box gene 2 0.999
Prrx1 paired related homeobox 1 0.999
Col2a1 collagen, type II, alpha 1 0.999
Gli2 GLI-Kruppel family member GLI2 0.998
Eya1 eyes absent 1 homolog (Drosophila) 0.998
Col1a1 collagen, type I, alpha 1 0.998
Bmp4 bone morphogenetic protein 4 0.998
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.998
Meox2 mesenchyme homeobox 2 0.998
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.997
Foxc2 forkhead box C2 0.997
Dlx5 distal-less homeobox 5 0.997
Prrx2 paired related homeobox 2 0.997
Lhx1 LIM homeobox protein 1 0.996
Sox9 SRY-box containing gene 9 0.996
Otx2 orthodenticle homolog 2 (Drosophila) 0.996
Hoxa3 homeobox A3 0.995
Bmp7 bone morphogenetic protein 7 0.995
Hoxd11 homeobox D11 0.995
Msx1 homeobox, msh-like 1 0.993
Nodal nodal 0.993
Pkd1 polycystic kidney disease 1 homolog 0.993
Twist2 twist homolog 2 (Drosophila) 0.992
Pitx1 paired-like homeodomain transcription factor 1 0.991
Hoxa2 homeobox A2 0.991
Chrd chordin 0.990
Pbx1 pre B-cell leukemia transcription factor 1 0.989
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.989
Pax9 paired box gene 9 0.989
Fgf3 fibroblast growth factor 3 0.989
En1 engrailed 1 0.989
Hoxb3 homeobox B3 0.988
Pax6 paired box gene 6 0.988
Hoxa9 homeobox A9 0.987
Pthlh parathyroid hormone-like peptide 0.986
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.986
Pten phosphatase and tensin homolog 0.986
Hoxd13 homeobox D13 0.985
Tgfbr2 transforming growth factor, beta receptor II 0.984
Tgfb2 transforming growth factor, beta 2 0.983
Smad6 MAD homolog 6 (Drosophila) 0.982
Hoxb6 homeobox B6 0.982
Pax8 paired box gene 8 0.981
Tbx3 T-box 3 0.979
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.979
Rarb retinoic acid receptor, beta 0.978
Fbn1 fibrillin 1 0.974
Acvr1 activin A receptor, type 1 0.974
Alx3 aristaless-like homeobox 3 0.972
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.972
Wt1 Wilms tumor 1 homolog 0.970
Fgf18 fibroblast growth factor 18 0.969
Zic3 zinc finger protein of the cerebellum 3 0.965
Gdf5 growth differentiation factor 5 0.965
Gsc goosecoid homeobox 0.962
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.962
Hoxd3 homeobox D3 0.961
Twist1 twist homolog 1 (Drosophila) 0.960
Foxa2 forkhead box A2 0.959
Snai1 snail homolog 1 (Drosophila) 0.958
Rybp RING1 and YY1 binding protein 0.956
Lhx3 LIM homeobox protein 3 0.956
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.955
Alx4 aristaless-like homeobox 4 0.955
Gdnf glial cell line derived neurotrophic factor 0.954
Lox lysyl oxidase 0.949
Rnf2 ring finger protein 2 0.949
Wnt6 wingless-related MMTV integration site 6 0.948
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.945
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.942
Isl1 ISL1 transcription factor, LIM/homeodomain 0.941
Foxg1 forkhead box G1 0.937
Gata4 GATA binding protein 4 0.935
Hoxa11 homeobox A11 0.935
Tbx15 T-box 15 0.931
Hoxa13 homeobox A13 0.928
Tcf21 transcription factor 21 0.923
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.922
Hoxb1 homeobox B1 0.922
T brachyury 0.918
Bdnf brain derived neurotrophic factor 0.910
Bnc1 basonuclin 1 0.906
Tbx2 T-box 2 0.906
Hoxb4 homeobox B4 0.903
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.934
Col3a1 collagen, type III, alpha 1 0.919
Col12a1 collagen, type XII, alpha 1 0.808
Bgn biglycan 0.799
Lox lysyl oxidase 0.474
Lamc1 laminin, gamma 1 0.286
Col1a2 collagen, type I, alpha 2 0.282
Pcolce procollagen C-endopeptidase enhancer 0.261
Col5a1 collagen, type V, alpha 1 0.229
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.187
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.144
Aebp1 AE binding protein 1 0.115
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.107
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.104
Col5a2 collagen, type V, alpha 2 0.087
Loxl1 lysyl oxidase-like 1 0.079
Eln elastin 0.079
Fn1 fibronectin 1 0.071
Postn periostin, osteoblast specific factor 0.062
Fgfr2 fibroblast growth factor receptor 2 0.052
Prrx1 paired related homeobox 1 0.045
Lef1 lymphoid enhancer binding factor 1 0.042
Col15a1 collagen, type XV, alpha 1 0.041
Shox2 short stature homeobox 2 0.041
Slit3 slit homolog 3 (Drosophila) 0.039
Tcfe2a transcription factor E2a 0.038
Tek TEK tyrosine kinase, endothelial 0.036
Col4a1 collagen, type IV, alpha 1 0.036
Tgfbr2 transforming growth factor, beta receptor II 0.030
Igfbp5 insulin-like growth factor binding protein 5 0.030
Tnc tenascin C 0.029
Hoxa1 homeo box A1 0.029
Myh9 myosin, heavy chain 9, non-muscle 0.028
Mmp2 matrix metallopeptidase 2 0.028
Lect1 leukocyte cell derived chemotaxin 1 0.028
Enpep glutamyl aminopeptidase 0.028
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.025
Dab2 disabled homolog 2 (Drosophila) 0.024
Scarf2 scavenger receptor class F, member 2 0.024
Fbn1 fibrillin 1 0.023
Socs3 suppressor of cytokine signaling 3 0.023
Fstl1 follistatin-like 1 0.023
Ece1 endothelin converting enzyme 1 0.023
Col6a2 collagen, type VI, alpha 2 0.023
Efna5 ephrin A5 0.023
Angpt2 angiopoietin 2 0.023
Fkbp10 FK506 binding protein 10 0.022
Col11a2 collagen, type XI, alpha 2 0.021
Ptbp1 polypyrimidine tract binding protein 1 0.019
Prrx2 paired related homeobox 2 0.019
Sod3 superoxide dismutase 3, extracellular 0.019
Bmp6 bone morphogenetic protein 6 0.018
Fmod fibromodulin 0.018
Col14a1 collagen, type XIV, alpha 1 0.017
Vcan versican 0.017
Galr1 galanin receptor 1 0.017
Mybpc2 myosin binding protein C, fast-type 0.017
Gprc5c G protein-coupled receptor, family C, group 5, member C 0.017
Pecam1 platelet/endothelial cell adhesion molecule 1 0.016
Hoxc4 homeo box C4 0.016
Znf503 zinc finger protein 503 0.016
Msx2 msh homeobox 2 0.015
Psen1 presenilin 1 0.015
S1pr2 sphingosine-1-phosphate receptor 2 0.015
Cercam cerebral endothelial cell adhesion molecule 0.015
Col4a2 collagen, type IV, alpha 2 0.015
Srpx sushi-repeat-containing protein, X-linked 0.015
Tgfb2 transforming growth factor, beta 2 0.015
Nfya nuclear transcription factor-Y alpha 0.014
Hoxd9 homeo box D9 0.014
Hoxb7 homeo box B7 0.014
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.014
Ltbp4 latent transforming growth factor beta binding protein 4 0.014
Egr2 early growth response 2 0.014
Flt1 FMS-related tyrosine kinase 1 0.014
Baiap2 BAI1-associated protein 2 0.014
Chad chondroadherin 0.014
Agtr1a angiotensin II receptor, type 1a 0.014
Hapln1 hyaluronan and proteoglycan link protein 1 0.013
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.013
Pcsk1 proprotein convertase subtilisin/kexin type 1 0.013
Cyyr1 cysteine/tyrosine-rich 1 0.013
Hoxa5 homeo box A5 0.012
Nup153 nucleoporin 153 0.012
Ager advanced glycosylation end product-specific receptor 0.012
Dmd dystrophin 0.012
Pear1 platelet endothelial aggregation receptor 1 0.012
Dnah8 dynein, axonemal, heavy chain 8 0.012
Trhr thyrotropin releasing hormone receptor 0.012
Notch1 Notch homolog 1, translocation-associated (Drosophila) 0.011
Rest RE1-silencing transcription factor 0.011
Foxd3 forkhead box D3 0.011
Gdf11 growth differentiation factor 11 0.011
Prl8a2 prolactin family 8, subfamily a, member 2 0.011
Grip1 glutamate receptor interacting protein 1 0.011
Pdgfb platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.011
Cp ceruloplasmin 0.011
Notch3 Notch homolog 3 (Drosophila) 0.011
Snai2 snail homolog 2 (Drosophila) 0.011
Bmp1 bone morphogenetic protein 1 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism