The network for 'astrocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

astrocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.

Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.976
RIN3 Ras and Rab interactor 3 0.951
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.950
SOX10 SRY (sex determining region Y)-box 10 0.947
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.929
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.879
EGFR epidermal growth factor receptor 0.835
PAX3 paired box 3 0.771
DRD2 dopamine receptor D2 0.756
ALB albumin 0.737
JAG1 jagged 1 0.719
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.691
BMPR1A bone morphogenetic protein receptor, type IA 0.672
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.669
BCAR1 breast cancer anti-estrogen resistance 1 0.667
GRB2 growth factor receptor-bound protein 2 0.604
MAX MYC associated factor X 0.554
PLAT plasminogen activator, tissue 0.524
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.506
IL1RAP interleukin 1 receptor accessory protein 0.491
BMP7 bone morphogenetic protein 7 0.482
IL1R1 interleukin 1 receptor, type I 0.442
DNM1 dynamin 1 0.431
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.429
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.410
SYNJ1 synaptojanin 1 0.387
CHD3 chromodomain helicase DNA binding protein 3 0.351
NOTCH3 notch 3 0.339
CAPN1 calpain 1, (mu/I) large subunit 0.330
FGF1 fibroblast growth factor 1 (acidic) 0.321
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.313
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.272
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 0.252
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.252
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.251
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.242
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.237
KIAA0408 KIAA0408 0.231
JAK2 Janus kinase 2 0.230
JAK1 Janus kinase 1 0.224
OLIG2 oligodendrocyte lineage transcription factor 2 0.209
SKI v-ski sarcoma viral oncogene homolog (avian) 0.209
RIN1 Ras and Rab interactor 1 0.207
GATA2 GATA binding protein 2 0.204
SNX9 sorting nexin 9 0.188
IFNGR1 interferon gamma receptor 1 0.187
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.172
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.167
FGA fibrinogen alpha chain 0.158
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.151
RUNX1 runt-related transcription factor 1 0.129
FSTL1 follistatin-like 1 0.129
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.126
F3 coagulation factor III (thromboplastin, tissue factor) 0.124
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.120
MAML1 mastermind-like 1 (Drosophila) 0.120
NECAB2 N-terminal EF-hand calcium binding protein 2 0.119
ADORA1 adenosine A1 receptor 0.117
FGFR2 fibroblast growth factor receptor 2 0.113
SOX2 SRY (sex determining region Y)-box 2 0.111
IGF1R insulin-like growth factor 1 receptor 0.107
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.106
GFAP glial fibrillary acidic protein 0.102
GHR growth hormone receptor 0.102
SOX11 SRY (sex determining region Y)-box 11 0.102
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.098
BMP2 bone morphogenetic protein 2 0.092
LIFR leukemia inhibitory factor receptor alpha 0.091
ABI2 abl-interactor 2 0.090
EP300 E1A binding protein p300 0.086
CDK6 cyclin-dependent kinase 6 0.086
POU3F2 POU class 3 homeobox 2 0.085
SEPT4 septin 4 0.084
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.084
OSMR oncostatin M receptor 0.081
NAMPT nicotinamide phosphoribosyltransferase 0.080
GADD45A growth arrest and DNA-damage-inducible, alpha 0.080
GRB7 growth factor receptor-bound protein 7 0.078
CFB complement factor B 0.074
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.074
TENC1 tensin like C1 domain containing phosphatase (tensin 2) 0.073
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.073
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.071
TAL1 T-cell acute lymphocytic leukemia 1 0.071
SPRR2A small proline-rich protein 2A 0.071
CRP C-reactive protein, pentraxin-related 0.071
SOS1 son of sevenless homolog 1 (Drosophila) 0.071
STAT1 signal transducer and activator of transcription 1, 91kDa 0.071
AHSG alpha-2-HS-glycoprotein 0.070
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.067
ITSN1 intersectin 1 (SH3 domain protein) 0.063
STAT5A signal transducer and activator of transcription 5A 0.062
LHX2 LIM homeobox 2 0.062
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.061
PLCG1 phospholipase C, gamma 1 0.061
DIS3L2 DIS3 mitotic control homolog (S. cerevisiae)-like 2 0.061
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.059
ORM1 orosomucoid 1 0.058
PXN paxillin 0.057
NCAN neurocan 0.057
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
dld deltaD 0.955
dla deltaA 0.951
shha sonic hedgehog a 0.936
ascl1a achaete-scute complex-like 1a (Drosophila) 0.936
fgf8a fibroblast growth factor 8 a 0.934
sox3 SRY-box containing gene 3 0.931
chd chordin 0.906
bmp2b bone morphogenetic protein 2b 0.901
ndr2 nodal-related 2 0.901
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.865
cdh2 cadherin 2, neuronal 0.865
mdkb midkine-related growth factor b 0.836
olig2 oligodendrocyte lineage transcription factor 2 0.768
flh floating head 0.768
lfng lunatic fringe homolog 0.765
mpz myelin protein zero 0.744
plp1a proteolipid protein 1a 0.732
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.719
mbp myelin basic protein 0.705
sox9a SRY-box containing gene 9a 0.694
otpb orthopedia homolog b 0.659
notch1a notch homolog 1a 0.626
foxn4 forkhead box N4 0.617
pou3f1 POU class 3 homeobox 1 0.614
dbx1a developing brain homeobox 1a 0.610
osr1 odd-skipped related 1 (Drosophila) 0.605
scn1ba sodium channel, voltage-gated, type I, beta a 0.586
col15a1b collagen, type XV, alpha 1b 0.572
neurod neurogenic differentiation 0.544
pax2a paired box gene 2a 0.523
gata1a GATA binding protein 1a 0.522
lingo1b leucine rich repeat and Ig domain containing 1b 0.514
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.492
pax6a paired box gene 6a 0.486
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.449
sox19a SRY-box containing gene 19a 0.426
mib mind bomb 0.420
gli1 GLI-Kruppel family member 1 0.409
shhb sonic hedgehog b 0.401
aplnrb apelin receptor b 0.401
cdx4 caudal type homeo box transcription factor 4 0.401
foxg1a forkhead box G1a 0.394
lhx1a LIM homeobox 1a 0.391
mecom MDS1 and EVI1 complex locus 0.385
sox1a SRY-box containing gene 1a 0.382
ascl1b achaete-scute complex-like 1b (Drosophila) 0.381
gsc goosecoid 0.378
her12 hairy-related 12 0.372
gdf6a growth differentiation factor 6a 0.351
zic4 zic family member 4 0.348
emx3 empty spiracles homeobox 3 0.336
her6 hairy-related 6 0.317
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.314
tp53 tumor protein p53 0.312
fzd8a frizzled homolog 8a 0.312
insm1b insulinoma-associated 1b 0.298
cdh5 cadherin 5 0.292
mdka midkine-related growth factor 0.282
arx aristaless related homeobox 0.275
tal1 T-cell acute lymphocytic leukemia 1 0.265
osr2 odd-skipped related 2 (Drosophila) 0.258
dmrt2a doublesex and mab-3 related transcription factor 2a 0.255
vsx2 visual system homeobox 2 0.249
stmn1b stathmin 1b 0.244
coe2 coe2 0.239
il6r interleukin 6 receptor 0.237
irx3a iroquois homeobox protein 3a 0.222
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.220
ripk2 receptor-interacting serine-threonine kinase 2 0.219
hnf1ba HNF1 homeobox Ba 0.219
notch3 notch homolog 3 0.214
nr2f1b nuclear receptor subfamily 2, group F, member 1b 0.213
sox2 SRY-box containing gene 2 0.212
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.211
pcna proliferating cell nuclear antigen 0.211
fgf3 fibroblast growth factor 3 0.209
emx2 empty spiracles homeobox 2 0.205
robo3 roundabout homolog 3 0.203
alcamb activated leukocyte cell adhesion molecule b 0.203
gpm6ab glycoprotein M6Ab 0.197
sfrp5 secreted frizzled-related protein 5 0.196
her4.2 hairy-related 4.2 0.195
klf4 Kruppel-like factor 4 0.190
sox17 SRY-box containing gene 17 0.188
serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 0.187
her15.1 hairy and enhancer of split-related 15.1 0.182
hhex hematopoietically expressed homeobox 0.174
dlb deltaB 0.173
nkx6.1 NK6 transcription factor related, locus 1 (Drosophila) 0.172
tuba1l tubulin, alpha 1, like 0.170
socs3a suppressor of cytokine signaling 3a 0.167
lmo2 LIM domain only 2 (rhombotin-like 1) 0.163
spry2 sprouty homolog 2 0.162
tbx16 T-box gene 16 0.161
her8a hairy-related 8a 0.151
klf4a Kruppel-like transcription factor 4a 0.149
tbx20 T-box 20 0.145
foxe3 forkhead box E3 0.144
pdzrn3 PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3 0.143
tbx1 T-box 1 0.143
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pax3 paired box gene 3 1.000
Emx1 empty spiracles homolog 1 (Drosophila) 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.999
Fgfr2 fibroblast growth factor receptor 2 0.996
Hand2 heart and neural crest derivatives expressed transcript 2 0.996
Hand1 heart and neural crest derivatives expressed transcript 1 0.996
Gli3 GLI-Kruppel family member GLI3 0.995
Sox9 SRY-box containing gene 9 0.993
Pax6 paired box gene 6 0.989
Fgf8 fibroblast growth factor 8 0.986
Fgfr1 fibroblast growth factor receptor 1 0.983
Gli2 GLI-Kruppel family member GLI2 0.975
Sox2 SRY-box containing gene 2 0.975
Isl1 ISL1 transcription factor, LIM/homeodomain 0.974
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.956
Nog noggin 0.951
En1 engrailed 1 0.917
Pax2 paired box gene 2 0.915
Tcfap2a transcription factor AP-2, alpha 0.900
Smo smoothened homolog (Drosophila) 0.894
Rara retinoic acid receptor, alpha 0.873
Nodal nodal 0.859
Gbx2 gastrulation brain homeobox 2 0.856
Neurod1 neurogenic differentiation 1 0.844
Alx4 aristaless-like homeobox 4 0.842
Neurog2 neurogenin 2 0.832
Eya1 eyes absent 1 homolog (Drosophila) 0.832
Foxc1 forkhead box C1 0.819
Prrx1 paired related homeobox 1 0.801
Dlx5 distal-less homeobox 5 0.778
Ntf3 neurotrophin 3 0.775
Msx1 homeobox, msh-like 1 0.774
Notch1 Notch gene homolog 1 (Drosophila) 0.762
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.760
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.753
Pax1 paired box gene 1 0.721
Ret ret proto-oncogene 0.707
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.683
Atoh7 atonal homolog 7 (Drosophila) 0.683
Gata4 GATA binding protein 4 0.679
Emx2 empty spiracles homolog 2 (Drosophila) 0.673
Meox2 mesenchyme homeobox 2 0.656
Trp53 transformation related protein 53 0.654
Id3 inhibitor of DNA binding 3 0.654
Bmp4 bone morphogenetic protein 4 0.633
Lamc1 laminin, gamma 1 0.630
Rarg retinoic acid receptor, gamma 0.623
Gsc goosecoid homeobox 0.623
Foxc2 forkhead box C2 0.622
Lmx1b LIM homeobox transcription factor 1 beta 0.613
Ptch1 patched homolog 1 0.593
Sox3 SRY-box containing gene 3 0.588
Foxg1 forkhead box G1 0.583
Sox10 SRY-box containing gene 10 0.563
Fgf10 fibroblast growth factor 10 0.561
Tlx3 T-cell leukemia, homeobox 3 0.559
Pbx1 pre B-cell leukemia transcription factor 1 0.528
Hes1 hairy and enhancer of split 1 (Drosophila) 0.517
Nhlh1 nescient helix loop helix 1 0.516
Id1 inhibitor of DNA binding 1 0.515
Lhx5 LIM homeobox protein 5 0.480
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.479
Col2a1 collagen, type II, alpha 1 0.460
Onecut1 one cut domain, family member 1 0.459
Zic3 zinc finger protein of the cerebellum 3 0.455
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.453
Ptf1a pancreas specific transcription factor, 1a 0.449
Insm1 insulinoma-associated 1 0.447
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.444
Hes5 hairy and enhancer of split 5 (Drosophila) 0.437
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.431
Neurog3 neurogenin 3 0.431
Neurog1 neurogenin 1 0.414
Tcf4 transcription factor 4 0.409
Dlx1 distal-less homeobox 1 0.406
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.404
Chrd chordin 0.403
Hoxc5 homeobox C5 0.396
Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 0.390
Alx3 aristaless-like homeobox 3 0.387
Hoxa1 homeobox A1 0.372
Pten phosphatase and tensin homolog 0.370
Tcf21 transcription factor 21 0.368
Hoxd3 homeobox D3 0.367
Fgf17 fibroblast growth factor 17 0.363
Tgfb2 transforming growth factor, beta 2 0.359
Vegfa vascular endothelial growth factor A 0.359
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.354
Sox11 SRY-box containing gene 11 0.348
Vangl2 vang-like 2 (van gogh, Drosophila) 0.346
Glra1 glycine receptor, alpha 1 subunit 0.339
Lmx1a LIM homeobox transcription factor 1 alpha 0.338
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.337
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.327
Foxd2 forkhead box D2 0.327
Vax1 ventral anterior homeobox containing gene 1 0.326
Prrx2 paired related homeobox 2 0.323
Hoxd11 homeobox D11 0.322
Wnt6 wingless-related MMTV integration site 6 0.320
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
S100a10 S100 calcium binding protein A10 0.620
Anxa2 annexin A2 0.521
S100a4 S100 calcium-binding protein A4 0.334
Anxa1 annexin A1 0.290
S100a6 S100 calcium binding protein A6 0.278
Lgals3 lectin, galactoside-binding, soluble, 3 0.267
Timp1 TIMP metallopeptidase inhibitor 1 0.216
S100a9 S100 calcium binding protein A9 0.187
S100a8 S100 calcium binding protein A8 0.183
Mt1a metallothionein 1a 0.156
Anxa5 annexin A5 0.136
Vim vimentin 0.132
S100a11 S100 calcium binding protein A11 (calizzarin) 0.128
Mgp matrix Gla protein 0.120
Cd63 Cd63 molecule 0.072
Lgals1 lectin, galactoside-binding, soluble, 1 0.065
A2m alpha-2-macroglobulin 0.043
Ifitm3 interferon induced transmembrane protein 3 0.036
Tspo translocator protein 0.032
Crip cysteine-rich intestinal protein 0.031
Capn2 calpain 2 0.030
Ahnak AHNAK nucleoprotein 0.028
Mag myelin-associated glycoprotein 0.027
Cd9 CD9 molecule 0.027
Gabrr2 gamma-aminobutyric acid (GABA) receptor, rho 2 0.026
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.025
Lox lysyl oxidase 0.024
Klk6 kallikrein related-peptidase 6 0.023
Apba2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.023
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.023
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.022
Mbp myelin basic protein 0.022
RGD1309537 similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A) 0.022
Acan aggrecan 0.021
Unc5b unc-5 homolog B (C. elegans) 0.020
Fn1 fibronectin 1 0.020
Arpc1b actin related protein 2/3 complex, subunit 1B 0.020
Ppy pancreatic polypeptide 0.019
Ccl2 chemokine (C-C motif) ligand 2 0.018
Ednrb endothelin receptor type B 0.018
Cd151 CD151 molecule (Raph blood group) 0.018
Pmp22 peripheral myelin protein 22 0.017
Tagln transgelin 0.016
Opn1mw opsin 1 (cone pigments), medium-wave-sensitive 0.016
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.015
Tax1bp3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.015
Ddr1 discoidin domain receptor tyrosine kinase 1 0.015
Plekhb1 pleckstrin homology domain containing, family B (evectins) member 1 0.014
Olig1 oligodendrocyte transcription factor 1 0.014
Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.014
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.014
Pllp plasma membrane proteolipid (plasmolipin) 0.014
Ppyr1 pancreatic polypeptide receptor 1 0.013
Ecel1 endothelin converting enzyme-like 1 0.013
Gja1 gap junction protein, alpha 1 0.013
Gna11 guanine nucleotide binding protein, alpha 11 0.013
Znf532 zinc finger protein 532 0.012
Tmod2 tropomodulin 2 0.012
Fxyd1 FXYD domain-containing ion transport regulator 1 0.012
Hmox1 heme oxygenase (decycling) 1 0.012
Sox10 SRY (sex determining region Y)-box 10 0.011
Cryaa crystallin, alpha A 0.011
Sncg synuclein, gamma (breast cancer-specific protein 1) 0.011
Grip2 glutamate receptor interacting protein 2 0.011
LOC290595 hypothetical gene supported by AF152002 0.011
Il12b interleukin 12B 0.011
Spp1 secreted phosphoprotein 1 0.011
Plp2 proteolipid protein 2 (colonic epithelium-enriched) 0.011
Apod apolipoprotein D 0.011
Myd88 myeloid differentiation primary response gene 88 0.011
Dnm1 dynamin 1 0.011
Ache acetylcholinesterase 0.010
Cstb cystatin B (stefin B) 0.010
Gfap glial fibrillary acidic protein 0.010
Gper G protein-coupled estrogen receptor 1 0.010
Mrgprx3 MAS-related GPR, member X3 0.010
Drd2 dopamine receptor D2 0.010
Msx2 msh homeobox 2 0.010
Sfrp4 secreted frizzled-related protein 4 0.010
Arhgap23 Rho GTPase activating protein 23 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism