The network for 'positive regulation of synaptic transmission' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of synaptic transmission

Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

Homo sapiens
Name Description Probability Func Analog Organism
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.998
MAPT microtubule-associated protein tau 0.998
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.995
DLG4 discs, large homolog 4 (Drosophila) 0.994
SNAP23 synaptosomal-associated protein, 23kDa 0.952
ARRB1 arrestin, beta 1 0.933
DRD2 dopamine receptor D2 0.930
SNAP25 synaptosomal-associated protein, 25kDa 0.925
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.886
GSK3B glycogen synthase kinase 3 beta 0.870
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.865
CRHR1 corticotropin releasing hormone receptor 1 0.854
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.834
CRH corticotropin releasing hormone 0.814
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.808
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.792
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.743
APP amyloid beta (A4) precursor protein 0.690
DLG2 discs, large homolog 2 (Drosophila) 0.672
ARHGAP1 Rho GTPase activating protein 1 0.662
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.638
STX1A syntaxin 1A (brain) 0.616
ADORA2A adenosine A2a receptor 0.591
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.588
VAC14 Vac14 homolog (S. cerevisiae) 0.519
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.506
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.494
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.477
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 0.397
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.394
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.393
NTF4 neurotrophin 4 0.387
APC adenomatous polyposis coli 0.372
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.359
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.357
RPH3A rabphilin 3A homolog (mouse) 0.355
FBXO7 F-box protein 7 0.352
SNAI1 snail homolog 1 (Drosophila) 0.327
NRXN1 neurexin 1 0.325
TK1 thymidine kinase 1, soluble 0.316
F11R F11 receptor 0.305
TOR1AIP2 torsin A interacting protein 2 0.301
EGR3 early growth response 3 0.295
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.283
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.281
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.275
KIAA0408 KIAA0408 0.273
RIMS1 regulating synaptic membrane exocytosis 1 0.270
IL8 interleukin 8 0.265
HIPK2 homeodomain interacting protein kinase 2 0.264
MAST1 microtubule associated serine/threonine kinase 1 0.264
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.263
CCK cholecystokinin 0.250
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.248
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.239
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.239
PRKCE protein kinase C, epsilon 0.238
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 0.237
EGR2 early growth response 2 0.235
MYO16 myosin XVI 0.232
MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.226
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.221
ACTL6B actin-like 6B 0.216
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.209
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.207
MATK megakaryocyte-associated tyrosine kinase 0.205
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.201
BRAF v-raf murine sarcoma viral oncogene homolog B1 0.199
STX5 syntaxin 5 0.199
PRKCG protein kinase C, gamma 0.198
DLG3 discs, large homolog 3 (Drosophila) 0.197
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.197
TRO trophinin 0.187
STMN2 stathmin-like 2 0.187
NGF nerve growth factor (beta polypeptide) 0.174
IER2 immediate early response 2 0.173
KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1 0.167
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.163
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.154
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.151
KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.149
GRIK1 glutamate receptor, ionotropic, kainate 1 0.145
TPPP tubulin polymerization promoting protein 0.145
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.144
GRIP1 glutamate receptor interacting protein 1 0.139
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.139
DDN dendrin 0.138
ADRB2 adrenergic, beta-2-, receptor, surface 0.138
TAC1 tachykinin, precursor 1 0.137
NECAB2 N-terminal EF-hand calcium binding protein 2 0.137
SNCAIP synuclein, alpha interacting protein 0.137
SDC2 syndecan 2 0.136
SYN2 synapsin II 0.135
NIN ninein (GSK3B interacting protein) 0.135
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.134
COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 0.133
ADORA1 adenosine A1 receptor 0.132
GRIA4 glutamate receptor, ionotrophic, AMPA 4 0.131
RIMS2 regulating synaptic membrane exocytosis 2 0.125
NLGN3 neuroligin 3 0.123
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-9 Protein UNC-9 0.708
goa-1 Protein GOA-1 0.481
unc-10 Protein UNC-10 0.468
pdfr-1 Protein PDFR-1 0.379
unc-36 Protein UNC-36 0.183
ist-1 Protein IST-1 0.182
F32B5.7 Protein F32B5.7 0.163
gar-3 Protein GAR-3 0.156
gar-2 Protein GAR-2 0.152
eat-4 Protein EAT-4 0.148
F45E4.3 Protein F45E4.3 0.129
glr-5 Protein GLR-5 0.088
itr-1 Protein ITR-1 0.082
trp-1 Protein TRP-1 0.081
mod-1 Protein MOD-1 0.078
myo-6 Protein MYO-6 0.077
aat-5 Protein AAT-5 0.075
jnk-1 Protein JNK-1 0.071
nrx-1 Protein NRX-1 0.068
CELE_R13H7.2 Protein R13H7.2 0.065
F54G2.1 Protein F54G2.1 0.061
ver-3 Protein VER-3 0.059
pdl-1 Protein PDL-1 0.058
exc-7 Protein EXC-7 0.058
apb-1 Protein APB-1 0.055
csnk-1 Protein CSNK-1 0.053
grk-2 Protein GRK-2 0.052
unc-2 Protein UNC-2 0.051
plc-3 Protein PLC-3 0.049
sol-1 Protein SOL-1 0.048
pkg-1 Protein PKG-1 0.047
frm-3 Protein FRM-3 0.047
T14B1.1 Protein T14B1.1 0.046
C43H6.4 Protein C43H6.4 0.046
magu-4 Protein MAGU-4 0.045
syg-1 Protein SYG-1 0.044
nlg-1 Protein NLG-1 0.043
ser-2 Protein SER-2 0.041
flt-1 Protein FLT-1 0.040
dyb-1 Protein DYB-1 0.040
slo-1 Protein SLO-1 0.038
let-23 Protein LET-23 0.036
inx-6 Protein INX-6 0.036
unc-116 Protein UNC-116 0.035
ZC190.4 Protein ZC190.4 0.035
unc-7 Protein UNC-7 0.033
haf-3 Protein HAF-3 0.032
fhod-1 Protein FHOD-1 0.032
pkc-1 Protein PKC-1 0.032
dop-5 Protein DOP-5 0.031
cal-4 Protein CAL-4 0.031
ins-1 Protein INS-1 0.030
klp-20 Protein KLP-20 0.030
mab-23 Protein MAB-23 0.029
twk-29 Protein TWK-29 0.029
pqn-39 Protein PQN-39 0.029
F59E12.6 Protein F59E12.6 0.029
plc-1 Protein PLC-1 0.028
mec-6 Protein MEC-6 0.028
R90.1 Protein R90.1 0.027
F55A4.2 Protein F55A4.2 0.027
ajm-1 Protein AJM-1 0.027
apg-1 Protein APG-1 0.027
psd-1 Protein PSD-1 0.026
egl-8 Protein EGL-8 0.024
sma-1 Protein SMA-1 0.024
mig-15 Protein MIG-15 0.024
pqn-89 Protein PQN-89 0.024
K09E4.4 Protein K09E4.4 0.024
ceh-57 Protein CEH-57 0.023
tbx-2 Protein TBX-2 0.023
camt-1 Protein CAMT-1 0.023
gpb-1 Protein GPB-1 0.023
let-60 Protein LET-60 0.022
CELE_C06B8.7 Protein C06B8.7 0.022
tax-6 Protein TAX-6 0.022
mig-17 Protein MIG-17 0.022
stn-1 Protein STN-1 0.022
prkl-1 Protein PRKL-1 0.022
ncs-5 Protein NCS-5 0.021
zoo-1 Protein ZOO-1 0.021
ced-10 Protein CED-10 0.021
unc-47 Protein UNC-47 0.021
syd-2 Protein SYD-2 0.021
R03G8.3 Protein R03G8.3 0.021
F49H12.3 Protein F49H12.3 0.021
grk-1 Protein GRK-1 0.020
rhgf-2 Protein RHGF-2 0.020
C03B1.7 Protein C03B1.7 0.020
cdc-42 Protein CDC-42 0.019
npr-2 Protein NPR-2 0.019
vav-1 Protein VAV-1 0.019
T14B4.8 Protein T14B4.8 0.019
inx-1 Protein INX-1 0.019
F28E10.1 Protein F28E10.1 0.019
nlp-31 Protein NLP-31 0.019
egl-5 Protein EGL-5 0.018
odr-2 Protein ODR-2 0.018
C31E10.5 Protein C31E10.5 0.018
cnd-1 Protein CND-1 0.018
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
GluRIIA Glutamate receptor IIA 0.976
brp bruchpilot 0.771
Nrx-1 Neurexin 1 0.613
Ank2 Ankyrin 2 0.508
neuroligin CG13772 gene product from transcript CG13772-RA 0.389
unc-104 CG8566 gene product from transcript CG8566-RB 0.361
nwk nervous wreck 0.350
hiw highwire 0.291
eag ether a go-go 0.195
Nmdar1 NMDA receptor 1 0.195
dnc dunce 0.191
fd85E forkhead domain 85E 0.180
CG42629 CG42629 gene product from transcript CG42629-RB 0.167
KaiRIA CG18039 gene product from transcript CG18039-RA 0.162
jeb jelly belly 0.158
stnA stoned A 0.156
Syx1A Syntaxin 1A 0.153
dlg1 discs large 1 0.123
stnB stoned B 0.118
CG32635 CG32635 gene product from transcript CG32635-RA 0.113
cac cacophony 0.098
CaMKII Calcium/calmodulin-dependent protein kinase II 0.098
Syt1 Synaptotagmin 1 0.096
stj straightjacket 0.094
VGlut Vesicular glutamate transporter 0.087
CG13253 CG13253 gene product from transcript CG13253-RB 0.083
rtGEF rho-type guanine exchange factor 0.081
dys dysfusion 0.074
Frq1 Frequenin 1 0.069
AdoR Adenosine receptor 0.066
Frq2 Frequenin 2 0.060
kdn knockdown 0.057
Snap Soluble NSF attachment protein 0.056
Octbeta2R CG33976 gene product from transcript CG33976-RA 0.053
fusl fuseless 0.052
Dap160 Dynamin associated protein 160 0.051
GluRIIE Glutamate receptor IIE 0.051
GluRIIB Glutamate receptor IIB 0.050
CG11317 CG11317 gene product from transcript CG11317-RA 0.050
para paralytic 0.049
Gad1 Glutamic acid decarboxylase 1 0.048
Snap25 Synapse protein 25 0.044
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.044
wit wishful thinking 0.043
unc-13 CG2999 gene product from transcript CG2999-RA 0.043
Pka-R1 cAMP-dependent protein kinase R1 0.043
so sine oculis 0.042
mtg mind the gap 0.040
n-syb n-synaptobrevin 0.039
CG43073 CG43073 gene product from transcript CG43073-RF 0.037
Smg1 CG32743 gene product from transcript CG32743-RA 0.036
Dab Disabled 0.036
Grip Glutamate receptor binding protein 0.036
CdsA CDP diglyceride synthetase 0.034
cpo couch potato 0.034
CCKLR-17D1 CCK-like receptor at 17D1 0.033
myoglianin CG1838 gene product from transcript CG1838-RD 0.032
rut rutabaga 0.031
hdc headcase 0.030
Bsg Basigin 0.030
SoxN SoxNeuro 0.029
cpx complexin 0.028
mtt mangetout 0.028
sev sevenless 0.028
TyrR Tyramine receptor 0.028
PIP5K59B CG3682 gene product from transcript CG3682-RE 0.027
CG10260 CG10260 gene product from transcript CG10260-RB 0.026
GluRIIC Glutamate receptor IIC 0.026
onecut CG1922 gene product from transcript CG1922-RA 0.025
Actbeta Activin-beta 0.025
Rab3 Rab-protein 3 0.024
CG34139 CG34139 gene product from transcript CG34139-RD 0.024
gl glass 0.023
Rim CG33547 gene product from transcript CG33547-RB 0.023
Nrt Neurotactin 0.023
CanA1 Calcineurin A1 0.022
Khc-73 Kinesin-73 0.022
Mpk2 CG5475 gene product from transcript CG5475-RB 0.021
elav embryonic lethal abnormal vision 0.021
CG31146 CG31146 gene product from transcript CG31146-RD 0.021
CG9339 CG9339 gene product from transcript CG9339-RG 0.021
Ric Ras which interacts with Calmodulin 0.021
simj simjang 0.021
VAChT CG32848 gene product from transcript CG32848-RA 0.020
Caki Calcium/calmodulin-dependent protein kinase 0.019
Amph Amphiphysin 0.017
stmA stambha A 0.017
HDAC6 CG6170 gene product from transcript CG6170-RA 0.017
rec recombination-defective 0.017
Nf1 Neurofibromin 1 0.017
l(2)k16918 lethal (2) k16918 0.017
shi shibire 0.017
Vmat Vesicular monoamine transporter 0.017
ewg erect wing 0.017
Dsk Drosulfakinin 0.017
Jra Jun-related antigen 0.016
dimm dimmed 0.015
CG15765 CG15765 gene product from transcript CG15765-RA 0.015
CDase Ceramidase 0.015
gig gigas 0.015
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.806
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.767
S100a6 S100 calcium binding protein A6 0.681
Stx1a syntaxin 1A (brain) 0.669
S100a8 S100 calcium binding protein A8 0.635
Syn1 synapsin I 0.589
Anxa2 annexin A2 0.563
Apba1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.550
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.448
Gad2 glutamate decarboxylase 2 0.439
Ppyr1 pancreatic polypeptide receptor 1 0.421
Csf1 colony stimulating factor 1 (macrophage) 0.410
Fgf7 fibroblast growth factor 7 0.409
Adora2a adenosine A2a receptor 0.378
Nrxn1 neurexin 1 0.372
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.367
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.347
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.346
Vamp2 vesicle-associated membrane protein 2 0.345
Vegp2 von Ebners gland protein 2 0.326
Grm5 glutamate receptor, metabotropic 5 0.317
Tacr2 tachykinin receptor 2 0.316
Adra2c adrenergic, alpha-2C-, receptor 0.314
Nfasc neurofascin 0.314
Hrh3 histamine receptor H3 0.306
Snap25 synaptosomal-associated protein 25 0.304
Npy5r neuropeptide Y receptor Y5 0.298
Uncx UNC homeobox 0.291
Kcnq2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.289
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.289
S100a9 S100 calcium binding protein A9 0.284
Nmbr neuromedin B receptor 0.278
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.270
Gnao1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.267
Gria1 glutamate receptor, ionotropic, AMPA 1 0.267
Nlgn3 neuroligin 3 0.266
Rims1 regulating synaptic membrane exocytosis 1 0.266
Grid1 glutamate receptor, ionotropic, delta 1 0.266
Grm7 glutamate receptor, metabotropic 7 0.265
Cd28 Cd28 molecule 0.264
Olr287 olfactory receptor 287 0.263
Prkcg protein kinase C, gamma 0.260
Shank2 SH3 and multiple ankyrin repeat domains 2 0.254
Anxa1 annexin A1 0.249
Egr2 early growth response 2 0.239
Kalrn kalirin, RhoGEF kinase 0.235
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.234
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.231
Adora1 adenosine A1 receptor 0.229
Faslg Fas ligand (TNF superfamily, member 6) 0.226
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.225
Fev FEV (ETS oncogene family) 0.222
Gabrd gamma-aminobutyric acid (GABA) A receptor, delta 0.219
Dlg4 discs, large homolog 4 (Drosophila) 0.207
Glp1r glucagon-like peptide 1 receptor 0.203
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.200
Camk4 calcium/calmodulin-dependent protein kinase IV 0.200
S100a10 S100 calcium binding protein A10 0.199
Cga glycoprotein hormones, alpha polypeptide 0.196
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.195
Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.195
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.194
Cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit 0.193
Ar androgen receptor 0.192
Cntn1 contactin 1 0.189
Acrv1 acrosomal vesicle protein 1 0.187
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.184
Ncr1 natural cytotoxicity triggering receptor 1 0.182
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.182
Nrxn3 neurexin 3 0.181
Camkv CaM kinase-like vesicle-associated 0.180
Crhbp corticotropin releasing hormone binding protein 0.176
Scn8a sodium channel, voltage gated, type VIII, alpha subunit 0.175
Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 0.175
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.172
Cit citron 0.169
Drd1a dopamine receptor D1A 0.168
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.167
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.166
Tac2 tachykinin 2 0.164
Egr1 early growth response 1 0.161
Fos FBJ osteosarcoma oncogene 0.160
Foxd3 forkhead box D3 0.159
Gabbr1 gamma-aminobutyric acid (GABA) B receptor 1 0.153
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.153
Cartpt CART prepropeptide 0.152
Ctsj cathepsin J 0.151
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.149
Dlgap2 discs, large (Drosophila) homolog-associated protein 2 0.148
Lalba lactalbumin, alpha 0.147
Prl prolactin 0.147
Mas1 MAS1 oncogene 0.145
S100a4 S100 calcium-binding protein A4 0.144
Vip vasoactive intestinal peptide 0.144
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.144
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.143
Gjb4 gap junction protein, beta 4 0.142
Grid2 glutamate receptor, ionotropic, delta 2 0.141
Kl Klotho 0.141
Avp arginine vasopressin 0.140
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism