The network for 'positive regulation of smoothened signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of smoothened signaling pathway

Any process that activates or increases the frequency, rate or extent of smoothened signaling.

Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 1.000
Shh sonic hedgehog 1.000
Pax2 paired box gene 2 0.998
Gli2 GLI-Kruppel family member GLI2 0.995
Nog noggin 0.975
Bmp4 bone morphogenetic protein 4 0.941
Gbx2 gastrulation brain homeobox 2 0.934
Fgf10 fibroblast growth factor 10 0.920
Chrd chordin 0.913
Lmx1a LIM homeobox transcription factor 1 alpha 0.911
Wnt5a wingless-related MMTV integration site 5A 0.892
Msx1 homeobox, msh-like 1 0.872
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.818
Foxc1 forkhead box C1 0.800
Fgfr2 fibroblast growth factor receptor 2 0.774
Fgfr3 fibroblast growth factor receptor 3 0.764
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.714
Nkx2-1 NK2 homeobox 1 0.694
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.690
Otx1 orthodenticle homolog 1 (Drosophila) 0.667
Pax3 paired box gene 3 0.631
Twist2 twist homolog 2 (Drosophila) 0.616
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.612
Pitx2 paired-like homeodomain transcription factor 2 0.600
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.581
Fgf8 fibroblast growth factor 8 0.559
Otx2 orthodenticle homolog 2 (Drosophila) 0.552
Disp1 dispatched homolog 1 (Drosophila) 0.546
Smo smoothened homolog (Drosophila) 0.537
Ret ret proto-oncogene 0.464
Gdnf glial cell line derived neurotrophic factor 0.456
En1 engrailed 1 0.430
Bmp7 bone morphogenetic protein 7 0.419
T brachyury 0.399
Rarb retinoic acid receptor, beta 0.394
Dlx5 distal-less homeobox 5 0.350
Wnt3a wingless-related MMTV integration site 3A 0.338
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.337
Pax8 paired box gene 8 0.335
Hand2 heart and neural crest derivatives expressed transcript 2 0.293
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.288
Gli1 GLI-Kruppel family member GLI1 0.286
Ctnnb1 catenin (cadherin associated protein), beta 1 0.279
Hoxd11 homeobox D11 0.252
Tcfap2a transcription factor AP-2, alpha 0.251
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.243
Pax6 paired box gene 6 0.241
Lmx1b LIM homeobox transcription factor 1 beta 0.237
Sfrp2 secreted frizzled-related protein 2 0.232
Wnt1 wingless-related MMTV integration site 1 0.224
Tbx15 T-box 15 0.219
Tgfb2 transforming growth factor, beta 2 0.214
Vangl2 vang-like 2 (van gogh, Drosophila) 0.206
Lrp2 low density lipoprotein receptor-related protein 2 0.205
Apaf1 apoptotic peptidase activating factor 1 0.204
Evc2 Ellis van Creveld syndrome 2 homolog (human) 0.203
Foxg1 forkhead box G1 0.200
Gas1 growth arrest specific 1 0.195
Lrp6 low density lipoprotein receptor-related protein 6 0.188
Lhx1 LIM homeobox protein 1 0.183
Acan aggrecan 0.178
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.176
Amhr2 anti-Mullerian hormone type 2 receptor 0.176
Eya1 eyes absent 1 homolog (Drosophila) 0.175
Emx2 empty spiracles homolog 2 (Drosophila) 0.160
Ihh Indian hedgehog 0.157
Fzd1 frizzled homolog 1 (Drosophila) 0.156
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.156
Pou3f3 POU domain, class 3, transcription factor 3 0.156
Efnb2 ephrin B2 0.155
Nrtn neurturin 0.151
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.148
Bnc1 basonuclin 1 0.144
Foxc2 forkhead box C2 0.143
Prrx2 paired related homeobox 2 0.143
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.137
Fgf15 fibroblast growth factor 15 0.136
Tcf21 transcription factor 21 0.130
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.128
Rnf2 ring finger protein 2 0.126
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.124
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.120
Tbx1 T-box 1 0.114
Fgf3 fibroblast growth factor 3 0.111
Alx4 aristaless-like homeobox 4 0.101
Efs embryonal Fyn-associated substrate 0.101
Fzd8 frizzled homolog 8 (Drosophila) 0.096
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.093
Hoxa1 homeobox A1 0.092
Fbln1 fibulin 1 0.091
Wnt4 wingless-related MMTV integration site 4 0.085
Msx2 homeobox, msh-like 2 0.084
Hmx3 H6 homeobox 3 0.084
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.083
Barx1 BarH-like homeobox 1 0.081
Rarg retinoic acid receptor, gamma 0.078
Pax9 paired box gene 9 0.078
Col11a1 collagen, type XI, alpha 1 0.077
Fzd10 frizzled homolog 10 (Drosophila) 0.076
Kif3a kinesin family member 3A 0.073
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
shha sonic hedgehog a 0.916
mib mind bomb 0.560
foxa2 forkhead box A2 0.533
fn1 fibronectin 1 0.329
ptch2 patched 2 0.230
twist1a twist1a 0.203
wif1 wnt inhibitory factor 1 0.137
prrx1a paired related homeobox 1a 0.107
foxa1 forkhead box A1 0.097
sulf1 sulfatase 1 0.091
cc2d2a coiled-coil and C2 domain containing 2A 0.079
dlx5a distal-less homeobox gene 5a 0.075
flh floating head 0.072
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.068
wnt5b wingless-type MMTV integration site family, member 5b 0.062
gli3 GLI-Kruppel family member GLI3 0.051
tbx1 T-box 1 0.051
boc brother of CDO 0.048
nog1 noggin 1 0.045
ift57 intraflagellar transport protein 57 0.043
dmd dystrophin 0.039
twist3 twist3 0.038
prrx1b paired related homeobox 1b 0.036
ihha Indian hedgehog homolog a 0.032
gli1 GLI-Kruppel family member 1 0.031
ift46 intraflagellar transport protein 46 0.028
ctgf connective tissue growth factor 0.028
nkx2.3 NK2 transcription factor related 3 0.025
cluap1 clusterin associated protein 1 0.024
mga MAX gene associated 0.024
wdr45l wdr45 like 0.021
fgfrl1a fibroblast growth factor receptor-like 1a 0.021
tbx15 T-box 15 0.020
gli2a GLI-Kruppel family member GLI2a 0.020
zgc:55573 zgc:55573 0.019
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.019
grem2 gremlin 2, cysteine knot superfamily 0.019
pax2a paired box gene 2a 0.018
vangl2 vang-like 2 (van gogh, Drosophila) 0.017
smo smoothened homolog (Drosophila) 0.016
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.016
lamb1a laminin, beta 1a 0.016
ift88 intraflagellar transport 88 homolog 0.015
ptch1 patched 1 0.015
lrrc6 leucine rich repeat containing 6 0.014
hoxa2b homeo box A2b 0.014
znf503 zinc finger protein 503 0.014
ptk2.1 protein tyrosine kinase 2a 0.014
irx5a iroquois homeobox protein 5a 0.013
spon1b spondin 1b 0.013
sfrp2 secreted frizzled-related protein 2 0.013
dla deltaA 0.012
fgf3 fibroblast growth factor 3 0.011
tbx2b T-box 2b 0.011
ip6k2 inositol hexaphosphate kinase 2 0.011
atp6v1b2 ATPase, H+ transporting, lysosomal V1 subunit B2 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SUFU suppressor of fused homolog (Drosophila) 0.983
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.786
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.744
STRN3 striatin, calmodulin binding protein 3 0.659
CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.373
STK36 serine/threonine kinase 36 0.229
APC adenomatous polyposis coli 0.222
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.131
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 0.127
PTCH1 patched 1 0.123
GLI3 GLI family zinc finger 3 0.071
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.070
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.070
STRN striatin, calmodulin binding protein 0.067
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.061
SLMAP sarcolemma associated protein 0.057
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.052
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.049
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.048
AR androgen receptor 0.047
GLI1 GLI family zinc finger 1 0.046
QPRT quinolinate phosphoribosyltransferase 0.045
CHMP1B chromatin modifying protein 1B 0.040
AXIN2 axin 2 0.038
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.038
GLIS2 GLIS family zinc finger 2 0.036
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.033
ITFG1 integrin alpha FG-GAP repeat containing 1 0.032
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.031
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.031
CTNNBIP1 catenin, beta interacting protein 1 0.031
TCF4 transcription factor 4 0.030
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.030
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.029
ZFP28 zinc finger protein 28 homolog (mouse) 0.028
BOC Boc homolog (mouse) 0.028
WNT11 wingless-type MMTV integration site family, member 11 0.028
PGRMC1 progesterone receptor membrane component 1 0.027
AMBRA1 autophagy/beclin-1 regulator 1 0.026
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.025
STAMBP STAM binding protein 0.024
CKAP4 cytoskeleton-associated protein 4 0.023
GLI2 GLI family zinc finger 2 0.022
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.020
ONECUT1 one cut homeobox 1 0.020
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.020
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.020
ACTN1 actinin, alpha 1 0.020
KIF5C kinesin family member 5C 0.019
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.019
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.019
WNK1 WNK lysine deficient protein kinase 1 0.018
MFAP4 microfibrillar-associated protein 4 0.018
GSC goosecoid homeobox 0.018
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.018
TCEA1 transcription elongation factor A (SII), 1 0.017
JUP junction plakoglobin 0.017
TWIST1 twist homolog 1 (Drosophila) 0.017
WNT4 wingless-type MMTV integration site family, member 4 0.017
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.017
VHL von Hippel-Lindau tumor suppressor 0.017
PTK7 PTK7 protein tyrosine kinase 7 0.017
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.016
EMD emerin 0.016
MN1 meningioma (disrupted in balanced translocation) 1 0.016
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.016
GPR161 G protein-coupled receptor 161 0.016
ERBB2IP erbb2 interacting protein 0.016
TCTEX1D2 Tctex1 domain containing 2 0.015
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.015
WIF1 WNT inhibitory factor 1 0.015
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.014
ZC3H18 zinc finger CCCH-type containing 18 0.014
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.014
VCL vinculin 0.014
SMO smoothened homolog (Drosophila) 0.014
NEU1 sialidase 1 (lysosomal sialidase) 0.014
NOTCH3 notch 3 0.014
FNDC1 fibronectin type III domain containing 1 0.014
EPHB3 EPH receptor B3 0.014
CRLF1 cytokine receptor-like factor 1 0.014
FOXF2 forkhead box F2 0.014
WNT2 wingless-type MMTV integration site family member 2 0.014
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.014
COL11A1 collagen, type XI, alpha 1 0.014
C22orf39 chromosome 22 open reading frame 39 0.014
WDR61 WD repeat domain 61 0.014
ZIC2 Zic family member 2 (odd-paired homolog, Drosophila) 0.014
CDX2 caudal type homeobox 2 0.014
DENND4A DENN/MADD domain containing 4A 0.014
BMP4 bone morphogenetic protein 4 0.014
PPP4C protein phosphatase 4, catalytic subunit 0.014
PAX7 paired box 7 0.014
FSTL1 follistatin-like 1 0.014
CDK11A cyclin-dependent kinase 11A 0.013
MYST2 MYST histone acetyltransferase 2 0.013
SFRP2 secreted frizzled-related protein 2 0.013
TUBA1A tubulin, alpha 1a 0.013
CHMP2B chromatin modifying protein 2B 0.013
GATA5 GATA binding protein 5 0.013
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.077
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.042
Unc5b unc-5 homolog B (C. elegans) 0.039
Rraga Ras-related GTP binding A 0.030
Tgfb2 transforming growth factor, beta 2 0.021
Ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.019
Pitpna phosphatidylinositol transfer protein, alpha 0.017
Nptn neuroplastin 0.017
Pctk2 PCTAIRE protein kinase 2 0.017
Fam65a family with sequence similarity 65, member A 0.015
Zwint ZW10 interactor 0.015
Arf4 ADP-ribosylation factor 4 0.015
Sult5a1 sulfotransferase family 5A, member 1 0.014
Capn6 calpain 6 0.014
Igfbp5 insulin-like growth factor binding protein 5 0.014
Ubn2 ubinuclein 2 0.013
Lamc1 laminin, gamma 1 0.013
Clec11a C-type lectin domain family 11, member a 0.012
Sdcbp syndecan binding protein 0.012
Rab7a RAB7A, member RAS oncogene family 0.012
Lnpep leucyl/cystinyl aminopeptidase 0.011
Gpr176 G protein-coupled receptor 176 0.011
Hprt1 hypoxanthine phosphoribosyltransferase 1 0.011
Pax8 paired box 8 0.011
Cpne3 copine III 0.010
Col8a1 collagen, type VIII, alpha 1 0.010
LOC100362331 rCG59612-like 0.010
Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism