The network for 'establishment or maintenance of cytoskeleton polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment or maintenance of cytoskeleton polarity

Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures.

Mus musculus
Name Description Probability Func Analog Organism
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1.000
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
Kif3a kinesin family member 3A 0.908
Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 0.900
Smad4 MAD homolog 4 (Drosophila) 0.881
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.853
Raver2 ribonucleoprotein, PTB-binding 2 0.852
Rac1 RAS-related C3 botulinum substrate 1 0.850
Vhl von Hippel-Lindau tumor suppressor 0.850
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.773
Rictor RPTOR independent companion of MTOR, complex 2 0.771
Stx12 syntaxin 12 0.698
Snrpd1 small nuclear ribonucleoprotein D1 0.680
Mtpn myotrophin 0.647
Bicd2 bicaudal D homolog 2 (Drosophila) 0.635
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.612
Jarid2 jumonji, AT rich interactive domain 2 0.607
Hnrnpk heterogeneous nuclear ribonucleoprotein K 0.603
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.587
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.581
Ctnnb1 catenin (cadherin associated protein), beta 1 0.574
Apc adenomatosis polyposis coli 0.551
Csnk1a1 casein kinase 1, alpha 1 0.544
Lrrk2 leucine-rich repeat kinase 2 0.544
Dync1i2 dynein cytoplasmic 1 intermediate chain 2 0.515
Fus fusion, derived from t(12;16) malignant liposarcoma (human) 0.467
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.451
Kif3b kinesin family member 3B 0.434
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.429
Hnrnpd heterogeneous nuclear ribonucleoprotein D 0.420
Ezh1 enhancer of zeste homolog 1 (Drosophila) 0.407
Gsk3b glycogen synthase kinase 3 beta 0.388
Vapa vesicle-associated membrane protein, associated protein A 0.381
Ap2b1 adaptor-related protein complex 2, beta 1 subunit 0.359
Smad3 MAD homolog 3 (Drosophila) 0.336
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.322
Rpgrip1l Rpgrip1-like 0.310
Rptor regulatory associated protein of MTOR, complex 1 0.309
Nptn neuroplastin 0.308
Stat5a signal transducer and activator of transcription 5A 0.287
Ccdc64 coiled-coil domain containing 64 0.286
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.276
Ncoa2 nuclear receptor coactivator 2 0.273
Sfn stratifin 0.267
Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like 0.260
Prkce protein kinase C, epsilon 0.250
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.237
Pfn2 profilin 2 0.237
Thbs1 thrombospondin 1 0.235
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.225
Wdr1 WD repeat domain 1 0.217
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.206
Kif5c kinesin family member 5C 0.200
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.200
Spna2 spectrin alpha 2 0.200
Ttc7 tetratricopeptide repeat domain 7 0.197
Kifap3 kinesin-associated protein 3 0.183
Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 0.182
Rtn4 reticulon 4 0.179
Hif1a hypoxia inducible factor 1, alpha subunit 0.178
Mapkap1 mitogen-activated protein kinase associated protein 1 0.176
Gja1 gap junction protein, alpha 1 0.175
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.172
Ctnnd1 catenin (cadherin associated protein), delta 1 0.172
Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein 0.171
Rab1 RAB1, member RAS oncogene family 0.170
U2af2 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 0.169
Lmna lamin A 0.168
Bmpr1a bone morphogenetic protein receptor, type 1A 0.165
Dstn destrin 0.162
Cltc clathrin, heavy polypeptide (Hc) 0.158
Msh2 mutS homolog 2 (E. coli) 0.158
Aplp2 amyloid beta (A4) precursor-like protein 2 0.152
Msn moesin 0.151
Raver1 ribonucleoprotein, PTB-binding 1 0.150
Pparg peroxisome proliferator activated receptor gamma 0.146
Lama5 laminin, alpha 5 0.142
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.140
Trp63 transformation related protein 63 0.139
Klc1 kinesin light chain 1 0.138
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.135
Pa2g4 proliferation-associated 2G4 0.134
Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 0.132
Arf4 ADP-ribosylation factor 4 0.130
Snx6 sorting nexin 6 0.130
Stxbp1 syntaxin binding protein 1 0.128
Cyfip1 cytoplasmic FMR1 interacting protein 1 0.127
Serinc1 serine incorporator 1 0.125
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.123
Smad1 MAD homolog 1 (Drosophila) 0.122
Macf1 microtubule-actin crosslinking factor 1 0.121
Lmnb1 lamin B1 0.121
Nf2 neurofibromatosis 2 0.117
Rab10 RAB10, member RAS oncogene family 0.116
Fkbp1a FK506 binding protein 1a 0.116
Gna13 guanine nucleotide binding protein, alpha 13 0.114
Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.113
Impad1 inositol monophosphatase domain containing 1 0.113
Clic4 chloride intracellular channel 4 (mitochondrial) 0.110
Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform 0.110
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
baz bazooka 0.990
Dhc64C Dynein heavy chain 64C 0.962
Lis-1 Lissencephaly-1 0.948
sqh spaghetti squash 0.927
Cdc42 CG12530 gene product from transcript CG12530-RA 0.924
rok Rho-kinase 0.887
Eb1 CG3265 gene product from transcript CG3265-RF 0.823
Rab5 Rab-protein 5 0.695
mi minus 0.677
sqd squid 0.670
Lam Lamin 0.609
osk oskar 0.588
par-6 CG5884 gene product from transcript CG5884-RA 0.553
Src64B Src oncogene at 64B 0.550
cact cactus 0.546
shg shotgun 0.528
par-1 CG8201 gene product from transcript CG8201-RA 0.488
BicD Bicaudal D 0.460
gish gilgamesh 0.448
jar jaguar 0.358
orb oo18 RNA-binding protein 0.329
spn-F CG12114 gene product from transcript CG12114-RA 0.319
aPKC atypical protein kinase C 0.292
Atx2 Ataxin-2 0.290
vas vasa 0.278
dp dumpy 0.270
chic chickadee 0.267
msn misshapen 0.254
ovo CG6824 gene product from transcript CG6824-RE 0.254
grk gurken 0.250
capu cappuccino 0.238
klar klarsicht 0.238
Pak3 CG14895 gene product from transcript CG14895-RA 0.231
wls wntless 0.221
Abl Abl tyrosine kinase 0.214
trc tricornered 0.213
Arp66B Actin-related protein 66B 0.211
sn singed 0.191
stai stathmin 0.189
rin rasputin 0.185
Kap3 Kinesin associated protein 3 0.179
scb scab 0.170
lkb1 CG9374 gene product from transcript CG9374-RJ 0.166
cpa capping protein alpha 0.162
dsh dishevelled 0.160
Pi3K21B CG2699 gene product from transcript CG2699-RA 0.153
Tm1 Tropomyosin 1 0.153
Ras64B Ras oncogene at 64B 0.143
BicC Bicaudal C 0.137
ens ensconsin 0.135
fs(1)N female sterile (1) Nasrat 0.134
Dlic Dynein light intermediate chain 0.133
Mnt CG13316 gene product from transcript CG13316-RD 0.128
sec5 CG8843 gene product from transcript CG8843-RA 0.124
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.121
Klp64D Kinesin-like protein at 64D 0.115
Top1 Topoisomerase 1 0.115
Gdi GDP dissociation inhibitor 0.114
Apc2 Adenomatous polyposis coli tumor suppressor homolog 2 0.111
Vrp1 Verprolin 1 0.110
ea easter 0.107
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.105
Klp10A CG1453 gene product from transcript CG1453-RA 0.104
Sop2 Suppressor of profilin 2 0.101
spir spire 0.100
sax saxophone 0.100
tacc transforming acidic coiled-coil protein 0.099
Fs(2)Ket Female sterile (2) Ketel 0.098
kug kugelei 0.098
Pkn Protein kinase related to protein kinase N 0.094
nuf nuclear fallout 0.094
Rala Ras-related protein 0.093
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.092
ras raspberry 0.091
wun wunen 0.090
arm armadillo 0.090
bel belle 0.088
otk off-track 0.088
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.087
puc puckered 0.087
Cdc27 CG8610 gene product from transcript CG8610-RA 0.086
Vang Van Gogh 0.084
toc toucan 0.084
armi armitage 0.083
lic licorne 0.081
sds22 CG5851 gene product from transcript CG5851-RA 0.080
neb nebbish 0.079
pum pumilio 0.076
katanin-60 katanin 60 0.073
Rac1 CG2248 gene product from transcript CG2248-RA 0.073
Rho1 CG8416 gene product from transcript CG8416-RB 0.071
vih vihar 0.071
Jra Jun-related antigen 0.070
Upf2 CG2253 gene product from transcript CG2253-RA 0.070
Nup154 Nucleoporin 154 0.070
exu exuperantia 0.069
AGO3 Argonaute 3 0.068
shark Src homology 2, ankyrin repeat, tyrosine kinase 0.068
ttk tramtrack 0.066
flr flare 0.065
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Homo sapiens
Name Description Probability Func Analog Organism
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 1.000
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1.000
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
SFN stratifin 0.999
EIF4A3 eukaryotic translation initiation factor 4A3 0.998
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.998
GSK3B glycogen synthase kinase 3 beta 0.996
APC adenomatous polyposis coli 0.996
OCRL oculocerebrorenal syndrome of Lowe 0.996
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.993
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.982
PRKCZ protein kinase C, zeta 0.978
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.978
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.976
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.975
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 0.974
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.969
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.966
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.956
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.953
RHOA ras homolog gene family, member A 0.931
ARHGAP1 Rho GTPase activating protein 1 0.922
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.919
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.887
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.879
CLIP1 CAP-GLY domain containing linker protein 1 0.783
HNRNPF heterogeneous nuclear ribonucleoprotein F 0.766
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.758
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.744
CDC25B cell division cycle 25 homolog B (S. pombe) 0.737
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.719
AKAP11 A kinase (PRKA) anchor protein 11 0.695
ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.639
PRKCI protein kinase C, iota 0.623
KEAP1 kelch-like ECH-associated protein 1 0.618
STRADA STE20-related kinase adaptor alpha 0.597
KIF5B kinesin family member 5B 0.537
MAPRE3 microtubule-associated protein, RP/EB family, member 3 0.526
AKAP9 A kinase (PRKA) anchor protein (yotiao) 9 0.525
CHN2 chimerin (chimaerin) 2 0.519
NCF2 neutrophil cytosolic factor 2 0.510
PTBP2 polypyrimidine tract binding protein 2 0.491
KIFAP3 kinesin-associated protein 3 0.457
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.450
PRR5 proline rich 5 (renal) 0.446
MARK2 MAP/microtubule affinity-regulating kinase 2 0.441
MAPT microtubule-associated protein tau 0.441
RANBP2 RAN binding protein 2 0.438
YBX1 Y box binding protein 1 0.433
SH3RF3 SH3 domain containing ring finger 3 0.432
DCAF7 DDB1 and CUL4 associated factor 7 0.423
SET SET nuclear oncogene 0.416
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.396
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.387
TACC3 transforming, acidic coiled-coil containing protein 3 0.384
LMO2 LIM domain only 2 (rhombotin-like 1) 0.383
PCBP1 poly(rC) binding protein 1 0.371
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.370
AKT1S1 AKT1 substrate 1 (proline-rich) 0.369
HMGA1 high mobility group AT-hook 1 0.369
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.352
NIN ninein (GSK3B interacting protein) 0.348
SRPK1 SRSF protein kinase 1 0.347
XIAP X-linked inhibitor of apoptosis 0.327
KIF1B kinesin family member 1B 0.323
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.319
CBFB core-binding factor, beta subunit 0.313
HDAC4 histone deacetylase 4 0.313
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.313
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 0.304
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.291
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.290
SRSF2 serine/arginine-rich splicing factor 2 0.281
CLASP2 cytoplasmic linker associated protein 2 0.277
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.276
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.269
RAB11FIP2 RAB11 family interacting protein 2 (class I) 0.263
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.261
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 0.238
SORBS3 sorbin and SH3 domain containing 3 0.227
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.225
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.217
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.214
STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) 0.213
STK4 serine/threonine kinase 4 0.205
ADAMTSL4 ADAMTS-like 4 0.202
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.189
JUP junction plakoglobin 0.187
SRPK2 SRSF protein kinase 2 0.186
TPX2 TPX2, microtubule-associated, homolog (Xenopus laevis) 0.183
NCKAP1 NCK-associated protein 1 0.183
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.180
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.175
BAD BCL2-associated agonist of cell death 0.174
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.174
PKP3 plakophilin 3 0.169
ITGB4 integrin, beta 4 0.166
RAB14 RAB14, member RAS oncogene family 0.163
LAD1 ladinin 1 0.156
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
TOR2 Tor2p 0.567
SLM1 Slm1p 0.485
YPK1 Ypk1p 0.423
TSC11 Tsc11p 0.409
SLM2 Slm2p 0.337
AVO1 Avo1p 0.167
RHO1 Rho1p 0.129
MOB1 Mob1p 0.077
ROM2 Rom2p 0.075
TOR1 Tor1p 0.056
BIT2 Bit2p 0.044
DBF20 Dbf20p 0.041
PEF1 Pef1p 0.040
LST8 Lst8p 0.031
YER064C hypothetical protein 0.030
MSS4 Mss4p 0.028
SGE1 Sge1p 0.028
MOB2 Mob2p 0.027
RDI1 Rdi1p 0.026
BIT61 Bit61p 0.022
TCO89 Tco89p 0.022
PRS2 Prs2p 0.022
SRD1 Srd1p 0.021
TAO3 Tao3p 0.021
BIG1 Big1p 0.020
GYL1 Gyl1p 0.020
SHE2 She2p 0.019
YLR162W hypothetical protein 0.019
LEU2 Leu2p 0.018
YLR264C-A hypothetical protein 0.018
YOL038C-A hypothetical protein 0.017
KRE9 Kre9p 0.017
MER1 Mer1p 0.017
KIC1 Kic1p 0.017
ARP10 Arp10p 0.016
THG1 Thg1p 0.016
YLR042C hypothetical protein 0.015
HLJ1 Hlj1p 0.015
MF(ALPHA)2 Mf(alpha)2p 0.015
URA3 Ura3p 0.015
YIL151C hypothetical protein 0.014
SPL2 Spl2p 0.014
YIR035C hypothetical protein 0.014
YMR295C hypothetical protein 0.014
YNL058C hypothetical protein 0.014
IML1 Iml1p 0.014
TSC3 Tsc3p 0.013
YAR068W hypothetical protein 0.013
YFR039C hypothetical protein 0.013
CHA1 Cha1p 0.013
ARO10 Aro10p 0.013
YLR108C hypothetical protein 0.013
CUP1-1 Cup1-1p 0.013
HXT3 Hxt3p 0.013
ATP6 Atp6p 0.013
YCH1 Ych1p 0.013
ARG8 Arg8p 0.013
RIO2 Rio2p 0.013
MF(ALPHA)1 Mf(alpha)1p 0.013
YBR013C hypothetical protein 0.013
UPS3 Ups3p 0.012
CRP1 Crp1p 0.012
AUA1 Aua1p 0.012
SEC72 Sec72p 0.012
CPD1 Cpd1p 0.012
ZPS1 Zps1p 0.012
DIC1 Dic1p 0.012
SWC7 Swc7p 0.012
OPT2 Opt2p 0.012
HPF1 Hpf1p 0.012
PFS1 Pfs1p 0.012
SCM4 Scm4p 0.012
YPR157W hypothetical protein 0.012
REE1 Ree1p 0.012
MYO1 Myo1p 0.011
YJL181W hypothetical protein 0.011
RHO4 Rho4p 0.011
INN1 Inn1p 0.011
SRX1 Srx1p 0.011
PCL9 Pcl9p 0.011
YOL013W-A hypothetical protein 0.011
DUR1,2 Dur1,2p 0.011
SWT1 Swt1p 0.011
IZH4 Izh4p 0.011
ARO9 Aro9p 0.011
AQY2 Aqy2p 0.011
SKS1 Sks1p 0.011
BNA4 Bna4p 0.011
MSB4 Msb4p 0.011
ERT1 Ert1p 0.011
ICS2 Ics2p 0.011
DUR3 Dur3p 0.011
FMT1 Fmt1p 0.011
ALT2 Alt2p 0.010
CDC15 Cdc15p 0.010
YKR075C hypothetical protein 0.010
YLL053C hypothetical protein 0.010
NCE103 Nce103p 0.010
RNP1 Rnp1p 0.010
YJL218W hypothetical protein 0.010