The network for 'dna catabolic process endonucleolytic' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna catabolic process endonucleolytic

The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.

Mus musculus
Name Description Probability Func Analog Organism
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.969
Dffb DNA fragmentation factor, beta subunit 0.847
Gbp5 guanylate binding protein 5 0.831
Pycard PYD and CARD domain containing 0.795
Casp1 caspase 1 0.705
Aim2 absent in melanoma 2 0.567
Il18 interleukin 18 0.360
Rb1 retinoblastoma 1 0.343
Tlr4 toll-like receptor 4 0.248
Apaf1 apoptotic peptidase activating factor 1 0.192
Fadd Fas (TNFRSF6)-associated via death domain 0.168
Bak1 BCL2-antagonist/killer 1 0.137
Brca1 breast cancer 1 0.133
Plin1 perilipin 1 0.116
Pms2 postmeiotic segregation increased 2 (S. cerevisiae) 0.089
Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.081
Ints7 integrator complex subunit 7 0.081
Cox5a cytochrome c oxidase, subunit Va 0.079
Uqcrb ubiquinol-cytochrome c reductase binding protein 0.077
Wrn Werner syndrome homolog (human) 0.076
Hells helicase, lymphoid specific 0.076
Cidec cell death-inducing DFFA-like effector c 0.070
Drosha drosha, ribonuclease type III 0.068
Nlrp3 NLR family, pyrin domain containing 3 0.066
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.065
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.065
Bid BH3 interacting domain death agonist 0.064
Ndufab1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 0.063
Uqcrc2 ubiquinol cytochrome c reductase core protein 2 0.063
Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) 0.063
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.062
Il1b interleukin 1 beta 0.061
Tgfbr2 transforming growth factor, beta receptor II 0.056
Hif1a hypoxia inducible factor 1, alpha subunit 0.055
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.053
Alx1 ALX homeobox 1 0.052
Ripk3 receptor-interacting serine-threonine kinase 3 0.051
Mcm10 minichromosome maintenance deficient 10 (S. cerevisiae) 0.048
Stk11 serine/threonine kinase 11 0.047
Mlh1 mutL homolog 1 (E. coli) 0.046
Casp8 caspase 8 0.046
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.045
Rbl1 retinoblastoma-like 1 (p107) 0.043
Ints9 integrator complex subunit 9 0.041
Idua iduronidase, alpha-L- 0.041
Gcsh glycine cleavage system protein H (aminomethyl carrier) 0.041
Plk4 polo-like kinase 4 (Drosophila) 0.039
Xpa xeroderma pigmentosum, complementation group A 0.039
Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A 0.037
Fancd2 Fanconi anemia, complementation group D2 0.035
Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.033
Plin4 perilipin 4 0.033
Mybl2 myeloblastosis oncogene-like 2 0.033
Vdac3 voltage-dependent anion channel 3 0.032
Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.032
Cfd complement factor D (adipsin) 0.031
Casp3 caspase 3 0.031
Ndufa12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 0.030
Ndufa5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.030
U2af1 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 0.029
Srsf9 serine/arginine-rich splicing factor 9 0.029
Cbx7 chromobox homolog 7 0.028
Apobec1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 0.028
Mrpl13 mitochondrial ribosomal protein L13 0.027
Sod2 superoxide dismutase 2, mitochondrial 0.027
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.026
Tmpo thymopoietin 0.026
Hdac1 histone deacetylase 1 0.025
Trip13 thyroid hormone receptor interactor 13 0.025
Clic1 chloride intracellular channel 1 0.025
Prim2 DNA primase, p58 subunit 0.024
Nudt1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.023
Casp7 caspase 7 0.023
Dhfr dihydrofolate reductase 0.023
Commd4 COMM domain containing 4 0.023
Adig adipogenin 0.023
Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein 0.022
Taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.022
Atr ataxia telangiectasia and Rad3 related 0.022
Cycs cytochrome c, somatic 0.022
Pola1 polymerase (DNA directed), alpha 1 0.022
Safb scaffold attachment factor B 0.022
Orc1 origin recognition complex, subunit 1 0.022
Fancm Fanconi anemia, complementation group M 0.022
Mastl microtubule associated serine/threonine kinase-like 0.021
Atp5f1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 0.021
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.021
Mcm8 minichromosome maintenance deficient 8 (S. cerevisiae) 0.021
Ppara peroxisome proliferator activated receptor alpha 0.021
Dtl denticleless homolog (Drosophila) 0.020
Chek2 CHK2 checkpoint homolog (S. pombe) 0.020
Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.020
Cops7b COP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana) 0.020
Mms22l MMS22-like, DNA repair protein 0.020
Mre11a meiotic recombination 11 homolog A (S. cerevisiae) 0.020
Prdx1 peroxiredoxin 1 0.020
Hhat hedgehog acyltransferase 0.020
Gfm1 G elongation factor, mitochondrial 1 0.019
Rad54l RAD54 like (S. cerevisiae) 0.019
Nthl1 nth (endonuclease III)-like 1 (E.coli) 0.019
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.016
l(2)gl lethal (2) giant larvae 0.014
eIF-4E Eukaryotic initiation factor 4E 0.013
Dl Delta 0.012
N Notch 0.011
aux auxillin 0.011
tgo tango 0.011
Tor Target of rapamycin 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.942
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.866
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.820
EXOSC3 exosome component 3 0.814
BCL2 B-cell CLL/lymphoma 2 0.693
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 0.589
EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) 0.586
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.474
BAK1 BCL2-antagonist/killer 1 0.468
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.339
BCL2L1 BCL2-like 1 0.320
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.291
BAX BCL2-associated X protein 0.264
EXOSC2 exosome component 2 0.247
POU5F1 POU class 5 homeobox 1 0.227
RAD51L1 RAD51-like 1 (S. cerevisiae) 0.224
BRCA1 breast cancer 1, early onset 0.219
EXOSC7 exosome component 7 0.194
H2AFX H2A histone family, member X 0.170
EXOSC4 exosome component 4 0.169
APAF1 apoptotic peptidase activating factor 1 0.160
DIS3L DIS3 mitotic control homolog (S. cerevisiae)-like 0.149
MSH6 mutS homolog 6 (E. coli) 0.146
DIS3 DIS3 mitotic control homolog (S. cerevisiae) 0.136
FANCD2 Fanconi anemia, complementation group D2 0.121
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.115
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.113
ERCC4 excision repair cross-complementing rodent repair deficiency, complementation group 4 0.112
EXOSC9 exosome component 9 0.108
C20orf94 chromosome 20 open reading frame 94 0.102
EXOSC1 exosome component 1 0.101
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.086
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.072
RAD50 RAD50 homolog (S. cerevisiae) 0.069
LIG4 ligase IV, DNA, ATP-dependent 0.064
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.063
XIAP X-linked inhibitor of apoptosis 0.059
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.057
C19orf39 chromosome 19 open reading frame 39 0.056
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.054
BRCA2 breast cancer 2, early onset 0.054
BID BH3 interacting domain death agonist 0.054
NBN nibrin 0.051
MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.050
TERF2 telomeric repeat binding factor 2 0.047
TNRC6A trinucleotide repeat containing 6A 0.047
EXOSC5 exosome component 5 0.046
C4orf14 chromosome 4 open reading frame 14 0.042
EXOSC10 exosome component 10 0.040
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.038
EXOSC8 exosome component 8 0.037
XAB2 XPA binding protein 2 0.035
ZSWIM7 zinc finger, SWIM-type containing 7 0.034
BAD BCL2-associated agonist of cell death 0.033
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.032
PRMT6 protein arginine methyltransferase 6 0.032
RAD18 RAD18 homolog (S. cerevisiae) 0.030
RBL2 retinoblastoma-like 2 (p130) 0.030
H3F3C H3 histone, family 3C 0.029
MUS81 MUS81 endonuclease homolog (S. cerevisiae) 0.028
RPA1 replication protein A1, 70kDa 0.028
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 0.028
ERCC1 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) 0.028
MDC1 mediator of DNA-damage checkpoint 1 0.026
BBC3 BCL2 binding component 3 0.026
RNR2 l-rRNA 0.025
RNF144B ring finger protein 144B 0.025
PALB2 partner and localizer of BRCA2 0.024
E2F1 E2F transcription factor 1 0.023
SOX2 SRY (sex determining region Y)-box 2 0.023
CDT1 chromatin licensing and DNA replication factor 1 0.023
TP53 tumor protein p53 0.023
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.023
ERCC6 excision repair cross-complementing rodent repair deficiency, complementation group 6 0.022
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.022
TNRC6C trinucleotide repeat containing 6C 0.022
PARP2 poly (ADP-ribose) polymerase 2 0.022
BIK BCL2-interacting killer (apoptosis-inducing) 0.022
RBL1 retinoblastoma-like 1 (p107) 0.021
BLM Bloom syndrome, RecQ helicase-like 0.020
AR androgen receptor 0.020
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.020
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.019
ATM ataxia telangiectasia mutated 0.019
HUWE1 HECT, UBA and WWE domain containing 1 0.019
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.019
RAD52 RAD52 homolog (S. cerevisiae) 0.019
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.018
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 0.018
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.018
TARBP2 TAR (HIV-1) RNA binding protein 2 0.018
MSH3 mutS homolog 3 (E. coli) 0.018
XPC xeroderma pigmentosum, complementation group C 0.017
WRN Werner syndrome, RecQ helicase-like 0.017
TNRC6B trinucleotide repeat containing 6B 0.017
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.017
TERF2IP telomeric repeat binding factor 2, interacting protein 0.017
BECN1 beclin 1, autophagy related 0.016
ONECUT1 one cut homeobox 1 0.016
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.015
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RAD1 Rad1p 0.884
MSH2 Msh2p 0.602
RAD14 Rad14p 0.169
RAD10 Rad10p 0.149
MSH3 Msh3p 0.109
SAW1 Saw1p 0.092
EXO1 Exo1p 0.047
DOT1 Dot1p 0.034
POL32 Pol32p 0.033
RAD5 Rad5p 0.029
MSH6 Msh6p 0.028
PSO2 Pso2p 0.027
YLR264C-A hypothetical protein 0.027
RAD53 Rad53p 0.026
SEN1 Sen1p 0.026
SRD1 Srd1p 0.025
YIR035C hypothetical protein 0.023
LEU2 Leu2p 0.021
RAD59 Rad59p 0.021
YAR068W hypothetical protein 0.021
YLR162W hypothetical protein 0.021
APN1 Apn1p 0.021
RAD18 Rad18p 0.021
YOL038C-A hypothetical protein 0.020
URA3 Ura3p 0.020
MER1 Mer1p 0.020
YOR342C hypothetical protein 0.019
ARG8 Arg8p 0.019
GYL1 Gyl1p 0.018
MEX67 Mex67p 0.018
CUP1-1 Cup1-1p 0.018
SLX4 Slx4p 0.017
ARP10 Arp10p 0.017
HO Hop 0.017
DBP5 Dbp5p 0.017
YLR042C hypothetical protein 0.017
RAD54 Rad54p 0.017
POL2 Pol2p 0.017
MUS81 Mus81p 0.016
HXT3 Hxt3p 0.016
RPS6A Rps6ap 0.016
POL30 Pol30p 0.016
YBR013C hypothetical protein 0.016
YAR066W hypothetical protein 0.016
ATP6 Atp6p 0.015
POL31 Pol31p 0.015
URA6 Ura6p 0.015
YPR157W hypothetical protein 0.015
YGR035C hypothetical protein 0.015
YOL013W-A hypothetical protein 0.014
ZPS1 Zps1p 0.014
SAE2 Sae2p 0.014
CPD1 Cpd1p 0.014
SMM1 Smm1p 0.014
MF(ALPHA)2 Mf(alpha)2p 0.014
HST3 Hst3p 0.014
SUT2 Sut2p 0.014
RPS5 Rps5p 0.014
XRS2 Xrs2p 0.014
BSC1 Bsc1p 0.014
SPL2 Spl2p 0.014
HPF1 Hpf1p 0.014
AUA1 Aua1p 0.013
SCM4 Scm4p 0.013
RAD17 Rad17p 0.013
SSL2 Ssl2p 0.013
FMT1 Fmt1p 0.013
IZH4 Izh4p 0.013
CSL4 Csl4p 0.013
YPR096C hypothetical protein 0.013
YHB1 Yhb1p 0.013
UPS3 Ups3p 0.013
OPT2 Opt2p 0.012
ALT2 Alt2p 0.012
TPC1 Tpc1p 0.012
CCA1 Cca1p 0.012
ARR2 Arr2p 0.012
YIL151C hypothetical protein 0.012
YLR040C hypothetical protein 0.012
TYE7 Tye7p 0.012
DIC1 Dic1p 0.012
TIR3 Tir3p 0.012
YAL037C-A hypothetical protein 0.012
COS12 Cos12p 0.012
RPS2 Rps2p 0.012
MMS21 Mms21p 0.012
YBL044W hypothetical protein 0.012
RMI1 Rmi1p 0.012
HDA2 Hda2p 0.012
YMR317W hypothetical protein 0.012
NRG2 Nrg2p 0.011
YKR075C hypothetical protein 0.011
YOL014W hypothetical protein 0.011
DUR1,2 Dur1,2p 0.011
YJL181W hypothetical protein 0.011
RRP45 Rrp45p 0.011
PTR2 Ptr2p 0.011
REE1 Ree1p 0.011
PRS2 Prs2p 0.011
CAR1 Car1p 0.011