The network for 'positive regulation of gtp catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of gtp catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate.

Mus musculus
Name Description Probability Func Analog Organism
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.987
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.969
Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 0.962
Hmha1 histocompatibility (minor) HA-1 0.954
Arrb2 arrestin, beta 2 0.948
Grb2 growth factor receptor bound protein 2 0.942
Rac1 RAS-related C3 botulinum substrate 1 0.919
Vav1 vav 1 oncogene 0.899
Braf Braf transforming gene 0.858
Bcl2 B-cell leukemia/lymphoma 2 0.840
Selplg selectin, platelet (p-selectin) ligand 0.840
Plxnb1 plexin B1 0.827
Wipf1 WAS/WASL interacting protein family, member 1 0.820
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.814
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.798
Cd37 CD37 antigen 0.783
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.774
Gpsm3 G-protein signalling modulator 3 (AGS3-like, C. elegans) 0.736
Ntf3 neurotrophin 3 0.733
Nf1 neurofibromatosis 1 0.726
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.724
Bax BCL2-associated X protein 0.711
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.700
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.697
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.688
Plxnd1 plexin D1 0.685
Epha1 Eph receptor A1 0.676
Efnb2 ephrin B2 0.658
Arhgap30 Rho GTPase activating protein 30 0.644
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.642
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.641
Laptm5 lysosomal-associated protein transmembrane 5 0.633
Dennd4b DENN/MADD domain containing 4B 0.632
Plxna1 plexin A1 0.624
Git1 G protein-coupled receptor kinase-interactor 1 0.608
Dock2 dedicator of cyto-kinesis 2 0.608
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.605
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.567
Cbl Casitas B-lineage lymphoma 0.563
Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent 0.539
Epha4 Eph receptor A4 0.538
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.536
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.536
Nckap1l NCK associated protein 1 like 0.524
Coro1a coronin, actin binding protein 1A 0.515
Rasa3 RAS p21 protein activator 3 0.513
Dlg4 discs, large homolog 4 (Drosophila) 0.509
Was Wiskott-Aldrich syndrome homolog (human) 0.506
Sox10 SRY-box containing gene 10 0.504
Eps15 epidermal growth factor receptor pathway substrate 15 0.492
Plekho2 pleckstrin homology domain containing, family O member 2 0.460
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.458
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.455
Mkl1 MKL (megakaryoblastic leukemia)/myocardin-like 1 0.453
Sash3 SAM and SH3 domain containing 3 0.451
Ppp1r9b protein phosphatase 1, regulatory subunit 9B 0.450
Fmnl1 formin-like 1 0.447
Drd2 dopamine receptor D2 0.444
Adrbk1 adrenergic receptor kinase, beta 1 0.444
Plekho1 pleckstrin homology domain containing, family O member 1 0.441
Kl klotho 0.437
Prkcd protein kinase C, delta 0.426
Rgl2 ral guanine nucleotide dissociation stimulator-like 2 0.423
Src Rous sarcoma oncogene 0.417
Rasgrp1 RAS guanyl releasing protein 1 0.417
Prkcc protein kinase C, gamma 0.415
Bcr breakpoint cluster region 0.409
Irf5 interferon regulatory factor 5 0.401
Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.400
Nrbp2 nuclear receptor binding protein 2 0.392
Wnt7a wingless-related MMTV integration site 7A 0.386
Sirpa signal-regulatory protein alpha 0.385
Rasgrp2 RAS, guanyl releasing protein 2 0.385
Vav3 vav 3 oncogene 0.384
Sh3bp1 SH3-domain binding protein 1 0.383
Pnpla2 patatin-like phospholipase domain containing 2 0.382
Marcks myristoylated alanine rich protein kinase C substrate 0.377
Hcls1 hematopoietic cell specific Lyn substrate 1 0.371
Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.367
Ncf1 neutrophil cytosolic factor 1 0.356
Myo1f myosin IF 0.355
Rasal3 RAS protein activator like 3 0.353
Tcfcp2l1 transcription factor CP2-like 1 0.350
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.337
Prkd2 protein kinase D2 0.336
Lsp1 lymphocyte specific 1 0.334
Ilk integrin linked kinase 0.331
Arhgap21 Rho GTPase activating protein 21 0.331
Rtkn rhotekin 0.327
Tgfa transforming growth factor alpha 0.325
Sipa1 signal-induced proliferation associated gene 1 0.324
Arhgap9 Rho GTPase activating protein 9 0.317
Mprip myosin phosphatase Rho interacting protein 0.310
Dnm1 dynamin 1 0.304
Srgap2 SLIT-ROBO Rho GTPase activating protein 2 0.303
Lepr leptin receptor 0.302
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.302
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.299
Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.299
Pxn paxillin 0.298
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
CELE_F47G4.4 Protein F47G4.4 0.206
rme-4 Protein RME-4 0.129
sem-5 Protein SEM-5 0.117
sad-1 Protein SAD-1 0.117
unc-26 Protein UNC-26 0.090
plc-3 Protein PLC-3 0.090
itr-1 Protein ITR-1 0.087
abts-1 Protein ABTS-1 0.086
rpm-1 Protein RPM-1 0.085
T19A5.1 Protein T19A5.1 0.079
mpk-1 Protein MPK-1 0.073
goa-1 Protein GOA-1 0.073
rig-6 Protein RIG-6 0.069
rgl-1 Protein RGL-1 0.063
lag-1 Protein LAG-1 0.060
CELE_W07A8.2 Protein W07A8.2 0.060
C11E4.6 Protein C11E4.6 0.057
F28B3.1 Protein F28B3.1 0.056
unc-79 Protein UNC-79 0.056
lin-45 Protein LIN-45 0.054
snf-1 Protein SNF-1 0.054
egrh-1 Protein EGRH-1 0.052
flh-2 Protein FLH-2 0.052
F52G3.1 Protein F52G3.1 0.051
nrx-1 Protein NRX-1 0.048
tag-341 Protein TAG-341 0.047
stau-1 Protein STAU-1 0.045
lin-48 Protein LIN-48 0.045
egl-8 Protein EGL-8 0.045
pme-5 Protein PME-5 0.044
eor-2 Protein EOR-2 0.043
magi-1 Protein MAGI-1 0.042
syd-1 Protein SYD-1 0.041
pqn-62 Protein PQN-62 0.040
unc-71 Protein UNC-71 0.040
abl-1 Protein ABL-1 0.038
sup-17 Protein SUP-17 0.037
nhr-6 Protein NHR-6 0.037
ric-8 Protein RIC-8 0.036
afd-1 Protein AFD-1 0.035
unc-53 Protein UNC-53 0.035
rps-2 Protein RPS-2 0.035
sav-1 Protein SAV-1 0.034
egl-36 Protein EGL-36 0.034
vhp-1 Protein VHP-1 0.032
unc-54 Protein UNC-54 0.031
CELE_T10D4.6 Protein T10D4.6 0.031
zfp-3 Protein ZFP-3 0.029
smp-1 Protein SMP-1 0.029
ptp-4 Protein PTP-4 0.029
cyld-1 Protein CYLD-1 0.028
pps-1 Protein PPS-1 0.028
zyg-9 Protein ZYG-9 0.028
T28B11.1 Protein T28B11.1 0.028
frm-3 Protein FRM-3 0.027
pak-1 Protein PAK-1 0.026
arx-1 Protein ARX-1 0.026
let-60 Protein LET-60 0.026
gly-7 Protein GLY-7 0.026
hpk-1 Protein HPK-1 0.026
plc-1 Protein PLC-1 0.026
mei-1 Protein MEI-1 0.025
pqn-39 Protein PQN-39 0.025
H06I04.1 Protein H06I04.1 0.025
CELE_T26A8.4 Protein T26A8.4 0.025
unc-14 Protein UNC-14 0.025
elt-6 Protein ELT-6 0.024
cdh-9 Protein CDH-9 0.024
dnj-25 Protein DNJ-25 0.024
sma-9 Protein SMA-9 0.024
esyt-2 Protein ESYT-2 0.024
morc-1 Protein MORC-1 0.024
C15H9.5 Protein C15H9.5 0.024
CELE_Y53F4B.4 Protein Y53F4B.4 0.023
T04F8.6 Protein T04F8.6 0.023
gei-4 Protein GEI-4 0.023
rsbp-1 Protein RSBP-1 0.023
coh-3 Protein COH-3 0.023
cah-6 Protein CAH-6 0.023
sam-10 Protein SAM-10 0.023
cogc-4 Protein COGC-4 0.022
eat-16 Protein EAT-16 0.022
pig-1 Protein PIG-1 0.022
ptp-1 Protein PTP-1 0.022
unc-31 Protein UNC-31 0.022
mig-15 Protein MIG-15 0.022
sym-4 Protein SYM-4 0.022
sto-4 Protein STO-4 0.022
unc-16 Protein UNC-16 0.022
zoo-1 Protein ZOO-1 0.022
ttx-1 Protein TTX-1 0.021
tpxl-1 Protein TPXL-1 0.021
CELE_M01B12.4 Protein M01B12.4 0.021
pat-3 Protein PAT-3 0.021
tag-232 Protein TAG-232 0.021
gsa-1 Protein GSA-1 0.021
unc-15 Protein UNC-15 0.021
gei-8 Protein GEI-8 0.021
apd-3 Protein APD-3 0.021
CELE_T20F10.5 Protein T20F10.5 0.020
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.518
bida BH3 interacting domain death agonist 0.383
si:ch211-232m7.1 si:ch211-232m7.1 0.352
mcl1b myeloid cell leukemia sequence 1b 0.351
bcl2 B-cell leukemia/lymphoma 2 0.305
cnn2 calponin 2 0.301
nf1a neurofibromin 1a 0.278
mcl1a myeloid cell leukemia sequence 1a 0.257
tpm4 tropomyosin 4 0.234
adrb2a adrenergic receptor, beta 2a 0.221
baxa bcl2-associated X protein, a 0.215
rtcd1 RNA terminal phosphate cyclase domain 1 0.203
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.201
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.197
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.194
tm9sf2 transmembrane 9 superfamily member 2 0.188
msna moesin a 0.180
rhag Rhesus blood group-associated glycoprotein 0.149
nf1b neurofibromin 1b 0.147
lmo3 LIM domain only 3 0.131
cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.128
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.127
ampd3 adenosine monophosphate deaminase 3 0.126
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.126
iqgap1 IQ motif containing GTPase activating protein 1 0.122
acsl4a acyl-CoA synthetase long-chain family member 4a 0.122
ilk integrin linked kinase 0.118
LOC565839 tumor necrosis factor alpha-induced protein 2-like 0.113
kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.106
irx1b iroquois homeobox protein 1, b 0.105
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.103
stc1l stanniocalcin 1, like 0.093
icn ictacalcin 0.092
anxa2a annexin A2a 0.090
casz1 castor zinc finger 1 0.090
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.087
gsna gelsolin a 0.085
pdlim1 PDZ and LIM domain 1 (elfin) 0.084
yrk Yes-related kinase 0.082
zgc:77517 zgc:77517 0.081
yap1 Yes-associated protein 1 0.080
dedd1 death effector domain-containing 1 0.078
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.076
ptgs2a prostaglandin-endoperoxide synthase 2a 0.075
dzip1 DAZ interacting protein 1 0.074
si:ch211-102c2.6 si:ch211-102c2.6 0.072
tsc22d3 TSC22 domain family, member 3 0.072
depdc1a DEP domain containing 1a 0.072
ckmt1 creatine kinase, mitochondrial 1 0.071
calcrla calcitonin receptor-like a 0.071
rcn1 reticulocalbin 1, EF-hand calcium binding domain 0.071
pak2a p21 (CDKN1A)-activated kinase 2a 0.069
LOC100331639 hypothetical protein LOC100331639 0.069
sox19a SRY-box containing gene 19a 0.067
sox4a SRY-box containing gene 4a 0.067
adrb3a adrenergic receptor, beta 3a 0.067
akt2 v-akt murine thymoma viral oncogene homolog 2 0.066
gro2 groucho 2 0.066
gng12a guanine nucleotide binding protein (G protein), gamma 12a 0.065
rtn1b reticulon 1b 0.065
pparg peroxisome proliferator activated receptor gamma 0.064
zgc:153997 zgc:153997 0.064
zgc:85727 zgc:85727 0.064
cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.063
unc5b unc-5 homolog B (C. elegans) 0.063
zgc:56116 zgc:56116 0.062
zgc:152984 zgc:152984 0.062
sox7 SRY-box containing gene 7 0.061
tagln2 transgelin 2 0.060
slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 0.060
arpc5a actin related protein 2/3 complex, subunit 5A 0.060
hs3st1l2 heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 2 0.060
tie2 endothelium-specific receptor tyrosine kinase 2 0.059
chac1 ChaC, cation transport regulator-like 1 0.059
rps6ka3a ribosomal protein S6 kinase, polypeptide 3a 0.059
gna14 guanine nucleotide binding protein (G protein), alpha 14 0.059
foxj1b forkhead box J1b 0.058
s100v2 S100 calcium binding protein V2 0.058
tbeta-a beta thymosin-like protein 2 0.058
ankrd6 ankyrin repeat domain 6 0.057
mcm6 MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae) 0.057
zbtb4 zinc finger and BTB domain containing 4 0.056
nrarpa notch-regulated ankyrin repeat protein a 0.056
efna1b ephrin A1b 0.055
zgc:112329 zgc:112329 0.055
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.055
eprs glutamyl-prolyl-tRNA synthetase 0.054
epb4.1l4 erythrocyte protein band 4.1-like 4 0.054
ptrfb polymerase I and transcript release factor b 0.054
smyd3 SET and MYND domain containing 3 0.053
boka BCL2-related ovarian killer a 0.053
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.053
tipin timeless interacting protein 0.053
tmem126a transmembrane protein 126A 0.053
ap3m2 adaptor-related protein complex 3, mu 2 subunit 0.053
s1pr1 sphingosine-1-phosphate receptor 1 0.053
ube2d1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.053
pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.053
tuba8l tubulin, alpha 8 like 0.052
jun jun proto-oncogene 0.052
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
rok Rho-kinase 0.798
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.697
Pten CG5671 gene product from transcript CG5671-RB 0.603
dos daughter of sevenless 0.571
RhoBTB CG5701 gene product from transcript CG5701-RA 0.405
cta concertina 0.399
Fak56D Focal Adhesion Kinase 0.319
cno canoe 0.318
Stat92E Signal-transducer and activator of transcription protein at 92E 0.307
plexB plexin B 0.307
Wnk CG7177 gene product from transcript CG7177-RA 0.294
mbt mushroom bodies tiny 0.285
mbc myoblast city 0.272
raps rapsynoid 0.258
puc puckered 0.254
Pkn Protein kinase related to protein kinase N 0.252
Caps Calcium activated protein for secretion 0.239
G-oalpha47A G protein oalpha 47A 0.234
smo smoothened 0.230
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.216
stg string 0.208
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.202
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.195
lgs legless 0.190
Abi Abelson interacting protein 0.190
neuroligin CG13772 gene product from transcript CG13772-RA 0.168
NaCP60E Na channel protein 60E 0.167
stai stathmin 0.167
rl rolled 0.155
pod1 CG4532 gene product from transcript CG4532-RF 0.131
Smg1 CG32743 gene product from transcript CG32743-RA 0.129
ken ken and barbie 0.126
unc-104 CG8566 gene product from transcript CG8566-RB 0.126
cenG1A centaurin gamma 1A 0.120
CG8155 CG8155 gene product from transcript CG8155-RA 0.119
siz schizo 0.115
LIMK1 LIM-kinase1 0.114
Myo31DF Myosin 31DF 0.114
CG2991 CG2991 gene product from transcript CG2991-RA 0.112
ptc patched 0.112
sima similar 0.111
Prp31 CG6876 gene product from transcript CG6876-RA 0.110
CG4853 CG4853 gene product from transcript CG4853-RA 0.108
neur neuralized 0.107
Dhc64C Dynein heavy chain 64C 0.105
Ephrin CG1862 gene product from transcript CG1862-RA 0.102
CG1968 CG1968 gene product from transcript CG1968-RB 0.102
frc fringe connection 0.101
l(2)k16918 lethal (2) k16918 0.097
Su(H) Suppressor of Hairless 0.094
sev sevenless 0.090
drk downstream of receptor kinase 0.089
rap retina aberrant in pattern 0.088
bif bifocal 0.088
mys myospheroid 0.087
CG17233 CG17233 gene product from transcript CG17233-RA 0.082
CG9426 CG9426 gene product from transcript CG9426-RA 0.081
CG8334 CG8334 gene product from transcript CG8334-RA 0.080
DAAM Dishevelled Associated Activator of Morphogenesis 0.079
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.076
Graf CG8948 gene product from transcript CG8948-RB 0.076
gek genghis khan 0.075
CG9941 CG9941 gene product from transcript CG9941-RA 0.075
Vps35 Vacuolar protein sorting 35 0.074
Vps45 Vacuolar protein sorting 45 0.074
garz gartenzwerg 0.074
sec6 CG5341 gene product from transcript CG5341-RA 0.072
CG1233 CG1233 gene product from transcript CG1233-RB 0.071
tutl turtle 0.071
Hr96 Hormone receptor-like in 96 0.069
alpha-Man-IIb CG4606 gene product from transcript CG4606-RA 0.069
CG6509 CG6509 gene product from transcript CG6509-RB 0.069
cdm cadmus 0.068
aux auxillin 0.066
Flo-2 flotillin 2 0.065
trio CG18214 gene product from transcript CG18214-RA 0.064
NELF-A CG5874 gene product from transcript CG5874-RA 0.064
CG7158 CG7158 gene product from transcript CG7158-RA 0.064
Med Medea 0.064
yata CG1973 gene product from transcript CG1973-RA 0.062
nej nejire 0.062
Gug Grunge 0.062
N Notch 0.062
Apc APC-like 0.059
pgant3 polypeptide GalNAc transferase 3 0.056
p130CAS CG1212 gene product from transcript CG1212-RA 0.055
Rheb CG1081 gene product from transcript CG1081-RA 0.055
Sbf SET domain binding factor 0.055
Ptpmeg CG1228 gene product from transcript CG1228-RD 0.055
gogo golden goal 0.054
Khc-73 Kinesin-73 0.054
Dab Disabled 0.052
sgl sugarless 0.052
Drl-2 Derailed 2 0.050
Hnf4 Hepatocyte nuclear factor 4 0.050
Rho1 CG8416 gene product from transcript CG8416-RB 0.049
ex expanded 0.049
Sos Son of sevenless 0.049
Smox Smad on X 0.049
Mbs Myosin binding subunit 0.048
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.998
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.996
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.992
PTK2 PTK2 protein tyrosine kinase 2 0.991
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.989
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.988
ARRB1 arrestin, beta 1 0.985
SFN stratifin 0.973
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.972
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.970
BCAR1 breast cancer anti-estrogen resistance 1 0.964
SH3RF1 SH3 domain containing ring finger 1 0.959
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.958
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.953
GSK3B glycogen synthase kinase 3 beta 0.951
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.930
ITSN1 intersectin 1 (SH3 domain protein) 0.924
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.922
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.919
RHOA ras homolog gene family, member A 0.911
TRAF1 TNF receptor-associated factor 1 0.910
NCF2 neutrophil cytosolic factor 2 0.866
S100A8 S100 calcium binding protein A8 0.858
EGFR epidermal growth factor receptor 0.854
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.844
SH3BP2 SH3-domain binding protein 2 0.836
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 0.823
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.818
S100A11 S100 calcium binding protein A11 0.814
TSC2 tuberous sclerosis 2 0.804
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.800
S100B S100 calcium binding protein B 0.790
BBS10 Bardet-Biedl syndrome 10 0.774
FMNL1 formin-like 1 0.755
GRB10 growth factor receptor-bound protein 10 0.743
ABI1 abl-interactor 1 0.728
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.726
NCKAP1 NCK-associated protein 1 0.723
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.722
CCR5 chemokine (C-C motif) receptor 5 0.710
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.710
RACGAP1 Rac GTPase activating protein 1 0.709
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.700
ILK integrin-linked kinase 0.699
SOS1 son of sevenless homolog 1 (Drosophila) 0.692
S100A9 S100 calcium binding protein A9 0.687
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.687
S100A6 S100 calcium binding protein A6 0.684
ZMYND11 zinc finger, MYND-type containing 11 0.674
DNM1 dynamin 1 0.666
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.665
GRB7 growth factor receptor-bound protein 7 0.647
EXOSC3 exosome component 3 0.641
MYO9B myosin IXB 0.638
SYNJ1 synaptojanin 1 0.633
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.623
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.586
EZR ezrin 0.585
NCK2 NCK adaptor protein 2 0.576
PKN3 protein kinase N3 0.574
PLCG1 phospholipase C, gamma 1 0.568
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.566
DOCK1 dedicator of cytokinesis 1 0.556
SH3KBP1 SH3-domain kinase binding protein 1 0.551
ADRBK1 adrenergic, beta, receptor kinase 1 0.538
VAV1 vav 1 guanine nucleotide exchange factor 0.536
S100A1 S100 calcium binding protein A1 0.528
CCL4 chemokine (C-C motif) ligand 4 0.516
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.510
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.504
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.494
DNM2 dynamin 2 0.490
TNF tumor necrosis factor 0.490
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.482
C7orf59 chromosome 7 open reading frame 59 0.472
TRAF2 TNF receptor-associated factor 2 0.466
MPRIP myosin phosphatase Rho interacting protein 0.465
ERBB2IP erbb2 interacting protein 0.461
TTN titin 0.459
S100A4 S100 calcium binding protein A4 0.457
LMNA lamin A/C 0.447
SOS2 son of sevenless homolog 2 (Drosophila) 0.442
RHOC ras homolog gene family, member C 0.439
ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 0.433
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.430
TSC1 tuberous sclerosis 1 0.427
RIN1 Ras and Rab interactor 1 0.423
AGAP5 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 0.421
ADAM15 ADAM metallopeptidase domain 15 0.408
PKP4 plakophilin 4 0.407
ZNF746 zinc finger protein 746 0.401
TRADD TNFRSF1A-associated via death domain 0.393
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.393
BIRC2 baculoviral IAP repeat containing 2 0.388
CCL2 chemokine (C-C motif) ligand 2 0.385
RND1 Rho family GTPase 1 0.382
AGAP7 ArfGAP with GTPase domain, ankyrin repeat and PH domain 7 0.381
ANKRD28 ankyrin repeat domain 28 0.376
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.182
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.092
Mapk9 mitogen-activated protein kinase 9 0.086
Shank2 SH3 and multiple ankyrin repeat domains 2 0.073
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.053
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.053
Nsf N-ethylmaleimide-sensitive factor 0.052
Copb1 coatomer protein complex, subunit beta 1 0.052
Wdr7 WD repeat domain 7 0.052
Amph amphiphysin 0.050
Clcn7 chloride channel 7 0.050
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.045
Inpp5d inositol polyphosphate-5-phosphatase D 0.045
Itpr1 inositol 1,4,5-triphosphate receptor, type 1 0.043
Adrbk1 adrenergic, beta, receptor kinase 1 0.043
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.042
Dlg3 discs, large homolog 3 (Drosophila) 0.041
Hk1 hexokinase 1 0.040
Dusp1 dual specificity phosphatase 1 0.040
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.039
Ylpm1 YLP motif containing 1 0.038
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.037
Braf v-raf murine sarcoma viral oncogene homolog B1 0.037
Cyth1 cytohesin 1 0.037
Epas1 endothelial PAS domain protein 1 0.037
Adcy5 adenylate cyclase 5 0.036
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.035
Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 0.035
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.034
Dnm1 dynamin 1 0.034
Anxa2 annexin A2 0.034
Sdc3 syndecan 3 0.033
Pja2 praja 2, RING-H2 motif containing 0.033
Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.032
Jtb jumping translocation breakpoint 0.032
Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.032
Kif16b kinesin family member 16B 0.032
Extl3 exostoses (multiple)-like 3 0.031
Anxa1 annexin A1 0.031
Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.031
Aif1l allograft inflammatory factor 1-like 0.031
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.031
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.030
Vps52 vacuolar protein sorting 52 homolog (S. cerevisiae) 0.030
Akap1 A kinase (PRKA) anchor protein 1 0.030
Svop SV2 related protein 0.030
Lphn2 latrophilin 2 0.030
Abcf3 ATP-binding cassette, subfamily F (GCN20), member 3 0.030
Scn8a sodium channel, voltage gated, type VIII, alpha subunit 0.029
Camk4 calcium/calmodulin-dependent protein kinase IV 0.028
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.028
Pi4ka phosphatidylinositol 4-kinase, catalytic, alpha 0.028
Homer1 homer homolog 1 (Drosophila) 0.027
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.027
Synrg synergin, gamma 0.027
Ap2a2 adaptor-related protein complex 2, alpha 2 subunit 0.026
Plcg1 phospholipase C, gamma 1 0.026
Sbf1 SET binding factor 1 0.026
Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.026
Sh3gl2 SH3-domain GRB2-like 2 0.026
Tgfbr2 transforming growth factor, beta receptor II 0.025
Trim9 tripartite motif-containing 9 0.025
Adar adenosine deaminase, RNA-specific 0.025
Apc adenomatous polyposis coli 0.025
Dapk3 death-associated protein kinase 3 0.025
Galnt10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) 0.025
Opcml opioid binding protein/cell adhesion molecule-like 0.024
Plekha6 pleckstrin homology domain containing, family A member 6 0.024
Ubn2 ubinuclein 2 0.024
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.024
Sept10 septin 10 0.023
Stx2 syntaxin 2 0.023
Unc13b unc-13 homolog B (C. elegans) 0.023
Prkcb protein kinase C, beta 0.023
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.023
Dpp6 dipeptidylpeptidase 6 0.023
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.023
Smg5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.022
Cx3cl1 chemokine (C-X3-C motif) ligand 1 0.022
Cfp complement factor properdin 0.022
Pld2 phospholipase D2 0.022
Epb41l1 erythrocyte membrane protein band 4.1-like 1 0.022
Cnksr2 connector enhancer of kinase suppressor of Ras 2 0.022
Pde2a phosphodiesterase 2A, cGMP-stimulated 0.022
Mmp17 matrix metallopeptidase 17 0.022
Arpc5 actin related protein 2/3 complex, subunit 5 0.021
Errfi1 ERBB receptor feedback inhibitor 1 0.021
Pdcd6 programmed cell death 6 0.021
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.021
Kidins220 kinase D-interacting substrate 220 0.021
Vsnl1 visinin-like 1 0.021
Hes5 hairy and enhancer of split 5 (Drosophila) 0.021
Mprip myosin phosphatase Rho interacting protein 0.021
Cap2 CAP, adenylate cyclase-associated protein, 2 (yeast) 0.020
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.020
Prkcg protein kinase C, gamma 0.020
Cdc34 cell division cycle 34 homolog (S. cerevisiae) 0.020
Abr active BCR-related gene 0.020
Snca synuclein, alpha (non A4 component of amyloid precursor) 0.020
Fgfr1 Fibroblast growth factor receptor 1 0.020
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
STE11 Ste11p 0.516
GCD6 Gcd6p 0.425
GYL1 Gyl1p 0.334
SPA2 Spa2p 0.261
RHO1 Rho1p 0.187
STE5 Ste5p 0.151
IRA1 Ira1p 0.150
PKC1 Pkc1p 0.143
MKK1 Mkk1p 0.136
MNN9 Mnn9p 0.132
ROM2 Rom2p 0.129
SUI3 Sui3p 0.120
FYV8 Fyv8p 0.094
VPS15 Vps15p 0.070
YIP3 Yip3p 0.067
FKH1 Fkh1p 0.065
PEA2 Pea2p 0.064
GCD7 Gcd7p 0.062
ATG20 Atg20p 0.058
BEM3 Bem3p 0.056
GPB2 Gpb2p 0.053
CDC24 Cdc24p 0.053
BFR1 Bfr1p 0.053
HRP1 Hrp1p 0.052
GCD11 Gcd11p 0.048
PTP2 Ptp2p 0.048
CYK3 Cyk3p 0.048
MDS3 Mds3p 0.047
PPE1 Ppe1p 0.047
AKL1 Akl1p 0.047
FIR1 Fir1p 0.046
GLO3 Glo3p 0.045
GCD1 Gcd1p 0.044
CHS1 Chs1p 0.043
STE4 Ste4p 0.041
YPT53 Ypt53p 0.040
MSG5 Msg5p 0.040
PRS2 Prs2p 0.040
FMS1 Fms1p 0.039
CDC50 Cdc50p 0.038
INP53 Inp53p 0.037
ENT1 Ent1p 0.037
YML002W hypothetical protein 0.036
GPR1 Gpr1p 0.036
SLT2 Slt2p 0.035
YDR186C hypothetical protein 0.034
YDL206W hypothetical protein 0.033
SLG1 Slg1p 0.032
NAT1 Nat1p 0.032
HSV2 Hsv2p 0.032
SIA1 Sia1p 0.031
TOM1 Tom1p 0.031
TUS1 Tus1p 0.031
YIL055C hypothetical protein 0.031
SPE3 Spe3p 0.030
SET1 Set1p 0.030
CDC12 Cdc12p 0.029
RPN14 Rpn14p 0.029
LEM3 Lem3p 0.029
FAA2 Faa2p 0.028
CMK2 Cmk2p 0.028
RGD2 Rgd2p 0.028
STE2 Ste2p 0.028
CCT4 Cct4p 0.027
SES1 Ses1p 0.027
DCD1 Dcd1p 0.027
ARP10 Arp10p 0.027
ACK1 Ack1p 0.027
YNL108C hypothetical protein 0.027
YGR126W hypothetical protein 0.026
MYO1 Myo1p 0.026
BEM2 Bem2p 0.026
FAR1 Far1p 0.026
NEO1 Neo1p 0.025
HYP2 Hyp2p 0.025
VPS38 Vps38p 0.025
YRB1 Yrb1p 0.025
KEL1 Kel1p 0.025
SVF1 Svf1p 0.025
INO2 Ino2p 0.025
YLR264C-A hypothetical protein 0.024
SAK1 Sak1p 0.024
SRD1 Srd1p 0.024
HUL4 Hul4p 0.024
MKK2 Mkk2p 0.024
SEC16 Sec16p 0.024
STE12 Ste12p 0.024
SKM1 Skm1p 0.023
SPR6 Spr6p 0.023
STB2 Stb2p 0.023
YGK3 Ygk3p 0.023
SSH4 Ssh4p 0.022
YGL036W hypothetical protein 0.022
ITR2 Itr2p 0.022
APM2 Apm2p 0.022
GGA2 Gga2p 0.021
YIR035C hypothetical protein 0.021
NYV1 Nyv1p 0.021
MER1 Mer1p 0.021
YOL038C-A hypothetical protein 0.021