IMP
Process View
The network for 'neural tube closure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
neural tube closure
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Gli3 | GLI-Kruppel family member GLI3 | 1.000 | |
| Shh | sonic hedgehog | 1.000 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 1.000 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 1.000 | |
| Tcfap2a | transcription factor AP-2, alpha | 1.000 | |
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 1.000 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 1.000 | |
| Pax3 | paired box gene 3 | 1.000 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 1.000 | |
| Foxc1 | forkhead box C1 | 1.000 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 1.000 | |
| Gli2 | GLI-Kruppel family member GLI2 | 1.000 | |
| Rarg | retinoic acid receptor, gamma | 1.000 | |
| Bmp4 | bone morphogenetic protein 4 | 1.000 | |
| Smo | smoothened homolog (Drosophila) | 1.000 | |
| Msx1 | homeobox, msh-like 1 | 1.000 | |
| Pbx1 | pre B-cell leukemia transcription factor 1 | 1.000 | |
| Eya1 | eyes absent 1 homolog (Drosophila) | 1.000 | |
| Prrx1 | paired related homeobox 1 | 1.000 | |
| Pax6 | paired box gene 6 | 1.000 | |
| Foxc2 | forkhead box C2 | 1.000 | |
| Rarb | retinoic acid receptor, beta | 1.000 | |
| Fgf8 | fibroblast growth factor 8 | 1.000 | |
| Lhx1 | LIM homeobox protein 1 | 0.999 | |
| Sox2 | SRY-box containing gene 2 | 0.999 | |
| Chrd | chordin | 0.999 | |
| Bmp7 | bone morphogenetic protein 7 | 0.999 | |
| Pax2 | paired box gene 2 | 0.999 | |
| Dlx5 | distal-less homeobox 5 | 0.999 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.998 | |
| Sox9 | SRY-box containing gene 9 | 0.998 | |
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.998 | |
| Hoxa1 | homeobox A1 | 0.997 | |
| Msx2 | homeobox, msh-like 2 | 0.997 | |
| Rara | retinoic acid receptor, alpha | 0.996 | |
| Foxg1 | forkhead box G1 | 0.996 | |
| Sall4 | sal-like 4 (Drosophila) | 0.996 | |
| Sema6a | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 0.994 | |
| Tbx1 | T-box 1 | 0.993 | |
| Nodal | nodal | 0.991 | |
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.991 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.990 | |
| Prrx2 | paired related homeobox 2 | 0.990 | |
| Ednra | endothelin receptor type A | 0.989 | |
| Acvr1 | activin A receptor, type 1 | 0.987 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.986 | |
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.986 | |
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.984 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.982 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.980 | |
| Nog | noggin | 0.978 | |
| En1 | engrailed 1 | 0.977 | |
| Fzd8 | frizzled homolog 8 (Drosophila) | 0.975 | |
| Apc | adenomatosis polyposis coli | 0.974 | |
| Vegfa | vascular endothelial growth factor A | 0.972 | |
| Zic3 | zinc finger protein of the cerebellum 3 | 0.972 | |
| Ptch1 | patched homolog 1 | 0.969 | |
| Hoxa2 | homeobox A2 | 0.960 | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.959 | |
| Gsc | goosecoid homeobox | 0.956 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.955 | |
| Sox11 | SRY-box containing gene 11 | 0.952 | |
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.950 | |
| Zic2 | zinc finger protein of the cerebellum 2 | 0.950 | |
| Pou5f1 | POU domain, class 5, transcription factor 1 | 0.945 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.945 | |
| Fgf10 | fibroblast growth factor 10 | 0.943 | |
| Pten | phosphatase and tensin homolog | 0.940 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.936 | |
| Ptk7 | PTK7 protein tyrosine kinase 7 | 0.934 | |
| Dvl2 | dishevelled 2, dsh homolog (Drosophila) | 0.933 | |
| Wnt3a | wingless-related MMTV integration site 3A | 0.932 | |
| Jag1 | jagged 1 | 0.930 | |
| Efna2 | ephrin A2 | 0.928 | |
| Lhx9 | LIM homeobox protein 9 | 0.924 | |
| Hoxa3 | homeobox A3 | 0.923 | |
| Meox2 | mesenchyme homeobox 2 | 0.922 | |
| T | brachyury | 0.899 | |
| Neurod1 | neurogenic differentiation 1 | 0.898 | |
| Smad4 | MAD homolog 4 (Drosophila) | 0.891 | |
| Tead2 | TEA domain family member 2 | 0.887 | |
| Pax8 | paired box gene 8 | 0.878 | |
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.873 | |
| Foxh1 | forkhead box H1 | 0.868 | |
| Wt1 | Wilms tumor 1 homolog | 0.863 | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.862 | |
| Mks1 | Meckel syndrome, type 1 | 0.862 | |
| Wnt5a | wingless-related MMTV integration site 5A | 0.861 | |
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.856 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.852 | |
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.850 | |
| Dvl3 | dishevelled 3, dsh homolog (Drosophila) | 0.849 | |
| Runx2 | runt related transcription factor 2 | 0.838 | |
| Sox4 | SRY-box containing gene 4 | 0.837 | |
| Tbx3 | T-box 3 | 0.821 | |
| Tsc2 | tuberous sclerosis 2 | 0.816 | |
| Neurog2 | neurogenin 2 | 0.812 | |
| Tcfap2c | transcription factor AP-2, gamma | 0.811 | |
| Hoxa11 | homeobox A11 | 0.806 | |
| Efs | embryonal Fyn-associated substrate | 0.802 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 0.603 | |
| DVL3 | dishevelled, dsh homolog 3 (Drosophila) | 0.601 | |
| TSC2 | tuberous sclerosis 2 | 0.581 | |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.570 | |
| ZFYVE9 | zinc finger, FYVE domain containing 9 | 0.553 | |
| LRRK2 | leucine-rich repeat kinase 2 | 0.517 | |
| BCOR | BCL6 corepressor | 0.513 | |
| SASS6 | spindle assembly 6 homolog (C. elegans) | 0.473 | |
| AXIN1 | axin 1 | 0.472 | |
| SMAD2 | SMAD family member 2 | 0.460 | |
| PPP1R16A | protein phosphatase 1, regulatory (inhibitor) subunit 16A | 0.426 | |
| APC | adenomatous polyposis coli | 0.401 | |
| SMAD3 | SMAD family member 3 | 0.372 | |
| ZFX | zinc finger protein, X-linked | 0.342 | |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.314 | |
| DVL1 | dishevelled, dsh homolog 1 (Drosophila) | 0.309 | |
| RXRA | retinoid X receptor, alpha | 0.302 | |
| SETD8 | SET domain containing (lysine methyltransferase) 8 | 0.293 | |
| TRRAP | transformation/transcription domain-associated protein | 0.288 | |
| C9orf89 | chromosome 9 open reading frame 89 | 0.279 | |
| MEOX2 | mesenchyme homeobox 2 | 0.279 | |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.276 | |
| SORBS3 | sorbin and SH3 domain containing 3 | 0.271 | |
| PCM1 | pericentriolar material 1 | 0.242 | |
| CNKSR2 | connector enhancer of kinase suppressor of Ras 2 | 0.230 | |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.214 | |
| MED16 | mediator complex subunit 16 | 0.210 | |
| ABI1 | abl-interactor 1 | 0.202 | |
| MBD2 | methyl-CpG binding domain protein 2 | 0.183 | |
| SEC24D | SEC24 family, member D (S. cerevisiae) | 0.172 | |
| DLG5 | discs, large homolog 5 (Drosophila) | 0.159 | |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.159 | |
| NCOA1 | nuclear receptor coactivator 1 | 0.149 | |
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.145 | |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) | 0.143 | |
| CREBBP | CREB binding protein | 0.142 | |
| WASF2 | WAS protein family, member 2 | 0.142 | |
| RASA1 | RAS p21 protein activator (GTPase activating protein) 1 | 0.141 | |
| GLI1 | GLI family zinc finger 1 | 0.136 | |
| PKP4 | plakophilin 4 | 0.132 | |
| CTBP2 | C-terminal binding protein 2 | 0.122 | |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.121 | |
| CSNK1D | casein kinase 1, delta | 0.116 | |
| CTBP1 | C-terminal binding protein 1 | 0.104 | |
| SH3BP4 | SH3-domain binding protein 4 | 0.104 | |
| PRKACA | protein kinase, cAMP-dependent, catalytic, alpha | 0.103 | |
| FAT1 | FAT tumor suppressor homolog 1 (Drosophila) | 0.103 | |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.102 | |
| LDB1 | LIM domain binding 1 | 0.101 | |
| SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 0.098 | |
| CSNK1E | casein kinase 1, epsilon | 0.098 | |
| ERBB2IP | erbb2 interacting protein | 0.098 | |
| DAB2 | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 0.097 | |
| BBS2 | Bardet-Biedl syndrome 2 | 0.096 | |
| MED25 | mediator complex subunit 25 | 0.096 | |
| USP22 | ubiquitin specific peptidase 22 | 0.087 | |
| SKI | v-ski sarcoma viral oncogene homolog (avian) | 0.085 | |
| VASP | vasodilator-stimulated phosphoprotein | 0.084 | |
| MED24 | mediator complex subunit 24 | 0.084 | |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.083 | |
| SIN3A | SIN3 homolog A, transcription regulator (yeast) | 0.082 | |
| NCOA6 | nuclear receptor coactivator 6 | 0.082 | |
| EP300 | E1A binding protein p300 | 0.081 | |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.081 | |
| TJP2 | tight junction protein 2 (zona occludens 2) | 0.080 | |
| TAF4 | TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa | 0.080 | |
| TSC1 | tuberous sclerosis 1 | 0.080 | |
| ESR1 | estrogen receptor 1 | 0.078 | |
| ORC6 | origin recognition complex, subunit 6 | 0.076 | |
| AKIP1 | A kinase (PRKA) interacting protein 1 | 0.071 | |
| BMP7 | bone morphogenetic protein 7 | 0.064 | |
| WASF1 | WAS protein family, member 1 | 0.061 | |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.061 | |
| BAIAP2 | BAI1-associated protein 2 | 0.060 | |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.060 | |
| HMOX2 | heme oxygenase (decycling) 2 | 0.060 | |
| SGSM2 | small G protein signaling modulator 2 | 0.058 | |
| EPAS1 | endothelial PAS domain protein 1 | 0.058 | |
| BBS9 | Bardet-Biedl syndrome 9 | 0.058 | |
| PBRM1 | polybromo 1 | 0.058 | |
| MTA1 | metastasis associated 1 | 0.058 | |
| NCF1 | neutrophil cytosolic factor 1 | 0.058 | |
| STRN3 | striatin, calmodulin binding protein 3 | 0.058 | |
| BMP2 | bone morphogenetic protein 2 | 0.057 | |
| FZD1 | frizzled homolog 1 (Drosophila) | 0.057 | |
| ZMYND11 | zinc finger, MYND-type containing 11 | 0.056 | |
| KIAA1377 | KIAA1377 | 0.056 | |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.056 | |
| WT1 | Wilms tumor 1 | 0.055 | |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.055 | |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.055 | |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.055 | |
| LGALS8 | lectin, galactoside-binding, soluble, 8 | 0.054 | |
| SP1 | Sp1 transcription factor | 0.054 | |
| SMAD4 | SMAD family member 4 | 0.054 | |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.054 | |
| CRMP1 | collapsin response mediator protein 1 | 0.054 | |
| FHL1 | four and a half LIM domains 1 | 0.053 | |
| NCOR1 | nuclear receptor corepressor 1 | 0.052 | |
| KIF14 | kinesin family member 14 | 0.051 |