The network for 'pituitary gland development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pituitary gland development

The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Pax2 paired box gene 2 1.000
Fgf8 fibroblast growth factor 8 1.000
Pax3 paired box gene 3 1.000
Sox9 SRY-box containing gene 9 1.000
Rarg retinoic acid receptor, gamma 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Nodal nodal 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Chrd chordin 1.000
Hand1 heart and neural crest derivatives expressed transcript 1 1.000
Eya1 eyes absent 1 homolog (Drosophila) 1.000
Tcfap2a transcription factor AP-2, alpha 1.000
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 1.000
Hand2 heart and neural crest derivatives expressed transcript 2 0.999
Tbx1 T-box 1 0.999
Fgf10 fibroblast growth factor 10 0.999
Isl1 ISL1 transcription factor, LIM/homeodomain 0.999
Bmp4 bone morphogenetic protein 4 0.999
Foxc1 forkhead box C1 0.999
Sox2 SRY-box containing gene 2 0.999
Lhx1 LIM homeobox protein 1 0.998
Hoxa1 homeobox A1 0.998
Msx1 homeobox, msh-like 1 0.998
Pax6 paired box gene 6 0.998
Dlx5 distal-less homeobox 5 0.997
Ctnnb1 catenin (cadherin associated protein), beta 1 0.996
Rarb retinoic acid receptor, beta 0.996
Fgfr1 fibroblast growth factor receptor 1 0.996
Gbx2 gastrulation brain homeobox 2 0.996
Prrx1 paired related homeobox 1 0.995
Fgfr3 fibroblast growth factor receptor 3 0.995
Hoxd13 homeobox D13 0.994
Lmx1b LIM homeobox transcription factor 1 beta 0.994
Emx1 empty spiracles homolog 1 (Drosophila) 0.993
Pitx1 paired-like homeodomain transcription factor 1 0.992
Foxc2 forkhead box C2 0.989
Gli2 GLI-Kruppel family member GLI2 0.987
Pax8 paired box gene 8 0.986
Emx2 empty spiracles homolog 2 (Drosophila) 0.983
Foxg1 forkhead box G1 0.980
Tbx3 T-box 3 0.979
Wnt3a wingless-related MMTV integration site 3A 0.974
Nog noggin 0.974
Lef1 lymphoid enhancer binding factor 1 0.970
Gsc goosecoid homeobox 0.968
Tgfbr2 transforming growth factor, beta receptor II 0.967
Alx4 aristaless-like homeobox 4 0.967
Smo smoothened homolog (Drosophila) 0.967
Pou5f1 POU domain, class 5, transcription factor 1 0.963
Lmx1a LIM homeobox transcription factor 1 alpha 0.959
Hoxa2 homeobox A2 0.959
Bmp7 bone morphogenetic protein 7 0.948
Lhx3 LIM homeobox protein 3 0.948
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.947
Acvr1 activin A receptor, type 1 0.940
En1 engrailed 1 0.937
Gdnf glial cell line derived neurotrophic factor 0.933
Ret ret proto-oncogene 0.929
Msx2 homeobox, msh-like 2 0.926
Wt1 Wilms tumor 1 homolog 0.921
Fgf3 fibroblast growth factor 3 0.910
Otx1 orthodenticle homolog 1 (Drosophila) 0.909
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.905
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.896
Rara retinoic acid receptor, alpha 0.895
Wnt1 wingless-related MMTV integration site 1 0.891
Gata4 GATA binding protein 4 0.887
Chd7 chromodomain helicase DNA binding protein 7 0.876
Vegfa vascular endothelial growth factor A 0.874
Insm1 insulinoma-associated 1 0.866
Pthlh parathyroid hormone-like peptide 0.866
Phox2b paired-like homeobox 2b 0.857
Sall4 sal-like 4 (Drosophila) 0.851
Sall3 sal-like 3 (Drosophila) 0.850
Ednra endothelin receptor type A 0.848
Pou3f3 POU domain, class 3, transcription factor 3 0.847
Nkx2-1 NK2 homeobox 1 0.846
Hoxd3 homeobox D3 0.845
Sox11 SRY-box containing gene 11 0.845
Prrx2 paired related homeobox 2 0.840
Foxf1a forkhead box F1a 0.837
Fgf15 fibroblast growth factor 15 0.835
Zic3 zinc finger protein of the cerebellum 3 0.832
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.826
Hes5 hairy and enhancer of split 5 (Drosophila) 0.825
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.818
Lhx5 LIM homeobox protein 5 0.813
Atoh7 atonal homolog 7 (Drosophila) 0.802
Foxh1 forkhead box H1 0.793
Pten phosphatase and tensin homolog 0.786
Hoxa3 homeobox A3 0.773
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.773
Alx3 aristaless-like homeobox 3 0.767
Pitx3 paired-like homeodomain transcription factor 3 0.750
Drd2 dopamine receptor D2 0.749
Twist2 twist homolog 2 (Drosophila) 0.743
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
shha sonic hedgehog a 1.000
fgf8a fibroblast growth factor 8 a 0.998
fgf3 fibroblast growth factor 3 0.997
bmp4 bone morphogenetic protein 4 0.994
eya1 eyes absent homolog 1 0.983
rx3 retinal homeobox gene 3 0.979
tbx1 T-box 1 0.975
ascl1a achaete-scute complex-like 1a (Drosophila) 0.965
sox2 SRY-box containing gene 2 0.964
pax2a paired box gene 2a 0.963
nkx2.2a NK2 transcription factor related 2a 0.929
tfap2a transcription factor AP-2 alpha 0.928
dla deltaA 0.928
dld deltaD 0.890
gli1 GLI-Kruppel family member 1 0.833
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.833
foxi1 forkhead box I1 0.829
mib mind bomb 0.824
pitx2 paired-like homeodomain transcription factor 2 0.747
notch1a notch homolog 1a 0.735
ntla no tail a 0.723
prdm1a PR domain containing 1a, with ZNF domain 0.676
foxa2 forkhead box A2 0.654
six3a sine oculis homeobox homolog 3a 0.603
foxd3 forkhead box D3 0.555
cdh2 cadherin 2, neuronal 0.525
foxg1a forkhead box G1a 0.525
dlx3b distal-less homeobox gene 3b 0.484
gli2a GLI-Kruppel family member GLI2a 0.484
dkk1b dickkopf 1b 0.481
six1b sine oculis homeobox homolog 1b 0.479
bmp2b bone morphogenetic protein 2b 0.478
dzip1 DAZ interacting protein 1 0.472
dbx1a developing brain homeobox 1a 0.435
flh floating head 0.423
fezf2 FEZ family zinc finger 2 0.423
six3b sine oculis homeobox homolog 3b 0.384
dlx2a distal-less homeobox gene 2a 0.380
six4a sine oculis homeobox homolog 4a 0.352
nkx2.1a NK2 homeobox 1a 0.351
msxc muscle segment homeobox C 0.333
otpb orthopedia homolog b 0.320
ndr2 nodal-related 2 0.296
sox3 SRY-box containing gene 3 0.263
grhl2b grainyhead-like 2b (Drosophila) 0.254
pou1f1 POU domain, class 1, transcription factor 1 0.242
pcdh8 protocadherin 8 0.226
dlx4b distal-less homeobox gene 4b 0.224
rx2 retinal homeobox gene 2 0.223
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.213
foxe3 forkhead box E3 0.213
hmx4 H6 family homeobox 4 0.208
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.202
twist3 twist3 0.194
otx2 orthodenticle homolog 2 0.187
fzd8a frizzled homolog 8a 0.177
nos1 nitric oxide synthase 1 (neuronal) 0.174
klf4 Kruppel-like factor 4 0.164
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.159
chd chordin 0.155
lhx5 LIM homeobox 5 0.144
wnt11 wingless-type MMTV integration site family, member 11 0.144
ptch2 patched 2 0.137
arx aristaless related homeobox 0.131
pax6a paired box gene 6a 0.130
tp63 tumor protein p63 0.125
wnt5b wingless-type MMTV integration site family, member 5b 0.124
foxd5 forkhead box D5 0.122
dlc deltaC 0.121
irx1b iroquois homeobox protein 1, b 0.121
pax6b paired box gene 6b 0.119
hoxb1b homeo box B1b 0.116
otx1b orthodenticle homolog 1b 0.115
lhx6 LIM homeobox 6 0.115
extl3 exostoses (multiple)-like 3 0.111
sox17 SRY-box containing gene 17 0.107
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.105
emx1 empty spiracles homeobox 1 0.102
gbx2 gastrulation brain homeo box 2 0.102
ptch1 patched 1 0.101
gli2b GLI-Kruppel family member GLI2b 0.097
gsc goosecoid 0.096
msgn1 mesogenin 1 0.096
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.095
sox19a SRY-box containing gene 19a 0.089
nkx2.2b NK2 transcription factor related 2b 0.085
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.082
pitx3 paired-like homeodomain transcription factor 3 0.081
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.078
lhx1a LIM homeobox 1a 0.076
dlx5a distal-less homeobox gene 5a 0.075
tll1 tolloid-like 1 0.074
szl sizzled 0.072
lhx2b LIM homeobox 2b 0.070
pax8 paired box gene 8 0.069
foxa3 forkhead box A3 0.066
otpa orthopedia homolog a 0.065
gbx1 gastrulation brain homeobox 1 0.065
neurod neurogenic differentiation 0.064
neurog1 neurogenin 1 0.064
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BMP2 bone morphogenetic protein 2 1.000
TAL1 T-cell acute lymphocytic leukemia 1 1.000
BMPR1A bone morphogenetic protein receptor, type IA 0.999
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.998
PAX3 paired box 3 0.988
DAXX death-domain associated protein 0.957
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.934
SOX2 SRY (sex determining region Y)-box 2 0.927
SMAD7 SMAD family member 7 0.921
BMP7 bone morphogenetic protein 7 0.900
TCF4 transcription factor 4 0.894
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.891
PTCH1 patched 1 0.876
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.873
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.838
FGFR1 fibroblast growth factor receptor 1 0.820
FSTL1 follistatin-like 1 0.738
AR androgen receptor 0.723
CTNND1 catenin (cadherin-associated protein), delta 1 0.590
SOX11 SRY (sex determining region Y)-box 11 0.583
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.568
PRMT6 protein arginine methyltransferase 6 0.546
NOTCH1 notch 1 0.531
PSEN1 presenilin 1 0.523
MTA3 metastasis associated 1 family, member 3 0.514
FOXD3 forkhead box D3 0.473
PAX8 paired box 8 0.471
SALL2 sal-like 2 (Drosophila) 0.461
AXIN1 axin 1 0.449
HIC1 hypermethylated in cancer 1 0.443
HIPK2 homeodomain interacting protein kinase 2 0.442
MDFI MyoD family inhibitor 0.402
GLIS2 GLIS family zinc finger 2 0.392
ATXN1L ataxin 1-like 0.361
MSX2 msh homeobox 2 0.355
JUP junction plakoglobin 0.345
SPEN spen homolog, transcriptional regulator (Drosophila) 0.307
LHX2 LIM homeobox 2 0.299
MARCKSL1 MARCKS-like 1 0.289
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 0.273
RBPMS RNA binding protein with multiple splicing 0.268
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.268
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.266
FOXG1 forkhead box G1 0.263
POU3F2 POU class 3 homeobox 2 0.257
VHL von Hippel-Lindau tumor suppressor 0.254
FGF1 fibroblast growth factor 1 (acidic) 0.226
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.220
PAX6 paired box 6 0.211
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.209
SFRP1 secreted frizzled-related protein 1 0.196
FOXC1 forkhead box C1 0.196
SMAD5 SMAD family member 5 0.195
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.190
SIX3 SIX homeobox 3 0.189
SOX21 SRY (sex determining region Y)-box 21 0.182
EYA2 eyes absent homolog 2 (Drosophila) 0.172
BMP4 bone morphogenetic protein 4 0.171
JAG1 jagged 1 0.167
NGFR nerve growth factor receptor 0.166
HDAC2 histone deacetylase 2 0.163
TBX2 T-box 2 0.163
CREBBP CREB binding protein 0.161
RCOR1 REST corepressor 1 0.161
FZD1 frizzled homolog 1 (Drosophila) 0.160
PTPRJ protein tyrosine phosphatase, receptor type, J 0.158
SOX9 SRY (sex determining region Y)-box 9 0.157
SNAI1 snail homolog 1 (Drosophila) 0.152
PKP4 plakophilin 4 0.146
MSX1 msh homeobox 1 0.146
HOXD9 homeobox D9 0.146
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 0.143
SMAD4 SMAD family member 4 0.142
GSK3B glycogen synthase kinase 3 beta 0.141
NEUROD1 neurogenic differentiation 1 0.140
FOXF1 forkhead box F1 0.136
FRMD5 FERM domain containing 5 0.135
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.134
INHBB inhibin, beta B 0.124
POU5F1 POU class 5 homeobox 1 0.123
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.123
STK36 serine/threonine kinase 36 0.116
MTA1 metastasis associated 1 0.116
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.115
SMO smoothened homolog (Drosophila) 0.115
KAT2B K(lysine) acetyltransferase 2B 0.115
CHD4 chromodomain helicase DNA binding protein 4 0.112
MEIS1 Meis homeobox 1 0.111
SMAD2 SMAD family member 2 0.109
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.109
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.108
HOXD13 homeobox D13 0.106
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.105
FOXO3 forkhead box O3 0.104
OTP orthopedia homeobox 0.103
LMX1A LIM homeobox transcription factor 1, alpha 0.101
ZHX1 zinc fingers and homeoboxes 1 0.099
ZIC3 Zic family member 3 (odd-paired homolog, Drosophila) 0.099
ZNF830 zinc finger protein 830 0.098
NKX2-2 NK2 homeobox 2 0.096
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Rattus norvegicus
Name Description Probability Func Analog Organism
Pax8 paired box 8 0.038
Mip major intrinsic protein of lens fiber 0.023
Fam65a family with sequence similarity 65, member A 0.020
Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 0.020
Ahr aryl hydrocarbon receptor 0.016
Th tyrosine hydroxylase 0.015
Uncx UNC homeobox 0.015
Ecel1 endothelin converting enzyme-like 1 0.014
Slc28a1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 0.014
Akap14 A kinase (PRKA) anchor protein 14 0.013
Gja5 gap junction protein, alpha 5 0.013
Hoxa2 homeo box A2 0.013
Krt5 keratin 5 0.012
Avpr1b arginine vasopressin receptor 1B 0.012
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.012
Gja3 gap junction protein, alpha 3 0.012
Scn9a sodium channel, voltage-gated, type IX, alpha 0.011
Gfap glial fibrillary acidic protein 0.010
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.010
Mfrp membrane frizzled-related protein 0.010
Grik1 glutamate receptor, ionotropic, kainate 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism