The network for 'midbrain development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

midbrain development

The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).

Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Shh sonic hedgehog 1.000
Pax2 paired box gene 2 0.999
En1 engrailed 1 0.984
Pax6 paired box gene 6 0.980
Emx1 empty spiracles homolog 1 (Drosophila) 0.979
Pax3 paired box gene 3 0.966
Fgfr1 fibroblast growth factor receptor 1 0.966
Foxc1 forkhead box C1 0.936
Emx2 empty spiracles homolog 2 (Drosophila) 0.919
Msx1 homeobox, msh-like 1 0.905
Gbx2 gastrulation brain homeobox 2 0.905
Fgfr2 fibroblast growth factor receptor 2 0.900
Nog noggin 0.889
Gli2 GLI-Kruppel family member GLI2 0.886
Tbx3 T-box 3 0.879
Lmx1a LIM homeobox transcription factor 1 alpha 0.878
App amyloid beta (A4) precursor protein 0.874
Hoxa13 homeobox A13 0.868
Hoxa11 homeobox A11 0.857
Lhx5 LIM homeobox protein 5 0.854
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.848
Fgf8 fibroblast growth factor 8 0.830
Lhx1 LIM homeobox protein 1 0.824
Pitx2 paired-like homeodomain transcription factor 2 0.812
Isl1 ISL1 transcription factor, LIM/homeodomain 0.803
Prrx2 paired related homeobox 2 0.799
Hes1 hairy and enhancer of split 1 (Drosophila) 0.794
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.782
Msx2 homeobox, msh-like 2 0.776
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.773
Foxg1 forkhead box G1 0.746
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.737
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.736
Rarg retinoic acid receptor, gamma 0.721
Smad3 MAD homolog 3 (Drosophila) 0.712
Ret ret proto-oncogene 0.692
Eya1 eyes absent 1 homolog (Drosophila) 0.673
Neurod1 neurogenic differentiation 1 0.652
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.648
Efna2 ephrin A2 0.632
Hoxa1 homeobox A1 0.587
Smad6 MAD homolog 6 (Drosophila) 0.586
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.578
Lhx3 LIM homeobox protein 3 0.570
Prnp prion protein 0.565
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.560
Rac1 RAS-related C3 botulinum substrate 1 0.530
Bmp4 bone morphogenetic protein 4 0.528
Sox2 SRY-box containing gene 2 0.525
Hoxd13 homeobox D13 0.521
Phox2a paired-like homeobox 2a 0.514
Hoxd11 homeobox D11 0.505
Fgf10 fibroblast growth factor 10 0.501
Phox2b paired-like homeobox 2b 0.496
Hand2 heart and neural crest derivatives expressed transcript 2 0.493
Pitx1 paired-like homeodomain transcription factor 1 0.488
Sox11 SRY-box containing gene 11 0.481
Ctnnb1 catenin (cadherin associated protein), beta 1 0.480
Tcfap2a transcription factor AP-2, alpha 0.462
Fgfr3 fibroblast growth factor receptor 3 0.448
Pbx1 pre B-cell leukemia transcription factor 1 0.434
Tcf21 transcription factor 21 0.428
Gdnf glial cell line derived neurotrophic factor 0.425
Neurog2 neurogenin 2 0.409
Dab1 disabled homolog 1 (Drosophila) 0.399
Pax8 paired box gene 8 0.398
Lef1 lymphoid enhancer binding factor 1 0.381
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.376
Snai1 snail homolog 1 (Drosophila) 0.366
Col2a1 collagen, type II, alpha 1 0.362
Gsc goosecoid homeobox 0.361
Pou3f3 POU domain, class 3, transcription factor 3 0.360
Wnt1 wingless-related MMTV integration site 1 0.358
Chd7 chromodomain helicase DNA binding protein 7 0.356
Hoxa2 homeobox A2 0.353
Dlx5 distal-less homeobox 5 0.349
Smo smoothened homolog (Drosophila) 0.344
Tbx15 T-box 15 0.342
Gdf5 growth differentiation factor 5 0.340
Sox9 SRY-box containing gene 9 0.340
Bmpr1a bone morphogenetic protein receptor, type 1A 0.335
Vax1 ventral anterior homeobox containing gene 1 0.325
Vangl2 vang-like 2 (van gogh, Drosophila) 0.323
Hes5 hairy and enhancer of split 5 (Drosophila) 0.315
Fzd7 frizzled homolog 7 (Drosophila) 0.315
Otx1 orthodenticle homolog 1 (Drosophila) 0.312
Hoxa10 homeobox A10 0.311
Bdnf brain derived neurotrophic factor 0.295
Chrd chordin 0.291
Drd2 dopamine receptor D2 0.288
Foxb1 forkhead box B1 0.288
Gas1 growth arrest specific 1 0.287
Tbx1 T-box 1 0.282
Lrp2 low density lipoprotein receptor-related protein 2 0.282
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.279
Foxc2 forkhead box C2 0.276
Myod1 myogenic differentiation 1 0.276
Insm1 insulinoma-associated 1 0.271
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ascl1a achaete-scute complex-like 1a (Drosophila) 0.982
dla deltaA 0.838
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.817
dld deltaD 0.793
eya1 eyes absent homolog 1 0.773
fgf3 fibroblast growth factor 3 0.718
gbx2 gastrulation brain homeo box 2 0.718
eng1a engrailed 1a 0.697
pax2a paired box gene 2a 0.659
wnt8b wingless-type MMTV integration site family, member 8b 0.658
gata3 GATA-binding protein 3 0.650
gpia glucose phosphate isomerase a 0.643
pax8 paired box gene 8 0.597
otx1b orthodenticle homolog 1b 0.568
dbx1a developing brain homeobox 1a 0.564
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.531
phox2a paired-like homeobox 2a 0.527
bhlhe22 basic helix-loop-helix family, member e22 0.519
nova2 neuro-oncological ventral antigen 2 0.509
otpb orthopedia homolog b 0.476
fgf4 fibroblast growth factor 4 0.463
notch3 notch homolog 3 0.443
irx7 iroquois homeobox protein 7 0.442
dmbx1a diencephalon/mesencephalon homeobox 1a 0.414
vcana versican a 0.401
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.386
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.383
scube2 signal peptide, CUB domain, EGF-like 2 0.382
foxd3 forkhead box D3 0.369
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.366
nkx2.2a NK2 transcription factor related 2a 0.362
pdzrn3 PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3 0.355
pea3 ETS-domain transcription factor pea3 0.349
her5 hairy-related 5 0.347
mab21l2 mab-21-like 2 0.322
grhl2b grainyhead-like 2b (Drosophila) 0.322
olig2 oligodendrocyte lineage transcription factor 2 0.316
zic4 zic family member 4 0.313
gpr126 G protein-coupled receptor 126 0.296
axin2 axin 2 (conductin, axil) 0.291
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.270
fgf8b fibroblast growth factor 8 b 0.267
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.262
eng2b engrailed 2b 0.259
neurod neurogenic differentiation 0.247
ptch2 patched 2 0.246
spry4 sprouty (Drosophila) homolog 4 0.242
sox2 SRY-box containing gene 2 0.237
bmp2b bone morphogenetic protein 2b 0.237
dlb deltaB 0.232
hoxb1b homeo box B1b 0.226
cobl cordon-bleu homolog (mouse) 0.225
il17rd interleukin 17 receptor D 0.224
nr2f1a nuclear receptor subfamily 2, group F, member 1a 0.202
tbx1 T-box 1 0.199
meis2.1 myeloid ecotropic viral integration site 2.1 0.196
wnt11 wingless-type MMTV integration site family, member 11 0.195
sall1a sal-like 1a (Drosophila) 0.193
rx3 retinal homeobox gene 3 0.192
tfap2a transcription factor AP-2 alpha 0.190
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.188
phox2b paired-like homeobox 2b 0.185
eng2a engrailed 2a 0.180
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.175
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.174
apc adenomatosis polyposis coli 0.168
pax6b paired box gene 6b 0.156
hand2 heart and neural crest derivatives expressed transcript 2 0.154
egr2b early growth response 2b 0.152
foxo3b forkhead box O3b 0.149
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.149
lhx6 LIM homeobox 6 0.148
pax2b paired box gene 2b 0.147
crabp2a cellular retinoic acid binding protein 2, a 0.146
sox3 SRY-box containing gene 3 0.145
mapk3 mitogen-activated protein kinase 3 0.139
otx5 orthodenticle homolog 5 0.138
fgf10a fibroblast growth factor 10a 0.133
wls wntless homolog (Drosophila) 0.131
ywhaqa tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a 0.126
hnrnpab heterogeneous nuclear ribonucleoprotein A/B 0.125
foxi1 forkhead box I1 0.123
appa amyloid beta (A4) precursor protein a 0.123
stm starmaker 0.122
eng1b engrailed 1b 0.120
rdh10a retinol dehydrogenase 10a 0.118
oc90 otoconin 90 0.117
tfap2b transcription factor AP-2 beta 0.115
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.115
cldnk claudin k 0.112
sp5l Sp5 transcription factor-like 0.109
hes6 hairy and enhancer of split 6 (Drosophila) 0.108
cdh6 cadherin 6 0.107
mbp myelin basic protein 0.107
sox1a SRY-box containing gene 1a 0.106
dusp6 dual specificity phosphatase 6 0.106
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.105
irx1b iroquois homeobox protein 1, b 0.105
nadl1.1 neural adhesion molecule L1.1 0.101
rx2 retinal homeobox gene 2 0.096
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.999
ZNF43 zinc finger protein 43 0.974
XIAP X-linked inhibitor of apoptosis 0.893
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.888
FGFR2 fibroblast growth factor receptor 2 0.859
S100B S100 calcium binding protein B 0.829
ZNF273 zinc finger protein 273 0.820
ZNF253 zinc finger protein 253 0.739
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.719
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.680
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.659
S100A1 S100 calcium binding protein A1 0.642
S100A6 S100 calcium binding protein A6 0.583
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.576
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.551
FGFR1 fibroblast growth factor receptor 1 0.496
ZNF675 zinc finger protein 675 0.494
FGF1 fibroblast growth factor 1 (acidic) 0.470
S100A16 S100 calcium binding protein A16 0.442
ANXA2 annexin A2 0.433
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.409
DTNA dystrobrevin, alpha 0.375
CFL1 cofilin 1 (non-muscle) 0.345
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.325
HIST1H2BF histone cluster 1, H2bf 0.320
RHOA ras homolog gene family, member A 0.317
ZNF85 zinc finger protein 85 0.305
S100A11 S100 calcium binding protein A11 0.296
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.288
ZNF117 zinc finger protein 117 0.287
ZNF708 zinc finger protein 708 0.282
ZNF91 zinc finger protein 91 0.244
HIST1H2BH histone cluster 1, H2bh 0.243
ZNF254 zinc finger protein 254 0.220
PKM2 pyruvate kinase, muscle 0.207
CAPNS1 calpain, small subunit 1 0.206
AREG amphiregulin 0.205
ZNF93 zinc finger protein 93 0.197
ZNF430 zinc finger protein 430 0.194
APAF1 apoptotic peptidase activating factor 1 0.193
PFN1 profilin 1 0.189
MDH1 malate dehydrogenase 1, NAD (soluble) 0.185
S100A4 S100 calcium binding protein A4 0.185
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.181
ZNF680 zinc finger protein 680 0.175
MDFI MyoD family inhibitor 0.159
FGF10 fibroblast growth factor 10 0.146
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.146
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.141
KIAA1683 KIAA1683 0.133
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.126
TRRAP transformation/transcription domain-associated protein 0.123
HUS1 HUS1 checkpoint homolog (S. pombe) 0.122
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.120
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.116
SMAD5 SMAD family member 5 0.114
LDHA lactate dehydrogenase A 0.106
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.105
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.102
SFN stratifin 0.096
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.096
S100A8 S100 calcium binding protein A8 0.093
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.093
ACTG1 actin, gamma 1 0.093
TMSB4X thymosin beta 4, X-linked 0.092
FGF2 fibroblast growth factor 2 (basic) 0.083
FAS Fas (TNF receptor superfamily, member 6) 0.083
NDRG1 N-myc downstream regulated 1 0.080
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.079
VDAC3 voltage-dependent anion channel 3 0.076
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.076
RIPK2 receptor-interacting serine-threonine kinase 2 0.071
S100A9 S100 calcium binding protein A9 0.071
RIPK3 receptor-interacting serine-threonine kinase 3 0.071
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.070
ARHGAP1 Rho GTPase activating protein 1 0.070
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.069
BCOR BCL6 corepressor 0.069
ANXA7 annexin A7 0.067
RHOG ras homolog gene family, member G (rho G) 0.067
MYO10 myosin X 0.067
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.066
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.062
MYH11 myosin, heavy chain 11, smooth muscle 0.061
PILRA paired immunoglobin-like type 2 receptor alpha 0.061
MSH3 mutS homolog 3 (E. coli) 0.060
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.060
ZNF682 zinc finger protein 682 0.057
FADD Fas (TNFRSF6)-associated via death domain 0.055
CFL2 cofilin 2 (muscle) 0.055
CRYAB crystallin, alpha B 0.055
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.054
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G 0.054
ZNF136 zinc finger protein 136 0.053
S100P S100 calcium binding protein P 0.052
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.051
DMD dystrophin 0.050
NOTCH1 notch 1 0.050
ZNF92 zinc finger protein 92 0.050
BCL2 B-cell CLL/lymphoma 2 0.047
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism