IMP
Process View
The network for 'midbrain hindbrain boundary maturation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
midbrain hindbrain boundary maturation
A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Shh | sonic hedgehog | 1.000 | |
| Gli3 | GLI-Kruppel family member GLI3 | 1.000 | |
| Pax2 | paired box gene 2 | 1.000 | |
| Fgf8 | fibroblast growth factor 8 | 1.000 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.999 | |
| Tbx1 | T-box 1 | 0.999 | |
| Foxc1 | forkhead box C1 | 0.999 | |
| Rarg | retinoic acid receptor, gamma | 0.999 | |
| Sox9 | SRY-box containing gene 9 | 0.996 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.995 | |
| Wnt3a | wingless-related MMTV integration site 3A | 0.994 | |
| Bmp7 | bone morphogenetic protein 7 | 0.994 | |
| Lhx1 | LIM homeobox protein 1 | 0.993 | |
| Msx1 | homeobox, msh-like 1 | 0.991 | |
| Foxc2 | forkhead box C2 | 0.991 | |
| Pax3 | paired box gene 3 | 0.990 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.988 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.988 | |
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.986 | |
| Bmp4 | bone morphogenetic protein 4 | 0.983 | |
| Smo | smoothened homolog (Drosophila) | 0.983 | |
| Dlx5 | distal-less homeobox 5 | 0.980 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.979 | |
| Gdnf | glial cell line derived neurotrophic factor | 0.979 | |
| Prrx2 | paired related homeobox 2 | 0.978 | |
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.978 | |
| Fgf10 | fibroblast growth factor 10 | 0.978 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 0.972 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.972 | |
| Rarb | retinoic acid receptor, beta | 0.970 | |
| Pax8 | paired box gene 8 | 0.969 | |
| Nog | noggin | 0.961 | |
| Twist2 | twist homolog 2 (Drosophila) | 0.943 | |
| Chrd | chordin | 0.933 | |
| Prrx1 | paired related homeobox 1 | 0.933 | |
| Hoxa1 | homeobox A1 | 0.932 | |
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.923 | |
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.917 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.917 | |
| T | brachyury | 0.907 | |
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.895 | |
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.872 | |
| Hoxa2 | homeobox A2 | 0.854 | |
| Hoxd11 | homeobox D11 | 0.842 | |
| Rara | retinoic acid receptor, alpha | 0.836 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.827 | |
| Msx2 | homeobox, msh-like 2 | 0.758 | |
| Fgf3 | fibroblast growth factor 3 | 0.757 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.757 | |
| Col2a1 | collagen, type II, alpha 1 | 0.752 | |
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.752 | |
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.745 | |
| Hoxd13 | homeobox D13 | 0.736 | |
| Hoxa13 | homeobox A13 | 0.723 | |
| Alx4 | aristaless-like homeobox 4 | 0.686 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.665 | |
| Hoxa3 | homeobox A3 | 0.660 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.658 | |
| Fgf15 | fibroblast growth factor 15 | 0.643 | |
| Fgf18 | fibroblast growth factor 18 | 0.634 | |
| En1 | engrailed 1 | 0.613 | |
| Hmx3 | H6 homeobox 3 | 0.611 | |
| Hoxd3 | homeobox D3 | 0.608 | |
| Gsc | goosecoid homeobox | 0.604 | |
| Emid2 | EMI domain containing 2 | 0.561 | |
| Vax1 | ventral anterior homeobox containing gene 1 | 0.549 | |
| Wnt4 | wingless-related MMTV integration site 4 | 0.537 | |
| Wnt6 | wingless-related MMTV integration site 6 | 0.533 | |
| Ptk7 | PTK7 protein tyrosine kinase 7 | 0.531 | |
| Hoxa11 | homeobox A11 | 0.528 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.526 | |
| Pax9 | paired box gene 9 | 0.524 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.511 | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.499 | |
| Gli1 | GLI-Kruppel family member GLI1 | 0.470 | |
| Hoxd9 | homeobox D9 | 0.466 | |
| Pou3f3 | POU domain, class 3, transcription factor 3 | 0.452 | |
| Pax1 | paired box gene 1 | 0.448 | |
| Neurog1 | neurogenin 1 | 0.444 | |
| Ret | ret proto-oncogene | 0.443 | |
| Tbx15 | T-box 15 | 0.412 | |
| Tbx3 | T-box 3 | 0.405 | |
| Tbx2 | T-box 2 | 0.404 | |
| Ephb2 | Eph receptor B2 | 0.396 | |
| Foxd2 | forkhead box D2 | 0.396 | |
| Hoxc5 | homeobox C5 | 0.378 | |
| Hoxa4 | homeobox A4 | 0.377 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.375 | |
| Tead3 | TEA domain family member 3 | 0.374 | |
| Ednra | endothelin receptor type A | 0.355 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.350 | |
| Col13a1 | collagen, type XIII, alpha 1 | 0.341 | |
| Rxra | retinoid X receptor alpha | 0.338 | |
| Bnc1 | basonuclin 1 | 0.332 | |
| Tcfap2c | transcription factor AP-2, gamma | 0.331 | |
| Sim2 | single-minded homolog 2 (Drosophila) | 0.321 | |
| Trp63 | transformation related protein 63 | 0.320 | |
| Foxn1 | forkhead box N1 | 0.318 | |
| Nodal | nodal | 0.316 | |
| Hoxb3 | homeobox B3 | 0.311 |
