IMP
Process View
The network for 'positive regulation of macrophage derived foam cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive regulation of macrophage derived foam cell differentiation
Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Src | Rous sarcoma oncogene | 0.943 | |
| Ldb3 | LIM domain binding 3 | 0.895 | |
| Apoa1 | apolipoprotein A-I | 0.842 | |
| Apoe | apolipoprotein E | 0.572 | |
| Prkce | protein kinase C, epsilon | 0.536 | |
| Csf1r | colony stimulating factor 1 receptor | 0.536 | |
| Esr1 | estrogen receptor 1 (alpha) | 0.310 | |
| Igf1 | insulin-like growth factor 1 | 0.282 | |
| Ghr | growth hormone receptor | 0.280 | |
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.266 | |
| Fabp4 | fatty acid binding protein 4, adipocyte | 0.225 | |
| Mapk14 | mitogen-activated protein kinase 14 | 0.216 | |
| Cav1 | caveolin 1, caveolae protein | 0.199 | |
| Pparg | peroxisome proliferator activated receptor gamma | 0.191 | |
| Tnfsf11 | tumor necrosis factor (ligand) superfamily, member 11 | 0.188 | |
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.165 | |
| Pik3r1 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | 0.165 | |
| Fbn1 | fibrillin 1 | 0.160 | |
| Cd5l | CD5 antigen-like | 0.157 | |
| Slc2a4 | solute carrier family 2 (facilitated glucose transporter), member 4 | 0.144 | |
| Csf2 | colony stimulating factor 2 (granulocyte-macrophage) | 0.143 | |
| Il3 | interleukin 3 | 0.141 | |
| Fcna | ficolin A | 0.141 | |
| Tnfrsf11a | tumor necrosis factor receptor superfamily, member 11a | 0.136 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.130 | |
| F10 | coagulation factor X | 0.124 | |
| Actb | actin, beta | 0.122 | |
| Clock | circadian locomotor output cycles kaput | 0.113 | |
| Cd36 | CD36 antigen | 0.097 | |
| Ywhab | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.091 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.087 | |
| Actn2 | actinin alpha 2 | 0.083 | |
| Mmp9 | matrix metallopeptidase 9 | 0.082 | |
| Trf | transferrin | 0.077 | |
| F13a1 | coagulation factor XIII, A1 subunit | 0.071 | |
| Il1rn | interleukin 1 receptor antagonist | 0.069 | |
| Npc1 | Niemann Pick type C1 | 0.069 | |
| Gjb2 | gap junction protein, beta 2 | 0.060 | |
| Vdr | vitamin D receptor | 0.059 | |
| Vim | vimentin | 0.054 | |
| Sycn | syncollin | 0.052 | |
| Arntl | aryl hydrocarbon receptor nuclear translocator-like | 0.052 | |
| Zg16 | zymogen granule protein 16 | 0.051 | |
| Clec4d | C-type lectin domain family 4, member d | 0.051 | |
| Lpl | lipoprotein lipase | 0.049 | |
| Sirpa | signal-regulatory protein alpha | 0.048 | |
| Pnliprp1 | pancreatic lipase related protein 1 | 0.045 | |
| Serpina10 | serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | 0.044 | |
| Gnptab | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 0.044 | |
| Ifng | interferon gamma | 0.044 | |
| Mtmr1 | myotubularin related protein 1 | 0.043 | |
| Pnpla2 | patatin-like phospholipase domain containing 2 | 0.042 | |
| Ccl7 | chemokine (C-C motif) ligand 7 | 0.042 | |
| Clps | colipase, pancreatic | 0.042 | |
| Thra | thyroid hormone receptor alpha | 0.041 | |
| Itih4 | inter alpha-trypsin inhibitor, heavy chain 4 | 0.041 | |
| Tcirg1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 | 0.040 | |
| Pip4k2a | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.040 | |
| Ctsk | cathepsin K | 0.039 | |
| Kit | kit oncogene | 0.039 | |
| Cyp2d26 | cytochrome P450, family 2, subfamily d, polypeptide 26 | 0.039 | |
| Homer1 | homer homolog 1 (Drosophila) | 0.038 | |
| Fam20c | family with sequence similarity 20, member C | 0.037 | |
| Ldlr | low density lipoprotein receptor | 0.037 | |
| Fbxw7 | F-box and WD-40 domain protein 7 | 0.036 | |
| Angptl4 | angiopoietin-like 4 | 0.036 | |
| Marco | macrophage receptor with collagenous structure | 0.036 | |
| Mat1a | methionine adenosyltransferase I, alpha | 0.036 | |
| Nsf | N-ethylmaleimide sensitive fusion protein | 0.035 | |
| Asgr2 | asialoglycoprotein receptor 2 | 0.035 | |
| Soat2 | sterol O-acyltransferase 2 | 0.035 | |
| Tgfbr2 | transforming growth factor, beta receptor II | 0.034 | |
| Prkca | protein kinase C, alpha | 0.033 | |
| Ppp3r1 | protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) | 0.032 | |
| Ptk2b | PTK2 protein tyrosine kinase 2 beta | 0.032 | |
| Amhr2 | anti-Mullerian hormone type 2 receptor | 0.031 | |
| F12 | coagulation factor XII (Hageman factor) | 0.031 | |
| Dmbt1 | deleted in malignant brain tumors 1 | 0.030 | |
| Apoc2 | apolipoprotein C-II | 0.030 | |
| Ambp | alpha 1 microglobulin/bikunin | 0.030 | |
| Gja1 | gap junction protein, alpha 1 | 0.029 | |
| Vnn3 | vanin 3 | 0.029 | |
| Cxcl2 | chemokine (C-X-C motif) ligand 2 | 0.029 | |
| Mitf | microphthalmia-associated transcription factor | 0.029 | |
| Itgb3 | integrin beta 3 | 0.029 | |
| Mcoln2 | mucolipin 2 | 0.028 | |
| Emr1 | EGF-like module containing, mucin-like, hormone receptor-like sequence 1 | 0.028 | |
| Areg | amphiregulin | 0.028 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.028 | |
| Abca1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.028 | |
| Prkcb | protein kinase C, beta | 0.028 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.027 | |
| Serpinc1 | serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 | 0.027 | |
| Col1a1 | collagen, type I, alpha 1 | 0.027 | |
| Hgd | homogentisate 1, 2-dioxygenase | 0.027 | |
| Prnp | prion protein | 0.026 | |
| Clec4a2 | C-type lectin domain family 4, member a2 | 0.026 | |
| F2 | coagulation factor II | 0.026 | |
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.026 | |
| Dlg3 | discs, large homolog 3 (Drosophila) | 0.026 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| MAP2K4 | mitogen-activated protein kinase kinase 4 | 0.586 | |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.079 | |
| SNTA1 | syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) | 0.052 | |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.051 | |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.051 | |
| IL8 | interleukin 8 | 0.050 | |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.029 | |
| COTL1 | coactosin-like 1 (Dictyostelium) | 0.026 | |
| ATF2 | activating transcription factor 2 | 0.023 | |
| CPNE6 | copine VI (neuronal) | 0.023 | |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.022 | |
| JUN | jun proto-oncogene | 0.021 | |
| DPP4 | dipeptidyl-peptidase 4 | 0.020 | |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.017 | |
| IL1B | interleukin 1, beta | 0.015 | |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.015 | |
| CXCL6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 0.015 | |
| ARRB1 | arrestin, beta 1 | 0.013 |