The network for 'g protein coupled receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

g protein coupled receptor signaling pathway

A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.

Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.999
Pgr progesterone receptor 0.994
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.985
Drd2 dopamine receptor D2 0.982
Ren1 renin 1 structural 0.976
Vegfa vascular endothelial growth factor A 0.967
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.959
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.955
Cnr1 cannabinoid receptor 1 (brain) 0.954
Npy1r neuropeptide Y receptor Y1 0.951
Grm1 glutamate receptor, metabotropic 1 0.950
Oprk1 opioid receptor, kappa 1 0.949
Kcnk3 potassium channel, subfamily K, member 3 0.947
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.946
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.946
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.941
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.941
Esr1 estrogen receptor 1 (alpha) 0.928
Cckbr cholecystokinin B receptor 0.926
Ednrb endothelin receptor type B 0.915
Thrb thyroid hormone receptor beta 0.910
Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 0.904
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.903
Tgfbr2 transforming growth factor, beta receptor II 0.891
Lep leptin 0.889
Clock circadian locomotor output cycles kaput 0.888
Nos3 nitric oxide synthase 3, endothelial cell 0.884
Kl klotho 0.880
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.873
Sstr1 somatostatin receptor 1 0.872
Nxph1 neurexophilin 1 0.868
Uts2r urotensin 2 receptor 0.866
Adrb1 adrenergic receptor, beta 1 0.864
Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 0.853
Selp selectin, platelet 0.852
Dio2 deiodinase, iodothyronine, type II 0.842
Oprm1 opioid receptor, mu 1 0.837
Tyr tyrosinase 0.828
Npy2r neuropeptide Y receptor Y2 0.825
Lhx3 LIM homeobox protein 3 0.824
Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 0.822
Mmp16 matrix metallopeptidase 16 0.821
Rgs9 regulator of G-protein signaling 9 0.818
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.817
Gnrhr gonadotropin releasing hormone receptor 0.815
Kcns2 K+ voltage-gated channel, subfamily S, 2 0.808
Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 0.808
Vav3 vav 3 oncogene 0.806
Bglap bone gamma carboxyglutamate protein 0.803
Cx3cr1 chemokine (C-X3-C) receptor 1 0.781
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.779
Flt1 FMS-like tyrosine kinase 1 0.775
Mc3r melanocortin 3 receptor 0.773
Plxnd1 plexin D1 0.771
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.769
Smad3 MAD homolog 3 (Drosophila) 0.764
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3 0.764
Ptk2 PTK2 protein tyrosine kinase 2 0.760
Kcnb1 potassium voltage gated channel, Shab-related subfamily, member 1 0.743
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.740
Rfpl4 ret finger protein-like 4 0.739
Crhr1 corticotropin releasing hormone receptor 1 0.735
Kiss1r KISS1 receptor 0.733
Neurog2 neurogenin 2 0.729
Rgs4 regulator of G-protein signaling 4 0.728
Itgax integrin alpha X 0.725
Nos1 nitric oxide synthase 1, neuronal 0.722
Syt1 synaptotagmin I 0.722
Arrb1 arrestin, beta 1 0.721
Msx1 homeobox, msh-like 1 0.719
Syn2 synapsin II 0.719
Slc12a5 solute carrier family 12, member 5 0.718
Arrb2 arrestin, beta 2 0.712
Ctnnb1 catenin (cadherin associated protein), beta 1 0.712
Grid1 glutamate receptor, ionotropic, delta 1 0.710
Cd247 CD247 antigen 0.708
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.704
Gad2 glutamic acid decarboxylase 2 0.698
Ncf1 neutrophil cytosolic factor 1 0.693
Olfr70 olfactory receptor 70 0.693
Opn1sw opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) 0.685
Gpr132 G protein-coupled receptor 132 0.685
Adora2a adenosine A2a receptor 0.683
Fgf14 fibroblast growth factor 14 0.683
Acvrl1 activin A receptor, type II-like 1 0.683
Htr4 5 hydroxytryptamine (serotonin) receptor 4 0.678
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.675
Npy6r neuropeptide Y receptor Y6 0.673
Mkl2 MKL/myocardin-like 2 0.670
Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 0.664
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.654
Gdnf glial cell line derived neurotrophic factor 0.654
Htr3a 5-hydroxytryptamine (serotonin) receptor 3A 0.648
Tgfb2 transforming growth factor, beta 2 0.644
Prrt1 proline-rich transmembrane protein 1 0.638
Drd3 dopamine receptor D3 0.635
Ccr5 chemokine (C-C motif) receptor 5 0.633
Homer1 homer homolog 1 (Drosophila) 0.629
Plxnb1 plexin B1 0.628
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 0.622
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
pkg-1 Protein PKG-1 0.949
pde-4 Protein PDE-4 0.762
pdfr-1 Protein PDFR-1 0.727
odr-3 Protein ODR-3 0.724
itr-1 Protein ITR-1 0.710
goa-1 Protein GOA-1 0.616
eat-4 Protein EAT-4 0.594
madd-4 Protein MADD-4 0.474
ser-7 Protein SER-7 0.467
mod-1 Protein MOD-1 0.395
unc-43 Protein UNC-43 0.368
CELE_R13H7.2 Protein R13H7.2 0.350
F52A8.1 Protein F52A8.1 0.328
npr-4 Protein NPR-4 0.322
kcc-1 Protein KCC-1 0.313
gpb-1 Protein GPB-1 0.310
eat-6 Protein EAT-6 0.289
cal-4 Protein CAL-4 0.285
egl-36 Protein EGL-36 0.280
best-18 Protein BEST-18 0.278
ser-3 Protein SER-3 0.257
CELE_H04M03.12 Protein H04M03.12 0.223
ser-2 Protein SER-2 0.219
egl-30 Protein EGL-30 0.217
nep-11 Protein NEP-11 0.213
cmd-1 Protein CMD-1 0.197
M01A8.2 Protein M01A8.2 0.194
nlp-15 Protein NLP-15 0.182
Y37D8A.2 Protein Y37D8A.2 0.178
C30B5.7 Protein C30B5.7 0.174
flp-7 Protein FLP-7 0.170
unc-25 Protein UNC-25 0.168
rskn-2 Protein RSKN-2 0.160
ida-1 Protein IDA-1 0.159
frm-1 Protein FRM-1 0.155
ist-1 Protein IST-1 0.155
lgc-46 Protein LGC-46 0.153
unc-2 Protein UNC-2 0.153
arrd-26 Protein ARRD-26 0.151
aat-5 Protein AAT-5 0.149
glb-33 Protein GLB-33 0.149
crp-1 Protein CRP-1 0.144
myo-6 Protein MYO-6 0.143
twk-40 Protein TWK-40 0.141
saeg-1 Protein SAEG-1 0.137
stim-1 Protein STIM-1 0.126
arrd-13 Protein ARRD-13 0.124
nlg-1 Protein NLG-1 0.123
sgca-1 Protein SGCA-1 0.115
cho-1 Protein CHO-1 0.114
Y56A3A.6 Protein Y56A3A.6 0.113
F28F5.4 Protein F28F5.4 0.113
ser-4 Protein SER-4 0.113
kin-20 Protein KIN-20 0.113
lite-1 Protein LITE-1 0.110
unc-73 Protein UNC-73 0.108
rsbp-1 Protein RSBP-1 0.108
xbx-3 Protein XBX-3 0.108
twk-30 Protein TWK-30 0.104
ogt-1 Protein OGT-1 0.103
CELE_C29F4.3 Protein C29F4.3 0.102
cdh-4 Protein CDH-4 0.102
dop-1 Protein DOP-1 0.102
unc-80 Protein UNC-80 0.101
unc-17 Protein UNC-17 0.100
CELE_Y53F4B.5 Protein Y53F4B.5 0.098
arrd-15 Protein ARRD-15 0.097
lrp-1 Protein LRP-1 0.097
unc-9 Protein UNC-9 0.097
R13A5.9 Protein R13A5.9 0.096
slo-2 Protein SLO-2 0.095
pdf-1 Protein PDF-1 0.095
npr-12 Protein NPR-12 0.094
W01A11.7 Protein W01A11.7 0.092
CELE_Y69H2.1 Protein Y69H2.1 0.091
glr-4 Protein GLR-4 0.087
npr-6 Protein NPR-6 0.087
unc-13 Protein UNC-13 0.086
sol-1 Protein SOL-1 0.085
unc-103 Protein UNC-103 0.084
daf-12 Protein DAF-12 0.081
DH11.5 Protein DH11.5 0.079
pes-7 Protein PES-7 0.079
gcy-28 Protein GCY-28 0.079
abts-3 Protein ABTS-3 0.079
twk-17 Protein TWK-17 0.079
C39B10.1 Protein C39B10.1 0.078
srr-3 Protein SRR-3 0.078
ncr-1 Protein NCR-1 0.077
F32B4.5 Protein F32B4.5 0.077
dmsr-8 Protein DMSR-8 0.076
aex-3 Protein AEX-3 0.075
gpa-14 Protein GPA-14 0.075
F54G2.1 Protein F54G2.1 0.073
M03F8.6 Protein M03F8.6 0.073
C25E10.12 Protein C25E10.12 0.073
C17B7.8 Protein C17B7.8 0.073
hot-7 Protein HOT-7 0.073
npr-27 Protein NPR-27 0.072
ima-3 Protein IMA-3 0.072
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Danio rerio
Name Description Probability Func Analog Organism
si:dkey-228g21.4 si:dkey-228g21.4 0.901
plcg1 phospholipase C, gamma 1 0.883
chat choline acetyltransferase 0.845
hrh1 histamine receptor H1 0.812
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.740
drd2b dopamine receptor D2b 0.720
npy8br neuropeptide Y receptor Y8b 0.706
oprk1 opioid receptor, kappa 1 0.698
adra2b adrenergic, alpha-2B-, receptor 0.685
LOC569642 hypothetical protein LOC569642 0.681
opn4l opsin 4, like 0.680
opn1lw1 opsin 1 (cone pigments), long-wave-sensitive, 1 0.680
gnat1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 0.676
rho rhodopsin 0.645
mchr1b melanin-concentrating hormone receptor 1b 0.611
opn1sw2 opsin 1 (cone pigments), short-wave-sensitive 2 0.606
opn4a opsin 4a (melanopsin) 0.593
kiss1 KiSS-1 metastasis-suppressor 0.593
mc4r melanocortin 4 receptor 0.591
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.588
LOC559201 similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3) 0.587
oprm1 opioid receptor, mu 1 0.576
ulk2 unc-51-like kinase 2 (C. elegans) 0.533
mao monoamine oxidase 0.524
pink1 PTEN induced putative kinase 1 0.465
cadm2b cell adhesion molecule 2b 0.448
mtnr1ba melatonin receptor type 1B a 0.442
htr1aa 5-hydroxytryptamine (serotonin) receptor 1A a 0.441
si:ch211-124k10.1 si:ch211-124k10.1 0.438
gnrhr3 gonadotropin releasing hormone receptor 3 0.436
trpc1 transient receptor potential cation channel, subfamily C, member 1 0.431
avpl arginine vasopressin-like 0.419
lin7a lin-7 homolog A (C. elegans) 0.418
dbh dopamine beta hydroxylase 0.399
tbx1 T-box 1 0.391
cyp19a1a cytochrome P450, family 19, subfamily A, polypeptide 1a 0.391
tac1 tachykinin 1 0.388
pi4kb phosphatidylinositol 4-kinase, catalytic, beta 0.386
esr2a estrogen receptor 2a 0.371
vangl2 vang-like 2 (van gogh, Drosophila) 0.364
gcm2 glial cells missing homolog 2 (Drosophila) 0.359
ptprc protein tyrosine phosphatase, receptor type, C 0.358
drd2a dopamine receptor D2a 0.355
adra2c adrenergic, alpha-2C-, receptor 0.352
LOC100331502 melanopsin-B-like 0.349
kcnn1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 0.344
gnrhr4 gonadotropin releasing hormone receptor 4 0.336
ntf7 neurotrophin 7 0.333
osr1 odd-skipped related 1 (Drosophila) 0.330
lhx8a LIM homeobox 8a 0.321
gucy2f guanylate cyclase 2F, retinal 0.311
gnat2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 0.310
mc1r melanocortin 1 receptor 0.310
pmch pro-melanin concentrating hormone 0.293
nbl1 neuroblastoma, suppression of tumorigenicity 1 0.289
kiss2 kisspeptin 2 0.282
adra2a adrenergic, alpha-2A-, receptor 0.275
LOC555482 tachykinin receptor 3-like 0.271
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.266
gna13a guanine nucleotide binding protein (G protein), alpha 13a 0.256
ildr1b immunoglobulin-like domain containing receptor 1b 0.256
opn1sw1 opsin 1 (cone pigments), short-wave-sensitive 1 0.251
slc8a4b solute carrier family 8 (sodium/calcium exchanger), member 4b 0.248
gc2 guanylyl cyclase 2 0.238
mchr1a melanin-concentrating hormone receptor 1a 0.229
gna14 guanine nucleotide binding protein (G protein), alpha 14 0.229
arr3a arrestin 3a, retinal (X-arrestin) 0.225
hdc histidine decarboxylase 0.219
c1qtnf4 C1q and tumor necrosis factor related protein 4 0.218
LOC793448 protein-glutamine gamma-glutamyltransferase K-like 0.215
oxtl oxytocin-like 0.215
cnga5 cyclic nucleotide gated channel alpha 5 0.213
pou1f1 POU domain, class 1, transcription factor 1 0.212
tshb thyroid stimulating hormone, beta subunit 0.212
scn1lab sodium channel, voltage-gated, type I like, alpha b 0.211
nlgn1 neuroligin 1 0.206
gnaq guanine nucleotide binding protein (G protein), q polypeptide 0.206
adra2db adrenergic, alpha-2D-, receptor b 0.204
gnai3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.203
itgb1a integrin, beta 1a 0.202
gnai2l guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like 0.199
pdca phosducin a 0.198
vdra vitamin D receptor a 0.198
opn4x1 opsin 4x1 0.196
camk2g2 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2 0.192
crb2b crumbs homolog 2b 0.186
gnrh3 gonadotropin-releasing hormone 3 0.183
gnav1 guanine nucleotide binding protein (G protein) alpha v1 0.183
paqr7b progestin and adipoQ receptor family member VII, b 0.181
LOC568691 opsin-3-like 0.179
pde6h phosphodiesterase 6H, cGMP-specific, cone, gamma 0.176
slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.173
insra insulin receptor a 0.173
arf1 ADP-ribosylation factor 1 0.167
tas2r202 taste receptor, type 2, member 202 0.166
ctsl1a cathepsin L, 1 a 0.165
slc18a3b solute carrier family 18 (vesicular acetylcholine), member 3b 0.164
wu:fc57f07 wu:fc57f07 0.163
fam84b family with sequence similarity 84, member B 0.162
irbp interphotoreceptor retinoid-binding protein 0.161
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
norpA no receptor potential A 1.000
trp transient receptor potential 1.000
Arr2 Arrestin 2 0.985
inaD inactivation no afterpotential D 0.981
rdgC retinal degeneration C 0.979
Galpha49B G protein alpha49B 0.976
ninaE neither inactivation nor afterpotential E 0.969
G-oalpha47A G protein oalpha 47A 0.958
Nrg Neuroglian 0.955
trpl trp-like 0.952
Nrx-1 Neurexin 1 0.947
CG42629 CG42629 gene product from transcript CG42629-RB 0.945
inaC inactivation no afterpotential C 0.925
rdgB retinal degeneration B 0.916
Octbeta2R CG33976 gene product from transcript CG33976-RA 0.903
beta-Spec beta Spectrin 0.895
oa2 octopamine receptor 2 0.892
Trh Tryptophan hydroxylase 0.890
CkIalpha Casein kinase Ialpha 0.882
Rac2 CG8556 gene product from transcript CG8556-RA 0.879
foxo forkhead box, sub-group O 0.876
Cng Cyclic-nucleotide-gated ion channel protein 0.870
Tbh Tyramine beta hydroxylase 0.855
rpr reaper 0.850
pain painless 0.830
Akt1 CG4006 gene product from transcript CG4006-RA 0.801
Snap25 Synapse protein 25 0.787
inx2 innexin 2 0.779
t tan 0.779
mtt mangetout 0.763
Ilp2 Insulin-like peptide 2 0.738
Arr1 Arrestin 1 0.725
sNPF short neuropeptide F precursor 0.706
dnc dunce 0.700
ninaA neither inactivation nor afterpotential A 0.698
Adar Adenosine deaminase acting on RNA 0.694
rdgA retinal degeneration A 0.693
Rh5 Rhodopsin 5 0.683
CG31619 CG31619 gene product from transcript CG31619-RC 0.672
Plc21C Phospholipase C at 21C 0.662
LanB1 CG7123 gene product from transcript CG7123-RA 0.632
Rh3 Rhodopsin 3 0.628
CG13253 CG13253 gene product from transcript CG13253-RB 0.597
CG16778 CG16778 gene product from transcript CG16778-RA 0.594
Ced-12 CG5336 gene product from transcript CG5336-RA 0.585
sNPF-R short neuropeptide F receptor 0.583
Rh6 Rhodopsin 6 0.576
drk downstream of receptor kinase 0.572
Dab Disabled 0.570
GABA-B-R3 metabotropic GABA-B receptor subtype 3 0.565
slo slowpoke 0.563
CG7191 CG7191 gene product from transcript CG7191-RA 0.563
CG31221 CG31221 gene product from transcript CG31221-RA 0.561
G-ialpha65A G protein alphai subunit 65A 0.559
CG13792 CG13792 gene product from transcript CG13792-RA 0.545
ena enabled 0.538
nwk nervous wreck 0.537
sda slamdance 0.535
NetB Netrin-B 0.520
Pde8 Phosphodiesterase 8 0.505
shi shibire 0.500
npf neuropeptide F 0.496
Rac1 CG2248 gene product from transcript CG2248-RA 0.488
SNF4Agamma SNF4/AMP-activated protein kinase gamma subunit 0.484
5-HT1A Serotonin receptor 1A 0.476
Gyc-89Db Guanylyl cyclase at 89Db 0.468
rut rutabaga 0.449
NLaz Neural Lazarillo 0.423
p120ctn Adherens junction protein p120 0.419
GABA-B-R2 metabotropic GABA-B receptor subtype 2 0.408
scb scab 0.404
Atf-2 Activating transcription factor-2 0.394
GluRIIA Glutamate receptor IIA 0.389
Ilp5 Insulin-like peptide 5 0.383
ia2 CG31795 gene product from transcript CG31795-RD 0.378
CG34400 CG34400 gene product from transcript CG34400-RD 0.378
chp chaoptic 0.377
Ast-C Allatostatin C 0.372
stai stathmin 0.368
NPFR1 neuropeptide F receptor 0.366
Tre1 trapped in endoderm-1 0.364
CG34354 CG34354 gene product from transcript CG34354-RA 0.360
Ank2 Ankyrin 2 0.357
CG31191 CG31191 gene product from transcript CG31191-RA 0.354
5-HT7 Serotonin receptor 7 0.354
pHCl CG33989 gene product from transcript CG33989-RD 0.348
Clk Clock 0.346
inaE inactivation no afterpotential E 0.341
Ggamma1 G protein gamma 1 0.330
raw CG12437 gene product from transcript CG12437-RB 0.327
Smg1 CG32743 gene product from transcript CG32743-RA 0.326
moody CG4322 gene product from transcript CG4322-RD 0.324
amn amnesiac 0.314
ninaC neither inactivation nor afterpotential C 0.309
jeb jelly belly 0.305
Rdl Resistant to dieldrin 0.304
dsf dissatisfaction 0.302
CG5890 CG5890 gene product from transcript CG5890-RB 0.299
CG13565 CG13565 gene product from transcript CG13565-RA 0.294
Gbeta76C G protein beta-subunit 76C 0.293
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Homo sapiens
Name Description Probability Func Analog Organism
ARRB1 arrestin, beta 1 1.000
CCR5 chemokine (C-C motif) receptor 5 0.999
CAV1 caveolin 1, caveolae protein, 22kDa 0.997
ADRBK1 adrenergic, beta, receptor kinase 1 0.997
DRD2 dopamine receptor D2 0.996
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.995
IL8 interleukin 8 0.992
ALB albumin 0.992
MAPT microtubule-associated protein tau 0.989
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.988
CCL4 chemokine (C-C motif) ligand 4 0.987
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.987
CXCL2 chemokine (C-X-C motif) ligand 2 0.986
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.986
HTR4 5-hydroxytryptamine (serotonin) receptor 4 0.979
PRKCG protein kinase C, gamma 0.979
NCF2 neutrophil cytosolic factor 2 0.977
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.974
CXCL9 chemokine (C-X-C motif) ligand 9 0.967
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 0.960
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.959
IFNG interferon, gamma 0.951
CCL5 chemokine (C-C motif) ligand 5 0.947
IL10 interleukin 10 0.945
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.942
CXCL10 chemokine (C-X-C motif) ligand 10 0.941
IL1B interleukin 1, beta 0.937
CCL8 chemokine (C-C motif) ligand 8 0.935
GPRASP1 G protein-coupled receptor associated sorting protein 1 0.926
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.923
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.918
CCR7 chemokine (C-C motif) receptor 7 0.914
CCL22 chemokine (C-C motif) ligand 22 0.914
CXCL3 chemokine (C-X-C motif) ligand 3 0.912
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.902
ARRB2 arrestin, beta 2 0.902
FGA fibrinogen alpha chain 0.899
GFAP glial fibrillary acidic protein 0.897
CHRNA4 cholinergic receptor, nicotinic, alpha 4 0.897
RGS1 regulator of G-protein signaling 1 0.892
CCL2 chemokine (C-C motif) ligand 2 0.871
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.870
SLC6A7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 0.868
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.865
GHRHR growth hormone releasing hormone receptor 0.856
CCL19 chemokine (C-C motif) ligand 19 0.855
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.854
PSEN1 presenilin 1 0.852
IGF1R insulin-like growth factor 1 receptor 0.849
CXCL5 chemokine (C-X-C motif) ligand 5 0.844
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.842
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.833
CCR1 chemokine (C-C motif) receptor 1 0.825
NPY neuropeptide Y 0.823
HRH3 histamine receptor H3 0.822
CYTIP cytohesin 1 interacting protein 0.821
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.815
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.809
CRHR2 corticotropin releasing hormone receptor 2 0.803
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.801
CCR4 chemokine (C-C motif) receptor 4 0.800
OPRK1 opioid receptor, kappa 1 0.799
RHOA ras homolog gene family, member A 0.796
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.791
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.779
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.779
KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9 0.772
CXCL11 chemokine (C-X-C motif) ligand 11 0.758
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.752
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.745
ADRA1D adrenergic, alpha-1D-, receptor 0.745
CRP C-reactive protein, pentraxin-related 0.743
CCK cholecystokinin 0.742
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.740
LAT linker for activation of T cells 0.735
CCKBR cholecystokinin B receptor 0.734
CCL11 chemokine (C-C motif) ligand 11 0.723
CDSN corneodesmosin 0.714
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.696
HMOX2 heme oxygenase (decycling) 2 0.696
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.695
CALCA calcitonin-related polypeptide alpha 0.695
AQP9 aquaporin 9 0.692
IL2RB interleukin 2 receptor, beta 0.687
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 0.682
IRS1 insulin receptor substrate 1 0.682
TBR1 T-box, brain, 1 0.681
IRF4 interferon regulatory factor 4 0.673
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.673
CXCR5 chemokine (C-X-C motif) receptor 5 0.668
PRKCA protein kinase C, alpha 0.665
CCL7 chemokine (C-C motif) ligand 7 0.664
MEOX2 mesenchyme homeobox 2 0.658
MLN motilin 0.658
SOCS3 suppressor of cytokine signaling 3 0.656
GRM1 glutamate receptor, metabotropic 1 0.653
CCL20 chemokine (C-C motif) ligand 20 0.652
GPR65 G protein-coupled receptor 65 0.649
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.645
ZBED1 zinc finger, BED-type containing 1 0.640
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.902
Cd4 Cd4 molecule 0.828
Sstr3 somatostatin receptor 3 0.824
Mc5r melanocortin 5 receptor 0.810
Olr1361 olfactory receptor 1361 0.789
Adora2a adenosine A2a receptor 0.771
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.741
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.718
Hpca hippocalcin 0.708
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.704
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.679
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.679
Crisp1 cysteine-rich secretory protein 1 0.661
Lim2 lens intrinsic membrane protein 2 0.652
Csf3 colony stimulating factor 3 (granulocyte) 0.648
Gfra2 GDNF family receptor alpha 2 0.644
Drd1a dopamine receptor D1A 0.644
Chrna6 cholinergic receptor, nicotinic, alpha 6 0.644
Trhr thyrotropin releasing hormone receptor 0.629
Cckar cholecystokinin A receptor 0.628
Fgf17 fibroblast growth factor 17 0.615
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.611
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.608
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.594
Olr1641 olfactory receptor 1641 0.586
Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.584
Prkcg protein kinase C, gamma 0.562
Phkg1 phosphorylase kinase, gamma 1 0.561
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.560
Gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.545
Chrm2 cholinergic receptor, muscarinic 2 0.545
Rgs4 regulator of G-protein signaling 4 0.537
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.534
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.532
Fgf14 fibroblast growth factor 14 0.529
Adcy10 adenylate cyclase 10 (soluble) 0.527
Apoa5 apolipoprotein A-V 0.524
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.520
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.519
Sgp158 proline-rich glycoprotein (sgp158) 0.518
Grp gastrin releasing peptide 0.512
Crhbp corticotropin releasing hormone binding protein 0.504
Arpp21 cAMP-regulated phosphoprotein 21 0.498
Myt1l myelin transcription factor 1-like 0.494
Avp arginine vasopressin 0.493
Fgb fibrinogen beta chain 0.488
Pth parathyroid hormone 0.484
Il9r interleukin 9 receptor 0.469
Kcnv1 potassium channel, subfamily V, member 1 0.467
Pde1b phosphodiesterase 1B, calmodulin-dependent 0.466
Vip vasoactive intestinal peptide 0.461
Il2ra interleukin 2 receptor, alpha 0.460
Chrng cholinergic receptor, nicotinic, gamma 0.460
Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 0.455
Rgs9 regulator of G-protein signaling 9 0.453
Sstr1 somatostatin receptor 1 0.450
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.446
Ar androgen receptor 0.422
Col10a1 collagen, type X, alpha 1 0.418
Cpne9 copine family member IX 0.417
Ccr3 chemokine (C-C motif) receptor 3 0.417
Scn8a sodium channel, voltage gated, type VIII, alpha subunit 0.413
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.409
Rup2 urinary protein 2 0.409
Mchr1 melanin-concentrating hormone receptor 1 0.409
Akr1c18 aldo-keto reductase family 1, member C18 0.406
Chrnb1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.403
Gipr gastric inhibitory polypeptide receptor 0.380
Grm6 glutamate receptor, metabotropic 6 0.378
Cntn4 contactin 4 0.374
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.372
Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 0.370
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.369
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.369
Mobp myelin-associated oligodendrocyte basic protein 0.367
Amph amphiphysin 0.367
Cd38 CD38 molecule 0.364
Trhr2 thyrotropin releasing hormone receptor 2 0.362
Slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.362
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.358
Nfasc neurofascin 0.357
Fgf2 fibroblast growth factor 2 0.356
Cnga3 cyclic nucleotide gated channel alpha 3 0.355
Sirpa signal-regulatory protein alpha 0.354
Il12b interleukin 12B 0.354
Esr2 estrogen receptor 2 (ER beta) 0.350
Semg1 semenogelin I 0.342
Prlh prolactin releasing hormone 0.340
Figf c-fos induced growth factor 0.339
Crhr1 corticotropin releasing hormone receptor 1 0.337
Hcrtr1 hypocretin (orexin) receptor 1 0.336
Ctrb1 chymotrypsinogen B1 0.332
Adora1 adenosine A1 receptor 0.332
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.332
Ccr5 chemokine (C-C motif) receptor 5 0.329
Reg3g regenerating islet-derived 3 gamma 0.329
Nrcam neuronal cell adhesion molecule 0.328
Mas1 MAS1 oncogene 0.325
Hcrtr2 hypocretin (orexin) receptor 2 0.312
Cps1 carbamoyl-phosphate synthetase 1 0.312
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
STE4 Ste4p 0.981
FUS3 Fus3p 0.941
STE5 Ste5p 0.906
FAR1 Far1p 0.900
STE7 Ste7p 0.871
CDC24 Cdc24p 0.867
SSK2 Ssk2p 0.654
MKK1 Mkk1p 0.638
PBS2 Pbs2p 0.544
STE11 Ste11p 0.542
STE2 Ste2p 0.526
BCK1 Bck1p 0.480
SSK1 Ssk1p 0.479
MSG5 Msg5p 0.471
PPZ1 Ppz1p 0.429
KDX1 Kdx1p 0.403
AGA2 Aga2p 0.361
NBP2 Nbp2p 0.335
BEM1 Bem1p 0.328
KSS1 Kss1p 0.306
MF(ALPHA)2 Mf(alpha)2p 0.266
STE12 Ste12p 0.234
MF(ALPHA)1 Mf(alpha)1p 0.218
HKR1 Hkr1p 0.191
RLM1 Rlm1p 0.191
ROM2 Rom2p 0.174
CLA4 Cla4p 0.165
MATALPHA1 Matalpha1p 0.165
SST2 Sst2p 0.148
STE18 Ste18p 0.132
SLT2 Slt2p 0.130
STE3 Ste3p 0.121
PTP2 Ptp2p 0.116
STE20 Ste20p 0.110
FYV8 Fyv8p 0.092
IRA1 Ira1p 0.084
GPA1 Gpa1p 0.079
YPT35 Ypt35p 0.070
RHO5 Rho5p 0.066
GIC2 Gic2p 0.061
DBF2 Dbf2p 0.060
BEM3 Bem3p 0.059
VPS15 Vps15p 0.058
BAR1 Bar1p 0.056
SKM1 Skm1p 0.052
FIR1 Fir1p 0.052
RHO1 Rho1p 0.051
BEM2 Bem2p 0.051
GDS1 Gds1p 0.051
SSK22 Ssk22p 0.045
GIP4 Gip4p 0.043
CAB3 Cab3p 0.042
EBS1 Ebs1p 0.041
FMP48 Fmp48p 0.041
VHS3 Vhs3p 0.041
SDP1 Sdp1p 0.041
FET4 Fet4p 0.040
YPL088W hypothetical protein 0.040
NAT1 Nat1p 0.040
KNH1 Knh1p 0.039
OSH7 Osh7p 0.039
TPK2 Tpk2p 0.039
UBP5 Ubp5p 0.038
KIC1 Kic1p 0.037
CLN3 Cln3p 0.037
OPY1 Opy1p 0.036
TFB1 Tfb1p 0.036
BCK2 Bck2p 0.036
MSB3 Msb3p 0.036
CDC55 Cdc55p 0.036
UBP11 Ubp11p 0.036
YOR338W hypothetical protein 0.035
GPB2 Gpb2p 0.035
SDS22 Sds22p 0.035
FUS2 Fus2p 0.035
PKC1 Pkc1p 0.034
RIM13 Rim13p 0.034
CRG1 Crg1p 0.034
PEP5 Pep5p 0.033
DIG1 Dig1p 0.032
GIC1 Gic1p 0.032
RAS2 Ras2p 0.032
YLR264C-A hypothetical protein 0.032
SRD1 Srd1p 0.032
MATALPHA2 Matalpha2p 0.031
AGA1 Aga1p 0.030
MKK2 Mkk2p 0.030
BFR1 Bfr1p 0.030
YLR162W hypothetical protein 0.030
DSE4 Dse4p 0.029
ACK1 Ack1p 0.029
NGL3 Ngl3p 0.028
TKL2 Tkl2p 0.028
MER1 Mer1p 0.028
ELP6 Elp6p 0.027
YOL038C-A hypothetical protein 0.027
AKR1 Akr1p 0.027
YNL234W hypothetical protein 0.027
YJL163C hypothetical protein 0.027
HXT11 Hxt11p 0.026