The network for 'skeletal system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

Danio rerio
Name Description Probability Func Analog Organism
sox9a SRY-box containing gene 9a 1.000
prdm1a PR domain containing 1a, with ZNF domain 0.999
bmp2b bone morphogenetic protein 2b 0.999
barx1 BarH-like homeobox 1 0.997
wu:fv91b12 wu:fv91b12 0.997
twist1a twist1a 0.996
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.996
gli2a GLI-Kruppel family member GLI2a 0.996
bmp2a bone morphogenetic protein 2a 0.996
ptch1 patched 1 0.995
foxi1 forkhead box I1 0.995
sox9b SRY-box containing gene 9b 0.992
gata3 GATA-binding protein 3 0.990
jag1b jagged 1b 0.987
twist3 twist3 0.985
col1a1a collagen, type I, alpha 1a 0.984
tp63 tumor protein p63 0.983
fli1a friend leukemia integration 1a 0.981
uxs1 UDP-glucuronic acid decarboxylase 1 0.976
dlx2a distal-less homeobox gene 2a 0.973
tbx1 T-box 1 0.971
bmp1a bone morphogenetic protein 1a 0.971
pitx3 paired-like homeodomain transcription factor 3 0.968
dlx3b distal-less homeobox gene 3b 0.967
fgf3 fibroblast growth factor 3 0.967
hoxc8a homeo box C8a 0.965
hoxa4a homeo box A4a 0.963
atoh1a atonal homolog 1a 0.962
crabp2a cellular retinoic acid binding protein 2, a 0.962
edn1 endothelin 1 0.960
raraa retinoic acid receptor, alpha a 0.954
hoxb4a homeo box B4a 0.951
shha sonic hedgehog a 0.950
dlb deltaB 0.945
bglap bone gamma-carboxyglutamate (gla) protein 0.933
chd chordin 0.932
fgf8a fibroblast growth factor 8 a 0.931
eya1 eyes absent homolog 1 0.931
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.929
disp1 dispatched homolog 1 (Drosophila) 0.927
notch2 notch homolog 2 0.927
foxa2 forkhead box A2 0.923
dlx5a distal-less homeobox gene 5a 0.923
sec24d SEC24 family, member D (S. cerevisiae) 0.918
fgf10a fibroblast growth factor 10a 0.916
prdm16 PR domain containing 16 0.915
col5a2l collagen, type V, alpha 2-like 0.913
pitx2 paired-like homeodomain transcription factor 2 0.909
egr1 early growth response 1 0.902
efnb2a ephrin B2a 0.885
six4b sine oculis homeobox homolog 4b 0.884
hoxb6a homeo box B6a 0.882
tfap2a transcription factor AP-2 alpha 0.869
hoxb5b homeo box B5b 0.868
tp53 tumor protein p53 0.868
brpf1 bromodomain and PHD finger containing, 1 0.867
osr1 odd-skipped related 1 (Drosophila) 0.866
hoxd4a homeo box D4a 0.860
fzd8a frizzled homolog 8a 0.860
hhip hedgehog interacting protein 0.858
ctgf connective tissue growth factor 0.857
sulf1 sulfatase 1 0.843
hoxa5a homeo box A5a 0.840
gata2a GATA-binding protein 2a 0.838
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.838
col5a1 procollagen, type V, alpha 1 0.833
gdf6a growth differentiation factor 6a 0.832
bmp4 bone morphogenetic protein 4 0.831
hoxc4a homeo box C4a 0.820
emx3 empty spiracles homeobox 3 0.811
col2a1a collagen type II, alpha-1a 0.811
loxl3b lysyl oxidase-like 3b 0.810
hoxa3a homeo box A3a 0.797
dlx4b distal-less homeobox gene 4b 0.784
cdx4 caudal type homeo box transcription factor 4 0.782
foxd3 forkhead box D3 0.769
pax2a paired box gene 2a 0.766
zgc:158603 zgc:158603 0.766
dmrt2a doublesex and mab-3 related transcription factor 2a 0.765
mecom MDS1 and EVI1 complex locus 0.764
ltk leukocyte tyrosine kinase 0.761
gpr126 G protein-coupled receptor 126 0.756
wnt11 wingless-type MMTV integration site family, member 11 0.754
si:ch211-173b8.2 si:ch211-173b8.2 0.752
snai1a snail homolog 1a (Drosophila) 0.749
meis1 myeloid ecotropic viral integration 1 0.743
twist1b twist1b 0.739
ndr2 nodal-related 2 0.737
nkx3.2 NK3 homeobox 2 0.737
enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.731
dlx4a distal-less homeobox gene 4a 0.720
tbx18 T-box 18 0.720
runx2b runt-related transcription factor 2b 0.719
hoxb2a homeo box B2a 0.713
chpf chondroitin polymerizing factor 0.712
hoxb3a homeo box B3a 0.702
ihha Indian hedgehog homolog a 0.696
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.693
furina furin (paired basic amino acid cleaving enzyme) a 0.692
fam20b family with sequence similarity 20, member B (H. sapiens) 0.691
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
SMAD3 SMAD family member 3 0.998
TP53 tumor protein p53 0.998
COL1A1 collagen, type I, alpha 1 0.994
CTGF connective tissue growth factor 0.990
RUNX1 runt-related transcription factor 1 0.988
SMAD7 SMAD family member 7 0.982
LOX lysyl oxidase 0.954
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.944
FBN1 fibrillin 1 0.943
HOXB5 homeobox B5 0.930
BMP2 bone morphogenetic protein 2 0.930
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.920
MYOD1 myogenic differentiation 1 0.915
HSPG2 heparan sulfate proteoglycan 2 0.910
NCOR2 nuclear receptor corepressor 2 0.905
COL3A1 collagen, type III, alpha 1 0.902
ELN elastin 0.897
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.883
EP300 E1A binding protein p300 0.883
HOXD9 homeobox D9 0.876
ATN1 atrophin 1 0.876
FN1 fibronectin 1 0.871
SMAD4 SMAD family member 4 0.867
DDR2 discoidin domain receptor tyrosine kinase 2 0.855
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.841
TAL1 T-cell acute lymphocytic leukemia 1 0.836
COL2A1 collagen, type II, alpha 1 0.835
PDX1 pancreatic and duodenal homeobox 1 0.832
TGFB1 transforming growth factor, beta 1 0.772
PBX1 pre-B-cell leukemia homeobox 1 0.758
TRIP6 thyroid hormone receptor interactor 6 0.752
HOXC8 homeobox C8 0.749
BMP4 bone morphogenetic protein 4 0.739
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.721
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.711
NOTCH3 notch 3 0.710
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.709
ESR1 estrogen receptor 1 0.704
PAX3 paired box 3 0.702
MEIS1 Meis homeobox 1 0.697
HOXA10 homeobox A10 0.695
LTBP2 latent transforming growth factor beta binding protein 2 0.690
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.686
NOTCH1 notch 1 0.681
POSTN periostin, osteoblast specific factor 0.677
MEOX2 mesenchyme homeobox 2 0.667
COL5A2 collagen, type V, alpha 2 0.667
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.662
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.661
EGFR epidermal growth factor receptor 0.659
FSTL1 follistatin-like 1 0.658
MSX1 msh homeobox 1 0.644
HOXA11 homeobox A11 0.639
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.634
PPARA peroxisome proliferator-activated receptor alpha 0.630
FGF1 fibroblast growth factor 1 (acidic) 0.612
MAPK1 mitogen-activated protein kinase 1 0.599
GH1 growth hormone 1 0.594
INHBA inhibin, beta A 0.591
ADAM15 ADAM metallopeptidase domain 15 0.588
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.586
POU3F2 POU class 3 homeobox 2 0.584
COL6A1 collagen, type VI, alpha 1 0.583
TNC tenascin C 0.582
HMGA2 high mobility group AT-hook 2 0.575
IGFBP5 insulin-like growth factor binding protein 5 0.571
FGF3 fibroblast growth factor 3 0.568
HOXB6 homeobox B6 0.565
SULF1 sulfatase 1 0.551
LBX1 ladybird homeobox 1 0.550
WNT1 wingless-type MMTV integration site family, member 1 0.549
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 0.544
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.541
HOXC6 homeobox C6 0.536
WNT2 wingless-type MMTV integration site family member 2 0.532
EGR1 early growth response 1 0.514
SMAD6 SMAD family member 6 0.508
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.507
LAMB1 laminin, beta 1 0.503
HOXC11 homeobox C11 0.503
DCN decorin 0.499
COL1A2 collagen, type I, alpha 2 0.498
THBS1 thrombospondin 1 0.492
MRC2 mannose receptor, C type 2 0.488
COL4A1 collagen, type IV, alpha 1 0.485
ACVR1 activin A receptor, type I 0.481
HOXA4 homeobox A4 0.472
RING1 ring finger protein 1 0.471
FBLN1 fibulin 1 0.468
TBX5 T-box 5 0.452
HOXB9 homeobox B9 0.450
PRRX2 paired related homeobox 2 0.446
FBLN2 fibulin 2 0.444
FGF18 fibroblast growth factor 18 0.442
LUM lumican 0.442
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.441
SOX1 SRY (sex determining region Y)-box 1 0.441
BGN biglycan 0.438
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.438
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Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Shh sonic hedgehog 1.000
Dlx5 distal-less homeobox 5 1.000
Prrx1 paired related homeobox 1 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Fgfr3 fibroblast growth factor receptor 3 1.000
Fgfr1 fibroblast growth factor receptor 1 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Pax3 paired box gene 3 1.000
Hand1 heart and neural crest derivatives expressed transcript 1 1.000
Bmp4 bone morphogenetic protein 4 1.000
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 1.000
Foxc1 forkhead box C1 0.999
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.999
Trp53 transformation related protein 53 0.999
Bmp7 bone morphogenetic protein 7 0.999
Tcfap2a transcription factor AP-2, alpha 0.999
Rarg retinoic acid receptor, gamma 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.999
Pbx1 pre B-cell leukemia transcription factor 1 0.999
Eya1 eyes absent 1 homolog (Drosophila) 0.999
Pax9 paired box gene 9 0.999
Pax2 paired box gene 2 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.999
Vegfa vascular endothelial growth factor A 0.999
Prrx2 paired related homeobox 2 0.999
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.999
Sox9 SRY-box containing gene 9 0.999
Hand2 heart and neural crest derivatives expressed transcript 2 0.999
Msx1 homeobox, msh-like 1 0.998
Twist2 twist homolog 2 (Drosophila) 0.998
Hoxa1 homeobox A1 0.998
Fgf8 fibroblast growth factor 8 0.998
Meox2 mesenchyme homeobox 2 0.998
Pten phosphatase and tensin homolog 0.998
Hoxd11 homeobox D11 0.998
Tgfb2 transforming growth factor, beta 2 0.997
Fgf10 fibroblast growth factor 10 0.997
Tbx1 T-box 1 0.996
Col2a1 collagen, type II, alpha 1 0.996
Col1a1 collagen, type I, alpha 1 0.996
Foxc2 forkhead box C2 0.996
Hoxa10 homeobox A10 0.995
Smo smoothened homolog (Drosophila) 0.995
Alx4 aristaless-like homeobox 4 0.995
Nog noggin 0.994
Zeb1 zinc finger E-box binding homeobox 1 0.994
Lmx1a LIM homeobox transcription factor 1 alpha 0.993
Runx2 runt related transcription factor 2 0.993
Psen1 presenilin 1 0.992
Tgfbr2 transforming growth factor, beta receptor II 0.992
Hoxa13 homeobox A13 0.991
Gsc goosecoid homeobox 0.990
Wnt3a wingless-related MMTV integration site 3A 0.989
Fbn1 fibrillin 1 0.989
Hoxd13 homeobox D13 0.988
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.985
Pitx1 paired-like homeodomain transcription factor 1 0.984
Twist1 twist homolog 1 (Drosophila) 0.983
Vangl2 vang-like 2 (van gogh, Drosophila) 0.981
Pkd1 polycystic kidney disease 1 homolog 0.981
Alx3 aristaless-like homeobox 3 0.980
Rarb retinoic acid receptor, beta 0.979
Chrd chordin 0.979
Gas1 growth arrest specific 1 0.979
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.978
Hoxa11 homeobox A11 0.977
Msx2 homeobox, msh-like 2 0.975
Hoxa2 homeobox A2 0.975
Pthlh parathyroid hormone-like peptide 0.975
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.974
Wnt5a wingless-related MMTV integration site 5A 0.970
Axl AXL receptor tyrosine kinase 0.969
Gbx2 gastrulation brain homeobox 2 0.969
Col6a2 collagen, type VI, alpha 2 0.968
Zic3 zinc finger protein of the cerebellum 3 0.966
Rnf2 ring finger protein 2 0.962
Pax1 paired box gene 1 0.961
Col11a1 collagen, type XI, alpha 1 0.961
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.960
Tbx3 T-box 3 0.957
Sox2 SRY-box containing gene 2 0.957
Sfrp2 secreted frizzled-related protein 2 0.956
Tbx15 T-box 15 0.954
Ptch1 patched homolog 1 0.953
Wt1 Wilms tumor 1 homolog 0.951
Hoxb3 homeobox B3 0.949
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.949
Thbs1 thrombospondin 1 0.948
Pou3f3 POU domain, class 3, transcription factor 3 0.947
Neurog3 neurogenin 3 0.946
Tcf21 transcription factor 21 0.942
Npr3 natriuretic peptide receptor 3 0.941
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.939
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.939
Alx1 ALX homeobox 1 0.939
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.938
Pax6 paired box gene 6 0.938
Mmp2 matrix metallopeptidase 2 0.933
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.937
Col3a1 collagen, type III, alpha 1 0.683
Col12a1 collagen, type XII, alpha 1 0.682
Egr2 early growth response 2 0.557
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.544
Col5a1 collagen, type V, alpha 1 0.460
Hoxb7 homeo box B7 0.434
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.388
Lum lumican 0.370
Col5a2 collagen, type V, alpha 2 0.365
Dbp D site of albumin promoter (albumin D-box) binding protein 0.345
Vim vimentin 0.297
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.260
Bmp6 bone morphogenetic protein 6 0.235
Hoxa1 homeo box A1 0.213
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.199
Pcolce procollagen C-endopeptidase enhancer 0.196
Lef1 lymphoid enhancer binding factor 1 0.192
Dab2 disabled homolog 2 (Drosophila) 0.190
Bgn biglycan 0.174
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.149
Col9a1 collagen, type IX, alpha 1 0.147
Uncx UNC homeobox 0.147
Igfbp5 insulin-like growth factor binding protein 5 0.146
Flt1 FMS-related tyrosine kinase 1 0.144
Tgfbr2 transforming growth factor, beta receptor II 0.140
Omp olfactory marker protein 0.139
Sdc3 syndecan 3 0.137
Ncan neurocan 0.136
Gpr176 G protein-coupled receptor 176 0.135
Pdpn podoplanin 0.131
Eln elastin 0.130
Chad chondroadherin 0.129
Esr1 estrogen receptor 1 0.124
Sod3 superoxide dismutase 3, extracellular 0.120
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.119
Col1a2 collagen, type I, alpha 2 0.118
Slc26a1 solute carrier family 26 (sulfate transporter), member 1 0.117
Twist2 twist homolog 2 (Drosophila) 0.110
Shox2 short stature homeobox 2 0.110
Cpz carboxypeptidase Z 0.108
Gja5 gap junction protein, alpha 5 0.107
Rara retinoic acid receptor, alpha 0.106
Plxnd1 plexin D1 0.105
Nfya nuclear transcription factor-Y alpha 0.104
Otx1 orthodenticle homeobox 1 0.101
Acan aggrecan 0.100
Hoxc4 homeo box C4 0.100
Hoxb8 homeo box B8 0.097
Fgfr2 fibroblast growth factor receptor 2 0.096
Sox17 SRY (sex determining region Y)-box 17 0.092
Scarf2 scavenger receptor class F, member 2 0.088
Sfrp4 secreted frizzled-related protein 4 0.088
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.088
Col8a1 collagen, type VIII, alpha 1 0.086
Rhd Rh blood group, D antigen 0.085
Fat2 FAT tumor suppressor homolog 2 (Drosophila) 0.085
Pld1 phospholipase D1 0.084
Trpm8 transient receptor potential cation channel, subfamily M, member 8 0.084
Ltbp4 latent transforming growth factor beta binding protein 4 0.083
Aebp1 AE binding protein 1 0.083
Igfbp4 insulin-like growth factor binding protein 4 0.082
Irs1 insulin receptor substrate 1 0.082
Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 0.081
Neurod2 neurogenic differentiation 2 0.080
Srpx sushi-repeat-containing protein, X-linked 0.080
Hapln1 hyaluronan and proteoglycan link protein 1 0.079
Fbn1 fibrillin 1 0.079
Prrx1 paired related homeobox 1 0.078
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.077
Degs2 degenerative spermatocyte homolog 2, lipid desaturase (Drosophila) 0.077
Pklr pyruvate kinase, liver and RBC 0.075
Lox lysyl oxidase 0.074
Nppc natriuretic peptide precursor C 0.074
Adarb2 adenosine deaminase, RNA-specific, B2 0.074
Mpz myelin protein zero 0.071
Cryge crystallin, gamma E 0.071
Ascl2 achaete-scute complex homolog 2 (Drosophila) 0.070
Pecam1 platelet/endothelial cell adhesion molecule 1 0.070
Ece1 endothelin converting enzyme 1 0.070
Tnc tenascin C 0.069
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.069
Prrx2 paired related homeobox 2 0.068
Dcn decorin 0.068
Anxa1 annexin A1 0.068
Capn6 calpain 6 0.067
Zfp469 zinc finger protein 469 0.066
Gdf11 growth differentiation factor 11 0.061
Anxa2 annexin A2 0.061
Gast gastrin 0.060
Slc6a5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5 0.059
Megf10 multiple EGF-like domains 10 0.059
Zyx zyxin 0.059
Lamc1 laminin, gamma 1 0.058
Ng23 Ng23 protein 0.058
P4hb prolyl 4-hydroxylase, beta polypeptide 0.058
Foxd4 forkhead box D4 0.058
Megf6 multiple EGF-like-domains 6 0.057
Cd44 Cd44 molecule 0.057
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.056
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism