The network for 'endodermal cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the endoderm.

Danio rerio
Name Description Probability Func Analog Organism
chd chordin 0.998
flh floating head 0.745
tbx1 T-box 1 0.605
emx3 empty spiracles homeobox 3 0.589
col2a1a collagen type II, alpha-1a 0.565
dlc deltaC 0.551
fgf8a fibroblast growth factor 8 a 0.528
tbx20 T-box 20 0.513
tbx2b T-box 2b 0.498
pcdh8 protocadherin 8 0.478
fgf3 fibroblast growth factor 3 0.476
tbx16 T-box gene 16 0.465
fli1a friend leukemia integration 1a 0.458
cdh1 cadherin 1, epithelial 0.447
notch3 notch homolog 3 0.434
pax2a paired box gene 2a 0.426
ntla no tail a 0.414
jag2 jagged 2 0.395
gata3 GATA-binding protein 3 0.378
bmp2b bone morphogenetic protein 2b 0.354
rarab retinoic acid receptor, alpha b 0.331
bmp4 bone morphogenetic protein 4 0.315
mespa mesoderm posterior a 0.294
mib mind bomb 0.287
gbx2 gastrulation brain homeo box 2 0.282
cdh2 cadherin 2, neuronal 0.254
foxg1a forkhead box G1a 0.248
her1 hairy-related 1 0.236
spry2 sprouty homolog 2 0.230
ndr1 nodal-related 1 0.208
fgfr4 fibroblast growth factor receptor 4 0.207
sox3 SRY-box containing gene 3 0.195
fgf17 fibroblast growth factor 17 0.191
her7 hairy and enhancer of split related-7 0.186
spry4 sprouty (Drosophila) homolog 4 0.181
hand2 heart and neural crest derivatives expressed transcript 2 0.180
mmp2 matrix metalloproteinase 2 0.174
fgfr2 fibroblast growth factor receptor 2 0.174
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.173
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.164
tll1 tolloid-like 1 0.155
efnb2a ephrin B2a 0.154
oep one-eyed pinhead 0.143
lhx1a LIM homeobox 1a 0.143
osr2 odd-skipped related 2 (Drosophila) 0.139
kdrl kinase insert domain receptor like 0.139
vent ventral expressed homeobox 0.133
tbx5a T-box 5a 0.111
msxb muscle segment homeobox B 0.110
wnt5b wingless-type MMTV integration site family, member 5b 0.108
gro2 groucho 2 0.105
notch2 notch homolog 2 0.103
sall4 sal-like 4 (Drosophila) 0.102
sox19b SRY-box containing gene 19b 0.099
six4b sine oculis homeobox homolog 4b 0.097
meis3 myeloid ecotropic viral integration site 3 0.097
egr2a early growth response 2a 0.097
eomesa eomesodermin homolog a 0.096
spns2 spinster homolog 2 (Drosophila) 0.096
snai1a snail homolog 1a (Drosophila) 0.091
bmp7a bone morphogenetic protein 7a 0.091
cdx4 caudal type homeo box transcription factor 4 0.090
traf4a tnf receptor-associated factor 4a 0.089
six3b sine oculis homeobox homolog 3b 0.087
dusp6 dual specificity phosphatase 6 0.085
isl1 islet1 0.083
foxi1 forkhead box I1 0.082
pitx2 paired-like homeodomain transcription factor 2 0.082
igfbp3 insulin-like growth factor binding protein 3 0.080
ephb4b eph receptor B4b 0.080
ndr2 nodal-related 2 0.079
lft1 lefty1 0.078
dharma dharma 0.078
bon bonnie and clyde 0.077
lhx1b LIM homeobox 1b 0.074
igf1rb insulin-like growth factor 1b receptor 0.073
hmx4 H6 family homeobox 4 0.072
prl prolactin 0.071
btg2 B-cell translocation gene 2 0.071
hoxd11a homeo box D11a 0.070
fn1 fibronectin 1 0.068
rx3 retinal homeobox gene 3 0.067
dcc deleted in colorectal carcinoma 0.066
pdgfaa platelet-derived growth factor alpha a 0.064
pcdh10b protocadherin 10b 0.064
gata2a GATA-binding protein 2a 0.063
boc brother of CDO 0.062
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.061
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.060
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.060
dlb deltaB 0.058
pou5f1 POU domain, class 5, transcription factor 1 0.056
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.056
twist1a twist1a 0.056
tbx6 T-box gene 6 0.055
hoxa11a homeo box A11a 0.055
ccm2 cerebral cavernous malformation 2 0.053
hoxa10b homeo box A10b 0.053
eya1 eyes absent homolog 1 0.053
nanos3 nanos homolog 3 0.053
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 0.989
tkv thickveins 0.965
Dad Daughters against dpp 0.787
rho rhomboid 0.719
smo smoothened 0.648
dsh dishevelled 0.628
Med Medea 0.581
ci cubitus interruptus 0.531
osa CG7467 gene product from transcript CG7467-RD 0.481
numb CG3779 gene product from transcript CG3779-RB 0.450
bnl branchless 0.409
shn schnurri 0.354
tld tolloid 0.299
gro groucho 0.297
cact cactus 0.254
put punt 0.244
eya eyes absent 0.237
ush u-shaped 0.223
zfh2 Zn finger homeodomain 2 0.215
Egfr Epidermal growth factor receptor 0.202
Su(H) Suppressor of Hairless 0.202
htl heartless 0.190
emc extra macrochaetae 0.185
Bre1 CG10542 gene product from transcript CG10542-RA 0.176
Tl Toll 0.176
sbb scribbler 0.175
en engrailed 0.172
kel kelch 0.140
Abl Abl tyrosine kinase 0.135
wg wingless 0.134
fz frizzled 0.131
sog short gastrulation 0.130
arm armadillo 0.126
CtBP C-terminal Binding Protein 0.123
aop anterior open 0.116
gek genghis khan 0.115
CG5591 CG5591 gene product from transcript CG5591-RA 0.109
Gef26 CG9491 gene product from transcript CG9491-RB 0.107
sgl sugarless 0.106
orb oo18 RNA-binding protein 0.101
sax saxophone 0.089
sty sprouty 0.083
phl pole hole 0.083
LanA Laminin A 0.081
dock dreadlocks 0.080
sr stripe 0.079
csw corkscrew 0.078
Mes2 CG11100 gene product from transcript CG11100-RB 0.077
cno canoe 0.077
Doc2 Dorsocross2 0.077
vvl ventral veins lacking 0.075
wls wntless 0.073
Sara Smad anchor for receptor activation 0.072
sd scalloped 0.072
ed echinoid 0.072
ttv tout-velu 0.069
frc fringe connection 0.067
myoglianin CG1838 gene product from transcript CG1838-RD 0.066
sll slalom 0.066
Ras64B Ras oncogene at 64B 0.065
nmo nemo 0.065
zfh1 Zn finger homeodomain 1 0.063
srp serpent 0.058
Smox Smad on X 0.058
stumps CG31317 gene product from transcript CG31317-RC 0.058
tsg twisted gastrulation 0.057
dap dacapo 0.054
rap retina aberrant in pattern 0.054
neur neuralized 0.053
Btk29A Btk family kinase at 29A 0.052
ovo CG6824 gene product from transcript CG6824-RE 0.051
Sos Son of sevenless 0.051
por porcupine 0.051
insc inscuteable 0.048
sqz squeeze 0.048
Ras85D Ras oncogene at 85D 0.048
rst roughest 0.048
scw screw 0.048
pan pangolin 0.046
R Roughened 0.045
mirr mirror 0.045
Sra-1 specifically Rac1-associated protein 1 0.044
dally division abnormally delayed 0.044
cg combgap 0.043
Gap1 GTPase-activating protein 1 0.042
NijA Ninjurin A 0.041
ea easter 0.041
kn knot 0.040
Axn Axin 0.039
Irk2 Inwardly rectifying potassium channel 2 0.039
G-oalpha47A G protein oalpha 47A 0.039
Ubqn Ubiquilin 0.039
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.039
ftz-f1 ftz transcription factor 1 0.038
krz kurtz 0.037
Fak56D Focal Adhesion Kinase 0.036
hbs hibris 0.035
sno strawberry notch 0.034
aux auxillin 0.034
klar klarsicht 0.034
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Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
SP1 Sp1 transcription factor 1.000
FGF1 fibroblast growth factor 1 (acidic) 1.000
PAX3 paired box 3 0.999
SMAD7 SMAD family member 7 0.999
POU3F2 POU class 3 homeobox 2 0.999
BMP2 bone morphogenetic protein 2 0.998
SMAD2 SMAD family member 2 0.996
BMPR1A bone morphogenetic protein receptor, type IA 0.995
FOXD3 forkhead box D3 0.993
SOX10 SRY (sex determining region Y)-box 10 0.990
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.988
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.986
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.986
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.959
SMAD1 SMAD family member 1 0.955
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.941
FKBP1A FK506 binding protein 1A, 12kDa 0.932
BMP7 bone morphogenetic protein 7 0.925
JAG1 jagged 1 0.887
SMAD4 SMAD family member 4 0.882
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.869
CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.850
SOX2 SRY (sex determining region Y)-box 2 0.833
RANBP2 RAN binding protein 2 0.807
LCK lymphocyte-specific protein tyrosine kinase 0.758
SMAD3 SMAD family member 3 0.743
NOTCH3 notch 3 0.743
SMAD5 SMAD family member 5 0.726
SYK spleen tyrosine kinase 0.705
LRP6 low density lipoprotein receptor-related protein 6 0.690
ZNF512B zinc finger protein 512B 0.686
CTNNBIP1 catenin, beta interacting protein 1 0.669
FGFR2 fibroblast growth factor receptor 2 0.662
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.650
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.645
NOG noggin 0.602
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.594
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.547
GDF5 growth differentiation factor 5 0.522
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.483
MEOX2 mesenchyme homeobox 2 0.425
WT1 Wilms tumor 1 0.400
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.386
FYN FYN oncogene related to SRC, FGR, YES 0.363
AXIN1 axin 1 0.357
FGF10 fibroblast growth factor 10 0.335
FGFR3 fibroblast growth factor receptor 3 0.329
CXXC5 CXXC finger protein 5 0.321
MAML1 mastermind-like 1 (Drosophila) 0.310
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.293
SMAD6 SMAD family member 6 0.272
HCK hemopoietic cell kinase 0.262
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.256
SALL2 sal-like 2 (Drosophila) 0.250
CSNK1E casein kinase 1, epsilon 0.240
PLCG1 phospholipase C, gamma 1 0.235
FSTL1 follistatin-like 1 0.228
NLK nemo-like kinase 0.222
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.221
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.218
CEP164 centrosomal protein 164kDa 0.215
MYB v-myb myeloblastosis viral oncogene homolog (avian) 0.212
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.203
JAG2 jagged 2 0.203
MARCKSL1 MARCKS-like 1 0.194
FGF2 fibroblast growth factor 2 (basic) 0.191
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.189
SOX11 SRY (sex determining region Y)-box 11 0.188
OTP orthopedia homeobox 0.175
BBS10 Bardet-Biedl syndrome 10 0.165
WDR61 WD repeat domain 61 0.165
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.161
MDFI MyoD family inhibitor 0.157
HCFC1 host cell factor C1 (VP16-accessory protein) 0.144
DSP desmoplakin 0.140
SKI v-ski sarcoma viral oncogene homolog (avian) 0.139
POU3F1 POU class 3 homeobox 1 0.137
HNF1A HNF1 homeobox A 0.136
KLHL12 kelch-like 12 (Drosophila) 0.132
SOX1 SRY (sex determining region Y)-box 1 0.119
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.118
KLF5 Kruppel-like factor 5 (intestinal) 0.116
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.116
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.116
HIPK2 homeodomain interacting protein kinase 2 0.113
SOX21 SRY (sex determining region Y)-box 21 0.111
TRAF4 TNF receptor-associated factor 4 0.110
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.109
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.106
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.096
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.096
CD22 CD22 molecule 0.094
MSX1 msh homeobox 1 0.092
FOXG1 forkhead box G1 0.090
SPRR2A small proline-rich protein 2A 0.089
GLIS2 GLIS family zinc finger 2 0.089
SH3BP2 SH3-domain binding protein 2 0.089
BMP4 bone morphogenetic protein 4 0.088
SOX5 SRY (sex determining region Y)-box 5 0.087
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Fgf8 fibroblast growth factor 8 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Bmp4 bone morphogenetic protein 4 1.000
Foxc1 forkhead box C1 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Hand1 heart and neural crest derivatives expressed transcript 1 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Pax2 paired box gene 2 1.000
Pax3 paired box gene 3 1.000
Fgfr1 fibroblast growth factor receptor 1 1.000
Chd7 chromodomain helicase DNA binding protein 7 1.000
Hand2 heart and neural crest derivatives expressed transcript 2 1.000
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 1.000
Sox2 SRY-box containing gene 2 1.000
Tcfap2a transcription factor AP-2, alpha 1.000
Eya1 eyes absent 1 homolog (Drosophila) 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Foxc2 forkhead box C2 1.000
Sox9 SRY-box containing gene 9 0.999
Dlx5 distal-less homeobox 5 0.999
Jag1 jagged 1 0.999
Msx1 homeobox, msh-like 1 0.999
Prrx1 paired related homeobox 1 0.999
Tbx1 T-box 1 0.999
Foxg1 forkhead box G1 0.999
Tbx3 T-box 3 0.999
Hoxa1 homeobox A1 0.999
Alx4 aristaless-like homeobox 4 0.998
Chrd chordin 0.997
Rarg retinoic acid receptor, gamma 0.997
Nodal nodal 0.996
Isl1 ISL1 transcription factor, LIM/homeodomain 0.995
Gbx2 gastrulation brain homeobox 2 0.992
Smo smoothened homolog (Drosophila) 0.989
Tgfb2 transforming growth factor, beta 2 0.988
Hes1 hairy and enhancer of split 1 (Drosophila) 0.988
Pitx1 paired-like homeodomain transcription factor 1 0.981
Gata4 GATA binding protein 4 0.980
Bmp7 bone morphogenetic protein 7 0.979
Wnt3a wingless-related MMTV integration site 3A 0.977
Efnb2 ephrin B2 0.975
Lrp6 low density lipoprotein receptor-related protein 6 0.971
Acvr1 activin A receptor, type 1 0.970
Pou5f1 POU domain, class 5, transcription factor 1 0.960
Msx2 homeobox, msh-like 2 0.958
Nog noggin 0.957
Sox11 SRY-box containing gene 11 0.957
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.950
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.938
Lef1 lymphoid enhancer binding factor 1 0.927
Emx1 empty spiracles homolog 1 (Drosophila) 0.920
Smad4 MAD homolog 4 (Drosophila) 0.901
Ednra endothelin receptor type A 0.897
Smad6 MAD homolog 6 (Drosophila) 0.886
Bmpr1a bone morphogenetic protein receptor, type 1A 0.884
Runx2 runt related transcription factor 2 0.876
Fgf10 fibroblast growth factor 10 0.868
Hoxd13 homeobox D13 0.863
Sall4 sal-like 4 (Drosophila) 0.850
Apc adenomatosis polyposis coli 0.847
Gli2 GLI-Kruppel family member GLI2 0.826
Smad1 MAD homolog 1 (Drosophila) 0.823
Gsc goosecoid homeobox 0.823
Zeb1 zinc finger E-box binding homeobox 1 0.812
Meox2 mesenchyme homeobox 2 0.801
Rarb retinoic acid receptor, beta 0.794
Bdnf brain derived neurotrophic factor 0.786
Fgfr3 fibroblast growth factor receptor 3 0.772
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.769
Lhx1 LIM homeobox protein 1 0.769
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.754
Nf1 neurofibromatosis 1 0.742
Prrx2 paired related homeobox 2 0.736
Psen1 presenilin 1 0.717
Rxra retinoid X receptor alpha 0.715
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.713
Ntf3 neurotrophin 3 0.707
Alx3 aristaless-like homeobox 3 0.706
Gata6 GATA binding protein 6 0.701
Wnt1 wingless-related MMTV integration site 1 0.669
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.664
Otx1 orthodenticle homolog 1 (Drosophila) 0.659
Zic3 zinc finger protein of the cerebellum 3 0.647
Pou3f3 POU domain, class 3, transcription factor 3 0.645
Emx2 empty spiracles homolog 2 (Drosophila) 0.644
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.635
Dll1 delta-like 1 (Drosophila) 0.586
Lhx3 LIM homeobox protein 3 0.574
Alx1 ALX homeobox 1 0.556
Hoxa3 homeobox A3 0.545
Hoxa2 homeobox A2 0.539
Fgf3 fibroblast growth factor 3 0.537
Hoxa13 homeobox A13 0.509
Pax6 paired box gene 6 0.497
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.489
En2 engrailed 2 0.483
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism