The network for 'bone mineralization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

bone mineralization

The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.

Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.808
twist2 twist2 0.472
col10a1 collagen, type X, alpha 1 0.464
bmp4 bone morphogenetic protein 4 0.407
cdh2 cadherin 2, neuronal 0.267
col2a1a collagen type II, alpha-1a 0.264
prdm5 PR domain containing 5 0.262
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.196
bmp2a bone morphogenetic protein 2a 0.136
bmp1a bone morphogenetic protein 1a 0.132
mgp matrix Gla protein 0.131
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.122
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.085
tbx5a T-box 5a 0.083
rargb retinoic acid receptor, gamma b 0.069
plod2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.067
mmp15b matrix metallopeptidase 15b 0.065
notch3 notch homolog 3 0.064
dlx2a distal-less homeobox gene 2a 0.063
zgc:111821 zgc:111821 0.050
shha sonic hedgehog a 0.050
xylt1 xylosyltransferase 1 0.050
LOC556849 ectonucleoside triphosphate diphosphohydrolase 5-like 0.049
axin1 axin 1 0.047
sec31a sec31 homolog A (S. cerevisiae) 0.042
cmyb transcription factor cmyb 0.042
bon bonnie and clyde 0.041
dusp6 dual specificity phosphatase 6 0.041
col1a2 collagen, type I, alpha 2 0.039
unc5c unc-5 homolog C (C. elegans) 0.039
acvr1l activin A receptor, type I like 0.038
sox9a SRY-box containing gene 9a 0.035
met met proto-oncogene (hepatocyte growth factor receptor) 0.035
disp1 dispatched homolog 1 (Drosophila) 0.033
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.032
bambib BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b 0.030
prdm1a PR domain containing 1a, with ZNF domain 0.029
nog3 noggin 3 0.029
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.029
itga3b integrin, alpha 3b 0.029
axin2 axin 2 (conductin, axil) 0.028
gpm6aa glycoprotein M6Aa 0.028
tgfb2 transforming growth factor, beta 2 0.028
wnt11r wingless-type MMTV integration site family, member 11, related 0.026
prdm16 PR domain containing 16 0.025
irf6 interferon regulatory factor 6 0.025
wnt10a wingless-type MMTV integration site family, member 10a 0.024
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.024
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.022
fgfrl1b fibroblast growth factor receptor-like 1b 0.020
inhbaa inhibin, beta Aa 0.020
ctnnb1 catenin (cadherin-associated protein), beta 1 0.020
ptch2 patched 2 0.020
pdzrn3 PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3 0.019
smoc2 secreted modular calcium binding protein 2 0.019
msxb muscle segment homeobox B 0.019
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.018
gata3 GATA-binding protein 3 0.018
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.018
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.018
cdh1 cadherin 1, epithelial 0.018
enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.018
smad9 MAD homolog 9 (Drosophila) 0.017
zfand5a zinc finger, AN1-type domain 5a 0.017
hsd17b12a hydroxysteroid (17-beta) dehydrogenase 12a 0.016
raraa retinoic acid receptor, alpha a 0.016
zgc:171553 zgc:171553 0.016
rcn3 reticulocalbin 3, EF-hand calcium binding domain 0.016
smad5 MAD homolog 5 (Drosophila) 0.016
bglap bone gamma-carboxyglutamate (gla) protein 0.016
foxi1 forkhead box I1 0.016
mecom MDS1 and EVI1 complex locus 0.015
fgf20a fibroblast growth factor 20a 0.015
col1a1a collagen, type I, alpha 1a 0.015
neo1 neogenin 1 0.015
si:dkeyp-110g5.2 si:dkeyp-110g5.2 0.015
col11a2 collagen type XI alpha-2 0.015
igf3 insulin-like growth factor 3 0.015
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.015
ecrg4a esophageal cancer related gene 4a 0.015
tbx2a T-box gene 2a 0.014
trim71 tripartite motif-containing 71 0.014
ptgs1 prostaglandin-endoperoxide synthase 1 0.014
LOC100004946 transient receptor potential cation channel subfamily M member 4-like 0.014
vcanb versican b 0.014
c8a complement component 8, alpha polypeptide 0.014
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.013
st3gal2l ST3 beta-galactoside alpha-2,3-sialyltransferase 2, like 0.013
hgfb hepatocyte growth factor b 0.013
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.013
spry4 sprouty (Drosophila) homolog 4 0.013
lepr leptin receptor 0.013
fgf10a fibroblast growth factor 10a 0.013
LOC100148804 mucin-2-like 0.013
kdrl kinase insert domain receptor like 0.013
pthlh parathyroid hormone-like hormone 0.013
robo1 roundabout homolog 1 0.013
tp63 tumor protein p63 0.012
prmt1 protein arginine methyltransferase 1 0.012
sema3d semaphorin 3d 0.012
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CCR5 chemokine (C-C motif) receptor 5 1.000
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.000
TGFB1 transforming growth factor, beta 1 0.999
CCL5 chemokine (C-C motif) ligand 5 0.999
CCL4 chemokine (C-C motif) ligand 4 0.977
CXCL9 chemokine (C-X-C motif) ligand 9 0.968
CCR7 chemokine (C-C motif) receptor 7 0.919
SMAD2 SMAD family member 2 0.890
VCAN versican 0.857
FGF1 fibroblast growth factor 1 (acidic) 0.850
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.819
FSTL1 follistatin-like 1 0.813
CCL8 chemokine (C-C motif) ligand 8 0.777
CCL22 chemokine (C-C motif) ligand 22 0.723
IFNG interferon, gamma 0.721
FKBP1A FK506 binding protein 1A, 12kDa 0.709
IL2RB interleukin 2 receptor, beta 0.691
BMPR1A bone morphogenetic protein receptor, type IA 0.682
TAL1 T-cell acute lymphocytic leukemia 1 0.677
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.675
TGFB3 transforming growth factor, beta 3 0.622
CXCL10 chemokine (C-X-C motif) ligand 10 0.586
CCR4 chemokine (C-C motif) receptor 4 0.550
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.543
SMAD7 SMAD family member 7 0.541
BMPR1B bone morphogenetic protein receptor, type IB 0.531
ACVR1 activin A receptor, type I 0.528
ENG endoglin 0.517
CCL2 chemokine (C-C motif) ligand 2 0.510
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.507
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.482
TGFBR1 transforming growth factor, beta receptor 1 0.480
GDF5 growth differentiation factor 5 0.464
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.451
COL1A2 collagen, type I, alpha 2 0.442
CXCL11 chemokine (C-X-C motif) ligand 11 0.438
CXCL13 chemokine (C-X-C motif) ligand 13 0.372
DPT dermatopontin 0.338
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.336
CCL13 chemokine (C-C motif) ligand 13 0.300
HDAC4 histone deacetylase 4 0.298
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.293
IL8 interleukin 8 0.285
TM4SF1 transmembrane 4 L six family member 1 0.269
CCR1 chemokine (C-C motif) receptor 1 0.265
BMP4 bone morphogenetic protein 4 0.259
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.250
TJP1 tight junction protein 1 (zona occludens 1) 0.243
NOG noggin 0.232
IRF4 interferon regulatory factor 4 0.231
DPP4 dipeptidyl-peptidase 4 0.223
FGF21 fibroblast growth factor 21 0.213
FGF10 fibroblast growth factor 10 0.203
KDM2B lysine (K)-specific demethylase 2B 0.201
IL10 interleukin 10 0.199
CCL11 chemokine (C-C motif) ligand 11 0.194
CXCR3 chemokine (C-X-C motif) receptor 3 0.194
CCL3 chemokine (C-C motif) ligand 3 0.192
GATA2 GATA binding protein 2 0.191
ITGB1BP3 integrin beta 1 binding protein 3 0.190
SETD8 SET domain containing (lysine methyltransferase) 8 0.189
CCL7 chemokine (C-C motif) ligand 7 0.186
CXCL12 chemokine (C-X-C motif) ligand 12 0.185
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.180
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.176
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.174
ELN elastin 0.172
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.172
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.165
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.162
ZFYVE9 zinc finger, FYVE domain containing 9 0.157
COL11A2 collagen, type XI, alpha 2 0.153
IL1B interleukin 1, beta 0.150
PTGIS prostaglandin I2 (prostacyclin) synthase 0.148
IL6 interleukin 6 (interferon, beta 2) 0.148
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.138
DMBT1 deleted in malignant brain tumors 1 0.138
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.135
EP300 E1A binding protein p300 0.132
PCGF1 polycomb group ring finger 1 0.129
CCR2 chemokine (C-C motif) receptor 2 0.128
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.127
TNF tumor necrosis factor 0.125
SLAMF7 SLAM family member 7 0.119
FGF8 fibroblast growth factor 8 (androgen-induced) 0.117
HIC1 hypermethylated in cancer 1 0.116
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.113
CCL19 chemokine (C-C motif) ligand 19 0.110
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.106
IDE insulin-degrading enzyme 0.103
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.096
BMP2 bone morphogenetic protein 2 0.094
PDCD6IP programmed cell death 6 interacting protein 0.091
ARRDC3 arrestin domain containing 3 0.089
RUNX1 runt-related transcription factor 1 0.089
INHBA inhibin, beta A 0.089
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.088
VCAM1 vascular cell adhesion molecule 1 0.085
IL10RA interleukin 10 receptor, alpha 0.082
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.081
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Mus musculus
Name Description Probability Func Analog Organism
Fgf8 fibroblast growth factor 8 0.946
Fgfr2 fibroblast growth factor receptor 2 0.940
Fgfr1 fibroblast growth factor receptor 1 0.924
Tgfb2 transforming growth factor, beta 2 0.894
Smo smoothened homolog (Drosophila) 0.855
Fgfr3 fibroblast growth factor receptor 3 0.843
Bmp4 bone morphogenetic protein 4 0.826
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.801
Smad6 MAD homolog 6 (Drosophila) 0.770
Lef1 lymphoid enhancer binding factor 1 0.747
Kl klotho 0.721
Gli2 GLI-Kruppel family member GLI2 0.717
Nodal nodal 0.714
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.670
Pthlh parathyroid hormone-like peptide 0.641
Rarg retinoic acid receptor, gamma 0.639
Nos3 nitric oxide synthase 3, endothelial cell 0.619
Hic1 hypermethylated in cancer 1 0.606
Ednra endothelin receptor type A 0.601
Pax8 paired box gene 8 0.599
Fbn1 fibrillin 1 0.571
Nf1 neurofibromatosis 1 0.570
Gpc3 glypican 3 0.524
Drd2 dopamine receptor D2 0.476
Fgf23 fibroblast growth factor 23 0.432
Prrx2 paired related homeobox 2 0.429
Efs embryonal Fyn-associated substrate 0.427
Scn5a sodium channel, voltage-gated, type V, alpha 0.427
Eln elastin 0.423
Prrx1 paired related homeobox 1 0.417
Fgf10 fibroblast growth factor 10 0.397
Shh sonic hedgehog 0.393
Foxf1a forkhead box F1a 0.391
Vdr vitamin D receptor 0.384
Gata6 GATA binding protein 6 0.381
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.375
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.365
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.343
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.332
Fgf3 fibroblast growth factor 3 0.322
Tgfbr2 transforming growth factor, beta receptor II 0.316
Smad7 MAD homolog 7 (Drosophila) 0.311
Tcfap2a transcription factor AP-2, alpha 0.308
Lhx6 LIM homeobox protein 6 0.303
Fut1 fucosyltransferase 1 0.302
Wnt7a wingless-related MMTV integration site 7A 0.301
Thra thyroid hormone receptor alpha 0.297
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.291
Tbx2 T-box 2 0.290
Adrb1 adrenergic receptor, beta 1 0.290
Col11a1 collagen, type XI, alpha 1 0.283
Gas1 growth arrest specific 1 0.281
Sox4 SRY-box containing gene 4 0.279
Duox2 dual oxidase 2 0.278
Alx4 aristaless-like homeobox 4 0.265
Emp2 epithelial membrane protein 2 0.254
Fzd2 frizzled homolog 2 (Drosophila) 0.253
Gli1 GLI-Kruppel family member GLI1 0.246
Bmp2 bone morphogenetic protein 2 0.245
Thrb thyroid hormone receptor beta 0.244
Lhx1 LIM homeobox protein 1 0.231
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.226
Fbln1 fibulin 1 0.221
Tbx3 T-box 3 0.220
Wnt5b wingless-related MMTV integration site 5B 0.218
Mmp11 matrix metallopeptidase 11 0.213
Foxc1 forkhead box C1 0.213
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.211
Wnt4 wingless-related MMTV integration site 4 0.210
Rxra retinoid X receptor alpha 0.209
Gli3 GLI-Kruppel family member GLI3 0.206
Ret ret proto-oncogene 0.203
Acan aggrecan 0.202
Hoxd13 homeobox D13 0.200
Epas1 endothelial PAS domain protein 1 0.195
Ccr2 chemokine (C-C motif) receptor 2 0.194
Tlr4 toll-like receptor 4 0.193
Ccr1 chemokine (C-C motif) receptor 1 0.191
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.190
Wt1 Wilms tumor 1 homolog 0.189
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.189
Fzd8 frizzled homolog 8 (Drosophila) 0.187
Htra3 HtrA serine peptidase 3 0.185
Ldlr low density lipoprotein receptor 0.183
Fzd1 frizzled homolog 1 (Drosophila) 0.178
Notch3 Notch gene homolog 3 (Drosophila) 0.177
Pnpla2 patatin-like phospholipase domain containing 2 0.175
Tpo thyroid peroxidase 0.171
She src homology 2 domain-containing transforming protein E 0.168
Gpr27 G protein-coupled receptor 27 0.168
Adra2a adrenergic receptor, alpha 2a 0.167
Hand1 heart and neural crest derivatives expressed transcript 1 0.166
Chad chondroadherin 0.165
Bmp5 bone morphogenetic protein 5 0.165
Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.165
Alx3 aristaless-like homeobox 3 0.165
Tal1 T-cell acute lymphocytic leukemia 1 0.164
Col22a1 collagen, type XXII, alpha 1 0.162
Aplnr apelin receptor 0.161
Bnc1 basonuclin 1 0.159
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Rattus norvegicus
Name Description Probability Func Analog Organism
Fgfr1 Fibroblast growth factor receptor 1 0.095
Smad7 SMAD family member 7 0.043
Jak2 Janus kinase 2 0.035
Jak1 Janus kinase 1 0.033
Pdcl phosducin-like 0.027
Slit3 slit homolog 3 (Drosophila) 0.026
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.022
Irs1 insulin receptor substrate 1 0.020
Vcan versican 0.019
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.016
Gna15 guanine nucleotide binding protein, alpha 15 0.015
Agtr1a angiotensin II receptor, type 1a 0.015
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.014
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.013
Soat1 sterol O-acyltransferase 1 0.013
Arl11 ADP-ribosylation factor-like 11 0.012
Mrc1 mannose receptor, C type 1 0.012
Nfia nuclear factor I/A 0.011
Lig3 ligase III, DNA, ATP-dependent 0.011
Cfp complement factor properdin 0.011
Lox lysyl oxidase 0.011
Snrk SNF related kinase 0.011
Col5a1 collagen, type V, alpha 1 0.011
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.010
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism