The network for 'endocrine pancreas development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endocrine pancreas development

The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.

Danio rerio
Name Description Probability Func Analog Organism
hoxb8a homeo box B8a 0.996
hoxc8a homeo box C8a 0.975
tbx1 T-box 1 0.963
hoxa4a homeo box A4a 0.961
foxa1 forkhead box A1 0.957
hlxb9la homeo box HB9 like a 0.936
pax6b paired box gene 6b 0.901
foxa2 forkhead box A2 0.886
hoxb5b homeo box B5b 0.881
nkx2.2a NK2 transcription factor related 2a 0.867
dkk1b dickkopf 1b 0.839
mnx1 motor neuron and pancreas homeobox 1 0.830
hoxc4a homeo box C4a 0.821
hoxb6b homeo box B6b 0.795
isl1 islet1 0.755
sst1.1 somatostatin 1, tandem duplicate 1 0.753
shhb sonic hedgehog b 0.744
hoxb5a homeo box B5a 0.712
sox1a SRY-box containing gene 1a 0.655
fgf8a fibroblast growth factor 8 a 0.651
olig2 oligodendrocyte lineage transcription factor 2 0.629
wif1 wnt inhibitory factor 1 0.608
hhex hematopoietically expressed homeobox 0.607
foxa3 forkhead box A3 0.604
nkx2.1a NK2 homeobox 1a 0.601
hmx3 homeo box (H6 family) 3 0.594
hand2 heart and neural crest derivatives expressed transcript 2 0.587
wnt11 wingless-type MMTV integration site family, member 11 0.569
pdx1 pancreatic and duodenal homeobox 1 0.560
dbx1a developing brain homeobox 1a 0.557
wnt8b wingless-type MMTV integration site family, member 8b 0.514
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.450
nkx6.2 NK6 transcription factor related, locus 2 0.433
neurod4 neurogenic differentiation 4 0.430
sfrp1a secreted frizzled-related protein 1a 0.424
lhx1a LIM homeobox 1a 0.423
wnt3a wingless-type MMTV integration site family, member 3A 0.419
hoxa9a homeo box A9a 0.419
dla deltaA 0.409
wnt4a wingless-type MMTV integration site family, member 4a 0.404
mab21l2 mab-21-like 2 0.403
sst2 somatostatin 2 0.402
hhip hedgehog interacting protein 0.395
hnf4a hepatocyte nuclear factor 4, alpha 0.371
gcga glucagon a and glucagon a-like 0.357
hoxc1a homeo box C1a 0.351
hoxd4a homeo box D4a 0.350
nkx2.3 NK2 transcription factor related 3 0.335
neurod neurogenic differentiation 0.328
ptf1a pancreas specific transcription factor, 1a 0.320
evx1 even-skipped homeobox 1 0.319
gata4 GATA-binding protein 4 0.318
oprd1b opioid receptor, delta 1b 0.309
atoh1b atonal homolog 1b 0.306
osr2 odd-skipped related 2 (Drosophila) 0.302
isl2a islet2a 0.291
wnt2 wingless-type MMTV integration site family member 2 0.284
dlb deltaB 0.284
sim2 single-minded homolog 2 (Drosophila) 0.275
wnt11r wingless-type MMTV integration site family, member 11, related 0.273
prox1 prospero-related homeobox gene 1 0.270
ephb4b eph receptor B4b 0.265
traf4a tnf receptor-associated factor 4a 0.260
wnt1 wingless-type MMTV integration site family, member 1 0.255
jag2 jagged 2 0.248
arx aristaless related homeobox 0.238
eng2a engrailed 2a 0.236
hoxc6a homeo box C6a 0.232
her5 hairy-related 5 0.232
ptch2 patched 2 0.213
gli1 GLI-Kruppel family member 1 0.208
ins preproinsulin 0.192
six4b sine oculis homeobox homolog 4b 0.188
six2a sine oculis-related homeobox 2a 0.185
hmx4 H6 family homeobox 4 0.182
wnt3 wingless-type MMTV integration site family, member 3 0.181
irx1b iroquois homeobox protein 1, b 0.175
gbx2 gastrulation brain homeo box 2 0.174
pax4 paired box 4 0.173
lhx1b LIM homeobox 1b 0.165
fgf3 fibroblast growth factor 3 0.165
barhl2 BarH-like 2 0.162
lhx5 LIM homeobox 5 0.154
jag1b jagged 1b 0.153
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.150
tal2 T-cell acute lymphocytic leukemia 2 0.142
gdf6a growth differentiation factor 6a 0.140
otpb orthopedia homolog b 0.138
hoxb10a homeo box B10a 0.138
dab1b disabled homolog 1b (Drosophila) 0.133
hnf1ba HNF1 homeobox Ba 0.132
gdnf glial cell derived neurotrophic factor 0.127
hoxb2a homeo box B2a 0.126
neurog1 neurogenin 1 0.125
inka1a induced in neural crest by AP2, 1a 0.125
ascl1b achaete-scute complex-like 1b (Drosophila) 0.124
ptch1 patched 1 0.123
pax2a paired box gene 2a 0.122
fgfr2 fibroblast growth factor receptor 2 0.121
sfrp1b secreted frizzled-related protein 1b 0.120
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.996
HNF4A hepatocyte nuclear factor 4, alpha 0.834
BMPR1A bone morphogenetic protein receptor, type IA 0.769
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.686
FOXA2 forkhead box A2 0.630
BMPR1B bone morphogenetic protein receptor, type IB 0.303
POU5F1 POU class 5 homeobox 1 0.250
CCND3 cyclin D3 0.245
NOG noggin 0.206
HNF1B HNF1 homeobox B 0.172
CCND1 cyclin D1 0.157
BAX BCL2-associated X protein 0.128
PROX1 prospero homeobox 1 0.127
HNF1A HNF1 homeobox A 0.106
IL6 interleukin 6 (interferon, beta 2) 0.097
CDX2 caudal type homeobox 2 0.095
IL6R interleukin 6 receptor 0.088
ONECUT1 one cut homeobox 1 0.088
PTCH1 patched 1 0.084
CDK6 cyclin-dependent kinase 6 0.057
NKX2-2 NK2 homeobox 2 0.052
FSTL1 follistatin-like 1 0.046
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.045
RB1 retinoblastoma 1 0.042
PTF1A pancreas specific transcription factor, 1a 0.037
MDFI MyoD family inhibitor 0.034
POU4F2 POU class 4 homeobox 2 0.031
CCND2 cyclin D2 0.031
NKX6-1 NK6 homeobox 1 0.030
PDX1 pancreatic and duodenal homeobox 1 0.030
FOXF2 forkhead box F2 0.025
BCL2L1 BCL2-like 1 0.025
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.024
PITX2 paired-like homeodomain 2 0.024
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.023
SIM2 single-minded homolog 2 (Drosophila) 0.023
MNX1 motor neuron and pancreas homeobox 1 0.022
FOXA1 forkhead box A1 0.020
SOX2 SRY (sex determining region Y)-box 2 0.020
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.020
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 0.019
FEV FEV (ETS oncogene family) 0.019
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.018
INHBB inhibin, beta B 0.017
BCL2 B-cell CLL/lymphoma 2 0.017
SOX1 SRY (sex determining region Y)-box 1 0.017
COL2A1 collagen, type II, alpha 1 0.017
LBX1 ladybird homeobox 1 0.017
MARCKSL1 MARCKS-like 1 0.016
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.016
SMAD6 SMAD family member 6 0.016
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 0.016
GJD2 gap junction protein, delta 2, 36kDa 0.015
PAX6 paired box 6 0.015
DLX2 distal-less homeobox 2 0.015
HOXD11 homeobox D11 0.015
HES2 hairy and enhancer of split 2 (Drosophila) 0.014
FOXF1 forkhead box F1 0.014
RBPMS RNA binding protein with multiple splicing 0.014
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.014
PYY peptide YY 0.013
PAX7 paired box 7 0.013
TBX1 T-box 1 0.013
NKX3-2 NK3 homeobox 2 0.013
DBN1 drebrin 1 0.013
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.012
HOXD9 homeobox D9 0.012
FZD8 frizzled homolog 8 (Drosophila) 0.012
DLX4 distal-less homeobox 4 0.012
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.012
HOXB9 homeobox B9 0.012
SIX3 SIX homeobox 3 0.012
HOXB13 homeobox B13 0.011
SOX11 SRY (sex determining region Y)-box 11 0.011
SKI v-ski sarcoma viral oncogene homolog (avian) 0.011
POU3F4 POU class 3 homeobox 4 0.011
ISL1 ISL LIM homeobox 1 0.011
HOXD10 homeobox D10 0.011
C1orf93 chromosome 1 open reading frame 93 0.011
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.011
LMX1B LIM homeobox transcription factor 1, beta 0.011
HOXB5 homeobox B5 0.011
LHX2 LIM homeobox 2 0.011
PAX1 paired box 1 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.998
Otx2 orthodenticle homolog 2 (Drosophila) 0.982
Onecut1 one cut domain, family member 1 0.979
Pdx1 pancreatic and duodenal homeobox 1 0.975
Fgf8 fibroblast growth factor 8 0.974
Pax6 paired box gene 6 0.954
Pax2 paired box gene 2 0.940
Hand2 heart and neural crest derivatives expressed transcript 2 0.939
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.872
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.865
Nog noggin 0.809
Lmx1a LIM homeobox transcription factor 1 alpha 0.795
Hes1 hairy and enhancer of split 1 (Drosophila) 0.780
Hand1 heart and neural crest derivatives expressed transcript 1 0.778
Gli3 GLI-Kruppel family member GLI3 0.775
Eya1 eyes absent 1 homolog (Drosophila) 0.713
Neurod1 neurogenic differentiation 1 0.713
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.713
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.708
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.702
Pax3 paired box gene 3 0.693
Neurog3 neurogenin 3 0.688
Gata6 GATA binding protein 6 0.686
Gbx2 gastrulation brain homeobox 2 0.617
Lmx1b LIM homeobox transcription factor 1 beta 0.609
Neurog1 neurogenin 1 0.602
En1 engrailed 1 0.591
Lhx1 LIM homeobox protein 1 0.583
Fgf3 fibroblast growth factor 3 0.565
Foxa2 forkhead box A2 0.553
Foxc1 forkhead box C1 0.526
Foxd2 forkhead box D2 0.506
Hoxa1 homeobox A1 0.489
Tcfap2a transcription factor AP-2, alpha 0.488
Hoxb5 homeobox B5 0.485
Hoxa2 homeobox A2 0.471
Lhx3 LIM homeobox protein 3 0.468
Nhlh1 nescient helix loop helix 1 0.457
Nkx6-1 NK6 homeobox 1 0.442
Msx1 homeobox, msh-like 1 0.432
Gata4 GATA binding protein 4 0.427
Pax8 paired box gene 8 0.423
Gdnf glial cell line derived neurotrophic factor 0.416
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.415
Emx1 empty spiracles homolog 1 (Drosophila) 0.406
Neurog2 neurogenin 2 0.405
Alx3 aristaless-like homeobox 3 0.405
Hmx3 H6 homeobox 3 0.404
Hoxd3 homeobox D3 0.399
Tbx1 T-box 1 0.396
Foxf1a forkhead box F1a 0.381
Pitx1 paired-like homeodomain transcription factor 1 0.381
Hes3 hairy and enhancer of split 3 (Drosophila) 0.378
Wnt1 wingless-related MMTV integration site 1 0.370
Fgf15 fibroblast growth factor 15 0.369
Gli2 GLI-Kruppel family member GLI2 0.366
Dlx5 distal-less homeobox 5 0.362
Fgf10 fibroblast growth factor 10 0.353
Pitx3 paired-like homeodomain transcription factor 3 0.336
Foxc2 forkhead box C2 0.326
Nkx2-1 NK2 homeobox 1 0.321
Sox9 SRY-box containing gene 9 0.308
Sox1 SRY-box containing gene 1 0.300
Alx4 aristaless-like homeobox 4 0.299
Sox7 SRY-box containing gene 7 0.299
Insm1 insulinoma-associated 1 0.289
Bmp4 bone morphogenetic protein 4 0.286
Otp orthopedia homolog (Drosophila) 0.283
Gpr27 G protein-coupled receptor 27 0.281
Tbx2 T-box 2 0.281
Sim1 single-minded homolog 1 (Drosophila) 0.278
Pax9 paired box gene 9 0.276
Hoxa3 homeobox A3 0.274
Fgf18 fibroblast growth factor 18 0.266
Lhx5 LIM homeobox protein 5 0.259
Prrx1 paired related homeobox 1 0.252
Fgfr2 fibroblast growth factor receptor 2 0.249
Emx2 empty spiracles homolog 2 (Drosophila) 0.233
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.231
Mesp1 mesoderm posterior 1 0.222
Adra2b adrenergic receptor, alpha 2b 0.209
Hoxa4 homeobox A4 0.204
Wnt2b wingless related MMTV integration site 2b 0.203
Tlx3 T-cell leukemia, homeobox 3 0.202
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.198
Uncx UNC homeobox 0.196
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.192
Isl1 ISL1 transcription factor, LIM/homeodomain 0.191
Wnt3a wingless-related MMTV integration site 3A 0.191
Prrx2 paired related homeobox 2 0.187
Hoxb4 homeobox B4 0.187
Snai1 snail homolog 1 (Drosophila) 0.186
Kiss1 KiSS-1 metastasis-suppressor 0.186
T brachyury 0.185
Hoxc5 homeobox C5 0.183
Sox2 SRY-box containing gene 2 0.181
Pitx2 paired-like homeodomain transcription factor 2 0.180
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.176
Atoh7 atonal homolog 7 (Drosophila) 0.174
Pou4f2 POU domain, class 4, transcription factor 2 0.172
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Rattus norvegicus
Name Description Probability Func Analog Organism
S100a6 S100 calcium binding protein A6 0.102
Anxa5 annexin A5 0.090
Anxa2 annexin A2 0.082
S100a10 S100 calcium binding protein A10 0.044
Arpc1b actin related protein 2/3 complex, subunit 1B 0.019
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism