IMP

Process View

Homo sapiens

17 genes annotated in human

Multi-species View

positive regulation of b cell activation

GO:0050871

Any process that activates or increases the frequency, rate or extent of B cell activation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of b cell activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of b cell activation" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2	B-cell CLL/lymphoma 2	0.985
BCL2L1	BCL2-like 1	0.962	Human
IL4R	interleukin 4 receptor	0.895
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.706
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.301
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.247
TICAM2	toll-like receptor adaptor molecule 2	0.220
BAX	BCL2-associated X protein	0.168	Human
GRAP2	GRB2-related adaptor protein 2	0.157
MYD88	myeloid differentiation primary response gene (88)	0.157
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.143
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.076	Mouse
TAL1	T-cell acute lymphocytic leukemia 1	0.068
BAD	BCL2-associated agonist of cell death	0.068
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.065	Mouse
IRAK1	interleukin-1 receptor-associated kinase 1	0.061
IL4	interleukin 4	0.060	Mouse
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.060
SYK	spleen tyrosine kinase	0.056	Mouse
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.055
BID	BH3 interacting domain death agonist	0.050
LAT	linker for activation of T cells	0.049
CSNK1G1	casein kinase 1, gamma 1	0.046
RIPK2	receptor-interacting serine-threonine kinase 2	0.046
NCOA3	nuclear receptor coactivator 3	0.044
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.042	Human
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.041
IL6R	interleukin 6 receptor	0.036
SH3BP2	SH3-domain binding protein 2	0.033
TNIP1	TNFAIP3 interacting protein 1	0.033
HDAC4	histone deacetylase 4	0.032
BTK	Bruton agammaglobulinemia tyrosine kinase	0.032
TP53BP1	tumor protein p53 binding protein 1	0.031
IL2RG	interleukin 2 receptor, gamma	0.030	Mouse
IRAK4	interleukin-1 receptor-associated kinase 4	0.030
NCF2	neutrophil cytosolic factor 2	0.026
CXCR4	chemokine (C-X-C motif) receptor 4	0.025
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.024
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.024
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.023
IRAK2	interleukin-1 receptor-associated kinase 2	0.023
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.023
BAK1	BCL2-antagonist/killer 1	0.023
STAP2	signal transducing adaptor family member 2	0.023
AMBRA1	autophagy/beclin-1 regulator 1	0.022
GAS7	growth arrest-specific 7	0.021
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.021
STK11	serine/threonine kinase 11	0.020
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.020
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.020
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.020
SLA	Src-like-adaptor	0.020
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.019
TRAF3IP3	TRAF3 interacting protein 3	0.019
IL2RB	interleukin 2 receptor, beta	0.018
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.018
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.018
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.018
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.018
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.017
FERMT2	fermitin family member 2	0.017
BLNK	B-cell linker	0.017
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.017
PCDH9	protocadherin 9	0.017
BCL10	B-cell CLL/lymphoma 10	0.016
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.016
BIK	BCL2-interacting killer (apoptosis-inducing)	0.016
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.016
EP300	E1A binding protein p300	0.016
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.015
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.015
SH3KBP1	SH3-domain kinase binding protein 1	0.015
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.015
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.015
CDK2	cyclin-dependent kinase 2	0.014
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.013
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.013
RNF144B	ring finger protein 144B	0.013
PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.013
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.013
FOXO1	forkhead box O1	0.013
TCF12	transcription factor 12	0.012	Human
NCOA2	nuclear receptor coactivator 2	0.012
JAK3	Janus kinase 3	0.012
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.012
BCL2A1	BCL2-related protein A1	0.012
LY96	lymphocyte antigen 96	0.012
TRAF1	TNF receptor-associated factor 1	0.012
C16orf53	chromosome 16 open reading frame 53	0.011
ENG	endoglin	0.011
TP53BP2	tumor protein p53 binding protein, 2	0.011
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.011
SELL	selectin L	0.011
CD22	CD22 molecule	0.011
IL7R	interleukin 7 receptor	0.011
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.011
TRAF2	TNF receptor-associated factor 2	0.011
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.011
SLAMF1	signaling lymphocytic activation molecule family member 1	0.011
NCOR2	nuclear receptor corepressor 2	0.010
LRMP	lymphoid-restricted membrane protein	0.010
PYCARD	PYD and CARD domain containing	0.010
PTEN	phosphatase and tensin homolog	0.010
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.010