IMP

Process View

Homo sapiens

37 genes annotated in human

negative regulation of translation

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of translation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of translation" (in gray)

Name	Description	Probability	Func Analog Organism
PABPC1	poly(A) binding protein, cytoplasmic 1	0.986
TOB1	transducer of ERBB2, 1	0.818
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.799
TNRC6A	trinucleotide repeat containing 6A	0.780
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.578
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.539
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.489
CNOT1	CCR4-NOT transcription complex, subunit 1	0.401	Worm
CNOT6	CCR4-NOT transcription complex, subunit 6	0.368	Fly
CNOT8	CCR4-NOT transcription complex, subunit 8	0.359	Fly
TOP1	topoisomerase (DNA) I	0.310
EIF4EBP3	eukaryotic translation initiation factor 4E binding protein 3	0.308
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.286
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.278
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.216
CNOT7	CCR4-NOT transcription complex, subunit 7	0.207	Fly
DICER1	dicer 1, ribonuclease type III	0.201
EIF2C4	eukaryotic translation initiation factor 2C, 4	0.176
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.169
TNRC6C	trinucleotide repeat containing 6C	0.168
SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein	0.156
CUL3	cullin 3	0.153
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.145
IPO8	importin 8	0.140
ZNF260	zinc finger protein 260	0.131
ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.128
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.126
MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	0.123
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.113
TNRC6B	trinucleotide repeat containing 6B	0.111	Human
SMN1	survival of motor neuron 1, telomeric	0.096
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.095
PAN3	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	0.091
ZNF420	zinc finger protein 420	0.090	Human
U2AF2	U2 small nuclear RNA auxiliary factor 2	0.086
EGR3	early growth response 3	0.079	Human
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.076
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.073
TSC2	tuberous sclerosis 2	0.073
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.073
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.072
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.071
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.069
BTG2	BTG family, member 2	0.069
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	0.063
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.059
MED25	mediator complex subunit 25	0.058
EGR1	early growth response 1	0.056	Human
FUBP1	far upstream element (FUSE) binding protein 1	0.056
HABP4	hyaluronan binding protein 4	0.055
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.055
THOC4	THO complex 4	0.051
TARDBP	TAR DNA binding protein	0.051
PRMT1	protein arginine methyltransferase 1	0.050
CNOT3	CCR4-NOT transcription complex, subunit 3	0.049
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.048
RPTOR	regulatory associated protein of MTOR, complex 1	0.047
BTG1	B-cell translocation gene 1, anti-proliferative	0.043	Human
RALY	RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))	0.042
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.042
ZNF529	zinc finger protein 529	0.041	Human
APC	adenomatous polyposis coli	0.040
EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1	0.040
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.038
ERN1	endoplasmic reticulum to nucleus signaling 1	0.038
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.037
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.037
ZNF567	zinc finger protein 567	0.037
PDIA3	protein disulfide isomerase family A, member 3	0.036
CPEB3	cytoplasmic polyadenylation element binding protein 3	0.035
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.035
WNK4	WNK lysine deficient protein kinase 4	0.035
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.035
KLHL12	kelch-like 12 (Drosophila)	0.035	Human
KLHL20	kelch-like 20 (Drosophila)	0.034	Human
RXRA	retinoid X receptor, alpha	0.034
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.032
PRMT6	protein arginine methyltransferase 6	0.032
E2F1	E2F transcription factor 1	0.032
LIN28B	lin-28 homolog B (C. elegans)	0.031
HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	0.031
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.031
IGF2	insulin-like growth factor 2 (somatomedin A)	0.030
KLHL2	kelch-like 2, Mayven (Drosophila)	0.029	Human
HNRNPR	heterogeneous nuclear ribonucleoprotein R	0.028	Human
ZFP30	zinc finger protein 30 homolog (mouse)	0.028	Human
DAPK1	death-associated protein kinase 1	0.028
CPEB4	cytoplasmic polyadenylation element binding protein 4	0.028	Human
HMGA2	high mobility group AT-hook 2	0.027
RBMX	RNA binding motif protein, X-linked	0.026
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.026
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.026
ZNF585A	zinc finger protein 585A	0.026
CNOT2	CCR4-NOT transcription complex, subunit 2	0.025	Fly
ZNF383	zinc finger protein 383	0.025
ZNF382	zinc finger protein 382	0.025
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.025
SFN	stratifin	0.025
FMR1	fragile X mental retardation 1	0.024	Mouse Fly
EGR2	early growth response 2	0.024	Human
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.024
BMI1	BMI1 polycomb ring finger oncogene	0.023
FBXO33	F-box protein 33	0.023
IER2	immediate early response 2	0.023
ZNF569	zinc finger protein 569	0.023
EEF1G	eukaryotic translation elongation factor 1 gamma	0.023
ZNF571	zinc finger protein 571	0.022	Human
EIF1AY	eukaryotic translation initiation factor 1A, Y-linked	0.022
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.022
EIF4A1	eukaryotic translation initiation factor 4A1	0.021
TAOK1	TAO kinase 1	0.021
INO80B	INO80 complex subunit B	0.021
ATG14	ATG14 autophagy related 14 homolog (S. cerevisiae)	0.020
SRSF3	serine/arginine-rich splicing factor 3	0.020
RPL28	ribosomal protein L28	0.019
CYorf15A	chromosome Y open reading frame 15A	0.019
GLTSCR2	glioma tumor suppressor candidate region gene 2	0.018
KLF6	Kruppel-like factor 6	0.018
ILF2	interleukin enhancer binding factor 2, 45kDa	0.018
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.018
PDCD6	programmed cell death 6	0.017
DAXX	death-domain associated protein	0.017
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.017
NONO	non-POU domain containing, octamer-binding	0.017
AIMP2	aminoacyl tRNA synthetase complex-interacting multifunctional protein 2	0.017
COL1A1	collagen, type I, alpha 1	0.016
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.016
SF1	splicing factor 1	0.016
YBX1	Y box binding protein 1	0.016	Zebrafish
PDIA4	protein disulfide isomerase family A, member 4	0.016
KDM5D	lysine (K)-specific demethylase 5D	0.016
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.016
USP46	ubiquitin specific peptidase 46	0.015
FAM126B	family with sequence similarity 126, member B	0.015
SMYD1	SET and MYND domain containing 1	0.015
UTY	ubiquitously transcribed tetratricopeptide repeat gene, Y-linked	0.015
UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1	0.015
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.015
CBX8	chromobox homolog 8	0.015
HNRNPA3	heterogeneous nuclear ribonucleoprotein A3	0.015
DNAJC3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.015
MTF2	metal response element binding transcription factor 2	0.015
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.015	Yeast
PCBP1	poly(rC) binding protein 1	0.015
MBNL1	muscleblind-like (Drosophila)	0.015
RPL8	ribosomal protein L8	0.015
ADAM12	ADAM metallopeptidase domain 12	0.015
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.015
SRSF6	serine/arginine-rich splicing factor 6	0.014
TRA2B	transformer 2 beta homolog (Drosophila)	0.014
PGAM1	phosphoglycerate mutase 1 (brain)	0.014
MAPK7	mitogen-activated protein kinase 7	0.014
CBX6	chromobox homolog 6	0.014
USP22	ubiquitin specific peptidase 22	0.014
CUX1	cut-like homeobox 1	0.014
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.014
BANP	BTG3 associated nuclear protein	0.014
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.014
PLRG1	pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)	0.013
MATR3	matrin 3	0.013
CSRNP1	cysteine-serine-rich nuclear protein 1	0.013
USP9Y	ubiquitin specific peptidase 9, Y-linked	0.013
RPL3	ribosomal protein L3	0.013
PURB	purine-rich element binding protein B	0.013
QARS	glutaminyl-tRNA synthetase	0.013
RPL32	ribosomal protein L32	0.013
CNBP	CCHC-type zinc finger, nucleic acid binding protein	0.013
PTBP2	polypyrimidine tract binding protein 2	0.013	Fly
TARBP2	TAR (HIV-1) RNA binding protein 2	0.013
TOB2	transducer of ERBB2, 2	0.013
PAWR	PRKC, apoptosis, WT1, regulator	0.013
PNRC1	proline-rich nuclear receptor coactivator 1	0.013
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.013
RBM22	RNA binding motif protein 22	0.012
GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	0.012
CSDA	cold shock domain protein A	0.012
PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	0.012
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.012
USP11	ubiquitin specific peptidase 11	0.012
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.012	Mouse
EIF4A3	eukaryotic translation initiation factor 4A3	0.012
RB1	retinoblastoma 1	0.012
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.012
RPS4Y1	ribosomal protein S4, Y-linked 1	0.012
CBX7	chromobox homolog 7	0.012
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.012
ACP5	acid phosphatase 5, tartrate resistant	0.012
LUC7L3	LUC7-like 3 (S. cerevisiae)	0.012
ZNF227	zinc finger protein 227	0.012
OTUD4	OTU domain containing 4	0.012
TSC22D4	TSC22 domain family, member 4	0.012
TMOD3	tropomodulin 3 (ubiquitous)	0.012
LNX1	ligand of numb-protein X 1	0.012
ZNF320	zinc finger protein 320	0.012
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.011
PLSCR1	phospholipid scramblase 1	0.011
NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)	0.011
HSPG2	heparan sulfate proteoglycan 2	0.011
DGCR14	DiGeorge syndrome critical region gene 14	0.011
GARS	glycyl-tRNA synthetase	0.011
AQR	aquarius homolog (mouse)	0.011
DUSP2	dual specificity phosphatase 2	0.011
PPIA	peptidylprolyl isomerase A (cyclophilin A)	0.011
IGF2R	insulin-like growth factor 2 receptor	0.011
GSK3B	glycogen synthase kinase 3 beta	0.011
DCP2	DCP2 decapping enzyme homolog (S. cerevisiae)	0.010
ZNF615	zinc finger protein 615	0.010
RNF2	ring finger protein 2	0.010
KLF4	Kruppel-like factor 4 (gut)	0.010
ANKRD17	ankyrin repeat domain 17	0.010
PCGF2	polycomb group ring finger 2	0.010
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.010
TROVE2	TROVE domain family, member 2	0.010
TGIF1	TGFB-induced factor homeobox 1	0.010
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.010
JUNB	jun B proto-oncogene	0.010
ZNF329	zinc finger protein 329	0.010
ZNF253	zinc finger protein 253	0.010
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	0.010
CTGF	connective tissue growth factor	0.010
ZBTB8A	zinc finger and BTB domain containing 8A	0.010
RPS18	ribosomal protein S18	0.010
KDM3B	lysine (K)-specific demethylase 3B	0.010
RAB3GAP2	RAB3 GTPase activating protein subunit 2 (non-catalytic)	0.010