IMP

Process View

Homo sapiens

3 genes annotated in human

regulation of wnt signaling pathway involved in heart development

Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of wnt signaling pathway involved in heart development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of wnt signaling pathway involved in heart development" (in gray)

Name	Description	Probability	Func Analog Organism
FOXD3	forkhead box D3	0.990
BMPR1A	bone morphogenetic protein receptor, type IA	0.964
NOTCH1	notch 1	0.957
CTNNBIP1	catenin, beta interacting protein 1	0.919
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.903
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.841
MAML1	mastermind-like 1 (Drosophila)	0.838
SP1	Sp1 transcription factor	0.816
SOX2	SRY (sex determining region Y)-box 2	0.813
PAX3	paired box 3	0.788
SOX10	SRY (sex determining region Y)-box 10	0.788
ATXN1L	ataxin 1-like	0.781
NCOR2	nuclear receptor corepressor 2	0.635
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.612
HCFC1	host cell factor C1 (VP16-accessory protein)	0.405
DSP	desmoplakin	0.377
GSK3B	glycogen synthase kinase 3 beta	0.351
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.346
FSTL1	follistatin-like 1	0.332
LRP6	low density lipoprotein receptor-related protein 6	0.242	Mouse
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.216
WDYHV1	WDYHV motif containing 1	0.189
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.142
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.121
ZFYVE9	zinc finger, FYVE domain containing 9	0.116
LRRK2	leucine-rich repeat kinase 2	0.106
SMAD7	SMAD family member 7	0.096
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.094
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.090
SNW1	SNW domain containing 1	0.074
SMAD3	SMAD family member 3	0.064
JAG1	jagged 1	0.053
WNT3A	wingless-type MMTV integration site family, member 3A	0.052
NOG	noggin	0.049
CIR1	corepressor interacting with RBPJ, 1	0.046
HMGA1	high mobility group AT-hook 1	0.044
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.040
MEOX2	mesenchyme homeobox 2	0.040
DSG2	desmoglein 2	0.040
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.036
PGR	progesterone receptor	0.036
APC	adenomatous polyposis coli	0.035
POU3F3	POU class 3 homeobox 3	0.034	Human
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.033
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.032
CAV1	caveolin 1, caveolae protein, 22kDa	0.030
SOX11	SRY (sex determining region Y)-box 11	0.030
KIAA0174	KIAA0174	0.030
MDFI	MyoD family inhibitor	0.028
NCOR1	nuclear receptor corepressor 1	0.025
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.024
CTNND1	catenin (cadherin-associated protein), delta 1	0.024
POU3F2	POU class 3 homeobox 2	0.023	Human
PDX1	pancreatic and duodenal homeobox 1	0.022
EP300	E1A binding protein p300	0.021
BMP2	bone morphogenetic protein 2	0.020
SOX21	SRY (sex determining region Y)-box 21	0.020
NOTCH2	notch 2	0.020
OTP	orthopedia homeobox	0.019
ADARB1	adenosine deaminase, RNA-specific, B1	0.018
SOX1	SRY (sex determining region Y)-box 1	0.018
CTNNBL1	catenin, beta like 1	0.017
BCL6	B-cell CLL/lymphoma 6	0.017
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.017
BMPR1B	bone morphogenetic protein receptor, type IB	0.017
PSEN1	presenilin 1	0.016
HES2	hairy and enhancer of split 2 (Drosophila)	0.016
PPARA	peroxisome proliferator-activated receptor alpha	0.016
POU4F1	POU class 4 homeobox 1	0.016	Human
KDM5A	lysine (K)-specific demethylase 5A	0.016
FZD8	frizzled homolog 8 (Drosophila)	0.016
RXRA	retinoid X receptor, alpha	0.016
BICD1	bicaudal D homolog 1 (Drosophila)	0.016
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.015
ZFPM1	zinc finger protein, multitype 1	0.015
USP54	ubiquitin specific peptidase 54	0.015
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.015
HSD17B14	hydroxysteroid (17-beta) dehydrogenase 14	0.015
BMP4	bone morphogenetic protein 4	0.015	Human
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.014
ITGB4	integrin, beta 4	0.014
LMO4	LIM domain only 4	0.014
NIN	ninein (GSK3B interacting protein)	0.014
PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	0.014
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.014
FAM46A	family with sequence similarity 46, member A	0.014
RABAC1	Rab acceptor 1 (prenylated)	0.014
OLIG2	oligodendrocyte lineage transcription factor 2	0.013
SALL2	sal-like 2 (Drosophila)	0.013
NOTCH3	notch 3	0.013
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.013
POGZ	pogo transposable element with ZNF domain	0.013
ZHX1	zinc fingers and homeoboxes 1	0.013
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.013
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.013
FRMD5	FERM domain containing 5	0.013
ATXN3	ataxin 3	0.013
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.012
TLX1	T-cell leukemia homeobox 1	0.012
NEUROG3	neurogenin 3	0.012
LHX1	LIM homeobox 1	0.012
MSX1	msh homeobox 1	0.012
ESR1	estrogen receptor 1	0.012
RAB5B	RAB5B, member RAS oncogene family	0.012
SFRP5	secreted frizzled-related protein 5	0.012
KIAA1191	KIAA1191	0.012
LHX5	LIM homeobox 5	0.012
PTPRF	protein tyrosine phosphatase, receptor type, F	0.012
OTX2	orthodenticle homeobox 2	0.012
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.011
NKX2-1	NK2 homeobox 1	0.011
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.011
GJD2	gap junction protein, delta 2, 36kDa	0.011
DLX4	distal-less homeobox 4	0.011
SIX5	SIX homeobox 5	0.011
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.011
UTF1	undifferentiated embryonic cell transcription factor 1	0.011
SOX18	SRY (sex determining region Y)-box 18	0.011
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.011
ZNF746	zinc finger protein 746	0.011
TLX2	T-cell leukemia homeobox 2	0.011
HOXD1	homeobox D1	0.011
GSC2	goosecoid homeobox 2	0.011
TGFB2	transforming growth factor, beta 2	0.011
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.011
NOVA2	neuro-oncological ventral antigen 2	0.011
TMEM44	transmembrane protein 44	0.011
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.011
SART1	squamous cell carcinoma antigen recognized by T cells	0.010
MAP2K6	mitogen-activated protein kinase kinase 6	0.010
FZD5	frizzled homolog 5 (Drosophila)	0.010
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.010
KLF5	Kruppel-like factor 5 (intestinal)	0.010
SIX2	SIX homeobox 2	0.010
ATXN1	ataxin 1	0.010
CHD6	chromodomain helicase DNA binding protein 6	0.010
XIAP	X-linked inhibitor of apoptosis	0.010
ISL1	ISL LIM homeobox 1	0.010
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.010