IMP

Process View

Homo sapiens

21 genes annotated in human

response to heat

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to heat"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to heat" (in gray)

Name	Description	Probability	Func Analog Organism
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.990	Yeast Fly
HSPB8	heat shock 22kDa protein 8	0.982	Fly
BAG3	BCL2-associated athanogene 3	0.822
HSPB1	heat shock 27kDa protein 1	0.794	Zebrafish
MAPK14	mitogen-activated protein kinase 14	0.778	Yeast Fly
CRYAB	crystallin, alpha B	0.579	Fly
HSPA8	heat shock 70kDa protein 8	0.575	Human Yeast Worm
FGFR2	fibroblast growth factor receptor 2	0.426
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.415
HDAC1	histone deacetylase 1	0.401
CDK9	cyclin-dependent kinase 9	0.335	Fly
RPLP1	ribosomal protein, large, P1	0.297
HSPH1	heat shock 105kDa/110kDa protein 1	0.280
HSPA1B	heat shock 70kDa protein 1B	0.278
FKBP4	FK506 binding protein 4, 59kDa	0.268
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.266	Yeast Fly
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.244
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.179
HSPA1A	heat shock 70kDa protein 1A	0.178
IL8	interleukin 8	0.157
MAP2K4	mitogen-activated protein kinase kinase 4	0.127	Human
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.126
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.123
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.117
THOC5	THO complex 5	0.114
IRAK2	interleukin-1 receptor-associated kinase 2	0.107
RPS3A	ribosomal protein S3A	0.101
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.096
NXF1	nuclear RNA export factor 1	0.092
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.089
LRRK2	leucine-rich repeat kinase 2	0.087
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.083
MAPK1	mitogen-activated protein kinase 1	0.083
RBBP7	retinoblastoma binding protein 7	0.080
NOSTRIN	nitric oxide synthase trafficker	0.069
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.069
DNM2	dynamin 2	0.066	Fly
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.065
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.064	Yeast
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.063
HDAC2	histone deacetylase 2	0.060
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.057	Worm
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.056	Yeast
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.056
VCP	valosin containing protein	0.055
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.054
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.052	Mouse
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.051
RBBP4	retinoblastoma binding protein 4	0.050	Human
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.050	Fly
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.048
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.048
IL1RN	interleukin 1 receptor antagonist	0.047
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.043
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.041	Rat
HSPB2	heat shock 27kDa protein 2	0.040	Rat Fly
CACYBP	calcyclin binding protein	0.039
FGF1	fibroblast growth factor 1 (acidic)	0.037
IL1B	interleukin 1, beta	0.036	Human Rat
AR	androgen receptor	0.036
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.033
SQSTM1	sequestosome 1	0.032
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.032
PPID	peptidylprolyl isomerase D	0.031	Yeast
PDIA3	protein disulfide isomerase family A, member 3	0.031
CAV1	caveolin 1, caveolae protein, 22kDa	0.030
FGF10	fibroblast growth factor 10	0.030	Human
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.029
FGFR1	fibroblast growth factor receptor 1	0.028
RPA1	replication protein A1, 70kDa	0.028
EIF2B4	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa	0.028
MYD88	myeloid differentiation primary response gene (88)	0.028
PARP1	poly (ADP-ribose) polymerase 1	0.028
RB1	retinoblastoma 1	0.028
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.028	Rat Fly
IL1RAP	interleukin 1 receptor accessory protein	0.028
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.027	Yeast
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.027
PRKCSH	protein kinase C substrate 80K-H	0.027
HNRPDL	heterogeneous nuclear ribonucleoprotein D-like	0.027
EP300	E1A binding protein p300	0.027
RPA2	replication protein A2, 32kDa	0.027
PTN	pleiotrophin	0.026
EED	embryonic ectoderm development	0.025
PDCD6IP	programmed cell death 6 interacting protein	0.025
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.025	Fly
IQGAP1	IQ motif containing GTPase activating protein 1	0.024
HSPE1	heat shock 10kDa protein 1 (chaperonin 10)	0.024
BAG2	BCL2-associated athanogene 2	0.024
COASY	CoA synthase	0.023
IRAK3	interleukin-1 receptor-associated kinase 3	0.023
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.022
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.022	Fly
STIP1	stress-induced-phosphoprotein 1	0.022
ARRB1	arrestin, beta 1	0.022
PPP5C	protein phosphatase 5, catalytic subunit	0.022
TARDBP	TAR DNA binding protein	0.021
MAPK3	mitogen-activated protein kinase 3	0.021
BAD	BCL2-associated agonist of cell death	0.021
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.021
VAC14	Vac14 homolog (S. cerevisiae)	0.021
TOP1	topoisomerase (DNA) I	0.020
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.020
NCF2	neutrophil cytosolic factor 2	0.020
CHD4	chromodomain helicase DNA binding protein 4	0.020
CBX1	chromobox homolog 1	0.019
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.019
MAP2K6	mitogen-activated protein kinase kinase 6	0.019	Human
PELI3	pellino homolog 3 (Drosophila)	0.019
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.019
LGALS3	lectin, galactoside-binding, soluble, 3	0.018
AFF1	AF4/FMR2 family, member 1	0.018
SOD2	superoxide dismutase 2, mitochondrial	0.018
CEP250	centrosomal protein 250kDa	0.018
BAG1	BCL2-associated athanogene	0.017
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.017
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.017
BBS10	Bardet-Biedl syndrome 10	0.017
NQO1	NAD(P)H dehydrogenase, quinone 1	0.017
HEXIM1	hexamethylene bis-acetamide inducible 1	0.016
MAP1S	microtubule-associated protein 1S	0.016
EGFR	epidermal growth factor receptor	0.016
LCK	lymphocyte-specific protein tyrosine kinase	0.016
RPN2	ribophorin II	0.016
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.015
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.015
GCLM	glutamate-cysteine ligase, modifier subunit	0.015
HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	0.015	Rat
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	0.015
DAPK1	death-associated protein kinase 1	0.015
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.015
ATF2	activating transcription factor 2	0.015
DUSP1	dual specificity phosphatase 1	0.015
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.014
MAPK9	mitogen-activated protein kinase 9	0.014	Yeast Worm Fly
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.014
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.014
DNM1	dynamin 1	0.014	Fly
DTX2	deltex homolog 2 (Drosophila)	0.014
RPLP0	ribosomal protein, large, P0	0.013
PARP2	poly (ADP-ribose) polymerase 2	0.013
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.013	Fly
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.013
RPS13	ribosomal protein S13	0.013
IL6	interleukin 6 (interferon, beta 2)	0.013
RANBP2	RAN binding protein 2	0.013
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.013
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.013
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.013
FGF7	fibroblast growth factor 7	0.013	Human
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.012
TXN	thioredoxin	0.012
XPO7	exportin 7	0.012
TCP1	t-complex 1	0.012
AMPH	amphiphysin	0.012
WASL	Wiskott-Aldrich syndrome-like	0.012
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.012
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.012
ARRB2	arrestin, beta 2	0.012
NONO	non-POU domain containing, octamer-binding	0.012
SNX9	sorting nexin 9	0.011
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.011
MAPT	microtubule-associated protein tau	0.011
EGLN1	egl nine homolog 1 (C. elegans)	0.011
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.011
UBL4A	ubiquitin-like 4A	0.011
RPS14	ribosomal protein S14	0.011
ITSN1	intersectin 1 (SH3 domain protein)	0.011
FGF2	fibroblast growth factor 2 (basic)	0.011	Human
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.011
THOC1	THO complex 1	0.011
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.010
SAP30	Sin3A-associated protein, 30kDa	0.010
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.010
SOCS3	suppressor of cytokine signaling 3	0.010	Rat
HSF1	heat shock transcription factor 1	0.010
GRB10	growth factor receptor-bound protein 10	0.010
MCM2	minichromosome maintenance complex component 2	0.010
GLRX3	glutaredoxin 3	0.010