IMP

Process View

Homo sapiens

4 genes annotated in human

Multi-species View

positive regulation of b cell mediated immunity

GO:0002714

Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of b cell mediated immunity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of b cell mediated immunity" (in gray)

Name	Description	Probability	Func Analog Organism
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	1.000
IL4R	interleukin 4 receptor	0.994
SYK	spleen tyrosine kinase	0.963
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.911	Human
PVRL4	poliovirus receptor-related 4	0.883
PVRL3	poliovirus receptor-related 3	0.684	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.674
GRAP2	GRB2-related adaptor protein 2	0.601
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.554
CD22	CD22 molecule	0.444
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.383
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.378
IL2RG	interleukin 2 receptor, gamma	0.361
ENG	endoglin	0.357
MDC1	mediator of DNA-damage checkpoint 1	0.304
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.243
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.242
FSTL1	follistatin-like 1	0.242
TJP1	tight junction protein 1 (zona occludens 1)	0.231
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.229
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.207
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.193
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.155
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.135	Mouse
CFH	complement factor H	0.134
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.115
NCOA6	nuclear receptor coactivator 6	0.091
TGFBR1	transforming growth factor, beta receptor 1	0.088
LMO2	LIM domain only 2 (rhombotin-like 1)	0.071
TGFB3	transforming growth factor, beta 3	0.064
MRAS	muscle RAS oncogene homolog	0.062
BCR	breakpoint cluster region	0.061
EPHB3	EPH receptor B3	0.061
UBASH3B	ubiquitin associated and SH3 domain containing B	0.061
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.058
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.054
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.048	Mouse
TMEM173	transmembrane protein 173	0.043
EPHB2	EPH receptor B2	0.037
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.037
CFI	complement factor I	0.036
C16orf53	chromosome 16 open reading frame 53	0.034
THBS1	thrombospondin 1	0.033
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.030
IL4	interleukin 4	0.027	Mouse
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.026
EPHB6	EPH receptor B6	0.025
VSIG4	V-set and immunoglobulin domain containing 4	0.025
BLNK	B-cell linker	0.025
BCL3	B-cell CLL/lymphoma 3	0.024
EPHA7	EPH receptor A7	0.023
GAB1	GRB2-associated binding protein 1	0.023
PLEK	pleckstrin	0.022
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.021
IGSF6	immunoglobulin superfamily, member 6	0.019
CD80	CD80 molecule	0.019
IRF4	interferon regulatory factor 4	0.019
FGL2	fibrinogen-like 2	0.018
CD53	CD53 molecule	0.018
SLA	Src-like-adaptor	0.018
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.018
GPR65	G protein-coupled receptor 65	0.018
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.018
TRAF5	TNF receptor-associated factor 5	0.017
TLR1	toll-like receptor 1	0.017
NRP1	neuropilin 1	0.017
LGALS1	lectin, galactoside-binding, soluble, 1	0.017
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.016
PABPN1	poly(A) binding protein, nuclear 1	0.016
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.016	Mouse
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.015
DAPK3	death-associated protein kinase 3	0.015
BTK	Bruton agammaglobulinemia tyrosine kinase	0.015
TRAF3IP2	TRAF3 interacting protein 2	0.015
ACVR2B	activin A receptor, type IIB	0.014
KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	0.014
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.014
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.014
CLEC7A	C-type lectin domain family 7, member A	0.014
TGFBR3	transforming growth factor, beta receptor III	0.014
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.014
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.014
LMNB1	lamin B1	0.014
CYBB	cytochrome b-245, beta polypeptide	0.014
CXCR5	chemokine (C-X-C motif) receptor 5	0.014
LCP1	lymphocyte cytosolic protein 1 (L-plastin)	0.013
LCK	lymphocyte-specific protein tyrosine kinase	0.013
ICAM1	intercellular adhesion molecule 1	0.013
SH2D2A	SH2 domain containing 2A	0.013
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.012
CD72	CD72 molecule	0.012
TYROBP	TYRO protein tyrosine kinase binding protein	0.012
RNASE6	ribonuclease, RNase A family, k6	0.012
MLL2	myeloid/lymphoid or mixed-lineage leukemia 2	0.012
TLR7	toll-like receptor 7	0.012
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.012
CD7	CD7 molecule	0.012
CD33	CD33 molecule	0.012
MAVS	mitochondrial antiviral signaling protein	0.012
ZBTB8A	zinc finger and BTB domain containing 8A	0.012
C3AR1	complement component 3a receptor 1	0.012
TIGIT	T cell immunoreceptor with Ig and ITIM domains	0.012
TRAF1	TNF receptor-associated factor 1	0.012
PRKCQ	protein kinase C, theta	0.012
OSMR	oncostatin M receptor	0.012
MNDA	myeloid cell nuclear differentiation antigen	0.012
CD226	CD226 molecule	0.012
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.011
DBN1	drebrin 1	0.011
TRAT1	T cell receptor associated transmembrane adaptor 1	0.011
CD68	CD68 molecule	0.011
SRSF4	serine/arginine-rich splicing factor 4	0.011
ARHGAP15	Rho GTPase activating protein 15	0.011
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.011
RBBP5	retinoblastoma binding protein 5	0.011
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.011
HP1BP3	heterochromatin protein 1, binding protein 3	0.011
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.011
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.011
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.011
AIF1	allograft inflammatory factor 1	0.011
CMIP	c-Maf-inducing protein	0.011
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.011
NFATC2IP	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein	0.011
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.011
LITAF	lipopolysaccharide-induced TNF factor	0.010
PASK	PAS domain containing serine/threonine kinase	0.010
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.010
CTSS	cathepsin S	0.010
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.010
H2AFV	H2A histone family, member V	0.010
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.010
MPEG1	macrophage expressed 1	0.010
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.010