IMP

Process View

Homo sapiens

15 genes annotated in human

cardiac muscle cell differentiation

The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cardiac muscle cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cardiac muscle cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.998	Mouse
RARA	retinoic acid receptor, alpha	0.965	Mouse
TTN	titin	0.944
TRIM63	tripartite motif containing 63	0.895
RXRA	retinoid X receptor, alpha	0.887	Mouse
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.830	Mouse Rat
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.651
NOTCH1	notch 1	0.644
BMPR1A	bone morphogenetic protein receptor, type IA	0.610	Human
NRP1	neuropilin 1	0.608
TBX5	T-box 5	0.561	Zebrafish Mouse
FKBP1A	FK506 binding protein 1A, 12kDa	0.556
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.533
NCOA1	nuclear receptor coactivator 1	0.475
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.464
HDAC4	histone deacetylase 4	0.417
ZYX	zyxin	0.396
COL4A2	collagen, type IV, alpha 2	0.395	Fly
BMP2	bone morphogenetic protein 2	0.335
MED25	mediator complex subunit 25	0.309
YAP1	Yes-associated protein 1	0.306
FSTL1	follistatin-like 1	0.259
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.259	Human
COL4A1	collagen, type IV, alpha 1	0.230	Fly
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.218	Human
LRP6	low density lipoprotein receptor-related protein 6	0.215
FLNA	filamin A, alpha	0.210
JAG1	jagged 1	0.205
CDK2	cyclin-dependent kinase 2	0.202
SMAD7	SMAD family member 7	0.194
TGFB1	transforming growth factor, beta 1	0.190
ACTN1	actinin, alpha 1	0.166
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.162	Mouse
MYOD1	myogenic differentiation 1	0.152
SPOP	speckle-type POZ protein	0.121
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.120
PDGFA	platelet-derived growth factor alpha polypeptide	0.117
TGFB3	transforming growth factor, beta 3	0.108
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.107
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.106
TSC2	tuberous sclerosis 2	0.103
NCOR2	nuclear receptor corepressor 2	0.090
ESR1	estrogen receptor 1	0.088
MYOZ1	myozenin 1	0.086
COL4A6	collagen, type IV, alpha 6	0.076	Fly
HNF4A	hepatocyte nuclear factor 4, alpha	0.072
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.063
OBSCN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.062
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.059
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.057
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.057
ACTN2	actinin, alpha 2	0.053
MYH9	myosin, heavy chain 9, non-muscle	0.049	Human
GDF5	growth differentiation factor 5	0.047
MYOG	myogenin (myogenic factor 4)	0.044
CREBBP	CREB binding protein	0.044
PDGFC	platelet derived growth factor C	0.043
NEB	nebulin	0.041	Human
NCOR1	nuclear receptor corepressor 1	0.040
COL4A5	collagen, type IV, alpha 5	0.037	Fly
ITGA7	integrin, alpha 7	0.036
FZD1	frizzled homolog 1 (Drosophila)	0.034
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.034
MYL9	myosin, light chain 9, regulatory	0.034
PRKD2	protein kinase D2	0.033
GATA4	GATA binding protein 4	0.033	Mouse Rat
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.033
GATAD2B	GATA zinc finger domain containing 2B	0.032
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.032
ACVR1	activin A receptor, type I	0.031
THBS1	thrombospondin 1	0.030
MKL1	megakaryoblastic leukemia (translocation) 1	0.029	Human
PRKG1	protein kinase, cGMP-dependent, type I	0.029
TNRC6A	trinucleotide repeat containing 6A	0.029
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.028
AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	0.028
CAPN3	calpain 3, (p94)	0.028
ND1	NADH dehydrogenase, subunit 1 (complex I)	0.027
CDK1	cyclin-dependent kinase 1	0.026	Rat
NCK2	NCK adaptor protein 2	0.026
NOTCH3	notch 3	0.026
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.026	Mouse
WDFY3	WD repeat and FYVE domain containing 3	0.025
AR	androgen receptor	0.025
FLNB	filamin B, beta	0.025
CCNB2	cyclin B2	0.025
ACTA2	actin, alpha 2, smooth muscle, aorta	0.025
LAMB1	laminin, beta 1	0.024
TCAP	titin-cap (telethonin)	0.024
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.022
CCNA2	cyclin A2	0.022
CAV1	caveolin 1, caveolae protein, 22kDa	0.021
ENG	endoglin	0.021
COL5A2	collagen, type V, alpha 2	0.020
TPM4	tropomyosin 4	0.020
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.019
VASP	vasodilator-stimulated phosphoprotein	0.019
TGFBR1	transforming growth factor, beta receptor 1	0.018	Human
MYPN	myopalladin	0.018
CNN2	calponin 2	0.017
SVIL	supervillin	0.017
ACTN4	actinin, alpha 4	0.017
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.017
ATXN1	ataxin 1	0.017
TGFB2	transforming growth factor, beta 2	0.017
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.017
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.017
CCNE1	cyclin E1	0.017
FHL3	four and a half LIM domains 3	0.016
MRPL41	mitochondrial ribosomal protein L41	0.016
ATXN1L	ataxin 1-like	0.016
IFITM1	interferon induced transmembrane protein 1 (9-27)	0.016
MDFI	MyoD family inhibitor	0.016
COL3A1	collagen, type III, alpha 1	0.015
HDAC9	histone deacetylase 9	0.015
NID1	nidogen 1	0.015
TNRC6C	trinucleotide repeat containing 6C	0.015
MKL2	MKL/myocardin-like 2	0.014	Human
COL1A2	collagen, type I, alpha 2	0.014
MYOCD	myocardin	0.014
COL5A1	collagen, type V, alpha 1	0.014
SMAD1	SMAD family member 1	0.014
VEGFA	vascular endothelial growth factor A	0.014	Mouse
COL1A1	collagen, type I, alpha 1	0.014
SMAD6	SMAD family member 6	0.014
MAPK9	mitogen-activated protein kinase 9	0.014
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.014
ZFYVE9	zinc finger, FYVE domain containing 9	0.014
OBSL1	obscurin-like 1	0.013
BMP4	bone morphogenetic protein 4	0.013
SUGT1	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	0.012
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.012
CKS2	CDC28 protein kinase regulatory subunit 2	0.012
ACVR1B	activin A receptor, type IB	0.012	Human
MAML1	mastermind-like 1 (Drosophila)	0.012	Mouse
COL16A1	collagen, type XVI, alpha 1	0.012
FN1	fibronectin 1	0.012
FAM46A	family with sequence similarity 46, member A	0.011
CALD1	caldesmon 1	0.011
FGF18	fibroblast growth factor 18	0.011
NCOA3	nuclear receptor coactivator 3	0.011
NID2	nidogen 2 (osteonidogen)	0.011
TLN1	talin 1	0.011
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.011
QKI	quaking homolog, KH domain RNA binding (mouse)	0.010
COL6A1	collagen, type VI, alpha 1	0.010
HIST2H3C	histone cluster 2, H3c	0.010
PGF	placental growth factor	0.010