IMP

Process View

Homo sapiens

15 genes annotated in human

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

GO:1902042

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of extrinsic apoptotic signaling pathway via death domain receptors" (in gray)

Name	Description	Probability	Func Analog Organism
CASP8	caspase 8, apoptosis-related cysteine peptidase	1.000
TEK	TEK tyrosine kinase, endothelial	0.988
FGA	fibrinogen alpha chain	0.942
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.933
FADD	Fas (TNFRSF6)-associated via death domain	0.902
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.823
FAS	Fas (TNF receptor superfamily, member 6)	0.821
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.788
FGB	fibrinogen beta chain	0.733
PLAU	plasminogen activator, urokinase	0.619
MAPK1	mitogen-activated protein kinase 1	0.609
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.583
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.475
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.458
MAP2K1	mitogen-activated protein kinase kinase 1	0.343
FGG	fibrinogen gamma chain	0.267
FTL	ferritin, light polypeptide	0.170
CRP	C-reactive protein, pentraxin-related	0.165
PLAUR	plasminogen activator, urokinase receptor	0.161
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.138
TRAF6	TNF receptor-associated factor 6	0.116
SQSTM1	sequestosome 1	0.114
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.089
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.088
PLAT	plasminogen activator, tissue	0.085
TRAF1	TNF receptor-associated factor 1	0.081
CFLAR	CASP8 and FADD-like apoptosis regulator	0.068
TNIP1	TNFAIP3 interacting protein 1	0.062
FASLG	Fas ligand (TNF superfamily, member 6)	0.057
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.056
FHL2	four and a half LIM domains 2	0.055
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.050
ANGPT2	angiopoietin 2	0.050	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.050
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.048
IRAK2	interleukin-1 receptor-associated kinase 2	0.044
SPHK1	sphingosine kinase 1	0.043
KLF5	Kruppel-like factor 5 (intestinal)	0.040
MAPK3	mitogen-activated protein kinase 3	0.039
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.036
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.036
DAXX	death-domain associated protein	0.034
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.033
CIB1	calcium and integrin binding 1 (calmyrin)	0.032
BIRC3	baculoviral IAP repeat containing 3	0.031
DUSP3	dual specificity phosphatase 3	0.030
TNIP2	TNFAIP3 interacting protein 2	0.029
PSEN1	presenilin 1	0.028
ANGPT1	angiopoietin 1	0.026	Human
OSMR	oncostatin M receptor	0.025
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.024
ORM1	orosomucoid 1	0.023
LRP1	low density lipoprotein receptor-related protein 1	0.023
IL8	interleukin 8	0.022
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.022
SOD1	superoxide dismutase 1, soluble	0.022
PEBP4	phosphatidylethanolamine-binding protein 4	0.021
OAZ1	ornithine decarboxylase antizyme 1	0.021
HMGB1	high mobility group box 1	0.020
ATXN3	ataxin 3	0.020
IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	0.019
XIAP	X-linked inhibitor of apoptosis	0.019
CD44	CD44 molecule (Indian blood group)	0.019
ICAM1	intercellular adhesion molecule 1	0.019
IRF1	interferon regulatory factor 1	0.019
ADM	adrenomedullin	0.019
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.017
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.017
DUSP1	dual specificity phosphatase 1	0.017
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.017
CASP8AP2	caspase 8 associated protein 2	0.017
F2	coagulation factor II (thrombin)	0.016
OPTN	optineurin	0.016
BAD	BCL2-associated agonist of cell death	0.016
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.016
AR	androgen receptor	0.016
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.015
RBBP8	retinoblastoma binding protein 8	0.015
TNF	tumor necrosis factor	0.014
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.014
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.014
SH3KBP1	SH3-domain kinase binding protein 1	0.013
FTH1	ferritin, heavy polypeptide 1	0.013
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.013
BCL2L1	BCL2-like 1	0.013
PEBP1	phosphatidylethanolamine binding protein 1	0.012
BAG1	BCL2-associated athanogene	0.012
STC1	stanniocalcin 1	0.012
TIMP1	TIMP metallopeptidase inhibitor 1	0.011
HMGN2	high mobility group nucleosomal binding domain 2	0.011
ITGA7	integrin, alpha 7	0.011
ITGB5	integrin, beta 5	0.011
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.011
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.011
SOD2	superoxide dismutase 2, mitochondrial	0.011
EMP3	epithelial membrane protein 3	0.011
IL6	interleukin 6 (interferon, beta 2)	0.011
SRI	sorcin	0.010
TRAF3	TNF receptor-associated factor 3	0.010
TRADD	TNFRSF1A-associated via death domain	0.010
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.010
MAPK14	mitogen-activated protein kinase 14	0.010
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.010