IMP

Process View

Homo sapiens

12 genes annotated in human

Multi-species View

female sex differentiation

GO:0046660

The establishment of the sex of a female organism by physical differentiation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "female sex differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "female sex differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
INSR	insulin receptor	0.530	Fly
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.491
NCF1	neutrophil cytosolic factor 1	0.261
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.232	Fly
BCL2	B-cell CLL/lymphoma 2	0.146	Mouse Rat
BCL2L1	BCL2-like 1	0.136	Mouse Rat
NRP1	neuropilin 1	0.129
CREBBP	CREB binding protein	0.122
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.119
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.108
TP53	tumor protein p53	0.108
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.106
ESR1	estrogen receptor 1	0.103	Mouse
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.094
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.078
CDK2	cyclin-dependent kinase 2	0.076
GRB10	growth factor receptor-bound protein 10	0.067
EGFR	epidermal growth factor receptor	0.061
PDX1	pancreatic and duodenal homeobox 1	0.060
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.058
POU5F1	POU class 5 homeobox 1	0.056
CCND1	cyclin D1	0.052
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.050
PLAU	plasminogen activator, urokinase	0.048
IRS1	insulin receptor substrate 1	0.047
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.045
AP1M1	adaptor-related protein complex 1, mu 1 subunit	0.045
FSTL1	follistatin-like 1	0.043
MPDZ	multiple PDZ domain protein	0.039
GAS6	growth arrest-specific 6	0.038
VEGFA	vascular endothelial growth factor A	0.037	Mouse
ACTB	actin, beta	0.036
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.036	Mouse
FGFR2	fibroblast growth factor receptor 2	0.034
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.034
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.034
GATA4	GATA binding protein 4	0.033
CCNE1	cyclin E1	0.032	Rat
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.030
TARDBP	TAR DNA binding protein	0.028
PRKCA	protein kinase C, alpha	0.028	Fly
TDGF1	teratocarcinoma-derived growth factor 1	0.026
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.026
IRS2	insulin receptor substrate 2	0.024
AXIN1	axin 1	0.024
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.023
RNR2	l-rRNA	0.023
PLAT	plasminogen activator, tissue	0.022
NF2	neurofibromin 2 (merlin)	0.021
BCAR1	breast cancer anti-estrogen resistance 1	0.020
BAK1	BCL2-antagonist/killer 1	0.020
SFN	stratifin	0.019
SP1	Sp1 transcription factor	0.019
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.019	Fly
JDP2	Jun dimerization protein 2	0.019
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.019
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.018
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.018
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.017
INHBA	inhibin, beta A	0.017
HDAC6	histone deacetylase 6	0.017
TOP1	topoisomerase (DNA) I	0.017
CHD8	chromodomain helicase DNA binding protein 8	0.017
NCOR2	nuclear receptor corepressor 2	0.017
PAX8	paired box 8	0.017
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.017	Fly
HIPK2	homeodomain interacting protein kinase 2	0.016
TRRAP	transformation/transcription domain-associated protein	0.015
BIK	BCL2-interacting killer (apoptosis-inducing)	0.015
CCDC6	coiled-coil domain containing 6	0.015
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.015
PGF	placental growth factor	0.015
EP300	E1A binding protein p300	0.015
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.015
LAT	linker for activation of T cells	0.014
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.014
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.014
CAV1	caveolin 1, caveolae protein, 22kDa	0.014
CSNK1D	casein kinase 1, delta	0.014
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.014
NCOA1	nuclear receptor coactivator 1	0.014
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.013
RAI1	retinoic acid induced 1	0.013
FANCB	Fanconi anemia, complementation group B	0.013
ZNF512B	zinc finger protein 512B	0.013
BRCA2	breast cancer 2, early onset	0.013	Mouse
KITLG	KIT ligand	0.012
FKBP1A	FK506 binding protein 1A, 12kDa	0.012
TP53BP2	tumor protein p53 binding protein, 2	0.012
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.012
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.012
ARRB1	arrestin, beta 1	0.012
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.012	Mouse
TMSB4X	thymosin beta 4, X-linked	0.012
TIMP2	TIMP metallopeptidase inhibitor 2	0.012
GDF5	growth differentiation factor 5	0.011
NDP	Norrie disease (pseudoglioma)	0.011
TEK	TEK tyrosine kinase, endothelial	0.011
HNRPDL	heterogeneous nuclear ribonucleoprotein D-like	0.011
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.011
RNF144B	ring finger protein 144B	0.011
PCGF2	polycomb group ring finger 2	0.011
CSNK1E	casein kinase 1, epsilon	0.011
VEGFC	vascular endothelial growth factor C	0.011
PPP5C	protein phosphatase 5, catalytic subunit	0.011
WT1	Wilms tumor 1	0.011	Mouse
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.010
CPE	carboxypeptidase E	0.010
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.010